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Fabric for fashion : the complete guide : natural and man-made fibers
Fabric For Fashion: The Complete Guide is the only book specifically for fashion designers to explain the behaviour and properties of different fabrics. Fashion design is largely determined by how the fabrics work, move, feel and look. The most successful fashion designers are those who understand their materials, who match design skill with technical knowledge. This book bridges that gap by providing a mix of practical information and industry vocabulary, visually examining generic fabric types, discussing the characteristics of fabrics and showing how to exploit materials to push the boundaries of design. With stunning colour photographs that show how fashion designers, both past and present, have worked with fabrics, the books prime objective is to stimulate creative exploration of the relationship of fabrics to fashion.
Book
Seeking Congruity Between Goals and Roles: A New Look at Why Women Opt Out of Science, Technology, Engineering, and Mathematics Careers
Although women have nearly attained equality with men in several formerly male-dominated fields, they remain underrepresented in the fields of science, technology, engineering, and mathematics (STEM). We argue that one important reason for this discrepancy is that STEM careers are perceived as less likely than careers in other fields to fulfill communal goals (e.g., working with or helping other people). Such perceptions might disproportionately affect women's career decisions, because women tend to endorse communal goals more than men. As predicted, we found that STEM careers, relative to other careers, were perceived to impede communal goals. Moreover, communal-goal endorsement negatively predicted interest in STEM careers, even when controlling for past experience and self-efficacy in science and mathematics. Understanding how communal goals influence people's interest in STEM fields thus provides a new perspective on the issue of women's representation in STEM careers.
Journal Article
Fodor's Prague
Offering value, a vibrant nightlife scene, and one of the most beautiful old cities in all of Europe, it's no wonder that Prague is the single most-visited destination in Eastern Europe. The full-color Fodor's Prague guide provides all the recommendations and tips travelers need for exploring this picturesque city.
Book
Molecular Epidemiology of Cross-Species Giardia duodenalis Transmission in Western Uganda
Giardia duodenalis is prevalent in tropical settings where diverse opportunities exist for transmission between people and animals. We conducted a cross-sectional study of G. duodenalis in people, livestock, and wild primates near Kibale National Park, Uganda, where human-livestock-wildlife interaction is high due to habitat disturbance. Our goal was to infer the cross-species transmission potential of G. duodenalis using molecular methods and to investigate clinical consequences of infection.
Real-time PCR on DNA extracted from fecal samples revealed a combined prevalence of G. duodenalis in people from three villages of 44/108 (40.7%), with prevalence reaching 67.5% in one village. Prevalence rates in livestock and primates were 12.4% and 11.1%, respectively. Age was associated with G. duodenalis infection in people (higher prevalence in individuals
Journal Article
Exploring the Perspectives of Parents of Individuals with Autism from Low-Resourced Communities to Inform Family Navigator Programs
Family navigator programs are becoming increasingly common among families of children with autism. Yet, it is unclear how family navigators are developed; by exploring the input of families of children with autism, such programs can be responsive to family needs. In this study, 12 parents of autistic children from low-resourced communities were interviewed to inform the development of a family navigator program. Findings demonstrated that programs need to prepare navigators to address barriers such as limited knowledge and difficulty accepting an autism diagnosis. Programs should teach navigators to use strategies with families including educating families about services and connecting families with peer support. Program content should reflect direct services, government services, and advocacy strategies. Implications are discussed.
Journal Article
Multiple Representations in Computational Thinking Tasks: A Clinical Study of Second-Grade Students
Computational thinking requires high cognitive load as students work to manage multiple tasks in their problem-solving environment. Through research in K-2 classrooms on computational thinking, we noticed that students lack the representational fluency needed to move from one form to another—such as moving from physical to more abstract representations. Therefore, the following research question was studied: How do second-grade students use and translate among representations to solve computational thinking tasks using the robot mouse game? To address this, we employed a task-based interview approach with three second-grade students who were engaged in four computational thinking tasks using the Code and Go Robot Mouse Coding Activity Set developed by Learning Resources. Through four clinical tasks involving the robot mouse, students solved puzzles set up to force them to make particular representational translations. Each translation involved a level of cognitive complexity the students needed to manage to successfully complete the task. We found that students translated between many different representations using concrete representations to ease translations, language as a scaffold between translations, and embodied movements as representations or to assist with translation. Furthermore, the levels of representational maturity showed by the students varied with the difficulty of the task, and the spatial orientation was particularly difficult for them. These results provide important insights into how learners may develop their ability to engage with abstract representations that will be part of future practices associated with activities in science, mathematics, engineering, and computational thinking.
Journal Article
State mindfulness mediates relation between brief mindfulness training and sustained engagement with social stressor across social anxiety levels
Objectives
One-in-five people experience anticipatory anxiety that impacts engagement in socially evaluative tasks. Metacognitive strategies have the potential to interrupt maladaptive cognitive-emotional cycles and facilitate greater engagement in such tasks. This study hypothesized that brief mindfulness training would increase participants’ likelihood of approaching a socially stressful task more than a brief distraction training by way of greater state mindfulness, and that participants would endorse relevant approach or avoidance motivations for their behavior. The study used an experimental design with random assignment to one of two metacognitive strategy conditions. University students (
n
= 140) with low-to-high social anxiety completed a 10-min mindfulness training or an active control distraction training, followed by a modified Trier Social Stress Test. Participants were instructed to practice the strategy before preparing for the speech, and were then given a choice to approach or avoid giving the speech. SPSS PROCESS was used to examine whether state mindfulness would mediate the relationship between the mindfulness condition and greater likelihood of approaching the speech. Hypotheses regarding mindfulness as a mediator and approach/avoidance motivations for approaching or avoiding the speech both received support. Extending upon cognitive-behavioral theories, social anxiety level may predispose avoidance of social-evaluative situations, though inducing increasing state mindfulness through brief mindfulness training might help mitigate avoidance and facilitate social approach when experiencing anxious affect.
Journal Article
Oral 8-aminoguanine against age-related retinal degeneration
Vision decline in the elderly, often due to retinal aging, predisposes individuals to pathologies like age-related macular degeneration. Currently, there are few effective oral treatments for this condition. Our study introduces an oral agent, 8-aminoguanine (8-AG), which targets age-related retinal degeneration using an aged Fischer 344 rat model. When administered in drinking water at a low dose for 8 weeks starting at 22 months of age, 8-AG significantly preserves retinal structure and function, as evidenced by increased retinal thickness, enhanced photoreceptor integrity, and improved electroretinogram responses. 8-AG reduces apoptosis, oxidative damage, and microglial/macrophage activation in aging retinae. 8-AG also mitigates retinal inflammation at transcriptional and cytokine levels. Extending treatment to 17 weeks further amplifies these protective effects. Given its efficacy in various disease models, 8-AG shows great promise as an anti-aging compound with the potential to mitigate common hallmarks of aging.
Oral treatment of a purine metabolite, 8-aminoguanine (8-AG) protects the retinal morphology and function during aging by mitigating hallmarks of aging, highlighting its potential in treating age-related retinal degeneration.
Journal Article
Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors
Background Arginine depletion interferes with pyrimidine metabolism and DNA damage repair pathways. Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI‐PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in cancer cells with argininosuccinate synthase 1 (ASS1) deficiency. The objective of this study was to assess safety and tolerability of ADI‐PEG 20 and PLD in patients with metastatic solid tumors. Methods Patients with advanced ASS1‐deficient solid tumors were enrolled in this phase 1 trial of ADI‐PEG 20 and PLD following a 3 + 3 design. Eligible patients were given intravenous PLD biweekly and intramuscular (IM) ADI‐PEG 20 weekly. Toxicity and efficacy were evaluated according to the Common Terminology Criteria for Adverse Events (version 4.0) and Response Evaluation Criteria in Solid Tumors (version 1.1), respectively. Results Of 15 enrolled patients, 9 had metastatic HER2‐negative breast carcinoma. We observed no dose‐limiting toxicities or treatment‐related deaths. One patient safely received 880 mg/m2 PLD in this study and 240 mg/m2 doxorubicin previously. Treatment led to stable disease in 9 patients and was associated with a median progression‐free survival time of 3.95 months in 15 patients. Throughout the duration of treatment, decreased arginine and increased citrulline levels in peripheral blood remained significant in a majority of patients. We detected no induction of anti‐ADI‐PEG 20 antibodies by week 8 in one third of patients. Conclusion Concurrent IM injection of ADI‐PEG 20 at 36 mg/m2 weekly and intravenous infusion of PLD at 20 mg/m2 biweekly had an acceptable safety profile in patients with advanced ASS1‐deficient solid tumors. Further evaluation of this combination is under discussion. This combination therapy with ADI‐PEG 20 and Doxil had a reversible and manageable toxicity profile, and patients tolerated the treatment. Tumor shrinkage and prolonged duration of therapy were observed in several patients.
Journal Article
