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"Johnston, H."
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Wildfires, Global Climate Change, and Human Health
Wildfires are increasingly common and projected to worsen with climate change. Health consequences include burns and mental health effects, as well as risks from air pollutants in smoke. Cutting carbon emissions to limit the global temperature increase to 2.0°C or 1.5°C above the preindustrial level would markedly reduce wildfire risks.
Journal Article
Critical Review of Health Impacts of Wildfire Smoke Exposure
Wildfire activity is predicted to increase in many parts of the world due to changes in temperature and precipitation patterns from global climate change. Wildfire smoke contains numerous hazardous air pollutants and many studies have documented population health effects from this exposure.
We aimed to assess the evidence of health effects from exposure to wildfire smoke and to identify susceptible populations.
We reviewed the scientific literature for studies of wildfire smoke exposure on mortality and on respiratory, cardiovascular, mental, and perinatal health. Within those reviewed papers deemed to have minimal risk of bias, we assessed the coherence and consistency of findings.
Consistent evidence documents associations between wildfire smoke exposure and general respiratory health effects, specifically exacerbations of asthma and chronic obstructive pulmonary disease. Growing evidence suggests associations with increased risk of respiratory infections and all-cause mortality. Evidence for cardiovascular effects is mixed, but a few recent studies have reported associations for specific cardiovascular end points. Insufficient research exists to identify specific population subgroups that are more susceptible to wildfire smoke exposure.
Consistent evidence from a large number of studies indicates that wildfire smoke exposure is associated with respiratory morbidity with growing evidence supporting an association with all-cause mortality. More research is needed to clarify which causes of mortality may be associated with wildfire smoke, whether cardiovascular outcomes are associated with wildfire smoke, and if certain populations are more susceptible.
Reid CE, Brauer M, Johnston FH, Jerrett M, Balmes JR, Elliott CT. 2016. Critical review of health impacts of wildfire smoke exposure. Environ Health Perspect 124:1334-1343; http://dx.doi.org/10.1289/ehp.1409277.
Journal Article
Murder, Inc. : the CIA under John F. Kennedy
\"A chronological narrative of the CIA's assassination operations during the Kennedy Administration\"-- Provided by publisher.
BOOK
Ambient particulate matter and biomass burning: an ecological time series study of respiratory and cardiovascular hospital visits in northern Thailand
Background
Exposure to particulate matter (PM) emitted from biomass burning is an increasing concern, particularly in Southeast Asia. It is not yet clear how the source of PM influences the risk of an adverse health outcome. The objective of this study was to quantify and compare health risks of PM from biomass burning and non-biomass burning sources in northern Thailand.
Methods
We collected ambient air pollutant data (PM with a diameter of < 10 μm [PM
10
], PM
2.5
, Carbon Monoxide [CO], Ozone [O
3
], and Nitrogen Dioxide [NO
2
]) from ground-based monitors and daily outpatient hospital visits in Thailand during 2014–2017. Outpatient data included chronic lower respiratory disease (CLRD), ischaemic heart disease (IHD), and cerebrovascular disease (CBVD). We performed an ecological time series analysis to evaluate the association between daily air pollutants and outpatient visits. We used the 90th and 95th percentiles of PM
10
concentrations to determine days of exposure to PM predominantly from biomass burning.
Results
There was significant intra annual variation in PM
10
levels, with the highest concentrations occurring during March, coinciding with peak biomass burning. Incidence Rate Ratios (IRRs) between daily PM
10
and outpatient visits were elevated most on the same day as exposure for CLRD = 1.020 (95% CI: 1.012 to 1.028) and CBVD = 1.020 (95% CI: 1.004 to 1.035), with no association with IHD = 0.994 (95% CI: 0.974 to 1.014). Adjusting for CO tended to increase effect estimates. We did not find evidence of an exposure response relationship with levels of PM
10
on days of biomass burning.
Conclusions
We found same-day exposures of PM
10
to be associated with certain respiratory and cardiovascular outpatient visits. We advise implementing measures to reduce population exposures to PM wherever possible, and to improve understanding of health effects associated with burning specific types of biomass in areas where such large-scale activities occur.
Journal Article
Method of medicine
\"Galen of Pergamum (129-?199/216), physician to the court of the emperor Marcus Aurelius, was a philosopher, scientist, and medical historian, a theoretician and practitioner, who wrote forcefully and prolifically on an astonishing range of subjects and whose impact on later eras rivaled that of Aristotle. Galen synthesized the entirety of Greek medicine as a basis for his own doctrines and practice, which comprehensively embraced theory, practical knowledge, experiment, logic, and a deep understanding of human life and society. Method of Medicine, a systematic and comprehensive account of the principles of treating injury and disease and one of Galen's greatest and most influential works. Enlivening the detailed case studies are many theoretical and polemical discussions, acute social commentary, and personal reflections. The Loeb Method of medicine is in three volumes.\"--Book jacket.
BOOK
Pneumococcal competence is a populational health sensor driving multilevel heterogeneity in response to antibiotics
Competence for natural transformation is a central driver of genetic diversity in bacteria. In the human pathogen
Streptococcus pneumoniae
, competence exhibits a populational character mediated by the stress-induced ComABCDE quorum-sensing (QS) system. Here, we explore how this cell-to-cell communication mechanism proceeds and the functional properties acquired by competent cells grown under lethal stress. We show that populational competence development depends on self-induced cells stochastically emerging in response to stresses, including antibiotics. Competence then propagates through the population from a low threshold density of self-induced cells, defining a biphasic Self-Induction and Propagation (SI&P) QS mechanism. We also reveal that a competent population displays either increased sensitivity or improved tolerance to lethal doses of antibiotics, dependent in the latter case on the competence-induced ComM division inhibitor. Remarkably, these surviving competent cells also display an altered transformation potential. Thus, the unveiled SI&P QS mechanism shapes pneumococcal competence as a health sensor of the clonal population, promoting a bet-hedging strategy that both responds to and drives cells towards heterogeneity.
Stress exposure shapes survival mechanisms in bacteria. Here, the authors show that individual pneumococcal cells react to stress by competence self-induction, which may propagate to non-competent cells, promoting multilevel heterogeneity and favouring survival.
Journal Article
Sex and Gender Differences in Occupational Hazard Exposures: a Scoping Review of the Recent Literature
Purpose of Review
Comparative research on sex and/or gender differences in occupational hazard exposures is necessary for effective work injury and illness prevention strategies. This scoping review summarizes the peer-reviewed literature from 2009 to 2019 on exposure differences to occupational hazards between men and women, across occupations, and within the same occupation.
Recent Findings
Fifty-eight studies retrieved from eight databases met our inclusion criteria. Of these, 30 studies were found on physical hazards, 38 studies on psychological/psychosocial hazards, 5 studies on biological hazards, and 17 studies on chemical hazards. The majority of studies reported that men were exposed to noise, vibration, medical radiation, physically demanding work, solar radiation, falls, biomechanical risks, chemical hazards, and blood contamination; while women were exposed to wet work, bullying and discrimination, work stress, and biological agents. Within the same occupations, men were more likely to be exposed to physical hazards, with the exception of women in health care occupations and exposure to prolonged standing. Women compared to men in the same occupations were more likely to experience harassment, while men compared to women in the same occupations reported higher work stress. Men reported more exposure to hazardous chemicals in the same occupations as women.
Summary
The review suggests that men and women have different exposures to occupational hazards and that these differences are not solely due to a gendered distribution of the labor force by occupation. Findings may inform prevention efforts seeking to reduce gender inequalities in occupational health. Future research is needed to explain the reasons for sex/gender inequality differences in exposures within the same occupation.
Journal Article