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"Joly, Agathe"
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The three musicians : a children's book
\"Beautifully illustrated in the style of Pablo Picasso, this tale of music's ability to soothe a savage beast introduces children to aspects of the great artist's work. The kingdom of Mirador is terrified of a monstrous, fire-spewing beast that lurks just outside the village walls. No one has actually seen the creature except for the king, whose constant reminder of impending danger turns the village gloomy and joyless. One spring day a troupe of musicians and their dog enters the gates. Suddenly there is fun and romance, song and dance. The people are no longer afraid--until the loathsome beast does, in fact, appear. What happens next will delight children and adults alike as the magic of art and music transforms screams of terror into peals of laughter. Drawing on details of Pablo Picasso's masterpiece Three Musicians, artist Vanessa Hiâe uses brightly hued watercolors, bold lines, and graphic images to familiarize children with Picasso's style. The book closes with a reproduction of Picasso's original painting and an engaging lesson on the artist's use of images and symbols, his fascination with theater and music, and his passionate pleas for peace in the wake of world war\"--Publisher's description.
Book
Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial
CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65–79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) negativity rate at 10
−5
by next-generation sequencing at 18 months from randomization. Key secondary endpoints included response rates, MRD assessment rates, survival and safety. The 18-month MRD negativity rates at 10
−5
were reported in 35 patients (26%, 95% confidence interval (CI) 19–34) in IsaRd versus 71 (53%, 95% CI 44–61) in Isa-VRd (odds ratio for MRD negativity 3.16, 95% CI 1.89–5.28,
P
< 0.0001). The MRD benefit was consistent across subgroups at 10
−5
and 10
−6
, and was already observed at month 12. The proportion of patients with complete response or better at 18 months was higher with Isa-VRd (58% versus 33%;
P
< 0.0001), as was the proportion of MRD negativity and complete response or better (37% versus 17%;
P
= 0.0003). At a median follow-up of 23.5 months, no difference was observed for survival times (immature data). The addition of weekly bortezomib did not significantly affect the relative dose intensity of IsaRd. Isa-VRd significantly increased MRD endpoints, including the 18-month negativity rate at 10
−5
, the primary endpoint, compared with IsaRd. This study proposes Isa-VRd as a new SOC for patients with NDMM that are TI. ClinicalTrials.gov identifier:
NCT04751877
.
In patients with newly diagnosed, transplant-ineligible multiple myeloma, addition of weekly bortzomib to isatuximab, lenalidomide and dexamethasone leads to increased minimal residual disease negativity compared with isatuximab, lenalidomide and dexamethasone.
Journal Article
Funny machines for George the sheep : a children's book inspired by Leonardo Da Vinci
George the sheep is troubled that when it begins to rain he shrinks-- but his ingenious shepherd devises a way to solve George's problem.
Book
Hedgehog signaling regulates Wolffian duct development through the primary cilium
Primary cilia play pivotal roles in embryonic patterning and organogenesis through transduction of the Hedgehog signaling pathway (Hh). Although mutations in Hh morphogens impair the development of the gonads and trigger male infertility, the contribution of Hh and primary cilia in the development of male reproductive ductules, including the epididymis, remains unknown. From a Pax2Cre; IFT88fl/fl knock-out mouse model, we found that primary cilia deletion is associated with imbalanced Hh signaling and morphometric changes in the Wolffian duct (WD), the embryonic precursor of the epididymis. Similar effects were observed following pharmacological blockade of primary cilia formation and Hh modulation on WD organotypic cultures. The expression of genes involved in extracellular matrix, mesenchymal-epithelial transition, canonical Hh and WD development was significantly altered after treatments. Altogether, we identified the primary cilia-dependent Hh signaling as a master regulator of genes involved in WD development. This provides new insights regarding the etiology of sexual differentiation and male infertility issues. Summary Sentence Modulation of primary-ciliogenesis and downstream Hedgehog signaling controls Wolffian duct development.
Journal Article
The two doves
A beloved emblem of world peace--the dove--comes to life in this moving story that introduces Pablo Picasso and his art to young readers.
BOOK
Emergency Care for Homeless Patients: A French Multicenter Cohort Study
Objectives. To determine whether homeless patients experience suboptimal care in the emergency department (ED) by the provision of fewer health care resources. Methods. We conducted a prospective multicenter cohort study in 30 EDs in France. During 72 hours in March 2015, all homeless patients that visited the participating EDs were included in the study. The primary health care service measure was the order by the physician of a diagnostic investigation or provision of a treatment in the ED. Secondary measures of health care services included ED waiting time, number and type of investigations per patient, treatment in the ED, and discharge disposition. Results. A total of 254 homeless patients and 254 nonhomeless patients were included. After excluding homeless patients that attended the ED for the sole purpose of housing, we analyzed 214 homeless and 214 nonhomeless. We found no significant difference between the 2 groups in terms of health care resource consumption, and for our secondary endpoints. Conclusions. We did not find significant differences in the level of medical care delivered in French EDs to homeless patients compared with matched nonhomeless patients.
Journal Article
The magical tree
\"Inspired by Klimt's famous mural The Tree of Life, this dreamily illustrated children's book tells the story of a magical tree whose fruit saves lives. Painted during the artist's \"golden period,\" Gustav Klimt's The Tree of Life has been interpreted in myriad ways. This children's book deftly incorporates the mysteries and depth of Klimt's masterpiece into a story for young readers. A young man is given a seed that grows into a beautiful fruit-bearing tree. After tasting the fruit, he can see into the future, including events that will put the lives of others in danger. A king and his lovely princess daughter test the boy's predictions, and love ensues. The book includes a gorgeous reproduction of The Tree of Life, along with information about Klimt and his work\"--Amazon.
Book
Science at Risk: The Urgent Need for Institutional Support of Long-Term Ecological and Evolutionary Research in an Era of Data Manipulation and Disinformation
Planet Earth and the biodiversity it supports are in crisis. Human impact on terrestrial, marine and freshwater ecosystems and the hundreds of thousands of organisms that inhabit them is global. To what extent can we push ecosystems before they collapse? Will species adapt to these changes and at what rate? What are the consequences, for the environment and humankind? These are some of the most pressing issues to date. Clear answers can only be addressed through long-term research programs that are extremely complex in their deployment, and by the analyses of the unique data they produce on species and ecosystem responses to change. Yet, too little institutional support and consideration have been given to long-term ecological and evolutionary research. We describe the action recently taken by the French National Center for Scientific Research (CNRS) to recognize and support long-term ecological and evolutionary research. We provide some salient examples of critical knowledge attainable only through long-term studies in ecology and evolution, before highlighting how global institutional schemes can not only support long-term research, but lead to informed conservation efforts and societal change. Now more than ever, as populism grows and fuels mis-and dis-informed politics, governmental programs are urgently needed to support data collection, establish data-grounded facts, inform political spheres, and refuel trust with society at large.
Paper
Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial
Abstract CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65–79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) negativity rate at 10 −5 by next-generation sequencing at 18 months from randomization. Key secondary endpoints included response rates, MRD assessment rates, survival and safety. The 18-month MRD negativity rates at 10 −5 were reported in 35 patients (26%, 95% confidence interval (CI) 19–34) in IsaRd versus 71 (53%, 95% CI 44–61) in Isa-VRd (odds ratio for MRD negativity 3.16, 95% CI 1.89–5.28, P < 0.0001). The MRD benefit was consistent across subgroups at 10 −5 and 10 −6 , and was already observed at month 12. The proportion of patients with complete response or better at 18 months was higher with Isa-VRd (58% versus 33%; P < 0.0001), as was the proportion of MRD negativity and complete response or better (37% versus 17%; P = 0.0003). At a median follow-up of 23.5 months, no difference was observed for survival times (immature data). The addition of weekly bortezomib did not significantly affect the relative dose intensity of IsaRd. Isa-VRd significantly increased MRD endpoints, including the 18-month negativity rate at 10 −5 , the primary endpoint, compared with IsaRd. This study proposes Isa-VRd as a new SOC for patients with NDMM that are TI. ClinicalTrials.gov identifier: NCT04751877 .
Magazine Article