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Particle size measurement of aerosolized particles from orally inhaled and nasal drug products (OINDPs) can be used to assess the likely deposition distribution in the human respiratory tract (HRT). Size is normally expressed in terms of aerodynamic diameter, since this scale directly relates to the mechanics of particle transport from inhaler to deposition locations. The multistage cascade impactor (CI) is the principal apparatus used to size fractionate aerosols in terms of their aerodynamic particle size distributions (APSDs). Clinically meaningful metrics, such as fine and coarse particle mass fractions, can be determined from the cumulative mass-weighted APSD. In effective data analysis (EDA), CI data are reduced to small and large particle mass. The sum and ratio of these metrics are used to characterize impactor-sized mass, without the need for stage groupings or other APSD interpretation. Aerosol characterization by full-resolution CI is complex, and so, an abbreviated impactor measurement has recently come to prominence. Here, multiple stages of the CI are reduced to just one or two size fractionating stages so that measures of fine (and extrafine) particle mass from a two-stage system can be directly determined without the need to group the mass of active pharmaceutical ingredient (API) on adjacent stages. Time-of-flight-based methods determine APSD more rapidly but require refinements such as single-particle mass spectroscopy to relate size measurements to API content. Alternatives for size characterizing OINDP aerosols are few; laser diffractometry is by far the most important, especially for nasal sprays and solution-based orally inhaled formulations in which there is no confounding of data from suspended excipient(s). Laser-phase Doppler anemometry (L-PDA) has also been shown to be useful for nasal sprays. If aerodynamic size-related information is not a priority, optical microscopy combined with Raman chemical imaging offers prospects for separate determination of API components in combination product-generated aerosols.

Incisive contributions from leading and emerging scholars in the field of Peace Studies In the Wiley Blackwell Companion to Religion and Peace, a team of renowned scholars delivers an authoritative and interdisciplinary sourcebook that addresses the key concepts, history, theories, models, resources, and practices in the complex and ambivalent relationship between religion and peace. The editors have included contributions from a wide range of perspectives and locations that reflect diverse methods and approaches. The Companion provides a collection grounded in experience and context that draws on established, developing, and new research characterized by academic rigor. The differences between the approaches taken by several religious traditions are fully explored and numerous case studies highlight relevant theories, models, and resources. Accessible as either a standalone collection or as a partner to the Companion to Religion and Violence, this edited volume also offers: * A thorough introduction to religion and its search for peace, including the relationships between religion and peace and theories and practices for studying the interplay between religion and peace * Comprehensive explorations of religion and peace in local contexts, including discussions of women's empowerment and peacebuilding in an Islamic context * Practical discussions of practices and embodiments of religion and peace, including treatments of museums for peace and self-religion in global peace movements * In-depth examinations of lived Christian theologies and building peace, including discussions of Martin Luther King Jr. and spiritual activism in Scotland Perfect for students and scholars of peacemaking, peacekeeping, and peace building, the Wiley Blackwell Companion to Religion and Peace will also earn a place in the libraries of anyone professionally or personally interested in the field of Peace or Religious Studies, International Relations, History, Politics, or Theology.

Although nasal inhalation products are becoming more and more important for the delivery of medicines, characterization of these products for quality control and assessment of bioequivalence is complicated. Most of the problems encountered are associated with the assessment of aerodynamic droplet/particle size distribution (APSD). The droplets produced by the various nasal devices are large, and for suspension products, individual droplets may contain multiple drug particles or none at all. Assessment of suspension products is further complicated by the presence of solid excipient particles. These complications make it imperative that the limitations of the instruments used for characterization as well as the underlying assumptions that govern the interpretation of data produced by these instruments are understood. In this paper, we describe various methodologies used to assess APSD for nasal inhalation products and discuss proper use, limitations, and new methodologies on the horizon.

Background: Determination of aerosol aerodynamic particle size distributions (APSD) from dry-powder inhalers (DPIs), following quality control procedures in the pharmacopeial compendia, requires that the flow through the measurement apparatus, comprising induction port, optional pre-separator, and cascade impactor, starts from zero on actuation of the inhaler, using a solenoid valve to apply vacuum to the apparatus exit. The target flow rate, governed by the inhaler resistance, is reached some time afterward. Understanding the behavior of the DPI design-specific flow rate-rise time curve can provide information about the kinetics of the initial powder dispersion in the inhaler and subsequent transport through the APSD measurement equipment. Accurate and precise measures of the internal volume of each component of this apparatus are required to enable reliable relationships to be established between this parameter and those defining the flow rate-rise time curve. Methods: An improved method is described that involves progressive withdrawal of an accurately known volume of air from the interior passageways of the apparatus-on-test that are closed to the outside atmosphere. This approach is applicable for determining internal volumes of components having complex internal geometries. Filling some components with water, along with volumetric or gravimetric measurement, has proven valuable for the induction port and for checking other measurements. Results: Values of internal volume are provided for the USP (United States Pharmacopeia)/PhEur (European Pharmacopoeia) induction port, the Next-Generation Impactor (NGI™) with and without its pre-separator, and various Andersen 8-stage cascade impactor configurations with and without their pre-separators. Conclusion: These data are more accurate and precise, and therefore update those reported by Copley et al.

Multiple sources must be consulted to determine the most appropriate procedures for the laboratory-based performance evaluation of aqueous oral inhaled products (OIPs) for the primary measures, dose uniformity/delivery, and aerodynamic particle (droplet) size distribution (APSD). These sources have been developed at different times, mainly in Europe and North America, during the past 25 years by diverse organizations, including pharmacopeial chapter/monograph development committees, regulatory agencies, and national and international standards bodies. As a result, there is a lack of consistency across all the recommendations, with the potential to cause confusion to those developing performance test methods. We have reviewed key methodological aspects of source guidance documents identified by a survey of the pertinent literature and evaluated the underlying evidence supporting their recommendations for the evaluation of these performance measures. We have also subsequently developed a consistent series of solutions to guide those faced with the various associated challenges when developing OIP performance testing methods for oral aqueous inhaled products.

This book explores how media and religion combine to play a role in promoting peace and inciting violence. It analyses a wide range of media - from posters, cartoons and stained glass to websites, radio and film - and draws on diverse examples from around the world, including Iran, Rwanda and South Africa. Part One considers how various media forms can contribute to the creation of violent environments: by memorialising past hurts; by instilling fear of the 'other'; by encouraging audiences to fight, to die or to kill neighbours for an apparently greater good. Part Two explores how film can bear witness to past acts of violence, how film-makers can reveal the search for truth, justice and reconciliation, and how new media can become sites for non-violent responses to terrorism and government oppression. To what extent can popular media arts contribute to imagining and building peace, transforming weapons into art, swords into ploughshares? Jolyon Mitchell skillfully combines personal narrative, practical insight and academic analysis.

The aerosol literature has properly identified aerodynamic size of the inhaled product as one of many competing factors influencing aerosol behavior in the lung. Since there are many influences on clinical response, we believe that the approach advocated by these members of the Small Airways Study Group of the Respiratory Effectiveness Group is not helpful at all to the practicing clinician. [...]factors that determine where a therapeutic aerosol deposits within the respiratory tract, thereby affecting in vivo outcomes, include the inspiratory flow rate profile, the temperature and humidity within the respiratory tract (which influence particle growth), and more complex aspects associated with the differing types and degrees of lung disease (airway obstruction, changes to airway morphology, parenchymal destruction, etc.). (13) Setting rigid limits for the different sized fractions of an inhaled aerosol, therefore, takes no account of differences in particle regional deposition behavior associated with age-related airway development and also ignores the changes resulting from disease in these neonatal and pediatric patients. [...]we assert that the particle size property of therapeutic aerosols is always a continuum with no convenient boundaries between subfractions extrafine, fine, and coarse particles.