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Since the year 2000, artists have increasingly employed tools, methods, and aesthetics associated with scientific practice to produce forms of art that assert themselves as kinds of experimental and empirical knowledge production parallel to and in critical dialogue with science. Anthropologists, intrigued by the work of art in the age of its technoscientific affiliation, have taken notice. This article discusses bio art, eco art, and surveillance art that have gathered, or might yet reward, anthropological attention, particularly as it might operate as an allied form of cultural critique. We focus on art that takes oceans as its concern, tuning to anthropological interests in translocal connection, climate change, and the politics of the extraterritorial. We end with a call for decolonizing art-science and for an anti-colonial aesthetics of oceanic worlds.

Acute kidney injury (AKI), a common complication in paediatric intensive care units (PICU), is associated with increased morbidity and mortality. In this single centre, prospective, observational cohort study, neutrophil gelatinase-associated lipocalin in urine (uNGAL) and plasma (pNGAL) and renal angina index (RAI), and combinations of these markers, were assessed for their ability to predict severe (stage 2 or 3) AKI in children and young people admitted to PICU. In PICU children and young people had initial and serial uNGAL and pNGAL measurements, RAI calculation on day 1, and collection of clinical data, including serum creatinine measurements. Primary outcomes were severe AKI and renal replacement therapy (RRT). Secondary outcomes were length of stay, hospital acquired infection and mortality. The area under the Receiver Operating Characteristic (ROC) curves and Youden index was used to determine biomarker performance and identify optimum cut-off values. Of 657 children recruited, 104 met criteria for severe AKI (15∙8%) and 47 (7∙2%) required RRT. Severe AKI was associated with increased length of stay, hospital acquired infection, and mortality. The area under the curve (AUC) for severe AKI prediction for Day 1 uNGAL, Day 1 pNGAL and RAI were 0.75 (95% Confidence Interval [CI] 0∙69, 0∙81), 0∙64 (95% CI 0∙56, 0∙72), and 0.73 (95% CI 0∙65, 0∙80) respectively. The optimal combination of measures was RAI and day 1 uNGAL, giving an AUC of 0∙80 for severe AKI prediction (95% CI 0∙71, 0∙88). In this heterogenous PICU cohort, urine or plasma NGAL in isolation had poorer prediction accuracy for severe AKI than in previously reported homogeneous populations. However, when combined together with RAI, they produced good prediction for severe AKI.

Henoch Schonlein Purpura (HSP) is the commonest systemic vasculitis of childhood typically presenting with a palpable purpuric rash and frequently involving the renal system. We are the first group to clinically assess, critically analyse and subsequently revise a nurse led monitoring pathway for this condition.A cohort of 102 children presenting with HSP to a secondary/tertiary level UK paediatric hospital over a five year period, were monitored using a nurse led care pathway. Using this cohort, the incidence (6.21 cases per 100,000 children per year) and natural disease course of HSP nephritis (46% initial renal inflammation; 9% subsequent renal referral; 1% renal biopsy and immunosuppression) was determined. Older patients were at higher risk of requiring a renal referral (renal referral 12.3 (8.4-13.5) years vs. normal outcome 6.0 (3.7-8.5) years; p<0.01). A normal urinalysis on day 7 had a 97% (confidence interval 90 to 99%) negative predictive value in predicting a normal renal outcome.Using this data and existing literature base, The Alder Hey Henoch Schonlein Purpura Pathway was developed, a revised pathway for the screening of poor renal outcome in HSP. This is based on a six-month monitoring period for all patients presenting with HSP, which importantly prioritises patients according to the urine findings on day 7 and thus intensively monitors those at higher risk of developing nephritis. The pathway could be easily adapted for use in different settings and resources.The introduction of a standardised pathway for the monitoring of HSP will facilitate the implementation of disease registries to further our understanding of the condition and permit future clinical trials.

Early childhood practitioners are often reluctant to see themselves as leaders and managers. However, all those who work with young children and their families, whatever their level of experience and competence, have to undertake both of these roles on a daily basis.This book encourages practitioners to recognise their active involvement in leadership and management in relation to their work as team leader or team member, and in their work with parents and other professionals, to ensure appropriate and effective provision for young children.The authors identify a number of key principles involved in effective early years leadership and management, which focus on the idea that: Leadership is about influencing others to improve and enhance children's care, learning and developmentLeadership is only effective if it develops the leadership of others by supporting a team or group in meeting their declared aims or visionLeadership is ultimately distributed, shared and dispersed in early childhood settingsThese principles are supported by a detailed exploration of the statutory demands made on practitioners working with young children and their families, and reference to relevant literature drawn from both early childhood studies and leadership theories.As well as providing guidance on the roles, responsibilities and tasks facing early childhood leaders, the book features a number of case studies and practical tasks, giving life to concepts and ideas and enabling readers to apply theories and policies to their own work settings. Additional activities at the end of each chapter further support practitioners in fulfilling their leadership and management roles in practice. Leadership and Management in the Early Yearsis an essential text for early years and early childhood studies students as well as practitioners particularly those who are aiming for Early Years Professional Status.

BackgroundSteroid-resistant nephrotic syndrome (SRNS), commonly caused by focal segmental glomerulosclerosis (FSGS), is associated with progression to stage 5 chronic kidney disease, requirement for kidney replacement therapy and a risk of disease recurrence post-kidney transplantation. Ofatumumab (OFA) is a fully humanised monoclonal antibody to CD20, with similar mechanisms of action to rituximab (RTX).MethodsWe report a case series of seven UK patients (five paediatric, two adult), all of whom developed FSGS recurrence after kidney transplantation and received OFA as part of their therapeutic intervention. All also received concomitant plasmapheresis. The 2-year outcome of these seven patients is reported, describing clinical course, kidney function and proteinuria.ResultsFour patients (all paediatric) achieved complete urinary remission with minimal proteinuria 12 months post-treatment. Three of those four also had normal graft function. Two patients showed partial remission—brief improvement to non-nephrotic proteinuria (197 mg/mmol) in one patient, maintained improvement in kidney function (estimated glomerular filtration rate 76 ml/min/1.73 m2) in the other. One patient did not demonstrate any response.ConclusionsOFA may represent a useful addition to therapeutic options in the management of FSGS recurrence post-transplantation, including where RTX has shown no benefit. Concomitant plasmapheresis in all patients prevents any definitive conclusion that OFA was the beneficial intervention.

Adam Pendleton's decision to shoot his 2016 portrait of Yvonne Rainer in black and white opens up the possibility of a formally seamless appropriation and reframing of the 1978 black-and-white film of Trio A, Rainer's most famous choreographic work, first presented in 1966. Pendleton's appropriation, nesting, and recoding of Rainer's film footage - using most of Trio A - functions through a systematic signification of seaming that is communicated by the heavy sampling of this recorded dance. Just Back from Los Angeles: A Portrait of Yvonne tiainer premiered at Anthology Film Archives on Jan 9,2017 as part of the commissioning biennial Performa, and it now exists in a gallery-distributed edition. Featuring the legendary theorist-performer of Minimalism's heyday, Pendleton's film both honors Rainer's brainy, unabashed feminism and stands for a new generation confronting Minimalism's seventies episteme.

This accessible text provides guidance on the inclusion of young children with special educational needs or disabilities in a variety of early education settings.The author highlights the complexity of early identification and assessment of children described as having special educational needs.

Background In juvenile-onset systemic lupus erythematosus (JSLE), renal involvement (lupus nephritis) is frequently seen and can result in long-term morbidity. This prospective longitudinal study aimed to identify the utility of standard and/or novel biomarkers for monitoring and predicting lupus nephritis in a real world setting. Methods Using an unselected JSLE cohort, urine samples were collected during routine clinical review. Protein concentrations of urinary monocyte chemo-attractant protein 1 (uMCP1) and neutrophil gelatinase-associated lipocalin (uNGAL) were analysed along with standard disease activity markers, and were compared with current and subsequent disease activity. Results JSLE patients ( n  = 64; median age 14.1 years) were seen at 3 (interquartile range: 2–5) clinical reviews over 364 (182–532) days. Multivariate analysis demonstrated uMCP1 and serum C3 as independent variables ( p  < 0.001) for active renal disease at the time of the current review. uMCP1 was an excellent predictor of improved renal disease over time (AUC: 0.81; p  = 0.013). uNGAL was a good predictor of worsened renal disease activity (AUC 0.76; p  = 0.04) over time. Conclusion Biomarkers (uMCP1, serum C3) can indicate current renal involvement in JSLE, whilst uMCP1 and uNGAL are able to predict subsequent renal disease activity changes. Moving towards biomarker-led monitoring may improve the renal outcome for our patients.

A provisional taxonomy of contemporary-art-world keywords dangling from the prefix re is discussed. Taxonomizing a phenomenon far more pervasive and insistent than just another stage of postmodern pastiche, appropriation, or simulation. Paradoxically, today's returns have gravitated toward postwar moments in which the originary object of art was already under assault, pushed into process, performance, transience, only to induce a renewed fantasy of presence and objecthood, as if finally to arrest and reify works once fervently held to resist such calcification. Among the terms with prefix re include readymade and reanimate.

Jones discusses the artist-function and posthumous art history. Most art history is about dead artists. This is a statistical reality, but occasionally it forms the theme of art itself, as when the photographer Hippolyte Bayard constructed a documentation of himself in 1840 as already dead. The posthumous reputation of the artist needs care and tending in its relationship to the market. An appropriate caretaker is not an undertaker embalming the corpus along with the corpse. Rather, the sensitive executor is like a gardener, familiar with art’s ecology, tending the work that remains, balancing the compost of images, discourse, and materials that generate the capacity for new readings with exhibitions, careful collection placements, and even an openness to contemporary artistic appropriations that keep the original art alive. What is certain is that the artist-function must be deftly handled, balancing production between conception and delegation, between outsourced labor and its arrogation by an author/artist, between market supply and collector demand—in the end, balancing desire and satiety within the murmuring crowd. We all participate in the artist-function.