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239
result(s) for
"Jones, Gareth (Gareth P.)"
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Outback attack
The Ninja Meerkats go to Australia to rescue a kidnapped professor, and run into the evil Ringmaster.
Book
Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets
The objective of this study was to demonstrate the efficacy of acute inactivation of brain areas by cooling in the behaving ferret and to demonstrate that cooling auditory cortex produced a localisation deficit that was specific to auditory stimuli. The effect of cooling on neural activity was measured in anesthetized ferret cortex. The behavioural effect of cooling was determined in a benchmark sound localisation task in which inactivation of primary auditory cortex (A1) is known to impair performance. Cooling strongly suppressed the spontaneous and stimulus-evoked firing rates of cortical neurons when the cooling loop was held at temperatures below 10°C, and this suppression was reversed when the cortical temperature recovered. Cooling of ferret auditory cortex during behavioural testing impaired sound localisation performance, with unilateral cooling producing selective deficits in the hemifield contralateral to cooling, and bilateral cooling producing deficits on both sides of space. The deficit in sound localisation induced by inactivation of A1 was not caused by motivational or locomotor changes since inactivation of A1 did not affect localisation of visual stimuli in the same context.
Journal Article
Hollywood showdown
The fearless ninja meerkats face their deadly foe, Ringmaster, in Hollywood.
Book
Oxycodone and Naloxone Combination: A 12-Week Follow-up in 20 Patients Shows Effective Analgesia Without Opioid-Induced Bowel Dysfunction
Introduction
Opioid analgesics are widely regarded to be highly effective but are equally known for their side effects on the bowel. A new combination of the opioid analgesic oxycodone and naloxone has been developed to combat opioid-induced bowel dysfunction (OIBD) whilst still being effective as an analgesic. The aim of this observational study was to assess the analgesic efficacy of this new combination and to analyze its effect on bowel function.
Methods
Twenty-six patients underwent a trial of this new combination, with 21 patients reaching week 8 and 18 reaching week 12.
Results
A significant reduction was seen in the pain severity score at weeks 4, 8, and 12 (
P
< 0.05), and a significant improvement in the bowel function index was again seen at these points (
P
< 0.001 at week 4 and 12,
P
< 0.05 at week 8). In the patients’ global impression of change, 83.3% of patients rated the new medication as an improvement compared to their previous regimen, and 87.5% rated it overall as “good” or “very good.”
Conclusion
This small single-center study suggests that the use of ONC in selected patients could lead to an improvement in pain severity and pain interference with a significant improvement in OIBD. Compliance with the combination is good, and it is generally well tolerated.
Journal Article
No true Echo
\"Teenaged Eddie meets a new girl who is a Senior Echo Time Agent from the future, come to his town to investigate the origin of time travel. Soon Eddie is swept up in the investigation and in time. But time travel is a dangerous business, and Eddie will learn more than he wants to know about his long-dead mother\"-- Provided by publisher.
Book
The Vestibular System Mediates Sensation of Low-Frequency Sounds in Mice
The mammalian inner ear contains sense organs responsible for detecting sound, gravity and linear acceleration, and angular acceleration. Of these organs, the cochlea is involved in hearing, while the sacculus and utriculus serve to detect linear acceleration. Recent evidence from birds and mammals, including humans, has shown that the sacculus, a hearing organ in many lower vertebrates, has retained some of its ancestral acoustic sensitivity. Here we provide not only more evidence for the retained acoustic sensitivity of the sacculus, but we also found that acoustic stimulation of the sacculus has behavioral significance in mammals. We show that the amplitude of an elicited auditory startle response is greater when the startle stimuli are presented simultaneously with a low-frequency masker, including masker tones that are outside the sensitivity range of the cochlea. Masker-enhanced auditory startle responses were also observed in otoconia-absent Nox3 mice, which lack otoconia but have no obvious cochlea pathology. However, masker enhancement was not observed in otoconia-absent Nox3 mice if the low-frequency masker tones were outside the sensitivity range of the cochlea. This last observation confirms that otoconial organs, most likely the sacculus, contribute to behavioral responses to low-frequency sounds in mice.
Journal Article
The eye of the monkey
\"An Indian emerald with mystical powers has been stolen from under the noses of the monkeys who guard it. The meerkats team up with kung fu supremo the Delhi Llama to investigate.\"--Amazon.com.
Book
The clan of the scorpion
\"Armed to the teeth with ninja know-how, this ultimate fighting force has one goal--to thwart the evil Ringmaster's plans for world domination.\"--Amazon.com.
Book
Successful use of stellate ganglion block and a new centrally acting analgesic with dual mode of action in a resistant temporomandibular joint pain
Stellate ganglion blocks have been shown to provide effective pain relief in a number of different conditions involving the upper body. This was demonstrated in a 65-year-old woman who had experienced severe debilitating pain in her left temporomandibular joint (TMJ) and the surrounding area of her face for over 10 years. The pain was unresponsive to indomethacin, carbamazepine, sodium valproate, gabapentin, lithium, melatonin and amitriptyline. She had also had four surgical procedures to the TMJ without success. The pain was partially responsive to Syndol tablets and pregabalin, although the use of pregabalin was limited by its adverse effects. The patient underwent 13 ultrasound guided stellate ganglion blocks over a 24-month period which demonstrated 90% pain relief for up to 10 weeks. Pulsed radio frequency lesioning showed no benefit over stellate ganglion block. More recently, tapentadol was found to be effective and this replaced the stellate ganglion blocks.
Journal Article