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Effects of Allopurinol on the Progression of Chronic Kidney Disease
This randomized trial assessed whether urate-lowering treatment with allopurinol could attenuate eGFR decline in at-risk patients with stage 3 or 4 chronic kidney disease. Allopurinol did not slow the decline in eGFR as compared with placebo.
Journal Article
Proficiency Testing/External Quality Assessment: Current Challenges and Future Directions
Proficiency testing (PT), or external quality assessment (EQA), is intended to verify on a recurring basis that laboratory results conform to expectations for the quality required for patient care.
Key factors for interpreting PT/EQA results are knowledge of the commutability of the samples used and the process used for target value assignment. A commutable PT/EQA sample demonstrates the same numeric relationship between different measurement procedures as that expected for patients' samples. Noncommutable PT/EQA samples frequently have a matrix-related bias of unknown magnitude that limits interpretation of results. PT/EQA results for commutable samples can be used to assess accuracy against a reference measurement procedure or a designated comparison method. In addition, the agreement of the results between different measurement procedures for commutable samples reflects that which would be seen for patients' samples. PT/EQA results for noncommutable samples must be compared to a peer group mean/median of results from participants who use measurement procedures that are expected to have the same or very similar matrix-related bias. Peer group evaluation is used to asses whether a laboratory is using a measurement procedure in conformance to the manufacturer's specifications and/or in conformance to other laboratories using the same technology. A noncommutable PT/EQA sample does not give meaningful information about the relationship of results for patients' samples between different measurement procedures.
PT/EQA provides substantial value to the practice of laboratory medicine by assessing the performance of individual laboratories and, when commutable samples are used, the status of standardization or harmonization among different measurement procedures.
Journal Article
Mongrels : a novel
Set in the deep South, Mongrels is a deeply moving, sometimes grisly, and surprisingly funny novel that follows an unnamed narrator as he comes of age under the care of his aunt and uncle - who are werewolves.
Book
Divergence Estimation in the Presence of Incomplete Lineage Sorting and Migration
This article focuses on the problem of estimating a species tree from multilocus data in the presence of incomplete lineage sorting and migration. I develop a mathematical model similar to IMa2 (Hey 2010) for the relevant evolutionary processes which allows both the population size parameters and the migration rates between pairs of species tree branches to be integrated out. I then describe a BEAST2 package DENIM (Divergence estimation notwithstanding ILS and migration) which is based on this model and which uses an approximation to sample from the posterior. The approximation is based on the assumption that migrations are rare, and it only samples from certain regions of the posterior which seem likely given this assumption. The method breaks down if there is a lot of migration. Using simulations, Leaché et al. (2014) showed that using the standard multispecies coalescent model to infer a species tree can result in poor accuracy if migration is present. I reanalyze this simulated data to explore DENIM’s performance and demonstrate substantial improvements in accuracy over *BEAST. I also reanalyze an empirical data set.
Journal Article
My heart is a chainsaw
\"In her quickly gentrifying rural lake town Jade sees recent events only her encyclopedic knowledge of horror films could have prepared her for in this latest novel from the Jordan Peele of horror literature, Stephen Graham Jones. \"Some girls just don't know how to die...\" Shirley Jackson meets Friday the 13th in My Heart Is a Chainsaw, written by the New York Times bestselling author of The Only Good Indians Stephen Graham Jones, called \"a literary master\" by National Book Award winner Tananarive Due and \"one of our most talented living writers\" by Tommy Orange. Alma Katsu calls My Heart Is a Chainsaw \"a homage to slasher films that also manages to defy and transcend genre.\" On the surface is a story of murder in small-town America. But beneath is its beating heart: a biting critique of American colonialism, Indigenous displacement, and gentrification, and a heartbreaking portrait of a broken young girl who uses horror movies to cope with the horror of her own life. Jade Daniels is an angry, half-Indian outcast with an abusive father, an absent mother, and an entire town that wants nothing to do with her. She lives in her own world, a world in which protection comes from an unusual source: horror movies...especially the ones where a masked killer seeks revenge on a world that wronged them. And Jade narrates the quirky history of Proofrock as if it is one of those movies. But when blood actually starts to spill into the waters of Indian Lake, she pulls us into her dizzying, encyclopedic mind of blood and masked murderers, and predicts exactly how the plot will unfold. Yet, even as Jade drags us into her dark fever dream, a surprising and intimate portrait emerges...a portrait of the scared and traumatized little girl beneath the Jason Voorhees mask: angry, yes, but also a girl who easily cries, fiercely loves, and desperately wants a home. A girl whose feelings are too big for her body. My Heart Is a Chainsaw is her story, her homage to horror and revenge and triumph\"-- Provided by publisher.
Book
Secrecy
Although expansions of state secrecy and the countervailing leaks of classified documents imbue the anthropology of secrecy with urgent relevance, secrecy has a long-standing status as a paradigmatically anthropological topic. In the ethnographic record, initiatory secrets often stand for the quiddity of culture, and the revelation of concealed realities is an organizing trope in much ethnographic writing. While situating research on secrecy as a reflection of epistemological and ethical dimensions of cultural anthropology more broadly, this review simultaneously explores parallels between different anthropological traditions by focusing on descriptions of the media through which social relations involving secrecy are transacted. Attending to ethnographic accounts of the way secrets travel across different media and coexist simultaneously in various mediated states provides both a novel intellectual framework for surveying recent research and a basis for conceptualizing the anthropology of secrecy itself as a practice that involves intermedial and transmedial knowledge flows.
Journal Article