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On guard
\"She is the star player on her basketball team, until her sister is injured in a violent crime. Instantly, her game is derailed, and she becomes a second victim. Can she save her scholarship season?\"-- Provided by publisher.
Book
Functional agonism of insect odorant receptor ion channels
In insects, odor cues are discriminated through a divergent family of odorant receptors (ORs). A functional OR complex consists of both a conventional odorant-binding OR and a nonconventional coreceptor (Orco) that is highly conserved across insect taxa. Recent reports have characterized insect ORs as ion channels, but the precise mechanism of signaling remains unclear. We report the identification and characterization of an Orco family agonist, VUAA1, using the Anopheles gambiae coreceptor (AgOrco) and other orthologues. These studies reveal that the Orco family can form functional ion channels in the absence of an odor-binding OR, and in addition, demonstrate a first-in-class agonist to further research in insect OR signaling. In light of the extraordinary conservation and widespread expression of the Orco family, VUAA1 represents a powerful new family of compounds that can be used to disrupt the destructive behaviors of nuisance insects, agricultural pests, and disease vectors alike.
Journal Article
Slammed : Honda Civic
\"After getting out of reform school, DeAndre lands back in the life that put him there: racing souped-up cars with stolen parts. But in trying to earn back his Detroit cred--and his girlfriend--he'll learn what it really means to win\"-- Provided by publisher.
Book
Suction use in ureterorenoscopy: A systematic review and meta‐analysis of comparative studies
Objectives Ureterorenoscopy is seeing a bloom of technological advances, one of which is incorporating suction. The objective of this study is to systematically review existing literature regarding suction use in rigid and flexible ureterorenoscopy and perform meta‐analysis of studies comparing suction versus no suction ureteroscopy or mini percutaneous nephrolithotomy (PCNL). Methods A literature search was performed (November 2023) in MEDLINE, Embase and Cochrane CENTRAL. Study protocol was registered at PROSPERO (CRD42023482360). Comparative studies (observational and randomized) were eligible for inclusion if they compared suction versus no suction group and reported at least one primary outcome of interest (stone‐free or complication rate). Results Sixteen studies (5 randomized and 11 observational), analysing 1086 and 1109 patients in standard and suction groups, respectively, were included. Final stone‐free rates (SFRs), overall and infectious complications and length of hospital stay exhibited significant improvement when suction was used. When mini‐PCNL was compared with flexible ureterorenoscopy with suction, no differences were found in terms of stone‐free and infectious complications rates. Conclusions Ureterorenoscopy is a commonly performed endoscopic procedure for urolithiasis treatment, the success of which is defined by SFRs and complication rates. Application of suction via ureteral access sheaths, ureteral catheters or scopes may provide improved SFRs, reduced overall and infectious complication rates, along with a reduction in length of hospital stay. Further randomized studies are needed to validate these findings and standardize indications and protocols.
Journal Article
Body shot
\"Meghan's the toughest girl in her dojo with a great future in the sport, but behind her is a painful history. Betrayed by a parent and by a coach, Meghan trusts only two old friends: one who pushes her to confront her past, the other who pulls Meghan down with her in a pill-popping daze\"-- Provided by publisher.
Book
Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease
Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine. While oligodendrocytes have been extensively studied due to their high levels of GALC, the contribution of astrocytes to disease pathogenesis remains to be fully elucidated. In the current study, we generated induced pluripotent stem cells (iPSCs) from two donors with infantile onset Krabbe disease and differentiated them into cultures of astrocytes. Krabbe astrocytes recapitulated many key findings observed in humans and rodent models of the disease, including the accumulation of psychosine and elevated expression of the pro-inflammatory cytokine IL-6. Unexpectedly, Krabbe astrocytes had higher levels of glucosylceramide and ceramide, and displayed compensatory changes in genes encoding glycosphingolipid biosynthetic enzymes, suggesting a shunting away from the galactosylceramide and psychosine pathway. In co-culture, Krabbe astrocytes negatively impacted the survival of iPSC-derived human neurons while enhancing survival of iPSC-derived human microglia. Substrate reduction approaches targeting either glucosylceramide synthase or serine palmitoyltransferase to reduce the sphingolipids elevated in Krabbe astrocytes failed to rescue their detrimental impact on neuron survival. Our results suggest that astrocytes may contribute to the progression of Krabbe disease and warrant further exploration into their role as therapeutic targets.
Journal Article
Head kick
\"Nong Vang dreams one day he'll become a MMA superstar, but his real life turns into a nightmare when his bully big brother returns to town. This young Hmong ultimate fighter can trash talk, but inside the cage, can he find the courage and skill to achieve success?\"-- Provided by publisher.
Book
Potential of AI-Driven Chatbots in Urology: Revolutionizing Patient Care Through Artificial Intelligence
Purpose of Review
Artificial intelligence (AI) chatbots have emerged as a potential tool to transform urology by improving patient care and physician efficiency. With an emphasis on their potential advantages and drawbacks, this literature review offers a thorough assessment of the state of AI-driven chatbots in urology today.
Recent Findings
The capacity of AI-driven chatbots in urology to give patients individualized and timely medical advice is one of its key advantages. Chatbots can help patients prioritize their symptoms and give advice on the best course of treatment. By automating administrative duties and offering clinical decision support, chatbots can also help healthcare providers. Before chatbots are widely used in urology, there are a few issues that need to be resolved. The precision of chatbot diagnoses and recommendations might be impacted by technical constraints like system errors and flaws. Additionally, issues regarding the security and privacy of patient data must be resolved, and chatbots must adhere to all applicable laws. Important issues that must be addressed include accuracy and dependability because any mistakes or inaccuracies could seriously harm patients. The final obstacle is resistance from patients and healthcare professionals who are hesitant to use new technology or who value in-person encounters.
Summary
AI-driven chatbots have the potential to significantly improve urology care and efficiency. However, it is essential to thoroughly test and ensure the accuracy of chatbots, address privacy and security concerns, and design user-friendly chatbots that can integrate into existing workflows. By exploring various scenarios and examining the current literature, this review provides an analysis of the prospects and limitations of implementing chatbots in urology.
Journal Article
Side control
\"Jackson James wants three things: to succeed in MMA, to join the military like his father, and to protect his little brother from the dangers all around him. With so many challenges, and the wrinkle of a new romance, Jackson struggles to maintain control\"-- Provided by publisher.
Book
Are complications reported in clinical studies just the tip of the iceberg?
In their study, Lombardo et al. provide an evaluation of adverse events associated with ureteral stents, as catalogued in the Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database over the past decade [1]. In use since the 1990s and not designed for academic research purposes, submissions to MAUDE are often incomplete and lack information on hospital settings or surgeon experience. In this context, MAUDE’s anonymous nature becomes a crucial advantage, offering an unfiltered look into adverse events. [...]MAUDE deserves recognition, and its merits should be expanded upon.
Journal Article