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"Jones, Rebecca"
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At the crossroads : Nigerian travel writing and literary culture in Yoruba and English
Throughout the twentieth century, Nigerians have been writing about their travels within Nigeria using a variety of media and forms, from serialised newspaper travelogues to personal diaries, autobiographies and online narratives. These works offer important insights into how Nigerians have represented Nigeria to itself and to the world.0 This is the first book to examine the production of Nigerian travel narratives about Nigeria in the century from colonisation to independence. Rebecca Jones argues that we can read these texts both as the products of a local Nigerian print culture, and through their articulations with global travel writing traditions. Focusing on travel writing published from 1914 to 2014 in the Yoruba-speaking region of southwestern Nigeria, home to a well-established and prolific writing and print culture in both Yoruba and English, this cultural history of Nigerian travel comprises close readings of these works, and argues that the production of travel writing in the region can be read not simply as a foreign import, but as a cluster of genres with a cohesive local history.
Book
Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis
Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications.
To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA.
Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000.
Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years.
The effect of age on pregnancy outcome was investigated by random effects meta-analysis and meta-regression. Stillbirth rates were correlated to rates of maternal diabetes, obesity, hypertension and use of assisted reproductive therapies (ART).
Out of 1940 identified titles; 63 cohort studies and 12 case-control studies were included in the meta-analysis. AMA increased the risk of stillbirth (OR 1.75, 95%CI 1.62 to 1.89) with a population attributable risk of 4.7%. Similar trends were seen for risks of FGR, neonatal death, NICU unit admission restriction and GDM. The relationship between AMA and stillbirth was not related to maternal morbidity or ART.
Stillbirth risk increases with increasing maternal age. This is not wholly explained by maternal co-morbidities and use of ART. We propose that placental dysfunction may mediate adverse pregnancy outcome in AMA. Further prospective studies are needed to directly test this hypothesis.
Journal Article
Dressage with mind, body & soul : a 21st-century approach to the science and spirituality of riding and horse-and-rider well-being
\"A new approach to the classical methods of training dressage horses--methods that can cause the animals undue physical and emotional distress--these powerful new techniques from world-renowned horse trainer and behaviorist Linda Tellington-Jones improve not only the dressage horse's performance but also its well-being. The guide employs the author's legendary TTouch method and features practical dressage-training information on topics such as relaxing the overly touchy horse, focusing the overly playful horse, improving balance and transitions, and solving problems with stage fright. In addition to the providing the tips and techniques needed to ensure that the horse relishes its role in the art of dressage, numerous case studies of the top horses, riders, and trainers Tellington-Jones has worked with in her career are also included\"-- Provided by publisher.
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Autism spectrum disorder
Autism spectrum disorder is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-income countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in post-mortem, neuroimaging and electrophysiological studies. Initially, it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement, that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs of people with autism, and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with autism throughout much of life and need to be considered, along with the perspectives of autistic individuals, in both research and practice.
Autism spectrum disorder — or autism — is a neurodevelopmental disorder that typically manifests in young children. This Primer by Lord and colleagues reviews the epidemiology, mechanisms, clinical detection and treatment of autism.
Journal Article
Matthew and Tilly
Like all good friends, Matthew and Tilly have an occasional tiff, but their friendship prevails despite their differences.
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Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak
The heart develops from 2 sources of mesoderm progenitors, the first and second heart field (FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage tracing and live imaging, we find the FHF and SHF are subdivided into distinct pools of progenitors in gastrulating mouse embryos at earlier stages than previously thought. Each subpopulation has a distinct origin in the primitive streak. The first progenitors to leave the primitive streak contribute to the left ventricle, shortly after right ventricle progenitor emigrate, followed by the outflow tract and atrial progenitors. Moreover, a subset of atrial progenitors are gradually incorporated in posterior locations of the FHF. Although cells allocated to the outflow tract and atrium leave the primitive streak at a similar stage, they arise from different regions. Outflow tract cells originate from distal locations in the primitive streak while atrial progenitors are positioned more proximally. Moreover, single-cell RNA sequencing demonstrates that the primitive streak cells contributing to the ventricles have a distinct molecular signature from those forming the outflow tract and atrium. We conclude that cardiac progenitors are prepatterned within the primitive streak and this prefigures their allocation to distinct anatomical structures of the heart. Together, our data provide a new molecular and spatial map of mammalian cardiac progenitors that will support future studies of heart development, function, and disease.
Journal Article
Increased global transcription activity as a mechanism of replication stress in cancer
Cancer is a disease associated with genomic instability that often results from oncogene activation. This in turn leads to hyperproliferation and replication stress. However, the molecular mechanisms that underlie oncogene-induced replication stress are still poorly understood. Oncogenes such as HRAS
V12
promote proliferation by upregulating general transcription factors to stimulate RNA synthesis. Here we investigate whether this increase in transcription underlies oncogene-induced replication stress. We show that in cells overexpressing HRAS
V12
, elevated expression of the general transcription factor TATA-box binding protein (TBP) leads to increased RNA synthesis, which together with R-loop accumulation results in replication fork slowing and DNA damage. Furthermore, overexpression of TBP alone causes the hallmarks of oncogene-induced replication stress, including replication fork slowing, DNA damage and senescence. Consequently, we reveal that increased transcription can be a mechanism of oncogene-induced DNA damage, providing a molecular link between upregulation of the transcription machinery and genomic instability in cancer.
Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.
Journal Article
Disney bedtime favorites
\"Sweet dreams! Get ready for bedtime with all your favorite Disney and Disney-Pixar characters. Help Rapunzel and Flynn find a way to get Max to sleep, explore the Pride Lands at night with Simba and Nala, have an after-dark underwater adventure with Marlin and Nemo, and more! This enchanting collection, feauturing new stories, makes bedtime fun!\"--Back cover. \"The third edition of this top-selling storybook has been updated with new stories and illustrations. With eighteen stories, gilded pages, and over 250 pieces of spot and full-page art, this storybook collection is a must-have for bedtime!\"--Amazon.
BOOK
A Retrospective Cross-Sectional Study on the Prevalence of E-cigarette Use Among College Students
E-cigarette use among young adults is a major public health concern. Approximately 17.7–40% of college students have tried or are currently using e-cigarettes. While a few studies have examined e-cigarette use among youth, opportunity exists to understand psychosocial factors that influence college students’ e-cigarette behavior. The main purpose of this study is to examine the associations between the constructs of self-efficacy, knowledge, depression and anxiety symptoms, and e-cigarette use among college students. A retrospective cross-sectional survey (20-items) design was used for data collection. Bivariate analysis and analysis of variance (ANOVA) were used to evaluate associations between the independent variables and the dependent variable. A total of 872 college students between the ages of 18 and 25 completed the survey in Qualtrics. A significant association between gender and frequency of e-cigarette use was found (χ
2
= 22.94, p < .001). ANOVA results showed significant relationships between knowledge [F (3, 808) = 9.01, p < 0.001], self-efficacy [F (3, 808) = 4.85, p < 0.01], depression [F (3,808) = 8.31, p < .05], and e-cigarette use. Post hoc analysis revealed students who never used e-cigarettes scored higher on knowledge and self-efficacy than students who used every day, somedays or rarely, indicating never-users have higher knowledge of negative effects associated with e-cigarette use and have higher self-confidence than e-cigarette users. The study’s findings highlight that modifiable factors such as knowledge about harmful effects of e-cigarettes and self-confidence are associated with low e-cigarette use. Interventions could be designed to target these modifiable factors.
Journal Article