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Jongwoo Han’s Networked Information Technologies, Elections, and Politics: Korea and the United States is a study on the changes that have been occurring in elections, politics, and democratic movements in both the United States and Korea. There has undoubtedly been a paradigm shift in political discourse, as the industrial age mass media-based public sphere gives way to the new networked information technologies (NNIT)-based cyber sphere. Analyzing and comparing Korea’s presidential election in 2002 and the United States’ 2008 presidential election, Han discusses the impact of NNITs in electoral politics, as previously apolitical young generations have become more involved and transformed themselves into both a cohesive voting bloc and a formidable constituency. Han also addresses the role of NNITs in Korea’s beef crisis and President Obama’s legislation battle to reform the U.S. health care system, revealing unprecedented opportunities to observe this major change occurring in political systems during the so-called Information Age.

Why does North Korea want to possess nuclear capabilities? In order to find the answer to this question, we must have an accurate understanding of the history and structure of the North Korean regime. So far, we have only formed conjectures and predictions regarding North Korea based on our own perspectives; we now need to deal with and consider North Korea “as is” to reach viable solutions to the issues North Korea presents. This volume contains analyses of the most salient, critical issues pertinent to understanding the North Korean regime, penned by representative Korean scholars of North Korea. As such, the book examines the historical formation of North Korea, the identities of those power elite, and the relative stability (or instability, as the case may be) of the new regime under Kim Jong-un. Also an important aspect to consider is the possibility of socio-economic change in North Korea. Though North Korea has remained relatively static vis-à-vis its political and military systems, it is in the process of becoming rapidly marketized, having continued various attempts to modify its economic policy. In the social realm, said economic shift has elicited the polarization of the disparate classes and the expansion of individualism. Such social transformations, obscured by the easily visible political reality of North Korea, can provide solid grounds for determining the future of the North Korea regime. Moreover, it is imperative that we accurately understand the motivation behind North Korea’s intention to develop nuclear weapons—namely, the expansion of deterrence. We must recognize the reasons for the North Korean hostility toward the United States from the very beginning of the DPRK formation and the North Korean fixation on nuclear weapons development. Further, we need to understand the nature of relations between China and North Korea—relations on which the international community has focused since North Korea began its nuclear testing—as well as the history and structure of relations between North and South Korea. Only when we accurately understand North Korea can we reach solutions to the North Korean nuclear issue. The studies in this volume by Korean scholars will reveal the veiled background of the visible phenomena and thereby help the readers to correctly understand the North Korean behaviors hitherto misunderstood (or even those that were impossible to understand).

A co-operative study was conducted to determine the clinical characteristics of patients with moyamoya disease who were diagnosed and treated at neurosurgical institutes in Korea before 1995. Twenty-six hospitals contributed 505 cases and among them, the clinical characteristics of 334 patients with definite moyamoya disease were evaluated. The number of patients began to increase from the late 1980s, and after that approximately 20 patients were treated each year. There were two age peaks: from six to 15 and from 31 to 40 years of age. Haemorrhagic manifestations occurred in approximately 43% of the patients. The major clinical manifestations were haemorrhage in adults (62.4%) and ischaemia in children (61.2%). Overall 54.5% of the patients experienced decreased consciousness levels, mainly due to intracranial haemorrhage or cerebral infarction. In the patients with ischemic manifestations, the adult patients were more likely to have cerebral infarction than the pediatric patients (80% vs. 39%) and the pediatric patients were more likely to have TIA (61% vs. 25%). Thirty eight percent of the patients underwent bypass surgery and 53% of these procedures were performed bilaterally. Treatment policies, including indications for bypass surgery and commonly used drugs, were somewhat different according to the institution. Overall favorable outcome was 73%, and the most significant factor affecting poor outcome was haemorrhagic manifestation. This article describes the characteristics of 334 patients with moyamoya disease, who were diagnosed and treated at neurosurgical institutes in Korea before 1995.[PUBLICATION ABSTRACT]

The cerebellum is involved in the learning and retention of motor skills. Using animal and human models, a number of studies have shown that long-term motor skill training induces structural and functional plasticity in the cerebellum. The aim of this study was to investigate whether macroscopic alteration in the volume of cerebellum occurs in basketball players who had learned complex motor skills and practiced them intensively for a long time. Three-dimensional magnetic resonance imaging volumetry was performed in basketball players ( n  = 19) and healthy controls ( n  = 20), and the volumes of cerebellum and vermian lobules were compared between two groups. Although there was no macroscopic plasticity detected in the cerebellum as a whole, detailed parcellation of cerebellum revealed morphological enlargement in the vermian lobules VI–VII (declive, folium, and tuber) of basketball players ( P  < 0.0166), which might then be interpreted as evidence for plasticity. This finding suggests that the extensive practice and performance of sports-related motor skills activate structural plasticity of vermian lobules in human cerebellum and suggests that vermian VI–VII plays an important role in motor learning.

No book has addressed the simultaneous phenomena of Korea’s rapid economic development and its vibrant democratization in a single coherent paradigm. The late developmentalist approach emphasizes the strong role of Korea’s state and bureaucratic efficiency but does not explain how political development was concurrent with the economic miracles in the Han River; modernization and dependence theories also fail to explain the aspect of simultaneity in this phenomenon. What these three theories commonly miss is the unique relationship between state and society in Korea’s long history of political culture. In this book, Jongwoo Han takes a holistic approach to understanding these phenomena by examining the state’s role in the unprecedented economic development and society’s capabilities to resist the state’s centralized power. Han re-articulates state-society relations through Onuf’s social constructivist approach based on three rules of a political community: hegemony, hierarchy, and heteronomy. This book expands upon this effort to re-construct the state and society relations in two ways. First, it produces case studies of the capital city of Hanyang (Joseon Dynasty from 1392 to 1910), Kyeongseong (Japanese colonial control from 1910 to 1945), and Seoul (1945-current). The capital city is analyzed as a container for the major ideologies and ways of thinking that have shaped three important political eras. Second, i adopts two indigenous thoughts, Neo-Confucianism and geomancy, as sources of the main political and cultural ideologies that shape Korea’s state and society relations. These sources have never been treated as units of political analysis. This book finds that both Neo-Confucianism and geomancy, over two periods of Hanyang and Kyeongseong, are two main contributing factors of the emergence of the developmental state and vibrant democracy in Korea in the Seoul era.

In our pursuit of developing catalytic porous coordination networks, we designed and prepared two redox-active bis(triester)hexavanadates, [V 6O13{(CH2O)3CNHCO(4C 5H4N)}2]-2 and [V6O 13{(CH2O)3CNHCO(4-C6H4COOH)} 2]-2. These two bridging ligands readily react with transition metal ions to yield various redox-active open-framework materials. A pyridine-terminated bis(triester)hexavanadate, [V6O13{(CH2O) 3CNHCO(4C5H4N)}2] -2, an analogue to 4,4'-bipyridine, reacts with four divalent first-row transition metal ions (MnII, CoII, Ni II or ZnII) to produce one-dimensional (1D) coordination chains connected by hydrogen bonds. The materials can be chemically reduced and re-oxidized by dioxygen. However, the pyridine-terminated hexavanadate does not form stable open-framework structures. The benzoic acid-terminated hexavanadate assembled by d-(CoII) and f-block (GdIII, TbIII, or YbIII) elements form open framework materials. Lanthanides and the benzoic acid functional groups form paddle-wheel cluster moieties to generate two-dimensional layers interconnected by hydrogen bonds between a secondary amine moiety and a bridging oxo group of the POM. Among three f-block elements, only the Yb material maintains framework integrity. Thus, the coordination polymers assembled Yb catalyze aerobic oxidation of PrSH to its oxidized product PrSSPr in a heterogeneous fashion. More robust and sophisticated structures were fabricated by employing mixed-ligand approaches. In these approaches, the benzoic acid-terminated hexavanadate is mixed with conventional organic bridging ligands, such as 4,4'-biphenyldicarboxylic acid, bis(4-carboxyphenyl)acetylene, or 4,4'-bipyridine- N,N'-oxide, and the combined ligand-mixtures are complexed with Co II, or LnIII (Ln = Tb, Gd, or Yb) to yield various open-framework materials. The combination of 4,4'-bipyridine-N,N' -dioxide, the benzoic acid-terminated bis(alkoxo)he xavanadate, and TbIII lead to pillared-layer type, three-dimensional net-work materials. Although the dimensions of channels are significantly diminished in the material, the network material successfully catalyzes two oxidation reactions: PrSH to PrSSPr by air and tetrahydrothiophene (THT) to tetrahydrothiophene oxide (THTO) by tert-butylhydroperoxide. This work show a new way of building up catalytic materials with well-defined catalytically active POM units.

Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer cells survive under metabolic stress conditions by altering lipid metabolism, which may alter their sensitivity to ferroptosis. However, the association between lipid metabolism and ferroptosis is not completely understood. In this study, we found that the expression of elongation of very longchain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) is up-regulated in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization. In contrast, these enzymes are silenced by DNA methylation in intestinal-type GCs, rendering cells resistant to ferroptosis. Lipid profiling and isotope tracing analyses revealed that intestinal-type GCs are unable to generate arachidonic acid (AA) and adrenic acid (AdA) from linoleic acid. AA supplementation of intestinal-type GCs restores their sensitivity to ferroptosis. Based on these data, the polyunsaturated fatty acid (PUFA) biosynthesis pathway plays an essential role in ferroptosis; thus, this pathway potentially represents a marker for predicting the efficacy of ferroptosis-mediated cancer therapy.

Hypothalamic neurons including proopiomelanocortin (POMC)-producing neurons regulate body weights. The non-motile primary cilium is a critical sensory organelle on the cell surface. An association between ciliary defects and obesity has been suggested, but the underlying mechanisms are not fully understood. Here we show that inhibition of ciliogenesis in POMC-expressing developing hypothalamic neurons, by depleting ciliogenic genes IFT88 and KIF3A, leads to adulthood obesity in mice. In contrast, adult-onset ciliary dysgenesis in POMC neurons causes no significant change in adiposity. In developing POMC neurons, abnormal cilia formation disrupts axonal projections through impaired lysosomal protein degradation. Notably, maternal nutrition and postnatal leptin surge have a profound impact on ciliogenesis in the hypothalamus of neonatal mice; through these effects they critically modulate the organization of hypothalamic feeding circuits. Our findings reveal a mechanism of early life programming of adult adiposity, which is mediated by primary cilia in developing hypothalamic neurons. Ciliary defects and obesity has been associated, but the underlying mechanism is unclear. Here, the authors show that inhibition of ciliogenesis in POMC neurons during development results in lysosomal protein degradation-dependent axonal disruption and adult obesity in mice.

This study aimed to investigate the effects of a two-day forest therapy program on individuals with chronic widespread pain. Sixty one employees of a public organization providing building and facilities management services within the Seoul Metropolitan area participated in the study. Participants were assigned to an experimental group (n = 33) who participated in a forest therapy program or a control group (n = 28) on a non-random basis. Pre- and post-measures of heart rate variability (HRV), Natural Killer cell (NK cell) activity, self-reported pain using the visual analog scale (VAS), depression level using the Beck Depression Inventory (BDI), and health-related quality of life measures using the EuroQol Visual Analog Scale (EQ-VAS) were collected in both groups. The results showed that participants in the forest therapy group, as compared to the control group, showed physiological improvement as indicated by a significant increase in some measures of HRV and an increase in immune competence as indicated by NK cell activity. Participants in the forest therapy group also reported significant decreases in pain and depression, and a significant improvement in health-related quality of life. These results support the hypothesis that forest therapy is an effective intervention to relieve pain and associated psychological and physiological symptoms in individuals with chronic widespread pain.

The large-scale crossbar array is a promising architecture for hardware-amenable energy efficient three-dimensional memory and neuromorphic computing systems. While accessing a memory cell with negligible sneak currents remains a fundamental issue in the crossbar array architecture, up-to-date memory cells for large-scale crossbar arrays suffer from process and device integration (one selector one resistor) or destructive read operation (complementary resistive switching). Here, we introduce a self-selective memory cell based on hexagonal boron nitride and graphene in a vertical heterostructure. Combining non-volatile and volatile memory operations in the two hexagonal boron nitride layers, we demonstrate a self-selectivity of 10 10 with an on/off resistance ratio larger than 10 3 . The graphene layer efficiently blocks the diffusion of volatile silver filaments to integrate the volatile and non-volatile kinetics in a novel way. Our self-selective memory minimizes sneak currents on large-scale memory operation, thereby achieving a practical readout margin for terabit-scale and energy-efficient memory integration. Designing large-scale crossbar arrays for energy efficient neuromorphic computing systems remains a challenge. Here, the authors propose Van der Waals (h-BN/graphene/h-BN) self-selective memory design able to combine, in the same cell, non-volatile and volatile behaviors with negligible sneak current.