Explore the vast range of titles available.

Over 10 million patients undergoing non-cardiac surgery annually experience major cardiovascular complications within 30 days, many due to destabilized atherosclerotic plaques. Reverse cholesterol transport (RCT), a key pathway for cholesterol removal by HDL and apoA-I, is critical in preventing plaque progression. While surgery-induced inflammation is known to impair HDL function, its effects on RCT and plaque stability remain unclear. To isolate the impact of surgical inflammation, independent of blood loss, we developed an abdominal laparotomy model in mice on a Western diet, minimizing blood loss and avoiding perioperative blood sampling. We assessed plasma cholesterol efflux capacity, performed proteomic analysis of HDL, and analyzed atherosclerotic plaques for lipid content, perilipin-2 (PLIN2), cleaved-caspase-3 (c-Casp-3), and necrotic core expansion. A novel dual-label, dual-cell-type RCT model was developed to compare RCT from macrophage-derived (BMDMs) and vascular smooth muscle cells (VSMCs)-derived foam cells. Recombinant apoA-I (rApoA-I) was tested for therapeutic rescue of impaired RCT. Surgery significantly reduced RCT for at least 48 hours, paralleled by a drop in cholesterol efflux capacity and inflammatory remodeling of HDL, marked by elevated serum amyloid A (SAA1/2) and reduced apoA-I. Plaques showed a 1.6-fold increase in intracellular lipids and PLIN2 expression at 24 hours post-surgery, with elevated c-Casp-3 indicating lipid-driven apoptosis. Foam cell analysis revealed increased PLIN2 in both CD45 (leukocyte) and CD45 (non-leukocyte) subtypes, with leukocyte foam cells expressing higher PLIN2. c-Casp-3 apoptotic cells were predominantly PLIN2 and of both leukocytic and non-leukocytic origin. By day 15, the necrotic core area increased by 1.5-fold with sustained loss of plaque cellularity. Using our dual-cell-type RCT model, we found that surgery significantly impaired BMDM RCT , while VSMC RCT remained largely unaffected, highlighting foam cell subtype-specific vulnerability to surgical inflammation. These findings were mirrored in general surgery patients, whose postoperative plasma exhibited markedly reduced cholesterol efflux capacity. In mice, rApoA-I treatment partially restored RCT and reduced plaque lipid accumulation. Surgical inflammation acutely impairs HDL function and RCT, triggering lipid accumulation, foam cell apoptosis, and accelerated plaque destabilization independent of blood loss. Immediate restoration of apoA-I at the time of surgery, aiming to counteract the acute phase response, may offer a targeted strategy to reduce postoperative cardiovascular risk.

While Christian counseling is a burgeoning field, it seems to lack clear philosophical and methodological definitions. This is particularly true when it comes to the human-divine relationship in that few theories or models exist that can guide practitioners in assessment and intervention of the human-divine relationship in order to improve it. Attachment theory offers relational concepts that can be applied to a person's relationship with God thus offering guidelines for soulcare providers. Attachment theory describes the relationship between God and persons in similar fashion with the Bible. Adoption is understood to be the central doctrine that relates to attachment, but it is aided by justification by faith, union with Christ, naming God \"Abba,\" and the testimony of the Spirit. While attachment theory holds much in common with biblical principles, it also has several deficiencies including biological reductionism and limited teleology. Attachment theory is most applicable to Christianity in a post-postmodern ideology that allows for metanarrative but also takes seriously the subjective elements of experience as these experiences form narratives through a hermeneutic function in which persons interpret reality. Paul Ricoeur's concept of testimony aids in explaining the way in which life experiences form a narrative that fuels concepts of self, others, and relationships and the manner in which this process if transformed. Ricoeur's ideas have much in common with the Adult Attachment Interview in which adult's state of mind toward attachment is revealed through the type of narrative they produce about attachment. The primary indicator of such is the level of coherence in the person's narrative. It is proposed that a similar narrative interview, entitled the Adult Attachment to God Interview (AAGI), could produce indicators of a person's level of security and primary attachment strategy. Through testimony analysis, the soulcare provider can discover the level of coherence of a person's narrative concerning life with God and thus encounter the type of attachment a person has with God. Furthermore, the interview process will give insights into types of interventions that will aid the person in developing a more cohesive narrative and thus a more secure relationship with God.

Premium Subscription In addition to your convenient home delivery service, receive unlimited access to Kitsap Sun on the web, smartphone and tablet. * Home delivery service * KitsapSun.com * Kitsap Sun for the iPad * Kitsap Sun for iPhone and Android * Electronic Newspaper As low as 3 months for the price of 1 Subscribe Now Digital Subscription Receive unlimited access to Kitsap Sun on the web, smartphone and tablet. * KitsapSun.com * Kitsap Sun for the iPad * Kitsap Sun for iPhone and Android * Electronic Newspaper As low as 2 months for the price of 1 Subscribe Now Premium Subscription -- First Name Last Name* Email* Phone Number* House Number* Street Name Apt Find your account Create your new login Awesome!

Premium Subscription In addition to your convenient home delivery service, receive unlimited access to Kitsap Sun on the web, smartphone and tablet. * Home delivery service * KitsapSun.com * Kitsap Sun for the iPad * Kitsap Sun for iPhone and Android * Electronic Newspaper As low as 3 months for the price of 1 Subscribe Now Digital Subscription Receive unlimited access to Kitsap Sun on the web, smartphone and tablet. * KitsapSun.com * Kitsap Sun for the iPad * Kitsap Sun for iPhone and Android * Electronic Newspaper As low as 2 months for the price of 1 Subscribe Now Premium Subscription -- First Name Last Name* Email* Phone Number* House Number* Street Name Apt Find your account Create your new login Awesome!

Knudson, who broke the school record earlier this season, had two sub-par throws to start. Knudson, who is hoping to find a spot on the Washington State track and field team next year, has made a steady progression over the last three years.

Track and field coach Jim Felty and cross country coach Marty Krafcik (who is an assistant coach in the spring) believe the Klahowya senior has the potential to be one of the best distance runners to emerge from Kitsap County. In sixth grade, Ward was cut from the track and field team at his middle school in Tennessee (his family moved around as his father is in the military).

Even Texas, where high school football is king, limits spring football to 18 days (with no summer contact).

Boys, LaForrest Church, sr., middle distance; Nick Sleigh, sr., middle distance; Zach Sleigh, sr., middle distance; Bastian Tabacchi, Jr, sprints; Blaine Pervinich, sr., throws; Chris Willet, sr., sprints, long jump; Jacob Yarbrough, sr., distance; Joey Woods, sr., sprints, jumps; Isiah Cotton, Jr, sprints, jumps; Jake Stanley, Jr, throws. Boys, Tyler Cox, sr., middle distance; Matt Stone, sr., sprints; Joe Misenti, sr., pole vault, sprints; Taylor Wilson, Jr, javelin; Jay Terry, sr., hurdles; Casey Brink, so., hurdles, throws; Austin Harper, Jr, middle distance; Tyler Martinez-Green, Jr, middle distance; Nich Allen, so., sprints, relays; Jackson Garber, so., middle distance, jumps; Ryan Abbott, sr., sprints, jumps, Morgan Leader, so., sprints, relays; Issac Pyne, so., sprints, relays; Gordon Shelton-Jenck, sr., distance; Sean Simonsen, Jr, distance.