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Here we present a comprehensive mass cytometry analysis of peripheral innate lymphoid cell (ILC) subsets in relapsing/remitting MS (RRMS) patients prior to and after onset of cladribine tablets (CladT). ILC analysis was conducted on CyTOF data from peripheral blood mononuclear cells (PBMC) of MS patients before, 2 and 6 months after onset of CladT, and non-MS controls. Dimensionality reduction was used for immunophenotyping ILC subsets. CladT reduced all ILC subsets, except for CD56bright NK cells and ILC2. Furthermore, CD38+ NK cell and CCR6+ ILC3 were excluded from CladT-induced immune cell reductions. Post-CladT replenishment by immature ILC was noted by increased CD5+ ILC1 proportions at 2 months, and boosted CD38−CD56bright NK cell numbers at 6 months. CladT induce immune cell depletion among ILC but exclude CD56bright NK cells and ILC2 subsets, as well as CD38+ NK cell and CCR6+ ILC3 immunophenotypes. Post-CladT ILC expansions indicate ILC reconstitution towards a more tolerant immune system phenotype.

EDELWEISS-III is a direct dark matter search experiment, running 800 g heat-and-ionization cryogenic germanium detectors equipped with Full InterDigitized electrodes (FID) for the rejection of near-surface events. We report a preliminary analysis for a subset of the data (35 kg · days) as well as future prospects for low-mass WIMPs seach.

The future Ricochet experiment aims at searching for new physics in the electroweak sector by providing a high precision measurement of the Coherent Elastic Neutrino-Nucleus Scattering (CENNS) process down to the sub-100 eV nuclear recoil energy range. The experiment will deploy a kg-scale low-energy-threshold detector array combining Ge and Zn target crystals 8.8 m away from the 58 MW research nuclear reactor core of the Institut Laue Langevin (ILL) in Grenoble, France. Currently, the Ricochet Collaboration is characterizing the backgrounds at its future experimental site in order to optimize the experiment’s shielding design. The most threatening background component, which cannot be actively rejected by particle identification, consists of keV-scale neutron-induced nuclear recoils. These initial fast neutrons are generated by the reactor core and surrounding experiments (reactogenics), and by the cosmic rays producing primary neutrons and muon-induced neutrons in the surrounding materials. In this paper, we present the Ricochet neutron background characterization using 3 He proportional counters which exhibit a high sensitivity to thermal, epithermal and fast neutrons. We compare these measurements to the Ricochet Geant4 simulations to validate our reactogenic and cosmogenic neutron background estimations. Eventually, we present our estimated neutron background for the future Ricochet experiment and the resulting CENNS detection significance. Our results show that depending on the effectiveness of the muon veto, we expect a total nuclear recoil background rate between 44 ± 3 and 9 ± 2 events/day/kg in the CENNS region of interest, i.e. between 50 eV and 1 keV. We therefore found that the Ricochet experiment should reach a statistical significance of 4.6 to 13.6  σ for the detection of CENNS after one reactor cycle, when only the limiting neutron background is considered.

CUPID-Mo is a bolometric experiment to search for neutrinoless double-beta decay ( 0 ν β β ) of 100 Mo . In this article, we detail the CUPID-Mo detector concept, assembly and installation in the Modane underground laboratory, providing results from the first datasets. The CUPID-Mo detector consists of an array of 20 100 Mo -enriched 0.2 kg Li 2 MoO 4 crystals operated as scintillating bolometers at ∼ 20 mK . The Li 2 MoO 4 crystals are complemented by 20 thin Ge optical bolometers to reject α events by the simultaneous detection of heat and scintillation light. We observe a good detector uniformity and an excellent energy resolution of 5.3 keV (6.5 keV) FWHM at 2615 keV, in calibration (physics) data. Light collection ensures the rejection of α particles at a level much higher than 99.9% – with equally high acceptance for γ / β events – in the region of interest for 100 Mo 0 ν β β . We present limits on the crystals’ radiopurity: ≤ 3 μ Bq/kg of 226 Ra and ≤ 2 μ Bq/kg of 232 Th . We discuss the science reach of CUPID-Mo, which can set the most stringent half-life limit on the 100 Mo 0 ν β β decay in half-a-year’s livetime. The achieved results show that CUPID-Mo is a successful demonstrator of the technology developed by the LUMINEU project and subsequently selected for the CUPID experiment, a proposed follow-up of CUORE, the currently running first tonne-scale bolometric 0 ν β β experiment.

We report the measurement of the two-neutrino double-beta ($2\\nu\\beta\\beta$) decay of $^{100}$Mo to the ground state of $^{100}$Ru using lithium molybdate (\\crystal) scintillating bolometers. The detectors were developed for the CUPID-Mo program and operated at the EDELWEISS-III low background facility in the Modane underground laboratory. From a total exposure of $42.235$ kg$\\times$d, the half-life of $^{100}$Mo is determined to be $T_{1/2}^{2\\nu}=[7.12^{+0.18}_{-0.14}\\,\\mathrm{(stat.)}\\pm0.10\\,\\mathrm{(syst.)}]\\times10^{18}$ years. This is the most accurate determination of the $2\\nu\\beta\\beta$ half-life of $^{100}$Mo to date. We also confirm, with the statistical significance of $>3\\sigma$, that the single-state dominance model of the $2\\nu\\beta\\beta$ decay of $^{100}$Mo is favored over the high-state dominance model.

The CUPID-Mo experiment to search for 0νββ decay in 100Mo has been recently completed after about 1.5 years of operation at Laboratoire Souterrain de Modane (France). It served as a demonstrator for CUPID, a next generation 0νββ decay experiment. CUPID-Mo was comprised of 20 enriched Li2100MoO4 scintillating calorimeters, each with a mass of ∼0.2 kg, operated at ∼20 mK. We present here the final analysis with the full exposure of CUPID-Mo (100Mo exposure of 1.47 kg×year) used to search for lepton number violation via 0νββ decay. We report on various analysis improvements since the previous result on a subset of data, reprocessing all data with these new techniques. We observe zero events in the region of interest and set a new limit on the 100Mo 0νββ decay half-life of T1/20ν>1.8×1024 year (stat. + syst.) at 90% CI. Under the light Majorana neutrino exchange mechanism this corresponds to an effective Majorana neutrino mass of mββ <(0.28-0.49) eV, dependent upon the nuclear matrix element utilized.

We present the noise performance of high electron mobility transistors (HEMT) developed by CNRS/C2N laboratory. Various HEMT’s gate geometries with 2 pF to 230 pF input capacitance have been studied at 4  K. A model for both voltage and current noises has been developed with frequency dependence up to 1  MHz. These HEMTs exhibit low dissipation, excellent noise performance and can advantageously replace traditional Si-JFETs for the readout of high impedance thermal sensor and semiconductor ionization cryogenic detectors. Our model predicts that cryogenic germanium detectors of 30  g with 10  eV heat and 20  eV ee baseline resolution are feasible if read out by HEMT-based amplifiers. Such resolution allows for high discrimination between nuclear and electron recoils at low threshold. This capability is of major interest for coherent elastic neutrino scattering and low-mass dark matter experiments such as Ricochet and EDELWEISS.

The sensitivities of light Dark matter particle searches with cryogenic detectors are mostly limited by large backgrounds of events that do not produce ionization signal. The CRYOSEL project develops a new technique, where this background in a germanium cryogenic detector is rejected by using the signals from a superconducting single electron device (SSED) sensor designed to detect the phonons emitted through the Neganov–Trofimov–Luke effect by the e - h + pairs as they drift in a nearby very high-field region. A tag on signals from this device should suppress the heat-only background. The measurement of the response to IR laser pulses of the first CRYOSEL prototype show the relevance of such sensor technology.

The future Ricochet experiment aims to search for new physics in the electroweak sector by measuring the Coherent Elastic Neutrino-Nucleus Scattering process from reactor antineutrinos with high precision down to the sub-100 eV nuclear recoil energy range. While the Ricochet collaboration is currently building the experimental setup at the reactor site, it is also finalizing the cryogenic detector arrays that will be integrated into the cryostat at the Institut Laue Langevin in early 2024. In this paper, we report on recent progress from the Ge cryogenic detector technology, called the CryoCube. More specifically, we present the first demonstration of a 30 eVee (electron equivalent) baseline ionization resolution (RMS) achieved with an early design of the detector assembly and its dedicated High Electron Mobility Transistor (HEMT) based front-end electronics with a total input capacitance of about 40 pF. This represents an order of magnitude improvement over the best ionization resolutions obtained on similar phonon-and-ionization germanium cryogenic detectors from the EDELWEISS and SuperCDMS dark matter experiments, and a factor of three improvement compared to the first fully-cryogenic HEMT-based preamplifier coupled to a CDMS-II germanium detector with a total input capacitance of 250 pF. Additionally, we discuss the implications of these results in the context of the future Ricochet experiment and its expected background mitigation performance.

CUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation 0 ν β β decay experiment, CUPID. It consisted of an array of 20 enriched Li 2 100 MoO 4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the 2 ν β β decay and other processes with high precision. We also measure the radio-purity of the Li 2 100 MoO 4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.7  - 0.8 + 0.9  (stat) - 0.7 + 1.5  (syst)  × 10 - 3  counts/ Δ E FWHM / mol iso / year , the lowest in a bolometric 0 ν β β decay experiment.