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Reaching the border of the capable energy limit in existing battery technology has turned research attention away from the rebirth of unstable Li‐metal anode chemistry in order to achieve exceptional performance. Strict regulation of the dendritic Li surface reaction, which results in a short circuit and safety issues, should be achieved to realize Li‐metal batteries. Herein, this study reports a surface‐flattening and interface product stabilizing agent employing methyl pyrrolidone (MP) molecular dipoles in the electrolyte for cyclable Li‐metal batteries. The excellent stability of the Li‐metal electrode over 600 cycles at a high current density of 5 mA cm−2 has been demonstrated using an optimal concentration of the MP additive. This study has identified the flattening surface reconstruction and crystal rearrangement behavior along the stable (110) plane assisted by the MP molecular dipoles. The stabilization of the Li‐metal anodes using molecular dipole agents has helped develop next‐generation energy storage devices using Li‐metal anodes, such as Li–air, Li–S, and semi‐solid‐state batteries. This study reports a N‐methyl‐2‐pyrrolidone (MP) molecular dipoles as an anode surface flattening and interfacial stabilizing agent to achieve longer lifespan and high stability Li‐metal batteries. The simple process of dissolving the MP into the electrolyte offers advantages including a dendrite suppression, modulation of chemical components in solid electrolyte interface layer and crystal rearrangement during Li deposition, thereby enhancing cell stability.

Background and Objectives: Remodeling and healing of the graft are crucial processes for long-term graft survival after anterior cruciate ligament reconstruction (ACLR). However, few studies have objectively evaluated the differences in graft healing between autografts and allografts. This study aimed to compare the status of the anterior cruciate ligament (ACL) grafts between hamstring tendon (HT) autografts and tibialis anterior tendon (TAT) allografts using second-look arthroscopy. Materials and Methods: The outcomes of 193 consecutive patients (153 males and 40 females, with an average age of 30.38 and BMI of 25.43 kg/m2) who underwent second-look arthroscopy following primary ACLR were retrospectively reviewed. Prior to participating in this study, all patients provided written informed consent. The patients were divided into two groups: those with HT autografts and those with TAT allografts. Confounding factors were matched between the two groups using propensity score matching (PSM). ACL graft status was assessed during second-look arthroscopy using a numeric scale system based on the degree of four parameters: graft tension, continuity, synovium coverage, and vascular marking. Clinical outcomes were assessed using the Lysholm and International Knee Documentation Committee (IKDC) scores. Graft status and clinical outcomes were compared between the two groups. Additionally, a subgroup analysis based on the timing of the second-look arthroscopy (12–24 months vs. >24 months after the initial ACLR) was conducted. Results: After PSM, 62 patients were included in each group. The second-look arthroscopy was conducted at 23.6 ± 6.6 months for the HT group and at 24.0 ± 7.9 months for the TAT group (p = 0.749). The continuity and tension of the ACL graft were not significantly different between the two groups (p = 0.146 and 0.075, respectively). However, the TAT group exhibited significantly inferior synovial coverage and vascular marking of the ACL graft compared with the HT group (p = 0.021 and 0.007, respectively). These findings were consistent regardless of the timing of the second-look arthroscopy. Clinical outcomes, according to the Lysholm and IKDC scores, significantly improved in both groups with no significant differences (p = 0.386 and 0.733, respectively). Conclusions: Although there were no differences in graft tension and continuity between HT autografts and TAT allografts, the biological healing of ACL grafts, in terms of synovialization and vascularization, was superior in HT autografts compared to TAT allografts.

Background Peri-implantitis is a biofilm-driven inflammatory condition that often requires surgical intervention. This case series aimed to evaluate the clinical outcomes of implantoplasty guided by a biofluorescence imaging system (BIS) in the surgical treatment of peri-implantitis. Methods Seven patients (13 implants) with peri-implantitis underwent BIS-guided flap surgery and selective implantoplasty. Probing depth (PD) and bleeding on probing (BOP) were assessed at baseline, and at 1, 3, and 6 months postoperatively, as well as at the final follow-up. Nonparametric statistical analyses were used to evaluate longitudinal changes across time points. Results A total of 7 patients (3 males and 4 females; mean age 71.9 ± 10.0 years) with 13 implants diagnosed with peri‑implantitis were included. The mean follow‑up period was 9.9 ± 2.7 months. The mean PD significantly decreased from 6.8 ± 1.5 mm at baseline to 3.0 ± 1.4 mm at the final follow‑up ( p  < 0.001), and BOP was completely resolved in all implants. All implants remained clinically stable, with no complications or recurrence. Conclusions BIS enabled the accurate identification of mature biofilm and facilitated site‑specific, conservative decontamination. This selective approach, which targets infected surfaces while preserving implant structure, may be clinically advantageous for peri‑implantitis management. Further randomized controlled trials are warranted to validate these findings.

Industrial robots play a crucial role in modern manufacturing, but ensuring safe human–robot collaboration remains a challenge. Traditional collision avoidance methods, such as physical barriers and emergency stops, are limited in efficiency and flexibility. This study proposes the Asymmetry Elliptical Likelihood Potential Field (AELPF) algorithm, a novel real-time collision avoidance system inspired by autonomous driving technologies. The AELPF method leverages LiDAR sensors to dynamically compute an asymmetric elliptical repulsive field, enabling precise obstacle detection and avoidance in 3D environments. Unlike conventional potential field approaches, the AELPF accounts for both vertical and horizontal deviations, allowing it to adapt to complex industrial settings. To quantify the performance of AELPF, we compare it to two commonly used algorithms: the Vector Field Histogram (VFH) and the Follow the Gap Method (FGM). In terms of processing time, the VFH algorithm requires 50 ms per cycle, while the FGM algorithm operates at 22 ms. In contrast, the the AELPF, when using only a single channel, processes at 12 ms, which is significantly faster than both the VFH and FGM. These results indicate that the AELPF not only provides faster decision-making but also ensures smoother, more responsive navigation in dynamic environments. Both simulation and physical experiments confirm that the AELPF significantly improves obstacle avoidance, particularly in the z-axis direction, reducing the risk of collisions while maintaining operational efficiency.

The purpose of this study was to develop a microcapsule-type self-healing coating system that could self-heal cracks and then maintain the healed state even upon crack expansion. Mixtures consisting of a photoinitiator and two methacrylate components, bismethacryloxypropyl-terminated polydimethylsiloxane (BMT-PDMS) and monomethacryloxypropyl-terminated PDMS (MMT-PDMS), were transformed into viscoelastic semi-solids through photoreaction. The viscoelasticity of the reacted mixtures could be controlled by varying the mass ratio of the two methacrylates. Through a stretchability test, the optimal composition mixture was chosen as a healing agent. Microcapsules loaded with the healing agent were prepared and dispersed in a commercial undercoating to obtain a self-healing coating formulation. The formulation was applied onto mortar specimens, and then cracks were generated in the coating by using a universal testing machine (UTM). Cracks with around a 150-μm mean width were generated and were allowed to self-heal under UV light. Then, the cracks were expanded up to 650 μm in width. By conducting a water sorptivity test at each expanded crack width, the self-healing efficiency and capability of maintaining the healed state were evaluated. The B-M-1.5-1-based coating showed a healing efficiency of 90% at a 150-μm crack width and maintained its healing efficiency (about 80%) up to a 350-μm crack width. This self-healing coating system is promising for the protection of structural materials that can undergo crack formation and expansion.

COVID-19 antibody detection is dependent on highly specialized, time-consuming techniques, such as PCR separation, DNA amplification, and other methods such as spectrophotometric absorption. For these reasons, specialized technical training is necessary because individual diagnostic treatment is difficult. We have attempted to perform rapid sensing with a detection time of only 30 s. Additionally, we used a wearable multi-layer graphene oxide nanocolloid synthetic skin tattoo probe assay for influenza and COVID-19 virus detection with an electrochemical antigen–antibody redox ionic titration circuit. Cyclic voltametric−2 V~2.0 V potential windows were used. The diagnostic detection limit was determined using stripping anodic and cathodic amplifiers, and the working probe was fabricated with a graphene molecule structure with a virus antigen-immobilized amplifier. With redox potential strength obtained within −1.0 V~−1.3 V ionic activity, anodic and cathodic current linearly increased in the phosphate-buffered saline 5 mL electrolyte. The results indicate that instant detection was enabled via individual and wearable tattoo sensors.

There have been studies recently on bubble-column scrubbers with low cost and high efficiency for the absorption and treatment of hazardous gases in the event of a chemical spill. Bubble columns are vulnerable to freezing at temperatures below zero because the absorbents generally do not circulate. To address this issue, this study focused on the applicability, absorbed amount, and performance of brine as an absorbent. Under three different temperatures, i.e., −5 °C, −8 °C and −10 °C we examined brine (NaCl, CaCl2, and MgCl2) by varying the concentration required at each temperature. Following the experiments, CaCl2 brine was determined as the optimal brine for its absorption performance and affordability. Based on the experimental results, the absorption performance for ammonia, ethylene oxide, and methylamine, which are hazardous and water-soluble gases among accident preparedness substances (APS), was tested by using ASEPN PLUS. Our results suggested although the efficiency dropped by about 5% to 25% when brine was used as an absorbent, it can be used at the low temperatures because the gas solubility increased with decreasing temperature. Therefore, if brine, as an alternative, is used at temperatures about 15 °C, it can operate efficiently and stably without deterioration in the absorption performance. Given our experimental results and design data on the absorbed amount and absorbent replacement period for major hazardous gases are utilized to prevent bubble columns from freezing, it can be commercially used for small and medium-sized enterprises because it can help reduce installation and operation costs.

Background and objectives: Previous studies consistently found no significant difference between supervised and home-based rehabilitation after anterior cruciate ligament reconstruction (ACLR). However, the function of the nonoperative knee, hamstring strength at deep flexion, and neuromuscular control have been overlooked. This prospective observational study was performed to investigate the outcomes after ACLR in operative and nonoperative knees between supervised and home-based rehabilitations. Materials and Methods: After surgery, instructional videos demonstrating the rehabilitation process and exercises were provided for the home-based rehabilitation group. The supervised rehabilitation group visited our sports medicine center and physical therapists followed up all patients during the entire duration of the study. Isokinetic muscle strength and neuromuscular control (acceleration time (AT) and overall stability index (OSI)) of both operative and nonoperative knees, as well as patient-reported knee function (Lysholm score), were measured and compared between the two groups 6 months and 1 year postoperatively. Results: The supervised rehabilitation group showed higher muscle strength of hamstring and quadriceps in nonoperative knees at 6 months (hamstring, p = 0.033; quadriceps, p = 0.045) and higher hamstring strength in operative and nonoperative knees at 1 year (operative knees, p = 0.035; nonoperative knees, p = 0.010) than the home-based rehabilitation group. At 6 months and 1 year, OSIs in operative and nonoperative knees were significantly better in the supervised rehabilitation group than in the home-based rehabilitation group (operative knees, p < 0.001, p < 0.001; nonoperative knees, p < 0.001, p < 0.001, at 6 months and 1 year, respectively). At 1 year, the supervised rehabilitation group also demonstrated faster AT of the hamstrings (operative knees, p = 0.016; nonoperative knees, p = 0.036). Lysholm scores gradually improved in both groups over 1 year; however, the supervised rehabilitation group showed higher scores at 1 year (87.3 ± 5.8 vs. 75.6 ± 15.1, p = 0.016). Conclusions: This study demonstrated that supervised rehabilitation may offer additional benefits in improving muscle strength, neuromuscular control, and patient-reported knee function compared with home-based rehabilitation up to 1 year after ACLR.

BackgroundNano-sized drug delivery system has been widely studied as a potential technique to promote tumor-specific delivery of anticancer drugs due to its passive targeting property, but resulting in very restricted improvements in its systemic administration so far. There is a requirement for a different approach that dramatically increases the targeting efficiency of therapeutic agents at targeted tumor tissues.MethodsTo improve the tumor-specific accumulation of anticancer drugs and minimize their undesirable toxicity to normal tissues, a tumor-implantable micro-syringe chip (MSC) with a drug reservoir is fabricated. As a clinically established delivery system, six liposome nanoparticles (LNPs) with different compositions and surface chemistry are prepared and their physicochemical properties and cellular uptake are examined in vitro. Subsequently, MSC-guided intratumoral administration is studied to identify the most appropriate for the higher tumor targeting efficacy with a uniform intratumoral distribution. For efficient cancer treatment, pro-apoptotic anticancer prodrugs (SMAC-P-FRRG-DOX) are encapsulated to the optimal LNPs (SMAC-P-FRRG-DOX encapsulating LNPs; ApoLNPs), then the ApoLNPs are loaded into the 1 μL-volume drug reservoir of MSC to be delivered intratumorally for 9 h. The tumor accumulation and therapeutic effect of ApoLNPs administered via MSC guidance are evaluated and compared to those of intravenous and intratumoral administration of ApoLNP in 4T1 tumor-bearing mice.ResultsMSC is precisely fabricated to have a 0.5 × 4.5 mm needle and 1 μL-volume drug reservoir to achieve the uniform intratumoral distribution of LNPs in targeted tumor tissues. Six liposome nanoparticles with different compositions of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (PC), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (PS), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)2000] (PEG2000-DSPE) are prepared with average sizes of 100–120 nm and loaded into the 1 μL-volume drug reservoir in MSC. Importantly negatively charged 10 mol% of PS-containing LNPs are very slowly infused into the tumor tissue through the micro-syringe of the MSC over 6 h. The intratumoral targeting efficiency of MSC guidance is 93.5%, effectively assisting the homogeneous diffusion of LNPs throughout the tumor tissue at 3.8- and 2.7-fold higher concentrations compared to the intravenous and intratumoral administrations of LNPs, respectively. Among the six LNP candidates 10 mol% of PS-containing LNPs are finally selected for preparing pro-apoptotic SMAC-P-FRRG-DOX anticancer prodrug-encapsulated LNPs (ApoLNPs) due to their moderate endocytosis rate high tumor accumulation and homogenous intratumoral distribution. The ApoLNPs show a high therapeutic effect specifically to cathepsin B-overexpressing cancer cells with 6.6 μM of IC50 value while its IC50 against normal cells is 230.7 μM. The MSC-guided administration of ApoLNPs efficiently inhibits tumor growth wherein the size of the tumor is 4.7- and 2.2-fold smaller than those treated with saline and intratumoral ApoLNP without MSC, respectively. Moreover, the ApoLNPs remarkably reduce the inhibitor of apoptosis proteins (IAPs) level in tumor tissues confirming their efficacy even in cancers with high drug resistance.ConclusionThe MSC-guided administration of LNPs greatly enhances the therapeutic efficiency of anticancer drugs via the slow diffusion mechanism through micro-syringe to tumor tissues for 6 h, whereas they bypass most hurdles of systemic delivery including hepatic metabolism, rapid renal clearance, and interaction with blood components or other normal tissues, resulting in the minimum toxicity to normal tissues. The negatively charged ApoLNPs with cancer cell-specific pro-apoptotic prodrug (SMAC-P-FRRG-DOX) show the highest tumor-targeting efficacy when they are treated with the MSC guidance, compared to their intravenous or intratumoral administration in 4T1 tumor-bearing mice. The MSC-guided administration of anticancer drug-encapsulated LNPs is expected to be a potent platform system that facilitates overcoming the limitations of systemic drug administration with low delivery efficiency and serious side effects.

In this study, we investigated the effects of gamma irradiation on the antioxidant activity and metabolite profiles of Euphorbia maculata calli (PC3012). Gamma irradiation at various doses (0, 0.05, 0.5, and 10 kGy) significantly enhanced the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS+) radical scavenging activities of the callus extracts of PC3012 in a dose-dependent manner. High-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF/MS) analyses revealed that irradiation increased the lysophospholipid content, although no new antioxidant compounds were formed. Furthermore, a PLS-DA analysis revealed evident metabolic differences between non-irradiated and irradiated samples, which were further verified by statistical validation. These findings suggest that gamma irradiation induces specific biochemical modifications that enhance the bioactive properties of PC3012 calli. This technology exhibits potential for utilization in the natural product and food sectors, particularly in the development of functional foods and nutraceuticals with improved health benefits.