Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,496
result(s) for
"Jung, Paul"
Sort by:
كارل يونج
تناول هذا الكتاب حياة كارل يونج منذ طفولته المبكرة حتى سنواته في جامعة بازل، وعلاقته الوثيقة بسيجموند فرويد، وانفصاله عنه، بعد أن رأى فرويد في يونج خليفته وولي عهده شخصا سيواصل عمله ويطوره، الوريث الذي كان يسعى إليه لاستكمال مسيرة التحليل النفسي، لكن أصبح الانفصال أمرا لا مفر منه. ولاستكشاف أفكار يونج استعرض الكتاب مآسي جوته في فاوست ونيتشه في هكذا تكلم زرادشت، فضلا عن الدور الذي لعبه الكتاب الأحمر، الذي كتب بين عامي 1914 و1930، ولكن لم ينشر حتى عام 2009، الذي أسهم في تطور فكر يونج.
Book
Protocols and Programs for High-Throughput Growth and Aging Phenotyping in Yeast
In microorganisms, and more particularly in yeasts, a standard phenotyping approach consists in the analysis of fitness by growth rate determination in different conditions. One growth assay that combines high throughput with high resolution involves the generation of growth curves from 96-well plate microcultivations in thermostated and shaking plate readers. To push the throughput of this method to the next level, we have adapted it in this study to the use of 384-well plates. The values of the extracted growth parameters (lag time, doubling time and yield of biomass) correlated well between experiments carried out in 384-well plates as compared to 96-well plates or batch cultures, validating the higher-throughput approach for phenotypic screens. The method is not restricted to the use of the budding yeast Saccharomyces cerevisiae, as shown by consistent results for other species selected from the Hemiascomycete class. Furthermore, we used the 384-well plate microcultivations to develop and validate a higher-throughput assay for yeast Chronological Life Span (CLS), a parameter that is still commonly determined by a cumbersome method based on counting \"Colony Forming Units\". To accelerate analysis of the large datasets generated by the described growth and aging assays, we developed the freely available software tools GATHODE and CATHODE. These tools allow for semi-automatic determination of growth parameters and CLS behavior from typical plate reader output files. The described protocols and programs will increase the time- and cost-efficiency of a number of yeast-based systems genetics experiments as well as various types of screens.
Journal Article
Global phylogeographical distribution of Gloeoporus dichrous
Phylogeographic analyses are efficient in ecological and evolutionary studies to discover the origin of a lineage, its dispersal routes, and the divergence of ancestral traits. Studies on widespread wood-decay fungi have revealed the phylogenetic division of several polypores based on geographical distribution. In this study, specimens of Gloeoporus dichrous , a cosmopolitan polypore species, were collected globally and analyzed for their geographic distribution. Multi-marker Bayesian molecular clock and haplotype analyses revealed a clear division of G . dichrous populations by continent. The species diverged from its neighboring clades 10.3 (16.0–5.6) million years ago, with Asian and North American populations at the center of divergence. Possible dispersal mechanisms and pathways are predicted and discussed based on the evaluated transfer routes. The biogeography of G . dichrous analyzed in this study represents a fraction of the polypore evolution and may advance the understanding of the overall evolution of wood-decay fungi.
Journal Article
Strange loop
\"It's the holiday season in Burnside, and everyone is getting into the spirit...including Harley Quinn and the Penguin! After the maid of mischief infects Barbara Gordon's company party with a killer virus, Batgirl must embark on a wild-goose chase around the city to find a cure. Meanwhile, a massive blizzard hits Gotham City without warning, and Batgirl must brave the bitter cold to discover the truth behind the storm. When the storm finally clears, Batgirl begins a thorough investigation into a string of attacks targeted toward women in Burnside. But she's not the only one searching. Can a father-daughter duo put their differences aside long enough to crack the case?\"-- Provided by publisher.
Book
Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human wellbeing. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Novel electrochemical and optical detection tools have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. Recently, researchers have designed sensitive and selective electrochemical and optical platforms by using new surface modifications, microfabrication techniques, and the decoration of diverse nanomaterials with unique properties for the detection of tryptophan and melatonin. However, there is a scarcity of review articles addressing the recent developments in the electrochemical and optical detection of tryptophan and melatonin. Here, we provide a critical and objective review of high-sensitivity tryptophan and melatonin sensors that have been developed over the past six years (2015 onwards). We review the principles, performance, and limitations of these sensors. We also address critical aspects of sensitivity and selectivity, limit and range of detection, fabrication process and time, durability, and biocompatibility. Finally, we discuss challenges related to tryptophan and melatonin detection and present future outlooks. Keywords: tryptophan, melatonin, electrochemical, sensors, voltammetry, optical
Journal Article
Robust perceptual-load-dependent audiovisual integration in adult ADHD
We perceive our daily-life surrounded by different senses (e.g., visual, and auditory). For a coherent percept, our brain binds those multiple streams of sensory stimulations, i.e., multisensory integration (MI). Dependent on stimulus complexity, early MI is triggered by bottom–up or late via top–down attentional deployment. Adult attention-deficit/hyperactivity disorder (ADHD) is associated with successful bottom–up MI and deficient top–down MI. In the current study, we investigated the robustness of the bottom–up MI by adding additional task demand varying the perceptual load. We hypothesized diminished bottom–up MI for high perceptual load for patients with ADHD. 18 adult patients with ADHD and 18 age- and gender-matched healthy controls participated in this study. In the visual search paradigm, a target letter was surrounded by uniform distractors (low load) or by different letters (high load). Additionally, either unimodal (visual flash, auditory beep) or multimodal (audiovisual) flanked the visual search. Linear-mixed modeling was used to investigate the influence of load on reaction times. Further, the race model inequality was calculated. Patients with ADHD showed a similar degree of MI performance like healthy controls, irrespective of perceptual load manipulation. ADHD patients violated the race model for the low load but not for the high-load condition. There seems to be robust bottom–up MI independent of perceptual load in ADHD patients. However, the sensory accumulation might be altered when attentional demands are high.
Journal Article
Population Genomics Reveals Chromosome-Scale Heterogeneous Evolution in a Protoploid Yeast
Yeast species represent an ideal model system for population genomic studies but large-scale polymorphism surveys have only been reported for species of the Saccharomyces genus so far. Hence, little is known about intraspecific diversity and evolution in yeast. To obtain a new insight into the evolutionary forces shaping natural populations, we sequenced the genomes of an expansive worldwide collection of isolates from a species distantly related to Saccharomyces cerevisiae: Lachancea kluyveri (formerly S. kluyveri). We identified 6.5 million single nucleotide polymorphisms and showed that a large introgression event of 1 Mb of GC-rich sequence in the chromosomal arm probably occurred in the last common ancestor of all L. kluyveri strains. Our population genomic data clearly revealed that this 1-Mb region underwent a molecular evolution pattern very different from the rest of the genome. It is characterized by a higher recombination rate, with a dramatically elevated A:T → G:C substitution rate, which is the signature of an increased GC-biased gene conversion. In addition, the predicted base composition at equilibrium demonstrates that the chromosome-scale compositional heterogeneity will persist after the genome has reached mutational equilibrium. Altogether, the data presented herein clearly show that distinct recombination and substitution regimes can coexist and lead to different evolutionary patterns within a single genome.
Journal Article
The Effect of Developmental Trauma on Brain Structures Involved in Threat and Memory Processing and Its Relation to Psychotic Experiences in Adulthood
Despite growing evidence of a causal association between developmental trauma (DT) and psychotic experiences (PEs), the precise neurobiological mechanisms underlying this association remain poorly understood. We examined the effect of DT on the structure of brain regions involved in threat and memory processing, and the role of these alterations in the association between DT and PEs.
This study used data from the Avon Longitudinal Study of Parents and Children, a large, population-based birth cohort in the United Kingdom. Data were available from 419 participants, including DT reported by the parents or the participants between ages 0 and 17 years, PEs at age 18, and volumes of regions involved in threat and memory processing in adulthood (mean = 21,2, SD = 1.5 years).
DT exposure was associated with increased odds of PEs (odds ratio [OR] = 1.64; 95% CI, 1.04-2.59, P = .035), with evidence supporting cumulative risk effects for exposure to multiple trauma types (B = 0.160, P < .001). DT was also associated with reduced left amygdala volumes (B = -0.011, P = .02) with evidence again supporting cumulative risk effect with multiple trauma types (B = -0.006, P = .01). Reduced bilateral amygdala volume was associated with an increased odds of PEs driven by the left amygdala (OR = 0.001, 95% CI, 0.000-0.154, P = .006).
These findings are consistent with theories that alterations in brain regions involved in threat and memory processing lie on the neurobiological pathway from DT to PEs, offering the possibility of prevention strategies for psychosis.
Journal Article
Comparative Mitochondrial Genomics within and among Yeast Species of the Lachancea Genus
Yeasts are leading model organisms for mitochondrial genome studies. The explosion of complete sequence of yeast mitochondrial (mt) genomes revealed a wide diversity of organization and structure between species. Recently, genome-wide polymorphism survey on the mt genome of isolates of a single species, Lachancea kluyveri, was also performed. To compare the mitochondrial genome evolution at two hierarchical levels: within and among closely related species, we focused on five species of the Lachancea genus, which are close relatives of L. kluyveri. Hence, we sequenced the complete mt genome of L. dasiensis, L. nothofagi, L. mirantina, L. fantastica and L. meyersii. The phylogeny of the Lachancea genus was explored using these data. Analysis of intra- and interspecific variability across the whole Lachancea genus led to the same conclusions regarding the mitochondrial genome evolution. These genomes exhibit a similar architecture and are completely syntenic. Nevertheless, genome sizes vary considerably because of the variations of the intergenic regions and the intron content, contributing to mitochondrial genome plasticity. The high variability of the intergenic regions stands in contrast to the high level of similarity of protein sequences. Quantification of the selective constraints clearly revealed that most of the mitochondrial genes are under purifying selection in the whole genus.
Journal Article