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"Jury, David"
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The Role of Paraventricular Nucleus of Thalamus in Sleep Disturbance Induced by Withdrawal from Repeated Ethanol Exposure
Sleep disturbance is known to be comorbid with withdrawal from repeated ethanol exposure and could be a negative reinforcement for the majority of people with alcohol use disorder (AUD). The paraventricular nucleus of the thalamus (PVT) has been highlighted for its function in integrating arousal states and associated modulation in sleep homeostasis. However, there is limited understanding of the involvement of PVT neurons in regulating sleep patterns, especially during withdrawal from chronic ethanol exposure. In this study, we investigated the potential function of the PVT in sleep disturbance during ethanol withdrawal using electrophysiology, in vivo calcium imaging, biochemical, and chemogenetic approaches. At 24 hours post-withdrawal from chronic intermittent ethanol exposure (CIE) for four weeks, there is an increase in wake time and a decrease in non-rapid eye movement (NREM) sleep. The calcium transient levels in the PVT neurons are positively correlated with the transition from sleep to wakefulness. CIE elevates the PVT neuronal activity in a subregion-specific manner, resulting in a significant rise in cFos levels in the anterior PVT (aPVT). Temporal suppression of aPVT excitatory neurons via chemogenetics ameliorates the disturbance in sleep patterns generated by CIE. The aPVT has a notable distinction in the expression of the m-type potassium channel subunit, KCNQ2, with a higher expression level compared to the posterior PVT (pPVT). While the expression of KCNQ2 in the aPVT is reduced in CIE mice, the restoration of KCNQ2 expression using viral gene transfer within the aPVT alleviates the sleep disturbances produced by CIE. This data indicates a significant role of the PVT in sleep disturbance during ethanol withdrawal, which may partially be due to the downregulation of M-channels, hence underscoring M-channels in the PVT as a potential therapeutic target for sleep disturbance in alcohol use disorder.
Journal Article
The little book of typographic ornament
\"This little book contains a beautiful and varied collection of typographic ornaments sourced from specimen books of type foundries, dating from 1700. David Jury explains how the need for typographic ornaments arose and developed, and sets them in their historical context. The chapters cover natural forms; geometric forms; rules and borders; wreaths, borders and scrolls; and pictorial ornaments. The last chapter charts the rise of the graphic designer over the last century, and how modern designers are now reinterpreting these typographic ornaments into new forms of art. The Little Book of Typographic Ornament will be an invaluable reference for graphic designers, as well as providing a source of copyright-free images.\"--Publisher's description.
Book
IRA wrecks Grand National
Sixty thousand racegoers were evacuated from Aintree yesterday when bomb warnings sent with recognised IRA codewords forced the abandonment of the 150th Grand National. An estimated 20,000 people were stranded in Liverpool when their cars and coaches were marooned inside the racecourse. With most of the city's hotels full, it meant a night in emergency accommodation. The 100 horses left at the Aintree course during evacuation were rescued after four hours after the RSPCA and racecourse officials persuaded police to let them be removed.
Newspaper Article
Doctors' hope is that rescue for Belma has not come too late
[Belma Salaka], whose fourth birthday is next week, was among the first of the airlifted patients to leave the plane at Heathrow Airport. She was barely visible as a hydraulic lift carried her down to a waiting London ambulance. Eleven-year-old Edhem Dedovic, dressed in denim and wearing a patch over his eye, stood and waved for several minutes before getting into an ambulance. He was taken by ambulance to University College Hospital still unaware he had lost his left eye. The adult victims were mainly men suffering injuries including amputated libs, infected bones, serious fractures and shrapnel injuries. Several had eye injuries and one man with severe spinal injury was expected to be taken to Stoke Mandeville Hospital, Aylesbury.
Newspaper Article
Stolen Turners get first public airing in 8 years
Shade and Darkness was tracked down two years ago by the gallery, which used pounds 3.5m from a pounds 24m insurance payout to fund the hunt. But the other work was not retrieved until shortly before Christmas. Details of the rescue operation have not been revealed while efforts continue to retrieve another work, by the German artist Caspar David Friedrich, stolen from the same exhibition in Germany. It does not belong to the [Tate]. Sandy Nairne, formerly director of programmes at Tate Britain and now director of the National Portrait Gallery, co-ordinated the search on behalf of the Tate.
Newspaper Article
Lifetime BBC man to be new head of Channel 4
MARK THOMPSON, the director of television at the BBC, is to be the new chief executive of Channel 4. The appointment to the pounds 400,000- plus post was to be announced last night; but Mr Thompson was said to be locked in last-minute talks with the BBC over the exact timing and terms of his departure. Channel 4 will almost certainly announce the appointment today and introduce Mr Thompson at a press conference. Mr Thompson, who has three children, is tall, amiable and has a bookish manner, with none of the slick, Armani-suited chic that epitomised the John Birt regime. Yet after cutting his teeth on Watchdog, the launch of BBC Breakfast News in 1982 and Newsnight, it was Mr Birt (made Lord Birt after he left the BBC, to be replaced by Mr Dyke) who picked him, aged 30, to become editor of the Nine O'Clock News. He was promptly given the task of steering through the BBC's plans for its new digital services, the two children's channels and BBC3 (from the old BBC Choice) and BBC4 (from BBC Knowledge).
Newspaper Article
Disney draws back from computer age
The opening of the latest Walt Disney blockbuster, The Hunchback of Notre Dame is being seen in the film industry as a successful riposte by the world's leading animation studio to the hi-tech cinematics now challenging its supremacy. Disney appears convinced there is still a market for traditional animation, despite the success of Toy Story, with its 3D computer-generated images. The Hunchback of Notre Dame opens across the country tomorrow, but the wonders of computer wizardry are already widespread. The stampede scene in The Lion King, released in Britain two years ago, was computer-generated, and there are numerous examples in the more recent film, Pocahontas. Even five years ago, the techniques were used in Beauty and the Beast.
Newspaper Article