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In Japan, the use of public-access defibrillation for patients with out-of-hospital cardiac arrest increased substantially from 2005 to 2013. The rate of 1-month survival with favorable neurologic outcome was significantly higher with than without public-access defibrillation. Owing to an emphasis on the chain of survival 1 , 2 as well as revisions to cardiopulmonary resuscitation (CPR) guidelines, 3 , 4 the rate of survival after out-of-hospital cardiac arrest in industrialized countries has been increasing, 5 – 7 but it remains low (approximately 10%). Early defibrillation plays a key role in improving survival after out-of-hospital cardiac arrest due to ventricular fibrillation (ventricular-fibrillation cardiac arrest). 8 Many reports have shown that public-access defibrillation by laypersons contributes to improving outcomes after out-of-hospital cardiac arrest, 9 – 12 and the introduction of public-access automated external defibrillators (AEDs) has been widely accepted in developed communities. 13 , 14 However, the effects of . . .

The American Heart Association recommends cardiopulmonary resuscitation (CPR) by bystanders with chest compression only for adults who have cardiac arrests, but not for children. We assessed the effect of CPR (conventional with rescue breathing or chest compression only) by bystanders on outcomes after out-of-hospital cardiac arrests in children. In a nationwide, prospective, population-based, observational study, we enrolled 5170 children aged 17 years and younger who had an out-of-hospital cardiac arrest from Jan 1, 2005, to Dec 31, 2007. Data collected included age, cause, and presence and type of CPR by bystander. The primary endpoint was favourable neurological outcome 1 month after an out-of-hospital cardiac arrest, defined as Glasgow-Pittsburgh cerebral performance category 1 or 2. 3675 (71%) children had arrests of non-cardiac causes and 1495 (29%) cardiac causes. 1551 (30%) received conventional CPR and 888 (17%) compression-only CPR. Data for type of CPR by bystander were not available for 12 children. Children who were given CPR by a bystander had a significantly higher rate of favourable neurological outcome than did those not given CPR (4·5% [110/2439] vs 1·9% [53/2719]; adjusted odds ratio [OR] 2·59, 95% CI 1·81–3·71). In children aged 1–17 years who had arrests of non-cardiac causes, favourable neurological outcome was more common after bystander CPR than no CPR (5·1% [51/1004] vs 1·5% [20/1293]; OR 4·17, 2·37–7·32). However, conventional CPR produced more favourable neurological outcome than did compression-only CPR (7·2% [45/624] vs 1·6% [six of 380]; OR 5·54, 2·52–16·99). In children aged 1–17 years who had arrests of cardiac causes, favourable neurological outcome was more common after bystander CPR than no CPR (9·5% [42/440] vs 4·1% [14/339]; OR 2·21, 1·08–4·54), and did not differ between conventional and compression-only CPR (9·9% [28/282] vs 8·9% [14/158]; OR 1·20, 0·55–2·66). In infants (aged <1 year), outcomes were uniformly poor (1·7% [36/2082] with favourable neurological outcome). For children who have out-of-hospital cardiac arrests from non-cardiac causes, conventional CPR (with rescue breathing) by bystander is the preferable approach to resuscitation. For arrests of cardiac causes, either conventional or compression-only CPR is similarly effective. Fire and Disaster Management Agency and the Ministry of Education, Culture, Sports, Science and Technology (Japan).

This paper proposes a flexible path-planning method for conducting agricultural observation tasks using multiple autonomous guided vehicles. The observation task was formulated as the rural postman problem by graphing the agricultural field to be observed and assigning costs to mandatory and optional paths. The observation area was re-divided according to the progress of each robot’s work, and the latest path was planned to minimize the difference between the working time of individual robots, thereby reducing the overall working time. Simulations were conducted to verify the influence of the parameters used in the proposed method. The effect of workload adjustment on progress delay was verified, and the increase in overall working time owing to delay was reduced by an average of 32.9%. A performance comparison was conducted using Google OR-Tools, software specialized for combinatorial optimization. Superior solutions with shorter computation times were obtained using the proposed method.

Although exercise-induced vascular adaptations have been extensively reported in racket sports athletes, the applicability of these findings to athletes in other overhead sports is unclear. This study aimed to investigate exercise-induced vascular adaptations in college male baseball players. Furthermore, since the training frequency of the upper arm may differ by baseball playing position, this study also focused on playing position-specific differences in brachial arterial adaptations. Cross-sectional study. Seventy-five baseball players and 23 sedentary young men aged 18–23 years participated in this study. The participants' brachial artery diameter, blood flow velocity, and blood flow volume were measured using an ultrasonic diagnostic imaging system. Brachial hemodynamic measurements of both hands were obtained randomly in a seated resting position. Baseball players demonstrated significantly greater brachial lean mass, circumference, arterial diameter, and blood flow volume than sedentary control participants. Statistically significant differences in brachial artery diameters between the non-dominant and dominant arms were observed only in the baseball pitcher group. Furthermore, body surface area- and brachial lean mass-corrected artery diameters in the dominant arm were also significantly larger than those in the non-dominant arm in the baseball pitcher group. A simple correlation analysis revealed a positive association between brachial lean mass/circumference and arterial diameter in all participants. These findings suggest asymmetrical exercise-induced vascular adaptations in the brachial artery of baseball players, particularly pitchers, indicating the potential role of playing position-specific demands in vascular remodeling. Understanding these adaptations may inform training strategies and help prevent injuries in baseball players.

“Yips” are involuntary movements that interfere with the automatic execution of sports movements. However, how the coordination among the various muscles necessary for sports movements is impaired in athletes with yips remains to be fully understood. This study aimed to assess whether muscle synergy analysis through non-negative matrix factorization (NMF) could identify impaired spatiotemporal muscle coordination in baseball players with throwing yips. Twenty-two college baseball players, including 12 with and 10 without yips symptoms participated in the study. Electromyographic activity was recorded from 13 ipsilateral upper extremity muscles during full-effort throwing. Muscle synergies were extracted through NMF. Cluster analysis was conducted to identify any common spatiotemporal patterns of muscle synergies in players with yips. Whether individual players with yips showed deviations in spatiotemporal patterns of muscle synergies compared with control players was also investigated. Four muscle synergies were extracted for each player, but none were specific to the yips group. However, a more detailed analysis of individual players revealed that two of the three players who presented dystonic symptoms during the experiment exhibited specific patterns that differed from those in control players. By contrast, each player whose symptoms were not reproduced during the experiment presented spatiotemporal patterns of muscle synergies similar to those of the control group. The results of this study indicate no common spatiotemporal pattern of muscle synergies specific to the yips group. Furthermore, these results suggest that the spatiotemporal pattern of muscle synergies in baseball throwing motion is not impaired in situations where symptoms are not reproduced even if the players have yips symptoms. However, muscle synergy analysis can identify the characteristics of muscle coordination of players who exhibit dystonic movements. These findings can be useful in developing personalized therapeutic strategies based on individual characteristics of yips symptoms.

Curling is a two-player, zero-sum, finite, complete-information, uncertain game in which stones are delivered to a point approximately 37 m (120 ft). Despite its popularity, the dynamics of curling stones are unclear, and significant variations exist in the conditions of curling stones and curling sheets. It is essential to have a highly reproducible delivery apparatus that can perform tests in various environments to clarify stone dynamics and evaluate curling stones and sheets more accurately. In this study, we developed a delivery robot capable of delivering stones as quickly and accurately as, if not better than, a human using a large-diameter pneumatic cylinder. The delivery robot could deliver stones with high repeatability at 2.0 to 4.0 m/s by controlling the velocity of the pneumatic cylinder using multiple solenoid valves. In addition, we verified the accuracy of the robot’s velocity meter using motion capture to ensure that the throwing velocity measured by the delivery robot was sufficiently accurate. Finally, we conducted repeated delivery experiments using the delivery robot and demonstrated that the robot could deliver stones with high repeatability.

The motor imagery ability is closely related to an individual’s motor performance in sports. However, whether motor imagery ability is diminished in athletes with yips, in whom motor performance is impaired, is unclear. Therefore, this cross-sectional study aimed to determine whether general motor imagery ability or vividness of motor imagery specific to throwing motion is impaired in baseball players with throwing yips. The study enrolled 114 college baseball players. They were classified into three groups: 33 players in the yips group, 26 in the recovered group (previously had yips symptoms but had resolved them), and 55 in the control group. They answered the revised version of the vividness of movement imagery questionnaire (VMIQ-2), which assesses general motor imagery ability. Furthermore, they completed a questionnaire that assesses both positive and negative motor imagery vividness specific to baseball throwing. In the former, they responded to their ability to vividly imagine accurately throwing a controlled ball, whereas in the latter, they responded to the vividness of their experience of negative motor imagery associated with baseball throwing, specifically the image of a wild throw. No significant difference in the VMIQ-2 was found among the three groups. While no significant difference in the vividness of positive motor imagery for ball throwing was found in either first-person visual or kinesthetic perspectives among the three groups, the yips group exhibited significantly higher vividness of negative motor imagery than the control group in both perspectives. These results indicate that negative motor imagery specific to baseball throwing may be associated with symptoms of yips. Therefore, interventions addressing psychological aspects, such as anxiety, which are potential causes of the generation of negative motor imagery, may be necessary to alleviate the symptoms of yips.

Juvenile loneliness is a risk factor for psychopathology in later life. Deprivation of early social experience due to peer rejection has a detrimental impact on emotional and cognitive brain function in adulthood. Accumulating evidence indicates that soy peptides have many positive effects on higher brain function in rodents and humans. However, the effects of soy peptide use on juvenile social isolation are unknown. Here, we demonstrated that soy peptides reduced the deterioration of behavioral and cellular functions resulting from juvenile socially-isolated rearing. We found that prolonged social isolation post-weaning in male C57BL/6J mice resulted in higher aggression and impulsivity and fear memory deficits at 7 weeks of age, and that these behavioral abnormalities, except impulsivity, were mitigated by ingestion of soy peptides. Furthermore, we found that daily intake of soy peptides caused upregulation of postsynaptic density 95 in the medial prefrontal cortex and phosphorylation of the cyclic adenosine monophosphate response element binding protein in the hippocampus of socially isolated mice, increased phosphorylation of the adenosine monophosphate-activated protein kinase in the hippocampus, and altered the microbiota composition. These results suggest that soy peptides have protective effects against juvenile social isolation-induced behavioral deficits via synaptic maturation and cellular functionalization.

Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia. To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patients with CAP and HCAP. A prospective observational study was conducted in hospitalized patients with pneumonia at 10 institutions in Japan. Pathogens identified as not susceptible to ceftriaxone, ampicillin-sulbactam, macrolides, and respiratory fluoroquinolones were defined as CAP drug-resistant pathogens (CAP-DRPs). In total, 1,413 patients (887 CAP and 526 HCAP) were analyzed. CAP-DRPs were more frequently found in patients with HCAP (26.6%) than in patients with CAP (8.6%). Independent risk factors for CAP-DRPs were almost identical in patients with CAP and HCAP. These included prior hospitalization (adjusted odds ratio [AOR], 2.06; 95% confidence interval [CI], 1.23-3.43), immunosuppression (AOR, 2.31; 95% CI, 1.05-5.11), previous antibiotic use (AOR, 2.45; 95% CI, 1.51-3.98), use of gastric acid-suppressive agents (AOR, 2.22; 95% CI, 1.39-3.57), tube feeding (AOR, 2.43; 95% CI, 1.18-5.00), and nonambulatory status (AOR, 2.45; 95% CI, 1.40-4.30) in the combined patients with CAP and HCAP. The area under the receiver operating characteristic curve for counting the number of risk factors was 0.79 (95% CI, 0.74-0.84). The clinical profile of HCAP was different from that of CAP. However, physicians can predict drug resistance in patients with either CAP or HCAP by taking account of the cumulative number of the risk factors. Clinical trial registered with https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000004001&language=E ; number UMIN000003306.

We aimed to investigate the association between serum lactate levels during cardiopulmonary resuscitation (CPR) and survival in patients with out-of-hospital cardiac arrest (OHCA). From the database of a multicenter registry on OHCA patients, we included adult nontraumatic OHCA patients transported to the hospital with ongoing CPR. Based on the serum lactate levels during CPR, the patients were divided into four quartiles: Q1 (≤ 10.6 mEq/L), Q2 (10.6–14.1 mEq/L), Q3 (14.1–18.0 mEq/L), and Q4 (> 18.0 mEq/L). The primary outcome was 1-month survival. Among 5226 eligible patients, the Q1 group had the highest 1-month survival (5.6% [74/1311]), followed by Q2 (3.6% [47/1316]), Q3 (1.7% [22/1292]), and Q4 (1.0% [13/1307]) groups. In the multivariable logistic regression analysis, the adjusted odds ratio of Q4 compared with Q1 for 1-month survival was 0.24 (95% CI 0.13–0.46). 1-month survival decreased in a stepwise manner as the quartiles increased ( p for trend < 0.001). In subgroup analysis, there was an interaction between initial rhythm and survival ( p for interaction < 0.001); 1-month survival of patients with a non-shockable rhythm decreased when the lactate levels increased ( p for trend < 0.001), but not in patients with a shockable rhythm ( p for trend = 0.72). In conclusion, high serum lactate level during CPR was associated with poor 1-month survival in OHCA patients, especially in patients with non-shockable rhythm.