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"Kaczmarczyk, Lisa C"
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Computers and society : computing for good
Because computer scientists make decisions every day that have societal context and influence, an understanding of society and computing together should be integrated into computer science education. Showing what you can do with your computing degree, Computers and Society: Computing for Good uses concrete examples and case studies to highlight the positive work of real computing professionals and organizations from around the world. Encouraging you to engage actively and critically with the material, the book offers a wealth of exercises and activities at the end of each chapter. Questions of varying difficulty ask you to apply the material to yourselves or your surroundings and to think critically about the material from the perspective of a future computing professional. The text also incorporates individual projects, team projects, short projects, and semester-long projects.
Book
Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression
Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnings of this trait and whether it directly drives disease progression is unclear. Here, we identify co-ordinate epigenetic inactivation of two epithelial-specific transcription factors, EHF and CDX1, as a mechanism driving differentiation loss in CRCs. Re-expression of EHF and CDX1 in poorly-differentiated CRC cells induced extensive chromatin remodelling, transcriptional re-programming, and differentiation along the enterocytic lineage, leading to reduced growth and metastasis. Strikingly, EHF and CDX1 were also able to reprogramme non-colonic epithelial cells to express colonic differentiation markers. By contrast, inactivation of EHF and CDX1 in well-differentiated CRC cells triggered tumour de-differentiation. Mechanistically, we demonstrate that EHF physically interacts with CDX1 via its PNT domain, and that these transcription factors co-operatively drive transcription of the colonic differentiation marker, VIL1. Compound genetic deletion of Ehf and Cdx1 in the mouse colon disrupted normal colonic differentiation and significantly enhanced colorectal tumour progression. These findings thus reveal a novel mechanism driving epithelial de-differentiation and tumour progression in CRC.
Journal Article