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Nirsevimab, a monoclonal antibody targeting RSV, led to decreased hospitalizations for RSV-associated lower respiratory tract infection in infants during their first RSV season, in an open-label, pragmatic trial.

This is the first English translation of the main contemporary accounts of the Crusade and death of the German Frederick I Barbarossa (ruled 1152-90). The most important of these, the 'History of the Expedition of the Emperor Frederick' was written soon after the events described, and is a crucial, and under-used source for the Third Crusade (at least in the Anglophone world). The account begins with two letters describing the disaster of Hattin and Saladin's subsequent conquest of most of the Holy Land (the second of these is addressed to the duke of Austria). It goes on to describe how the emperor took the Cross, the preparations and recruitment for the Crusade, the diplomatic contacts of Barbarossa with the Byzantine Emperor and the Sultan of Iconium in an attempt to secure a peaceful passage for the expedition, and the Crusade itself: the journey through the Balkans and the gruelling march through Asia Minor, beset by Turkish attack, until its arrival at Antioch on 21st July 1190, eleven days after the emperor had drowned while crossing a river in Cilician Armenia. The 'History' gives a vivid account of the sufferings of the German army as it traversed Asia Minor. The account of the expedition itself appears to be, or to be based upon an eyewitness record, cast in the form of (often) a daily memoir. However, it concludes with an account of the captivity and release of Richard I in Germany, Henry VI's conquest of the kingdom of Sicily, and of the preparations for a new Crusade under his leadership. In addition, a number of further accounts related to, and expanding, the 'History of the Expedition' have also been translated, including a contemporary newsletter about the death of the emperor, as well as the narrative of Otto of St Blasien, placing the Crusade into context twenty years later, and a contemporary account of the capture of Silves in Portugal by German crusaders on their way to the Holy Land in 1189. This collection is a valuable companion volume t

A particulate trap with combined regeneration has been developed for use in light duty vehicles with diesel engines. This new system was tested first on an engine test rig. On-road vehicle tests are going on since August 1998. The results obtained clearly demonstrate the feasibility of this system. With this system trap regeneration has to be ensured under worst case conditions (exhaust gas temperature<400° C). To meet this requirement electrical heating in combination with a fuel-borne catalyst is applied. Different filter materials such as cordierite wall flow and silicon carbide monoliths were tested on the engine test rig. The paper reports on results from the engine test rig as well as from on-road vehicle testing. An overview about pre-heating and regeneration examples are given and energy balances are presented.

Bekannt ist die Leutseligkeit des Kaisers Friedrich. Einst will er als Kronprinz den alten Kaiser aufsuchen in Babelsberg. Der Kronprinz fragt den Posten : Ist Se. Majestaet Schon ins Schloss zurueckgekehrt ? Der biedere Posten, der die Leutseligkeit des Kronprinzen kennt, antwortet : „Jawohl, Koenigliche Hoheit, Papachen sinn schon ringegangen !\" – Das ist dem hohen Herrn denn doch ein bisschen …

Metal supported catalysts, whose early development actually started in the sixties, are used today in a few isolated cases as starter catalysts, retrofit and underfloor catalysts of small dimensions. The new Porsche Carrera 4 is the first production car to use a large main catalytic converter with metal supports. This paper describes the design of this catalyst and the advantages of using the metal supports, especially the increase in power output due to the reduction of exhaust back pressure. Also benefits in catalytic performance could be determined. The major requirement in using large metal supports in production is mechanical sturdiness. In extensive vehicle, test bench and laboratory tests and according to the theoretical calculations, the support with S-design described here has met this requirement. In spite of some still existing disadvantages, both of which can be reduced with further development, the use of metal supported catalytic converters is a serious alternative to the conventional ceramic supported catalyst.