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Over the past decades, effective cancer therapies have resulted in a significant improvement in the survival rates for a number of cancers and an increase in the number of cancer survivors. Radiation therapy is widely used in the treatment of cancer, and it can induce various cardiotoxicities that differ considerably from chemotherapy-induced cardiotoxicity. They occur primarily as late radiation-induced complications, several years from the end of anticancer treatment and present as coronary artery disease, heart failure, pericardial disease, valvular heart disease and arrhythmias. Patients who recovered from cancer disease suffer from cardiac complications of anticancer treatment, it affects the quality of their lives and life expectancy, especially if the diagnosis is delayed. These patients may present distinct symptoms of cardiac injury, resulting from radiation-induced neurotoxicity and altered pain perception, which makes diagnosis difficult. This review highlights the need for a screening programme for patients who have undergone radiation therapy and which will subsequently have a potentially profound impact on morbidity and mortality.

The drivers behind regional differences of SARS-CoV-2 spread on finer spatio-temporal scales are yet to be fully understood. Here we develop a data-driven modelling approach based on an age-structured compartmental model that compares 116 Austrian regions to a suitably chosen control set of regions to explain variations in local transmission rates through a combination of meteorological factors, non-pharmaceutical interventions and mobility. We find that more than 60% of the observed regional variations can be explained by these factors. Decreasing temperature and humidity, increasing cloudiness, precipitation and the absence of mitigation measures for public events are the strongest drivers for increased virus transmission, leading in combination to a doubling of the transmission rates compared to regions with more favourable weather. We conjecture that regions with little mitigation measures for large events that experience shifts toward unfavourable weather conditions are particularly predisposed as nucleation points for the next seasonal SARS-CoV-2 waves.

ObjectiveCurrent generation left ventricular assist devices (LVADs) operate with a fixed rotation speed and no automated speed adjustment function. This study evaluates the concept of physiological pump speed optimisation based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET).MethodsThis prospective crossover study (NCT05063006) enrolled patients with implanted third-generation LVADs with hydrodynamic bearing. After resting speed optimisation, patients were randomised to a fixed-modified speed or modified-fixed speed CPET sequence. Fixed speed CPET maintained baseline pump settings. During the modified speed CPET, the LVAD speed was continuously altered to preserve periodic AVO.ResultsWe included 22 patients, the mean age was 58.4±7 years, 4.5% were women and 54.5% had ischaemic cardiomyopathy. Exertional AVO assessment was feasible in all subjects. Maintaining periodic AVO allowed to safely raise the pump speed from 2900 (IQR 2640–3000) to 3440 revolutions per minute (RPM) (IQR 3100–3700; p<0.001). As a result, peak oxygen consumption increased from 11.1±2.4 to 12.8±2.8 mL/kg/min (p<0.001) and maximum workload from 1.1 (IQR 0.9–1.5) to 1.2 W/kg (IQR 0.9–1.7; p=0.028). The Borg scale exertion level decreased from 15.2±1.5 to 13.5±1.2 (p=0.005).ConclusionsTransthoracic AVO imaging is possible during CPETs in patients with LVAD. Dynamic echo-guided pump speed adjustment based on the AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.

A bstract We present a study of Ξ c 0 → Ξ 0 π 0 , Ξ c 0 → Ξ 0 η , and Ξ c 0 → Ξ 0 η ′ decays using the Belle and Belle II data samples, which have integrated luminosities of 980 fb − 1 and 426 fb − 1 , respectively. We measure the following relative branching fractions B Ξ c 0 → Ξ 0 π 0 / B Ξ c 0 → Ξ − π + = 0.48 ± 0.02 stat ± 0.03 syst , B Ξ c 0 → Ξ 0 η / B Ξ c 0 → Ξ − π + = 0.11 ± 0.01 stat ± 0.01 syst , B Ξ c 0 → Ξ 0 η ′ / B Ξ c 0 → Ξ − π + = 0.08 ± 0.02 stat ± 0.01 syst for the first time, where the uncertainties are statistical (stat) and systematic (syst). By multiplying by the branching fraction of the normalization mode, B Ξ c 0 → Ξ − π + , we obtain the following absolute branching fraction results B Ξ c 0 → Ξ 0 π 0 = 6.9 ± 0.3 stat ± 0.5 syst ± 1.3 norm × 10 − 3 , B Ξ c 0 → Ξ 0 η = 1.6 ± 0.2 stat ± 0.2 syst ± 0.3 norm × 10 − 3 , B Ξ c 0 → Ξ 0 η ′ = 1.2 ± 0.3 stat ± 0.1 syst ± 0.2 norm × 10 − 3 , where the third uncertainties are from B Ξ c 0 → Ξ − π + . The asymmetry parameter for Ξ c 0 → Ξ 0 π 0 is measured to be α Ξ c 0 → Ξ 0 π 0 = − 0.90 ± 0.15 stat ± 0.23 syst .

A bstract We study the processes χ bJ ω and χ bJ ( π + π − π 0 ) non −ω ( J = 0, 1, 2) at center-of-mass energies from 10.73 to 11.02 GeV using a 142 . 5 fb − 1 data sample collected with the Belle detector at the KEKB asymmetric-energy e + e − collider; and at GeV using a 19 . 8 fb − 1 sample collected with Belle II at SuperKEKB. We find that the Υ(10753) state decays into χ bJ ω but not into χ bJ ( π + π − π 0 ) non −ω , while the Υ(10860) state, in contrast, decays into χ bJ ( π + π − π 0 ) non −ω but not into χ bJ ω . The mass and width of the Υ(10753) state are measured to be (10756 . 1 ± 3 . 4(stat . ) ± 2 . 7(syst . )) MeV/ c 2 and (32 . 2 ± 11 . 3(stat . ) ± 14 . 9(syst . )) MeV. The products of the partial width to e + e − and branching fractions for Υ(10753) → χ b 1 ω and Υ(10753) → χ b 2 ω are (1 . 57 ± 0 . 27(stat . ) ± 0 . 22(syst . )) eV and (1 . 39 ± 0 . 41(stat . ) ± 0 . 33(syst . )) eV.

A bstract We present the results of a search for the charged-lepton-flavor violating decays B 0 → K *0 τ ± ℓ ∓ , where ℓ ∓ is either an electron or a muon. The results are based on 365 fb − 1 and 711 fb − 1 datasets collected with the Belle II and Belle detectors, respectively. We use an exclusive hadronic B -tagging technique, and search for a signal decay in the system recoiling against a fully reconstructed B meson. We find no evidence for B 0 → K *0 τ ± ℓ ∓ decays and set upper limits on the branching fractions in the range of (2.9–6.4)×10 − 5 at 90% confidence level.

A bstract We present the result of a search for the charged-lepton-flavor violating decay τ − → μ − μ + μ − using a 424 fb − 1 sample of data recorded by the Belle II experiment at the SuperKEKB e + e − collider. The selection of e + e − → τ + τ − events is based on an inclusive reconstruction of the non-signal tau decay, and on a boosted decision tree to suppress background. We observe one signal candidate, which is compatible with the expectation from background processes. We set a 90% confidence level upper limit of 1 . 9 × 10 − 8 on the branching fraction of the τ − → μ − μ + μ − decay, which is the most stringent bound to date.

A bstract We report measurements of the absolute branching fractions , , and , where the latter is measured for the first time. The results are based on a 121.4 fb − 1 data sample collected at the Υ(10860) resonance by the Belle detector at the KEKB asymmetric-energy e + e − collider. We reconstruct one meson in events and measure yields of , D 0 , and D + mesons in the rest of the event. We obtain , , and , where the first uncertainty is statistical and the second is systematic. Averaging with previous Belle measurements gives and . For the production fraction at the Υ(10860), we find .

We report measurements of the e + e − →$$ B\\overline{B} $$B B ¯ ,$$ B{\\overline{B}}^{\\ast } $$B B ¯ ∗ , and$$ {B}^{\\ast }{\\overline{B}}^{\\ast } $$B ∗ B ¯ ∗ cross sections at four energies, 10653, 10701, 10746 and 10805 MeV, using data collected by the Belle II experiment. We reconstruct one B meson in a large number of hadronic final states and use its momentum to identify the production process. In the first 2 – 5 MeV above$$ {B}^{\\ast }{\\overline{B}}^{\\ast } $$B ∗ B ¯ ∗ threshold, the e + e − →$$ {B}^{\\ast }{\\overline{B}}^{\\ast } $$B ∗ B ¯ ∗ cross section increases rapidly. This may indicate the presence of a pole close to the threshold.