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Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we discovered a role for the sympathetic nervous system in stimulating a body-wide stem cell activation response to amputation that drives enhanced limb regeneration in axolotls. This response is mediated by adrenergic signaling, which coordinates distant cellular activation responses via the α -adrenergic receptor, and local regeneration responses via β-adrenergic receptors. Both α - and β-adrenergic signaling act upstream of mTOR signaling. Notably, systemically-activated axolotls regenerate limbs faster than naïve animals, suggesting a potential selective advantage in environments where injury from cannibalism or predation is common. This work challenges the predominant view that cellular responses underlying regeneration are confined to the injury site and argues instead for body-wide cellular priming as a foundational step that enables localized tissue regrowth.

The study explored the computer self-efficacy and implementation context on the use of KOHA ILS in the National Library of Nigeria and adopted the experimental descriptive survey design. The study was based on the Unified Theory of Acceptance and Use of Technology by Venkatesh, Moris, Davis and Davis (2003). The population ofthe study comprised 170 librarians from the NLN. Random sampling technique was used to choose a sample size of 150 respondents, 120 copies of the questionnaire representing 80% returned, were used for the analysis and 30 copies of the questionnaire (20%) invalid. Data collected were analyzed using significant mean value analysis. The hypotheses were tested at 0.05 level of significance, using the Pearson r Correlation statistic. The findings show that staff of NLN showed high level of computer-self efficacy for the use of Koha; some ICT facilities for Koha use such as computers, laptops, internet connectivity, etc., were either inadequate or non-existent in some branches; and staffs were not confident of performing trouble shooting operations when using Koha. The test of hypotheses revealed that facilitating conditions have no significant relationship with the use of KOHA ILS in the NLN; social influence significantly affect the use of KOHA ILS in the NLN; there is no significant relationship between computer self-efficacy of staff and use of KOHA ILS in the National Library of Nigeria; and behavioral intentions of staff on the deployment of KOHA ILS had significant influence on its use. Few recommendations were made based on the findings.