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In recent years, many methods for intrusion detection systems (IDS) have been designed and developed in the research community, which have achieved a perfect detection rate using IDS datasets. Deep neural networks (DNNs) are representative examples applied widely in IDS. However, DNN models are becoming increasingly complex in model architectures with high resource computing in hardware requirements. In addition, it is difficult for humans to obtain explanations behind the decisions made by these DNN models using large IoT-based IDS datasets. Many proposed IDS methods have not been applied in practical deployments, because of the lack of explanation given to cybersecurity experts, to support them in terms of optimizing their decisions according to the judgments of the IDS models. This paper aims to enhance the attack detection performance of IDS with big IoT-based IDS datasets as well as provide explanations of machine learning (ML) model predictions. The proposed ML-based IDS method is based on the ensemble trees approach, including decision tree (DT) and random forest (RF) classifiers which do not require high computing resources for training models. In addition, two big datasets are used for the experimental evaluation of the proposed method, NF-BoT-IoT-v2, and NF-ToN-IoT-v2 (new versions of the original BoT-IoT and ToN-IoT datasets), through the feature set of the net flow meter. In addition, the IoTDS20 dataset is used for experiments. Furthermore, the SHapley additive exPlanations (SHAP) is applied to the eXplainable AI (XAI) methodology to explain and interpret the classification decisions of DT and RF models; this is not only effective in interpreting the final decision of the ensemble tree approach but also supports cybersecurity experts in quickly optimizing and evaluating the correctness of their judgments based on the explanations of the results.

This study aimed to assess the performance of an artificial intelligence (AI) model for predicting clinical pregnancy using enhanced inner cell mass (ICM) and trophectoderm (TE) images. In this retrospective study, we included static images of 2555 day-5-blastocysts from seven in vitro fertilization centers in South Korea. The main outcome of the study was the predictive capability of the model to detect clinical pregnancies (gestational sac). Compared with the original embryo images, the use of enhanced ICM and TE images improved the average area under the receiver operating characteristic curve for the AI model from 0.716 to 0.741. Additionally, a gradient-weighted class activation mapping analysis demonstrated that the enhanced image-trained AI model was able to extract features from crucial areas of the embryo in 99% (506/512) of the cases. Particularly, it could extract the ICM and TE. In contrast, the AI model trained on the original images focused on the main areas in only 86% (438/512) of the cases. Our results highlight the potential efficacy of using ICM- and TE-enhanced embryo images when training AI models to predict clinical pregnancy.

Adversarial attack techniques in deep learning have been studied extensively due to its stealthiness to human eyes and potentially dangerous consequences when applied to real-life applications. However, current attack methods in black-box settings mainly employ a large number of queries for crafting their adversarial examples, hence making them very likely to be detected and responded by the target system (e.g., artificial intelligence (AI) service provider) due to its high traffic volume. A recent proposal able to address the large query problem utilizes a gradient-free approach based on Particle Swarm Optimization (PSO) algorithm. Unfortunately, this original approach tends to have a low attack success rate, possibly due to the model’s difficulty of escaping local optima. This obstacle can be overcome by employing a multi-group approach for PSO algorithm, by which the PSO particles can be redistributed, preventing them from being trapped in local optima. In this paper, we present a black-box adversarial attack which can significantly increase the success rate of PSO-based attack while maintaining a low number of query by launching the attack in a distributed manner. Attacks are executed from multiple nodes, disseminating queries among the nodes, hence reducing the possibility of being recognized by the target system while also increasing scalability. Furthermore, we utilize Multi-Group PSO with Random Redistribution (MGRR-PSO) for perturbation generation, performing better than the original approach against local optima, thus achieving a higher success rate. Additionally, we propose to efficiently remove excessive perturbation (i.e, perturbation pruning) by utilizing again the MGRR-PSO rather than a standard iterative method as used in the original approach. We perform five different experiments: comparing our attack’s performance with existing algorithms, testing in high-dimensional space in ImageNet dataset, examining our hyperparameters (i.e., particle size, number of clients, search boundary), and testing on real digital attack to Google Cloud Vision. Our attack proves to obtain a 100% success rate on MNIST and CIFAR-10 datasets and able to successfully fool Google Cloud Vision as a proof of the real digital attack by maintaining a lower query and wide applicability.

In recent years, numerous explainable artificial intelligence (XAI) use cases have been developed, to solve numerous real problems in industrial applications while maintaining the explainability level of the used artificial intelligence (AI) models to judge their quality and potentially hold the models accountable if they become corrupted. Therefore, understanding the state-of-the-art methods, pointing out recent issues, and deriving future directions are important to drive XAI research efficiently. This paper presents a systematic literature review of local explanation techniques and their practical applications in various industrial sectors. We first establish the need for XAI in response to opaque AI models and survey different local explanation methods for industrial AI applications. The number of studies is then examined with several factors, including industry sectors, AI models, data types, and XAI-based usage and purpose. We also look at the advantages and disadvantages of local explanation methods and how well they work in practical settings. The difficulties of using local explanation techniques are also covered, including computing complexity and the trade-off between precision and interpretability. Our findings demonstrate that local explanation techniques can boost industrial AI models’ transparency and interpretability and give insightful information about them. The efficiency of these procedures must be improved, and ethical concerns about their application must be resolved. This paper contributes to the increasing knowledge of local explanation strategies and offers guidance to academics and industry professionals who want to use these methods in practical settings.

Current embryo assessment methods for in vitro fertilization depend on subjective morphological assessments. Recently, artificial intelligence (AI) has emerged as a promising tool for embryo assessment; however, its clinical efficacy and trustworthiness remain unproven. Simulation studies may provide additional evidence, provided that they are meticulously designed to mitigate bias and variance. The primary objective of this study was to evaluate the benefits of an AI model for predicting clinical pregnancy through well-designed simulations. The secondary objective was to identify the characteristics of and potential bias in the subgroups of embryologists with varying degrees of experience. This simulation study involved a questionnaire-based survey conducted on 61 embryologists with varying levels of experience from 12 in vitro fertilization clinics. The survey was conducted via Google Forms (Google Inc) in three phases: (1) phase 1, an initial assessment (December 23, 2022, to January 22, 2023); (2) phase 2, a validation assessment (March 6, 2023, to April 5, 2023); and (3) phase 3 an AI-guided assessment (March 6, 2023, to April 5, 2023). Inter- and intraobserver assessments and the accuracy of embryo selection from 360 day-5 embryos before and after AI guidance were analyzed for all embryologists and subgroups of senior and junior embryologists. With AI guidance, the interobserver agreement increased from 0.355 to 0.527 and from 0.440 to 0.524 for junior and senior embryologists, respectively, thus reaching similar levels of agreement. In a test of accurate embryo selection with 90 questions, the numbers of correct responses by the embryologists only, embryologists with AI guidance, and AI only were 34 (38%), 45 (50%), and 59 (66%), respectively. Without AI, the average score (accuracy) of the junior group was 33.516 (37%), while that of the senior group was 35.967 (40%), with P<.001 in the t test. With AI guidance, the average score (accuracy) of the junior group increased to 46.581 (52%), reaching a level similar to that of the senior embryologists of 44.833 (50%), with P=.34. Junior embryologists had a higher level of trust in the AI score. This study demonstrates the potential benefits of AI in selecting embryos with high chances of pregnancy, particularly for embryologists with 5 years or less of experience, possibly due to their trust in AI. Thus, using AI as an auxiliary tool in clinical practice has the potential to improve embryo assessment and increase the probability of a successful pregnancy.

Deep neural networks (DNNs), especially those used in computer vision, are highly vulnerable to adversarial attacks, such as adversarial perturbations and adversarial patches. Adversarial patches, often considered more appropriate for a real-world attack, are attached to the target object or its surroundings to deceive the target system. However, most previous research employed adversarial patches that are conspicuous to human vision, making them easy to identify and counter. Previously, the spatially localized perturbation GAN (SLP-GAN) was proposed, in which the perturbation was only added to the most representative area of the input images, creating a spatially localized adversarial camouflage patch that excels in terms of visual fidelity and is, therefore, difficult to detect by human vision. In this study, the use of the method called eSLP-GAN was extended to deceive classifiers and object detection systems. Specifically, the loss function was modified for greater compatibility with an object-detection model attack and to increase robustness in the real world. Furthermore, the applicability of the proposed method was tested on the CARLA simulator for a more authentic real-world attack scenario.

Junctional proteins in cerebrovascular endothelial cells are essential for maintaining the barrier function of the blood-brain barrier (BBB), thus protecting the brain from the infiltration of pathogens. The present study showed that the potential therapeutic natural compound auraptene (AUR) enhances junction assembly in cerebrovascular endothelial cells by inducing antioxidant enzymes and the mitochondrial unfolded protein response (mtUPR). Treatment of mouse cerebrovascular endothelial cells with AUR enhanced the expression of junctional proteins, such as occludin, zonula occludens-1 (ZO-1) and vascular endothelial cadherin (VE-cadherin), by increasing the levels of mRNA encoding antioxidant enzymes. AUR treatment also resulted in the depolarization of mitochondrial membrane potential and activation of mtUPR. The ability of AUR to protect against ischemic conditions was further assessed using cells deprived of oxygen and glucose. Pretreatment of these cells with AUR protected against damage to junctional proteins, including occludin, claudin-5, ZO-1 and VE-cadherin, accompanied by a stress resilience response regulated by levels of ATF5, LONP1 and HSP60 mRNAs. Collectively, these results indicate that AUR promotes resilience against oxidative stress and improves junction assembly, suggesting that AUR may help maintain intact barriers in cerebrovascular endothelial cells.

For industrial design and the improvement of fluid flow simulations, computational fluid dynamics (CFD) solvers offer practical functions and conveniences. However, because iterative simulations demand lengthy computation times and a considerable amount of memory for sophisticated calculations, CFD solvers are not economically viable. Such limitations are overcome by CFD data-driven learning models based on neural networks, which lower the trade-off between accurate simulation performance and model complexity. Deep neural networks (DNNs) or convolutional neural networks (CNNs) are good illustrations of deep learning-based CFD models for fluid flow modeling. However, improving the accuracy of fluid flow reconstruction or estimation in these earlier methods is crucial. Based on interpolated feature data generation and a deep U-Net learning model, this work suggests a rapid laminar flow prediction model for inference of Naiver–Stokes solutions. The simulated dataset consists of 2D obstacles in various positions and orientations, including cylinders, triangles, rectangles, and pentagons. The accuracy of estimating velocities and pressure fields with minimal relative errors can be improved using this cutting-edge technique in training and testing procedures. Tasks involving CFD design and optimization should benefit from the experimental findings.

Cdc25B is an essential regulator for meiotic resumption in mouse oocytes. However, the role of this phosphatase during the later stage of the meiotic cell cycle is not known. In this study, we investigated the role of Cdc25B during metaphase II (MII) arrest in mouse oocytes. Cdc25B was extensively phosphorylated during MII arrest with an increase in the phosphatase activity toward Cdk1. Downregulation of Cdc25B by antibody injection induced the formation of a pronucleus-like structure. Conversely, overexpression of Cdc25B inhibited Ca2+-mediated release from MII arrest. Moreover, Cdc25B was immediately dephosphorylated and hence inactivated during MII exit, suggesting that Cdk1 phosphorylation is required to exit from MII arrest. Interestingly, this inactivation occurred prior to cyclin B degradation. Taken together, our data demonstrate that MII arrest in mouse oocytes is tightly regulated not only by the proteolytic degradation of cyclin B but also by dynamic phosphorylation of Cdk1.

Adversarial camouflage has garnered attention for its ability to attack object detectors from any viewpoint by covering the entire object's surface. However, universality and robustness in existing methods often fall short as the transferability aspect is often overlooked, thus restricting their application only to a specific target with limited performance. To address these challenges, we present Adversarial Camouflage for Transferable and Intensive Vehicle Evasion (ACTIVE), a state-of-the-art physical camouflage attack framework designed to generate universal and robust adversarial camouflage capable of concealing any 3D vehicle from detectors. Our framework incorporates innovative techniques to enhance universality and robustness, including a refined texture rendering that enables common texture application to different vehicles without being constrained to a specific texture map, a novel stealth loss that renders the vehicle undetectable, and a smooth and camouflage loss to enhance the naturalness of the adversarial camouflage. Our extensive experiments on 15 different models show that ACTIVE consistently outperforms existing works on various public detectors, including the latest YOLOv7. Notably, our universality evaluations reveal promising transferability to other vehicle classes, tasks (segmentation models), and the real world, not just other vehicles.