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The functions of most long non-coding RNAs (lncRNAs) are unknown. In contrast to proteins, lncRNAs with similar functions often lack linear sequence homology; thus, the identification of function in one lncRNA rarely informs the identification of function in others. We developed a sequence comparison method to deconstruct linear sequence relationships in lncRNAs and evaluate similarity based on the abundance of short motifs called k-mers. We found that lncRNAs of related function often had similar k-mer profiles despite lacking linear homology, and that k-mer profiles correlated with protein binding to lncRNAs and with their subcellular localization. Using a novel assay to quantify Xist-like regulatory potential, we directly demonstrated that evolutionarily unrelated lncRNAs can encode similar function through different spatial arrangements of related sequence motifs. K-mer-based classification is a powerful approach to detect recurrent relationships between sequence and function in lncRNAs. SEEKR is a method that deconstructs linear sequence relationships between lncRNAs and evaluates similarity on the basis of abundance of short motifs called k-mers. LncRNAs of related function often have similar k-mer profiles despite lacking linear homology.

Objective: To (1) examine the potentiality of using the robot PARO to mediate care provided by the family and (2) identify problems when utilizing PARO in the home context. Methods: Family members of 7 households were asked to use PARO for at least three times per week, over 1 to 3 months. Research data, including standardized assessments, interviews, and observations, were collected at initial and subsequent monthly visits. Collected data were analyzed through descriptive statistics and inductive thematic content analysis. Results: Out of the seven participants, five responded positively to PARO, thereby achieving their goals of improving activity engagement, relaxation, a respite from supervision, and improved mood. A positive initial interaction with PARO showed continued interest to it. Participants were observed to communicate with caregivers and relate to PARO. Discussion: The application of PARO at home is possibly influenced by the persons’ initial level of interest toward PARO. It is crucial to perform careful observation and assessment before deciding to use PARO within the home context to support the life of older persons with dementia.

Introduction To promote international collaborative partnerships, the master's program in occupational therapy at Tokyo Metropolitan University was developed in English as a part of the Asian Human Resource Development Project (AHRD project) for Medical Professionals funded by the Tokyo Metropolitan Government. Objective and methods In this paper, we focus on describing key concepts underpinning its development and implementation, as well as its successes, and the challenges associated with building partnerships with educational institutions in Asian countries. The AHRD project was implemented to enable the development of human resources from Asian countries to acquire advanced medical skills in Tokyo and contribute to the improvement of medical skills in their home countries, and to act as a bridge between Tokyo and Asian countries and promote both global partnerships with educational institutions and students’ international awareness. Result and conclusion Through the AHRD project, graduates from the master's program are expected to contribute to the improvement of health professions in their home country. In addition, based on the network established through this project, we have deepened our ties with Asian countries, developed global education through the continued international exchange of faculty and students, and enabled the development of international collaboration in education and research.

The effectiveness of PARO, animal-like robots, as robot-assisted therapy has shown a positive impact on non-pharmacological therapy. However, the effectiveness of caregivers presenting PARO to patients needs to be evaluated due to the different skills possessed by caregivers. The way caregivers present PARO to patients will impact the patients’ interest response towards PARO. We propose a system that can measure patients’ interest in PARO by recognizing the reciprocal attention between PARO and humans. We built the system by integrating human skeleton tracking and PARO’s posture detection. Human skeleton tracking is reconstructed from multiple Kinect Azure devices, while PARO’s posture detection is achieved using a single RGBD camera placed on top of the field. We extract the attention parameter by calculating the difference in gaze direction between PARO and humans. The results showed that the proposed method successfully detected the gaze interaction between PARO and humans with an average accuracy rate of 97.59%.

Purpose. To investigate the usability of public play spaces for children with disabilities by exploring their experiences in accessing and using these spaces and to further discuss recommendations for designing such spaces that are usable for these children. Methods. A hermeneutic phenomenological approach was employed to explore the experience of children with disabilities regarding the public play spaces. Seven children and their caregivers from two inclusive elementary schools in Central Java Province, Indonesia, participated in the study. Online semistructured interviews with the children were held using Zoom, followed by telephonic interviews with their parents. In addition, video recordings of the observation of the children’s participation in the play spaces were gathered. The interview and video observation data were analyzed using van Manen’s hermeneutic phenomenology thematic analysis method. Results. Five themes arose regarding the experiences of children with disabilities of accessing and using the public play spaces: (1) where time appeared to speed up, (2) “I like the tall one … I like extreme,” (3) fostering connectedness, (4) the need for a safe space, and (5) how a play space should be. Conclusion. The public play spaces have meaningful values for the children with disabilities and their family, as they offered the opportunities to play, explore, interact with friends and families, enjoy nature, interact with animals, and learn. However, it is essential to provide a safe space in which children are free from physical and emotional harm, so that they can fully participate with confidence and a sense of autonomy. Nevertheless, it was also found that children, regardless of their abilities, craved risky and challenging play opportunities. This study also highlights the necessity of awareness-raising intervention programs to foster the inclusion of children with disabilities in public play space settings.

Rationale. Sedentary activities are perpetuated by aging and the COVID-19 pandemic. While demands for video games grow, few studies explored the potential of virtual reality (VR) games to promote sports engagement and health among young adults. Objective. To examine sports engagement and health changes of young adults when utilizing a VR sports game and investigate the relationship between sports engagement and health. Method. This study used a single-group design with 20 participants, aged 19–29 years, with no preexisting health conditions. The VR game “Sports Scramble” was used thrice within a span of one week. Outcomes sought include sports engagement and health, measured through the Sports Engagement Scale (SES) and Short Form 36 (SF-36), respectively. Results. A significant difference (p<0.001) was found between the pre-posttest scores of the SES. Moreover, a positive trend was observed in terms of health with a significant difference (p<0.05) between pre-posttest scores of the SF-36’s vitality dimension. There were positive correlations among the dedication and vigor subscales of the SES with the dimensions of health. Conclusion. This study showed the potential of VR sports games in positively influencing sports engagement and health among participants with the vigor and dedication positively influencing health. Future studies may involve the exploration of the effectiveness of VR to promote engagement and health through a randomized controlled trial with a longer timeframe and across various populations.

Robot therapy, a mental health care through interactions with robots, has attracted attention as a new method of dementia care. In particular, the therapeutic seal robot named “PARO” is being widely used. When using PARO in elderly facilities, caregivers called “handlers” encourage the elderly people to interact with PARO. However, the usage of PARO was left to the handlers itself. Therefore, there was no intended effect in certain cases. To solve this problem, this study aims to develop a method to record the behaviors of handlers and the reactions of elderly people during the robot therapy and a method to support planning by analyzing the recorded data. A Bayesian network was applied to analyze the relationship between the handler’s behavior and the elderly people’s reactions. To verify usefulness, the experiment was conducted at four elderly facilities between November 2019 and January 2020. The participants were 12 handlers and 21 elderly people. We observed the robot therapy using PARO for 20 min, and subsequently, conducted interviews. Consequently, a model that visualized the relationship between the handler’s behaviors and the elderly people’s reactions was obtained from 40 observed cases. The interviews confirmed that the model was useful for planning a robot therapy.

Background To employ the benchmark dose (BMD) method in toxicological risk assessment, it is critical to understand how the BMD lower bound for reference dose calculation is selected following statistical fitting procedures of multiple mathematical models. The purpose of this study was to compare the performances of various combinations of model exclusion and selection criteria for quantal response data. Methods Simulation-based evaluation of model exclusion and selection processes was conducted by comparing validity, reliability, and other model performance parameters. Three different empirical datasets for different chemical substances were analyzed for the assessment, each having different characteristics of the dose-response pattern (i.e. datasets with rich information in high or low response rates, or approximately linear dose-response patterns). Results The best performing criteria of model exclusion and selection were different across the different datasets. Model averaging over the three models with the lowest three AIC (Akaike information criteria) values (MA-3) did not produce the worst performance, and MA-3 without model exclusion produced the best results among the model averaging. Model exclusion including the use of the Kolmogorov-Smirnov test in advance of model selection did not necessarily improve the validity and reliability of the models. Conclusions If a uniform methodological suggestion for the guideline is required to choose the best performing model for exclusion and selection, our results indicate that using MA-3 is the recommended option whenever applicable.

The COVID-19 pandemic is spreading across the globe, and it could take years for society to fully recover. Personal protective equipment (PPE), various hygiene measures, and social distancing have been implemented to reduce “human to human” contact, which is an essential part of outbreak prevention. The pressure of the pandemic combined with decreased communication and social contact have taken a toll on the mental health of many individuals, especially with respect to anxiety and depression. Effective use of robots and technology as a substitute for—or in coordination with—traditional medicine could play a valuable role in reducing psychological distress now more than ever. This paper summarizes the results of a comprehensive review of clinical research on PARO, a therapeutic seal robot, which has been used extensively as a biofeedback medical device and socially assistive robot in the field of mental health. PARO has proven to be an effective and economical non-pharmacological intervention method for both mental and physical well-being during the COVID-19 pandemic. Utilization of PARO during these times has provided more data for consideration and has helped in mitigating the negative stigma surrounding using robots in therapeutic settings.

Global health care education that cultivates international orientation is important for providing medical care in consideration of diverse backgrounds and collaboration with foreign medical professionals. Virtual international exchange programs could be a new type of global education in the present postpandemic era. This study aimed to examine the effectiveness of a virtual international exchange program in fostering quality academic and professional learning and international orientation from student perspectives across 5 countries. This research is expected to contribute to education for the development of global human resources in the health professions. This quasi-experimental study used a before-and-after design using a convergent parallel mixed methods approach. In this study, a 5-day interactive virtual program was offered to occupational therapy students from Bangladesh, Indonesia, Japan, the Philippines, and Thailand. The students were asked about their expectations and international orientation before the program, and about their evaluation of the program and international orientation afterward. Numerical data from a questionnaire on program expectations and evaluations were analyzed using descriptive statistics. Data on international orientation were subjected to qualitative analysis using steps for coding and theorization. In total, 29 students participated in the program, out of which 12 students (response ratio 41.4%) answered the research questionnaires both before and after the program. Overall, the students' expectations of the program were met in terms of expertise, scientific learning skills, and group interactions. Comparing before and after the program, mean scores of how the program met expectations increased, and the mean scores after the program in all 12 items asking about program evaluation were from 3.8 (SD 1.19) to 4.9 (SD 0.67; range: score 1 [lowest]-5 [highest]). Even though their motivation for participating in the program was not specific before the program, after the program, they reported having a more concrete image and specific form of what they learned from an international perspective. The participants enjoyed communication with others from diverse backgrounds while recognizing the difficulty of understanding different values. They also expressed satisfaction with their understanding of occupational therapy professionals and diverse societies, including medical systems from other countries. Even though the analyzed sample data were small, these findings suggest that the program in this study may provide the participants with valuable opportunities. The virtual exchange program could foster students to cultivate qualities such as problem-finding or problem-solving and having interactions with groups from diverse backgrounds.