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Cardiac surgery-associated acute kidney injury (CS-AKI) is a very serious and common complication after heart surgery. Standard knowledge of the etiology, treatment, and prognosis is a prerequisite for effective therapy. The etiology includes a set of predisposing pre-, intra-, and postoperative factors with varying incidence and severity. Although not specified yet, the treatment involves standard and modern modalities based on medication, nutrition, and dialysis as well as on alleviative measures. CS-AKI enhances the incidence of infections and hospitalization leading to increased morbidity and overall mortality. Early diagnosis and treatment reduce the risk of transition to a more severe stage of AKI or chronic kidney disease.

While completing the commissioning phase to prepare the Virgo interferometer for the next joint Observation Run (O4), the Virgo collaboration is also finalizing the design of the next upgrades to the detector to be employed in the following Observation Run (O5). The major upgrade will concern decreasing the thermal noise limit, which will imply using very large test masses and increased laser beam size. But this will not be the only upgrade to be implemented in the break between the O4 and O5 observation runs to increase the Virgo detector strain sensitivity. The paper will cover the challenges linked to this upgrade and implications on the detector’s reach and observational potential, reflecting the talk given at 12th Cosmic Ray International Seminar - CRIS 2022 held in September 2022 in Napoli.

CD44v6, a member of the CD44 family of transmembrane glycoproteins is a co-receptor for two receptor tyrosine kinases (RTKs), Met and VEGFR-2 (vascular endothelial growth factor receptor 2). CD44v6 is not only required for the activation of these RTKs but also for signalling. In order to understand the role of CD44v6 in Met and VEGFR-2 activation and signalling we tested whether CD44v6 binds to their ligands, HGF (hepatocyte growth factor) and VEGF (vascular endothelial growth factor), respectively. FACS analysis and cellular ELISA showed binding of HGF and VEGF only to cells expressing CD44v6. Direct binding of CD44v6 to HGF and VEGF was demonstrated in pull-down assays and the binding affinities were determined using MicroScale Thermophoresis, fluorescence correlation spectroscopy and fluorescence anisotropy. The binding affinity of CD44v6 to HGF is in the micromolar range in contrast with the high-affinity binding measured in the case of VEGF and CD44v6, which is in the nanomolar range. These data reveal a heparan sulfate-independent direct binding of CD44v6 to the ligands of Met and VEGFR-2 and suggest different roles of CD44v6 for these RTKs.

We use the gravitational wave (GW) events GW170817 and GW190521, together with their proposed electromagnetic counterparts, to constrain cosmological parameters and theories of gravity beyond General Relativity (GR). In particular we consider models with a time-varying Planck mass, large extra-dimensions, and a phenomenological parametrization covering several beyond-GR theories. In all three cases, this introduces a friction term into the GW propagation equation, effectively modifying the GW luminosity distance. We set constraints on \\(\\Lambda\\)CDM parameters and GR deviation parameters using two sets of priors on the Hubble constant and matter energy density. With priors set to the measured Planck's mission values, we find that with the inclusion of GW190521, the two GR deviation parameters constraints improves by a factor \\(\\sim 10\\), we report a number of spacetime dimensions compatible with \\(4\\) with an precision of \\(2.5\\%\\) (at 95\\% CL) and an upper limit to the variation of Netwon's constant at the epoch of GW170817 \\(<20\\%\\). With wide priors on the Hubble constant and matter energy density, we show that it is still possible to constrain the \\(\\Lambda\\)CDM parameters and GR deviation parameters conjointly from GW170817 and GW190521 obtaining constraints on GR deviation parameters which are a factor \\(2-6\\) worse than the results using restricted priors on \\(\\Lambda\\)CDM parameters.

Information about the mass spectrum of compact stars can be used to infer cosmological parameters from gravitational waves (GW) in the absence of redshift measurements obtained from electromagnetic (EM) observations. This method will be fundamental in measuring and testing cosmology with GWs for current and future ground-based GW detectors where the majority part of sources are detected without an associated EM counterpart. In this proceeding, we will discuss the prospects and limitations of this approach for studying cosmology. We will show that, even when assuming GW detectors with current sensitivities, the determination of the Hubble constant is strongly degenerate with the maximum mass for black hole production. We will discuss how assuming wrong models for the underlying population of black hole events can bias the Hubble constant estimate up to 40\\%.

A novel instrumented baffle surrounding the suspended end mirror in the input mode cleaner cavity of the Virgo interferometer was installed in spring 2021. Since then, the device has been regularly operated in the experiment and the obtained results indicate a good agreement with simulations of the stray light inside the optical cavity. The baffle will operate in the upcoming O4 observation run, serving as a demonstrator of the technology designed to instrument the baffles in front of the main mirrors in time for O5. In this paper we present a detailed description of the baffle design, including mechanics, front-end electronics, data acquisition, as well as optical and vacuum tests, calibration and installation procedures, and performance results.

Knowledge of the shape of the mass spectrum of compact objects can be used to help break the degeneracy between the mass and redshift of the gravitational wave (GW) sources, and thus can be used to infer cosmological parameters in the absence of redshift measurements obtained from electromagnetic observations. In this paper, we study extensively different aspects of this approach, including its computational limits and achievable accuracy. We focus on ground-based detectors with current and future sensitivities, we first perform the analysis of an extensive set of simulated data with a hierarchical Bayesian scheme inferring population and cosmological parameters. We consider a population model (power-law plus Gaussian) which exhibits characteristic scales (extremes of the mass spectrum, presence of an accumulation point) that allows an indirect estimate of the source redshift. Our analysis of this catalog highlights and quantifies the tight interplay between source population and cosmological parameters, as well as the influence of initial assumptions (whether formulated on the source or cosmological parameters). We then validate our results by an \"end-to-end\" analysis using simulated GW data and posterior samples generated from Bayesian samplers used for GW parameter estimation, thus mirroring the analysis chain used for observational data for the first time in literature. Our results then lead us to re-examine the estimation of \\(H_0\\) obtained with GWTC-1, and we show explicitly how population assumptions impact the final \\(H_0\\) result. Our results underline the importance of inferring population and cosmological parameters jointly (and not separately as is often assumed). The only exception, as we discuss, is if an electromagnetic counterpart was to be observed for all the BBH events: then the population assumptions have less impact on the estimation of cosmological parameters.

A new instrumented baffle was installed in Spring 2021 at Virgo surrounding the suspended mirror in the input mode cleaner triangular cavity. It serves as a demonstrator of the technology designed to instrument the baffles in the main arms in the near future. We present, for the first time, results on the measured scattered light distribution inside the cavity as determined by the new device using data collected between May and July 2021, with Virgo in commissioning phase and operating with an input laser power in the cavity of 28.5~W. The sensitivity of the baffle is discussed and the data is compared to scattered light simulations.

Gravitational waves provide a unique tool for observational astronomy. While the first LIGO--Virgo catalogue of gravitational-wave transients (GWTC-1) contains eleven signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals, it is imperative to have fast, flexible, and scalable inference techniques. In a previous paper, we introduced BILBY: a modular and user-friendly Bayesian inference library adapted to address the needs of gravitational-wave inference. In this work, we demonstrate that BILBY produces reliable results for simulated gravitational-wave signals from compact binary mergers, and verify that it accurately reproduces results reported for the eleven GWTC-1 signals. Additionally, we provide configuration and output files for all analyses to allow for easy reproduction, modification, and future use. This work establishes that BILBY is primed and ready to analyse the rapidly growing population of compact binary coalescence gravitational-wave signals.

Thoracic aortic dissections involving the ascending aorta represent one of the most dramatic and lethal emergencies in cardiovascular surgery. It is therefore critical to identify the mechanisms driving them and biomechanical analyses hold great clinical promise, since rupture/dissection occur when aortic wall strength is unable to withstand hemodynamic stresses. Although several studies have been done on the biomechanical properties of thoracic aortic aneurysms, few data are available about thoracic aortic dissections. Detailed mechanical tests with measurement of tissue thickness and failure properties were performed with a tensile-testing device on 445 standardized specimens, corresponding to 19 measurement sites per inner (intima with most of media)/outer layer (leftover media with adventitia); harvested from twelve patients undergoing emergent surgical repair for type A dissection. Our data suggested inherent differences in tissue properties between the origin of dissection and distal locations, i.e. thinner and stiffer inner layers that might render them more vulnerable to tearing despite their increased strength. The strength of tissue circumferentially was greater than that longitudinally, likely determining the direction of tear. The relative strengths of the inner: ∼{65,40}N/cm2 and outer layer: ∼{350,270}N/cm2 in the two principal directions of dissected tissue were differentiated from the intima: ∼{100,75}N/cm2, media: ∼{150,55}N/cm2, and adventitia: ∼{270,190}N/cm2 of non-dissected ascending aortic aneurysms (Sokolis et al., 2012), in favor of weaker inner and stronger outer layers, allowing an explanation as to why the presently-studied tissue suffered dissection, i.e. tear of the inner layers, and not rupture, i.e. full tearing across the entire wall thickness.