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"Karim, R."
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Marginality and Problem-Solving Effectiveness in Broadcast Search
We examine who the winners are in science problem-solving contests characterized by open broadcast of problem information, self-selection of external solvers to discrete problems from the laboratories of large research and development intensive companies, and blind review of solution submissions. Analyzing a unique data set of 166 science challenges involving over 12,000 scientists revealed that technical and social marginality, being a source of different perspectives and heuristics, plays an important role in explaining individual success in problem solving. The provision of a winning solution was positively related to increasing distance between the solver's field of technical expertise and the focal field of the problem. Female solvers-known to be in the \"outer circle\" of the scientific establishment-performed significantly better than men in developing successful solutions. Our findings contribute to the emerging literature on open and distributed innovation by demonstrating the value of openness, at least narrowly defined by disclosing problems, in removing barriers to entry to nonobvious individuals. We also contribute to the knowledge-based theory of the firm by showing the effectiveness of a market mechanism to draw out knowledge from diverse external sources to solve internal problems.
Journal Article
Potentially long-lasting effects of the pandemic on scientists
Two surveys of principal investigators conducted between April 2020 and January 2021 reveal that while the COVID-19 pandemic’s initial impacts on scientists’ research time seem alleviated, there has been a decline in the rate of initiating new projects. This dimension of impact disproportionately affects female scientists and those with young children and appears to be homogeneous across fields. These findings may have implications for understanding the long-term effects of the pandemic on scientific research.
The pandemic has caused disruption to many aspects of scientific research. In this Comment the authors describe the findings from surveys of scientists between April 2020 and January 2021, which suggests there was a decline in new projects started in that time.
Journal Article
Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance, Novelty, and Resource Allocation in Science
Selecting among alternative projects is a core management task in all innovating organizations. In this paper, we focus on the evaluation of frontier scientific research projects. We argue that the “intellectual distance” between the knowledge embodied in research proposals and an evaluator’s own expertise systematically relates to the evaluations given. To estimate relationships, we designed and executed a grant proposal process at a leading research university in which we randomized the assignment of evaluators and proposals to generate 2,130 evaluator–proposal pairs. We find that evaluators systematically give lower scores to research proposals that are closer to their own areas of expertise and to those that are highly novel. The patterns are consistent with biases associated with boundedly rational evaluation of new ideas. The patterns are inconsistent with intellectual distance simply contributing “noise” or being associated with private interests of evaluators. We discuss implications for policy, managerial intervention, and allocation of resources in the ongoing accumulation of scientific knowledge.
This paper was accepted by Lee Fleming, entrepreneurship and innovation
.
Journal Article
Incentives and Problem Uncertainty in Innovation Contests: An Empirical Analysis
Contests are a historically important and increasingly popular mechanism for encouraging innovation. A central concern in designing innovation contests is how many competitors to admit. Using a unique data set of 9,661 software contests, we provide evidence of two coexisting and opposing forces that operate when the number of competitors increases. Greater rivalry reduces the incentives of all competitors in a contest to exert effort and make investments. At the same time, adding competitors increases the likelihood that at least one competitor will find an extreme-value solution. We show that the effort-reducing effect of greater rivalry dominates for less uncertain problems, whereas the effect on the extreme value prevails for more uncertain problems. Adding competitors thus systematically increases overall contest performance for high-uncertainty problems. We also find that higher uncertainty reduces the negative effect of added competitors on incentives. Thus, uncertainty and the nature of the problem should be explicitly considered in the design of innovation tournaments. We explore the implications of our findings for the theory and practice of innovation contests.
This paper was accepted by Christian Terwiesch, operations management.
Journal Article
Unequal effects of the COVID-19 pandemic on scientists
COVID-19 has not affected all scientists equally. A survey of principal investigators indicates that female scientists, those in the ‘bench sciences’ and, especially, scientists with young children experienced a substantial decline in time devoted to research. This could have important short- and longer-term effects on their careers, which institution leaders and funders need to address carefully.
Journal Article
Is novel research worth doing? Evidence from peer review at 49 journals
There are long-standing concerns that peer review, which is foundational to scientific institutions like journals and funding agencies, favors conservative ideas over novel ones.We investigate the association between novelty and the acceptance of manuscripts submitted to a large sample of scientific journals. The data cover 20,538 manuscripts submitted between 2013 and 2018 to the journals Cell and Cell Reports and 6,785 manuscripts submitted in 2018 to 47 journals published by the Institute of Physics Publishing. Following previous work that found that a balance of novel and conventional ideas predicts citation impact, we measure the novelty and conventionality of manuscripts by the atypicality of combinations of journals in their reference lists, taking the 90th percentile most atypical combination as “novelty” and the 50th percentile as “conventionality.” We find that higher novelty is consistently associated with higher acceptance; submissions in the top novelty quintile are 6.5 percentage points more likely than bottom quintile ones to get accepted. Higher conventionality is also associated with acceptance (+16.3% top–bottom quintile difference). Disagreement among peer reviewers was not systematically related to submission novelty or conventionality, and editors select strongly for novelty even conditional on reviewers’ recommendations (+7.0% top–bottom quintile difference). Manuscripts exhibiting higher novelty were more highly cited. Overall, the findings suggest that journal peer review favors novel research that is well situated in the existing literature, incentivizing exploration in science and challenging the view that peer review is inherently antinovelty.
Journal Article
Special Section Introduction—Online Community as Space for Knowledge Flows
Online communities frequently create significant economic and relational value for community participants and beyond. It is widely accepted that the underlying source of such value is the collective flow of knowledge among community participants. We distinguish the conditions for flows of tacit and explicit knowledge in online communities and advance an unconventional theoretical conjecture: Online communities give rise to tacit knowledge flows between participants. The crucial condition for these flows is not the advent of novel, digital technology as often portrayed in the literature, but instead the technology’s domestication by humanity and the sociality it affords. This conjecture holds profound implications for theory and research in the study of management and organization, as well as their relation to information technology.
Journal Article
Cardiac repair and regeneration: cell therapy, in vivo reprogramming, and the promise of extracellular vesicles
Therapeutic interventions to replenish lost cardiomyocytes and recover myocardium functions following ischemic myocardial infarction (MI) remain major goals in the cardiac regeneration field. Clinical trials harnessing autologous or allogeneic cell therapy approaches from both cardiac and noncardiac cells sources, thus far, demonstrate marginal improvement. Moreover, complications such as arrythmias and graft rejections associated with cellular or organ-based therapies continue to prevail. Extracellular vesicles, on the other hand, are cell-derived, nano-sized, cargo-containing biomolecules that have emerged as potent alternatives to cell-based cardiac regeneration/replacement therapy. Recent studies demonstrate that most stem-cell-derived extracellular vesicles (Stem-EVs) are nonimmunogenic and carry cardioprotective therapeutic cargos. Moreover, administration of multiple Stem-EV types in animal models of acute MI results in reduced inflammation, apoptosis, smaller infarct size and improved cardiac functionality. With recent developments, engineered Stem-EVs with enhanced cardiac targeting, prolonged circulation and recombinant therapeutic cargos may tilt the cardiac regeneration field toward these novel cell-free biologics. Here we provide a brief overview of current approaches to repair and replenish damaged cardiomyocytes following MI via cell therapy and in vivo reprogramming, and we delve deeply into the therapeutic potentials of Stem-EVs in cardiac repair and regeneration.
Stem extracellular vesicles transform cardiac regeneration strategies
Heart disease is a leading cause of death worldwide, with heart failure being a major concern. Current treatments help manage symptoms but do not address the root cause: the loss of heart muscle cells (cardiomyocytes). This Article reviews new approaches to regenerate heart tissue after a heart attack. Researchers are exploring cell therapy, where cells are transplanted to repair the heart, and in vivo reprogramming, which involves converting existing cells into heart cells directly in the body. Another promising area is the use of extracellular vesicles, tiny particles released by cells that can carry healing signals to damaged heart tissue. These EVs can be derived from various stem cells and have shown potential in reducing inflammation and promoting heart repair in animal studies.
This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
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