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"Karl, C."
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Gustav Stresemann : the crossover artist
\"As a foreign minister and chancellor of Weimar Germany, Gustav Stresemann is a familiar figure for students of German history - one who, for many, embodied the best qualities of German interwar liberalism. However, a more nuanced and ambivalent picture emerges in this award-winning biography, which draws on extensive research and new archival material to enrich our understanding of Stresmann's public image and political career. It memorably explores the personality of a brilliant but flawed politician who endured class anxiety and social marginalization, and who died on the eve of Germany's descent into economic and political upheaval.\"--Provided by publisher.
Book
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination
The Omicron variant is rapidly becoming the dominant SARS-CoV-2 virus circulating globally. It is important to define reductions in virus neutralizing activity in the serum of convalescent or vaccinated individuals to understand potential loss of protection against infection by Omicron. We previously established that a 50% plaque reduction neutralization antibody titer (PRNT
50
) ≥25.6 in our live virus assay corresponded to the threshold for 50% protection from infection against wild-type (WT) SARS-CoV-2. Here we show markedly reduced serum antibody titers against the Omicron variant (geometric mean titer (GMT) < 10) compared to WT virus 3–5 weeks after two doses of BNT162b2 (GMT = 218.8) or CoronaVac vaccine (GMT = 32.5). A BNT162b2 booster dose elicited Omicron PRNT
50
titers ≥25.6 in 88% of individuals (22 of 25) who previously received 2 doses of BNT162b2 and 80% of individuals (24 of 30) who previously received CoronaVac. However, few (3%) previously infected individuals (1 of 30) or those vaccinated with three doses of CoronaVac (1 of 30) met this threshold. Our findings suggest that countries primarily using CoronaVac vaccines should consider messenger RNA vaccine boosters in response to the spread of Omicron. Studies evaluating the effectiveness of different vaccines against the Omicron variant are urgently needed.
Serum neutralizing antibody titers against the SARS-CoV-2 Omicron variant markedly increase after a third dose of BNT162b2 vaccine in individuals who previously received either two doses of the BNT162b2 vaccine or two doses of the CoronaVac vaccine.
Journal Article
مبادئ علم الاقتصاد الكلي /
تمثل الموضوعات التي يعالجها هذا الكتاب قاسما مشتركا بين كثير من التخصصات الدراسية التي تمنحها أقسام وكليات الاقتصاد وإدارة الأعمال والمحاسبة والتمويل وغيرها، الأمر الذي يجعل رفد تلك الأقسام والكليات بأحدث ما كتب في مجال الاقتصاد الكلي حاجة ملحة ومستمرة. من أجل تلبية جزء من تلك الحاجة وتوسيع الخيارات أمام الدارسين لهذا التخصص الأكاديمي تم اختيار الكتاب الذي بين أيدينا دون غيره لأسباب عدة ومنها المعالجة الواسعة والعرض الشائق للمادة العلمية بأسلوب إنشائي مبسط وسلس سهل الفهم مدعوما بالرسوم والصور والأشكال البيانية المناسبة. وكذلك، الخبرة التدريسية الواسعة لمؤلفيه والتي انعكست إيجابيا في أسلوب شرح موضوعات الكتاب وأفكاره. ساهم هذان السببان في انتشار هذا الكتاب واعتماده كمرجع علمي في العديد من الجامعات والكليات المرموقة حول العالم.
Book
Enhancing photoluminescence yields in lead halide perovskites by photon recycling and light out-coupling
In lead halide perovskite solar cells, there is at least one recycling event of electron–hole pair to photon to electron–hole pair at open circuit under solar illumination. This can lead to a significant reduction in the external photoluminescence yield from the internal yield. Here we show that, for an internal yield of 70%, we measure external yields as low as 15% in planar films, where light out-coupling is inefficient, but observe values as high as 57% in films on textured substrates that enhance out-coupling. We analyse in detail how externally measured rate constants and photoluminescence efficiencies relate to internal recombination processes under photon recycling. For this, we study the photo-excited carrier dynamics and use a rate equation to relate radiative and non-radiative recombination events to measured photoluminescence efficiencies. We conclude that the use of textured active layers has the ability to improve power conversion efficiencies for both LEDs and solar cells.
Recombinations govern losses in solar cells. Here, Richter
et al
. use transient spectroscopy to evaluate how re-absorption and re-emission of photons in perovskite absorbers affect intrinsic recombination coefficients, and to differentiate between external and internal photoluminescence quantum yields.
Journal Article
Legacy : a House of Night graphic novel
\"Zoey Redbird and her Nerd Herd discover the secret history of the vampyres on earth, involving the Amazon warriors, Circe, Cleopatra, and other historical figures, from whom the group of fledgling vampyres learn important lessons\"-- Provided by publisher.
Book
Placental genomics mediates genetic associations with complex health traits and disease
As the master regulator
in utero
, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we perform distal mediator-enriched transcriptome-wide association studies (TWAS) for 40 traits, integrating placental multi-omics from the Extremely Low Gestational Age Newborn Study. At
P
<
2.5
×
10
−
6
, we detect 248 GTAs, mostly for neonatal and metabolic traits, across 176 genes, enriched for cell growth and immunological pathways. In aggregate, genetic effects mediated by placental expression significantly explain 4 early-life traits but no later-in-life traits. 89 GTAs show significant mediation through distal genetic variants, identifying hypotheses for distal regulation of GTAs. Investigation of one hypothesis in human placenta-derived choriocarcinoma cells reveal that knockdown of mediator gene
EPS15
upregulates predicted targets
SPATA13
and
FAM214A
, both associated with waist-hip ratio in TWAS, and multiple genes involved in metabolic pathways. These results suggest profound health impacts of placental genomic regulation in developmental programming across the life course.
The impact of placental transcriptomics on fetal traits throughout development is not well understood. Here, the authors apply distal-SNP-enriched transcriptome-wide association studies to detect genetic contributions, mediated through fetal placental genomics, to developmental programming of complex traits across the life course.
Journal Article
Nightwing. Volume 3, False starts
\"Dick Grayson, a.k.a. Nightwing, has grown out of the shadow of his mentor Batman and decided to forge a new destiny for himself in Gotham City's neighboring town, Bludhaven. Unfortunately, it seems that no matter where Dick goes, his hometown will always follow him. After seeing the devastation caused by a massive earthquake, Nightwing finds himself in the middle of a decimated Gotham teaming with his Bat-family to help its citizens. Then, even as he makes his way back to Bludhaven, a familiar face that's equally friend and foe shows up at his doorstep: The Huntress! Legendary writer Chuck Dixon (BATMAN: KNIGHTFALL) pens these classic tales of Dick Grayson in NIGHTWING VOL. 3. Collects issues #20-29, as well as the special #1,000,000\"-- Provided by publisher.
Book
StomataCounter
Stomata regulate important physiological processes in plants and are often phenotyped by researchers in diverse fields of plant biology. Currently, there are no user-friendly, fully automated methods to perform the task of identifying and counting stomata, and stomata density is generally estimated by manually counting stomata.
We introduce StomataCounter, an automated stomata counting system using a deep convolutional neural network to identify stomata in a variety of different microscopic images. We use a human-in-the-loop approach to train and refine a neural network on a taxonomically diverse collection of microscopic images.
Our network achieves 98.1% identification accuracy on Ginkgo scanning electron microscropy micrographs, and 94.2% transfer accuracy when tested on untrained species.
To facilitate adoption of the method, we provide the method in a publicly available website at http://www.stomata.science/.
Journal Article
Infinity countdown companion
\"The events of the Infinity Countdown are felt across the Marvel Universe! Carol Danvers holds the Reality Stone - and with it meets the Captain Marvels of many worlds! Daredevil battles to keep Hell's Kitchen safe from the influence of the Mind Stone! And the Champions fight in deep space for...the Chitauri!? All this plus...Black Widow! Don't miss this blockbuster tie-in to the most explosive Marvel event of 2018! \" -- Page 4 of cover.
Book
Congenital heart disease risk loci identified by genome-wide association study in European patients
Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but still remain ill defined. We sought to identify genetic risk factors associated with CHD and to accomplish a functional analysis of SNP-carrying genes. We performed a genome-wide association study (GWAS) of 4034 White patients with CHD and 8486 healthy controls. One SNP on chromosome 5q22.2 reached genome-wide significance across all CHD phenotypes and was also indicative for septal defects. One region on chromosome 20p12.1 pointing to the MACROD2 locus identified 4 highly significant SNPs in patients with transposition of the great arteries (TGA). Three highly significant risk variants on chromosome 17q21.32 within the GOSR2 locus were detected in patients with anomalies of thoracic arteries and veins (ATAV). Genetic variants associated with ATAV are suggested to influence the expression of WNT3, and the variant rs870142 related to septal defects is proposed to influence the expression of MSX1. We analyzed the expression of all 4 genes during cardiac differentiation of human and murine induced pluripotent stem cells in vitro and by single-cell RNA-Seq analyses of developing murine and human hearts. Our data show that MACROD2, GOSR2, WNT3, and MSX1 play an essential functional role in heart development at the embryonic and newborn stages.
Journal Article