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result(s) for
"Karl, Herman"
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Hot adaptation
by
Hogendoorn, Daniel
,
Laws, David
,
Karl, Herman
in
Adaptation
,
Agricultural management
,
Collaboration
2014
We analyze the impact of conflict on the adaptive comanagement of social-ecological systems. We survey the risks and the resources that conflict creates and review experiences with public policy mediation as a set of practical hypotheses about how to work collaboratively under conditions of conflict. We analyze the significance of these features in the context of an approach to adaptive comanagement that we call “hot adaptation.” Hot adaptation is organized to draw on the energy and engagement that conflict provides to enhance the capacity for deliberation and learning around the wicked problems that constitute the working terrain of adaptive comanagement.
Journal Article
A Dialogue, Not a Diatribe: Effective Integration of Science and Policy through Joint Fact Finding
by
Wallace, Katherine H.
,
Susskind, Lawrence E.
,
Karl, Herman A.
in
19th century
,
Collaboration
,
Community
2007
None of these is true.5 Policymaking is not an entirely rational process of identifying problems and choosing optimal solutions, especially when scientists must make value-laden assumptions and extrapolations in the face of highly uncertain data to answer questions posed by policymakers.6 What is needed is a way to ensure, politics aside, that our understanding of the workings of complex ecological systems informs public policy choices about where and how development should proceed, how natural resources are managed to ensure sustainable supplies, and whether and how to regulate economic activities that pose a threat to human health and safety as well as environmental protection. In recognition that science is needed now more than ever to inform societal decisions, politicians, government and nongovernmental agencies, and citizens have been asking with a mounting sense of urgency for scientists and science organizations to make their research more relevant to society's needs and to become involved in policymaking.39 Yet even as scientists heed this call, more often than not, they still find themselves and their work ignored, marginalized, or misrepresented in deeply contentious environmental policy debates.
Journal Article
A Case of Multiple Organ Disseminated Cryptococcosis
2021
Cryptococcus neoformans is an encapsulated yeast found worldwide.1 Patients with immunosuppression, including individuals with HIV/AIDS, transplant recipients and/or individuals with other T-cell mediated immunosuppression are more susceptible to becoming infected with Cryptococcus neoformans than immunocompetent individuals.2 This is a case report of a 66-year-old woman who presented to the emergency department with an unsteady gait and urinary incontinence. Magnetic resonance imaging (MRI) on presentation showed a large C5-C6 central disc protrusion. The patient underwent surgical repair and was treated with five days of IV steroids. Later in the course of her hospitalization, she had an unexplained increasing leukocytosis and tachycardia with witnessed episodes of unresponsiveness. She subsequently had a pulseless electrical activity cardiac arrest and succumbed despite resuscitative efforts. A post-mortem diagnosis revealed Cryptococcus neoformans fungemia and disseminated cryptococcosis involving multiple organs. Disseminated cryptococcosis primarily affects the central nervous system3, and thus this report presents a rare case of disseminated cryptococcosis involving multiple organs.Cryptococcus neoformans is an encapsulated yeast found worldwide.1 Patients with immunosuppression, including individuals with HIV/AIDS, transplant recipients and/or individuals with other T-cell mediated immunosuppression are more susceptible to becoming infected with Cryptococcus neoformans than immunocompetent individuals.2 This is a case report of a 66-year-old woman who presented to the emergency department with an unsteady gait and urinary incontinence. Magnetic resonance imaging (MRI) on presentation showed a large C5-C6 central disc protrusion. The patient underwent surgical repair and was treated with five days of IV steroids. Later in the course of her hospitalization, she had an unexplained increasing leukocytosis and tachycardia with witnessed episodes of unresponsiveness. She subsequently had a pulseless electrical activity cardiac arrest and succumbed despite resuscitative efforts. A post-mortem diagnosis revealed Cryptococcus neoformans fungemia and disseminated cryptococcosis involving multiple organs. Disseminated cryptococcosis primarily affects the central nervous system3, and thus this report presents a rare case of disseminated cryptococcosis involving multiple organs.
Journal Article
Severe, Symptomatic Reinfection in a Patient with COVID-19
by
Selvaraj, Vijairam
,
Herman, Karl
,
Dapaah-Afriyie, Kwame
in
Aged
,
Betacoronavirus - immunology
,
Betacoronavirus - isolation & purification
2020
To date, there have only been a few reports of reinfections in COVID-19 patients. The possibility of being reinfected with COVID-19 is poorly understood. In this case report, we describe an individual who was initially diagnosed in April 2020 with COVID-19. Seven months later, he presented again to the hospital with shortness of breath and was found to have COVID-19 reinfection. We also summarize a list of all known cases of COVID-19 reinfection at this time.
Journal Article
A Case of Multiple Organ Disseminated Cryptococcosis
by
Masel, Rebecca
,
Herman, Karl
,
Dapaah-Afriyie, Kwame
in
Acquired immune deficiency syndrome
,
AIDS
,
Bacterial infections
2021
Cryptococcus neoformans is an encapsulated yeast found worldwide.1 Patients with immunosuppression, including individuals with HIV/AIDS, transplant recipients and/or individuals with other T-cell mediated immunosuppression are more susceptible to becoming infected with Ciyptococcus neoformans than immunocompetent individuals.2 This is a case report of a 66-year-old woman who presented to the emergency department with an unsteady gait and urinary incontinence. Magnetic resonance imaging (MRI) on presentation showed a large C5-C6 central disc protrusion. The patient underwent surgical repair and was treated with five days of IV steroids. Later in the course of her hospitalization, she had an unexplained increasing leukocytosis and tachycardia with witnessed episodes of unresponsiveness. she subsequently had a pulseless electrical activity cardiac arrest and succumbed despite resuscitative efforts. A post-mortem diagnosis revealed Ciyptococcus neoformans fungemia and disseminated cryptococcosis involving multiple organs. Disseminated cryptococcosis primarily affects the central nervous system3, and thus this report presents a rare case of disseminated cryptococcosis involving multiple organs.
Journal Article
Severe, Symptomatic Reinfection in a Patient with COVID-19
2020
To date, there have only been a few reports of reinfections in COVID-19 patients. The possibility of being reinfected with COVID-19 is poorly understood. In this case report, we describe an individual who was initially diagnosed in April 2020 with COVID-19. Seven months later, he presented again to the hospital with shortness of breath and was found to have COVID-19 reinfection. We also summarize a list of all known cases of COVID-19 reinfection at this time.
Journal Article
KMS conditions, standard real subspaces and reflection positivity on the circle group
2016
In the present paper we continue our investigations of the representation theoretic side of reflection positivity by studying positive definite functions on the additive group (R,+) satisfying a suitably defined KMS condition. These functions take values in the space Bil(V) of bilinear forms on a real vector space V. As in quantum statistical mechanics, the KMS condition is defined in terms of an analytic continuation of to the strip z ın C\\: 0 Im z b with a coupling condition (ib + t) = (t) on the boundary. Our first main result consists of a characterization of these functions in terms of modular objects ( J) (J an antilinear involution and > 0 selfadjoint with J J = ^-1) and an integral representation. Our second main result is the existence of a Bil(V)-valued positive definite function f on the group R_ = R ıd_ with (t) = -t satisfying f(t,) = (it) for t ın R. We thus obtain a 2b-periodic unitary one-parameter group on the GNS space H_f for which the one-parameter group on the GNS space H_ is obtained by Osterwalder--Schrader quantization. Finally, we show that the building blocks of these representations arise from bundle-valued Sobolev spaces corresponding to the kernels 1/(^2 - (d^2)/(dt^2) on the circle R/bZ of length b.
Chemical and physicochemical characterization of the sialic acid-specific lectin from Cepaea hortensis
2002
A sialic acid-specific lectin was isolated from the albumin glands of the garden snail
Cepaea hortensis by affinity chromatography on fetuin-Sepharose following gel filtration on Superdex 200. The purified native lectin showed a molecular mass of about 95 kDa by gel filtration and 100 kDa by SDS electrophoresis. It was cleaved by boiling in buffer containing SDS in three serological identical bands corresponding to molecular masses of about 24, 20 and 16 kDa, respectively. From these three fragments, only the 24- and the 20-kDa bands were found to be glycosylated. Only the three sugars mannose, galactose and
N-acetylglucosamine could be detected in a molar ratio of 3:8.6:2. The oligosaccharide moieties seem to be
N- and partially
O-glycosidic bound. Isoelectric focusing (IEF) of the purified lectin revealed a heterogeneous pattern with bands in the pH range of 4.3–5.0. Isolated bands of different isoelectric points showed in SDS electrophoresis the same three fragments with molecular masses of 24, 20 or 16 kDa. The heterogeneity of the lectin was revealed either by IEF or amino acid sequencing of internal tryptic peptides.
Journal Article
A Model Project for Exploring the Role of Sustainability Science in a Citizen-Centered, Collaborative Decision-Making Process
by
Turner, Christine
,
Karl, Herman A.
in
Citizen Participation
,
Communities
,
Community Involvement
2002
Science is essential in solving society's environmental problems, but scientific research & funding need direction based on societal concerns to address the problems. To this end, a 1998 partnership between a federal government science agency (the US Geological Survey) & San Francisco citizens in a community-based environmental decision-making process (Integrated Science & Community-Based Values) is described. This approach incorporated a full range of natural & social science data in a collaborative effort to develop consensus on land-use planning around the San Francisquito Creek watershed in Menlo Park, CA. This process also addressed communication of scientific findings to stakeholders. It included the development of games & simulations to assist the public in understanding the complex issues involved. This project serves as a test case in community-based interdisciplinary & collaborative problem solving that can be applied to other watersheds. 1 Table, 16 References. M. Pflum
Journal Article