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"Kavita"
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As the world ages : rethinking a demographic crisis
People are living longer, not only in wealthy countries but in developing nations. Western experts have long conceived of aging as a universal predicament--one that supposedly provokes the same welfare concerns in every context. In the twenty-first century, we must embrace a new approach that prioritizes local agendas and values. In this history of how gerontologists, doctors, social scientists, and activists came to define the issue of global aging, Sivaramakrishnan shows that the United Nations, private NGOs, and transnational philanthropic foundations embraced programs that reflected prevailing Western ideas about modernization. The dominant paradigm often assumed that, because large-scale growth of an aging population happened first in the West, developing societies will experience the issues of aging in the same ways and on the same terms as their Western counterparts. Focusing on South Asia and Africa, As the World Ages shows how regional voices have begun to question this one-size-fits-all model and have argued instead for an approach that responds to local needs and concerns.-- Provided by publisher
Book
Molecular link between dietary fibre, gut microbiota and health
Natural polysaccharides cellulose, hemicelluloses, inulin etc., galactooligosaccharides (GOS), and fructooligosaccharides (FOS) play a significant role in the improvement of gut microbiota balance and human health. These polysaccharides prevent pathogen adhesion that stimulates the immune system and gut barrier function by servicing as fermentable substrates for the gut microbiota. The gut microbiota plays a key role in the fermentation of non-digestible carbohydrates (NDCs) fibres. Moreover, the gut microbiota is responsible for the production of short-chain fatty acids (SCFAs) like acetate, propionate and butyrate. Acetate is the most abundant and it is used by many gut commensals to produce propionate and butyrate in a growth-promoting cross-feeding process. The dietary fibres affect the gut microbiome and play vital roles in signaling pathways. The SCFAs, acetate, butyrate, and propionate have been reported to affect on metabolic activities at the molecular level. Acetate affects the metabolic pathway through the G protein-coupled receptor (GPCR) and free fatty acid receptor 2 (FFAR2/GPR43) while butyrate and propionate transactivate the peroxisome proliferator-activated receptors
γ
(PPAR
γ
/NR1C3) and regulate the PPAR
γ
target gene
Angptl4
in colonic cells of the gut. The FFAR2 signaling pathway regulates the insulin-stimulated lipid accumulation in adipocytes and inflammation, however peptide tyrosine-tyrosine (PPY) and glucagon-like peptide 1 regulates appetite. The NDCs via gut microbiota dependent pathway regulate glucose homeostasis, gut integrity and hormone by GPCR, NF-kB, and AMPK-dependent processes.
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Journal Article
Pathology of Racism — A Call to Desegregate Teaching Hospitals
At our medical institutions, we immerse trainees in a two-tiered system. We teach them that some kinds of patients see residents and other kinds of patients see attendings. And worst of all, we teach them to pretend not to notice.
Journal Article
The last Plantagenet consorts : gender, genre, and historiography, 1440-1627
\"Most modern accounts of fifteenth-century queens understandably focus on separating what really happened from what was fabricated. What has not been considered in any detail, however, is the fabrications themselves as narratives, and as reflections of questions and anxieties that haunted their writers. By focusing on the relationship between gender and genre and the way embedded literary narratives echo across texts as disparate as chronicles, parliamentary proceedings, diplomatic correspondence, ballads, poetry, and drama, this study reveals hitherto unexplored tensions within these texts, generated by embedded narratives and their implications\"-- Provided by publisher.
Book
A Survey of Deep Convolutional Neural Networks Applied for Prediction of Plant Leaf Diseases
In the modern era, deep learning techniques have emerged as powerful tools in image recognition. Convolutional Neural Networks, one of the deep learning tools, have attained an impressive outcome in this area. Applications such as identifying objects, faces, bones, handwritten digits, and traffic signs signify the importance of Convolutional Neural Networks in the real world. The effectiveness of Convolutional Neural Networks in image recognition motivates the researchers to extend its applications in the field of agriculture for recognition of plant species, yield management, weed detection, soil, and water management, fruit counting, diseases, and pest detection, evaluating the nutrient status of plants, and much more. The availability of voluminous research works in applying deep learning models in agriculture leads to difficulty in selecting a suitable model according to the type of dataset and experimental environment. In this manuscript, the authors present a survey of the existing literature in applying deep Convolutional Neural Networks to predict plant diseases from leaf images. This manuscript presents an exemplary comparison of the pre-processing techniques, Convolutional Neural Network models, frameworks, and optimization techniques applied to detect and classify plant diseases using leaf images as a data set. This manuscript also presents a survey of the datasets and performance metrics used to evaluate the efficacy of models. The manuscript highlights the advantages and disadvantages of different techniques and models proposed in the existing literature. This survey will ease the task of researchers working in the field of applying deep learning techniques for the identification and classification of plant leaf diseases.
Journal Article
Global migration : challenges in the twenty-first century
\"Immigration today evokes passionate debates over questions of national identity, state sovereignty, and citizenship. Even as capital, goods, and services flow easily over national boundaries, human beings are subjected to intense scrutiny and resistance when crossing borders. In this collection of essays, distinguished scholars probe the challenges and opportunities that global migration presents for individuals, states, and societies grappling with questions of identity, belonging, and citizenship. Multidisciplinary in scope, the book demonstrates how forced and voluntary migrations intersect with global politics, from economic and environmental crises to human rights and security\"-- Provided by publisher.
Book
Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug therapy. But presently, detailed investigations have revealed their flaws as drug delivery carriers. Lipid polymer hybrid nanoparticles (LPHNPs) are advanced core–shell nanoconstructs with a polymeric core region enclosed by a lipidic layer, presumed to be derived from both liposomes and polymeric nanounits. This unique concept is of utmost importance as a combinable drug delivery platform in oncology due to its dual structured character. To add advantage and restrict one’s limitation by other, LPHNPs have been designed so to gain number of advantages such as stability, high loading of cargo, increased biocompatibility, rate-limiting controlled release, and elevated drug half-lives as well as therapeutic effectiveness while minimizing their drawbacks. The outer shell, in particular, can be functionalized in a variety of ways with stimuli-responsive moieties and ligands to provide intelligent holding and for active targeting of antineoplastic medicines, transport of genes, and theragnostic. This review comprehensively provides insight into recent substantial advancements in developing strategies for treating various cancer using LPHNPs. The bioactivity assessment factors have also been highlighted with a discussion of LPHNPs future clinical prospects.
Graphical Abstract
Journal Article