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Background Persons with Alzheimer’s disease and related dementias (ADRD) have been disproportionally impacted by the COVID‐19 pandemic, showing a significantly increased risk of infection and severe illness, including neurocognitive consequences. The National Alzheimer’s Coordinating Center collects rich longitudinal, standardized neurocognitive data from populations at high risk of COVID‐19 complications, including older adults who were cognitively normal prior to infection and those who had pre‐existing ADRD. These data, in combination with Electronic Health Records (EHR) clinic data, will be critical for understanding the complex pathophysiology and cognitive symptoms of COVID‐19 and the development of future therapeutics. To rapidly respond to the COVID‐19 epidemic, the present study developed a novel socio‐technical solution for the Alzheimer’s Disease Research Centers (ADRC) Program to expand longitudinal COVID‐19 data collection, integrate new data streams, and open the door to impactful new COVID‐19 and ADRD discoveries. Method We linked EHR, Medicare claims, and genetic data with rich standardized longitudinal cognitive assessment data collected from across the ADRC Program and housed at NACC. This project included the development and deployment of standardized IRB and consent language and a new data use agreement to provide access to all data steams within the LINKAGE enclave. It also leveraged an OMOP model to collect, harmonize, and integrate EHR data from participating ADRCs. The governance materials and technical pipelines developed will allow us to scale our solution across the heterogeneous consortium of 37 ADRCs. Result The new team science model we developed facilitates collaborations between informatics leaders and ADRD leaders within and across institutions. Our approach supports development and dissemination of best practices to advance data interoperability and will facilitate researchers asking and answering new questions at the intersection of COVID and ADRD. The projected cohort size for this pilot study across three ADRCs is: cognitively normal (1,109), mild cognitive impairment (214), and dementia (224). Conclusion Once scaled to the full ADRC Program, this platform will provide one of the largest and most comprehensive longitudinal multimodal datasets in the world for an age group at high risk for COVID‐19 infection. Additionally, the dataset includes valuable cognitive, behavioral, and genetic data collected prior to COVID‐19 infection.

Building a Ovββ experiment with the ability to probe neutrino mass in the inverted hierarchy region requires the combination of a large detector mass sensitive to Ovββ, on the order of 1-tonne, and unprecedented background levels, on the order of or less than 1 count per year in the Ovβ β signal region. The MAJORANA Collaboration proposes a design based on using high-purity enriched 76Ge crystals deployed in ultralow background electroformed Cu cryostats and using modern analysis techniques that should be capable of reaching the required sensitivity while also being scalable to a 1-tonne size. To demonstrate feasibility, the collaboration plans to construct a prototype system, the MAJORANA DEMONSTRATOR, consisting of 30 kg of 86% enriched 76Ge detectors and 30 kg of natural or isotope-76-depleted Ge detectors. We plan to deploy and evaluate two different Ge detector technologies, one based on a p-type configuration and the other on n-type.

With a death toll of 109, ValuJet Flight 592 is the worst air disaster in Florida history. The previous most deadly accident was Eastern Flight 401, which killed 101 passengers and crew in December 1972. -- Feb. 12, 1963: Northwest Orient Flight 705, a four-engine 720B, took off from Miami International Airport into severe afternoon thunderstorms. Fifteen minutes later, the plane broke apart in flight and dove into a remote area of the Everglades 42 miles west of the airport. All 43 on board perished. -- Jan. 13, 1982: Air Florida Flight 90, a twin-engine Boeing 737-200, took off from Washington National Airport during a heavy snowstorm. It was in the air for 30 seconds, rammed a bridge, crushed six cars and a truck, then crashed into the icy Potomac River. Of 79 aboard, four passengers and a crew member survived.

[Domingo] Pacheco should have been on ValuJet Flight 592 to Atlanta on Saturday, but he missed the plane when the left rear tire of his 1985 Cadillac blew on the Palmetto Expressway. \"I spent three hours in church today thanking the man upstairs,\" the 37-year-old trucker said on Sunday as he nervously waited to board ValueJet's 1 p.m. flight out of Miami International Airport. Pacheco, of Cutler Ridge, said he was racing to the airport on Saturday when his bad luck turned into his good fortune.

A partial list of passengers and crew aboard ValuJet Flight 592 from Miami to Atlanta, according to the airline:

-- Carlos Gonzalez, the church's missions director, who was a week shy of celebrating the one-year anniversary of his arrival in the United States from Venezuela. -- Lila Violeta, Gonzalez's teen-age niece. -- Roger and Dana Lane, newlyweds, who had just learned enough Spanish so they could minister in South America and teach English to Venezuelan children. The group spent a week in Venezuela staying with Gonzalez's relatives. They met with religious leaders to lay the foundation for a project they wanted to complete by summer, [Nathan] Sycks said. They wanted to build a church on a boat that would sail South American rivers.

Knowledge of locations and activities of cis-regulatory elements (CREs) is needed to decipher basic mechanisms of gene regulation and to understand the impact of genetic variants on complex traits. Previous studies identified candidate CREs (cCREs) using epigenetic features in one species, making comparisons difficult between species. In contrast, we conducted an interspecies study defining epigenetic states and identifying cCREs in blood cell types to generate regulatory maps that are comparable between species, using integrative modeling of eight epigenetic features jointly in human and mouse in our Validated Systematic Integration (VISION) Project. The resulting catalogs of cCREs are useful resources for further studies of gene regulation in blood cells, indicated by high overlap with known functional elements and strong enrichment for human genetic variants associated with blood cell phenotypes. The contribution of each epigenetic state in cCREs to gene regulation, inferred from a multivariate regression, was used to estimate epigenetic state Regulatory Potential (esRP) scores for each cCRE in each cell type, which were used to categorize dynamic changes in cCREs. Groups of cCREs displaying similar patterns of regulatory activity in human and mouse cell types, obtained by joint clustering on esRP scores, harbored distinctive transcription factor binding motifs that were similar between species. An interspecies comparison of cCREs revealed both conserved and species-specific patterns of epigenetic evolution. Finally, we showed that comparisons of the epigenetic landscape between species can reveal elements with similar roles in regulation, even in the absence of genomic sequence alignment.