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Creative confidence : unleashing the creative potential within us all
\"Too often, companies and individuals assume that creativity and innovation are the domain of the 'creative types.' But two of the leading experts in innovation, design, and creativity on the planet show us that each and every one of us is creative\"-- Provided by publisher.
Book
Developing therapeutic monoclonal antibodies at pandemic pace
The time from discovery to proof-of-concept trials could be reduced to 5–6 months from a traditional timeline of 10–12 months.
Journal Article
Otherworld chills : final tales of the otherworld
In the final installment of the Otherworld anthology series, Armstrong brings the clever wit, dark twists and intense suspense her readers have come to expect.
Book
Getting Eyes in the Home
Each year, U.S. child protection authorities investigate millions of families, disproportionately poor families and families of color. These investigations involve multiple home visits to collect information across numerous personal domains. How does the state gain such widespread entrée into the intimate, domestic lives of marginalized families? Predominant theories of surveillance offer little insight into this process and its implications. Analyzing observations of child maltreatment investigations in Connecticut and interviews with professionals reporting maltreatment, state investigators, and investigated mothers, this article argues that coupling assistance with coercive authority—a hallmark of contemporary poverty governance—generates an expansive surveillance of U.S. families by attracting referrals from adjacent systems. Educational, medical, and other professionals invite investigations of families far beyond those ultimately deemed maltreating, with the hope that child protection authorities’ dual therapeutic and coercive capacities can rehabilitate families, especially marginalized families. Yet even when investigations close, this arrangement, in which service systems channel families to an entity with coercive power, fosters apprehension among families and thwarts their institutional engagement. These findings demonstrate how, in an era of welfare retrenchment, rehabilitative poverty governance renders marginalized populations hypervisible to the state in ways that may reinforce inequality and marginality.
Journal Article
Employee Perceptions of the Effective Adoption of AI Principles
This study examines employee perceptions on the effective adoption of artificial intelligence (AI) principles in their organizations. 49 interviews were conducted with employees of 24 organizations across 11 countries. Participants worked directly with AI across a range of positions, from junior data scientist to Chief Analytics Officer. The study found that there are eleven components that could impact the effective adoption of AI principles in organizations: communication, management support, training, an ethics office(r), a reporting mechanism, enforcement, measurement, accompanying technical processes, a sufficient technical infrastructure, organizational structure, and an interdisciplinary approach. The components are discussed in the context of business code adoption theory. The findings offer a first step in understanding potential methods for the effective adoption of AI principles in organizations.
Journal Article
Cross-species regulatory sequence activity prediction
Machine learning algorithms trained to predict the regulatory activity of nucleic acid sequences have revealed principles of gene regulation and guided genetic variation analysis. While the human genome has been extensively annotated and studied, model organisms have been less explored. Model organism genomes offer both additional training sequences and unique annotations describing tissue and cell states unavailable in humans. Here, we develop a strategy to train deep convolutional neural networks simultaneously on multiple genomes and apply it to learn sequence predictors for large compendia of human and mouse data. Training on both genomes improves gene expression prediction accuracy on held out and variant sequences. We further demonstrate a novel and powerful approach to apply mouse regulatory models to analyze human genetic variants associated with molecular phenotypes and disease. Together these techniques unleash thousands of non-human epigenetic and transcriptional profiles toward more effective investigation of how gene regulation affects human disease.
Journal Article
Concealment and Constraint
With the expansion of state surveillance and enforcement efforts in recent decades, a growing literature examines how those vulnerable to punitive state contact strategize to evade it. This article draws on in-depth interviews with eighty-three low-income mothers to consider whether and how concerns about Child Protective Services (CPS), a widespread presence in poor communities with the power to remove children from their parents, inform poor mothers’ institutional engagement. Mothers recognized CPS reports as a risk in interactions with healthcare, educational, and social service systems legally mandated to report suspected child abuse or neglect. Departing from findings on responses to policing and immigration enforcement, I find that CPS concerns rarely prompted mothers to avoid systems wholesale. Within their system participation, however, mothers engaged in a selective or constrained visibility, concealing their hardships, home life, and parenting behavior from potential reporters. As reporting systems serve as vital sources of support for disadvantaged families, mothers’ practices of information management, while perhaps protecting them from CPS reports, may preclude opportunities for assistance and reinforce a sense of constraint in families’ institutional interactions.
Journal Article