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Precipitation affects many aspects of our everyday life. It is the primary source of freshwater and has significant socioeconomic impacts resulting from natural hazards such as hurricanes, floods, droughts, and landslides. Fundamentally, precipitation is a critical component of the global water and energy cycle that governs the weather, climate, and ecological systems. Accurate and timely knowledge of when, where, and how much it rains or snows is essential for understanding how the Earth system functions and for improving the prediction of weather, climate, freshwater resources, and natural hazard events. The Global Precipitation Measurement (GPM) mission is an international satellite mission specifically designed to set a new standard for the measurement of precipitation from space and to provide a new generation of global rainfall and snowfall observations in all parts of the world every 3 h. The National Aeronautics and Space Administration (NASA) and the Japan Aerospace and Exploration Agency (JAXA) successfully launched the Core Observatory satellite on 28 February 2014 carrying advanced radar and radiometer systems to serve as a precipitation physics observatory. This will serve as a transfer standard for improving the accuracy and consistency of precipitation measurements from a constellation of research and operational satellites provided by a consortium of international partners. GPM will provide key measurements for understanding the global water and energy cycle in a changing climate as well as timely information useful for a range of regional and global societal applications such as numerical weather prediction, natural hazard monitoring, freshwater resource management, and crop forecasting.

This study aimed to monitor the operating state of an induction motor, a type of electromagnetic motor, using a highly sensitive magnetic sensor, which could be applied for anomaly detection in the future. Monitoring the health of electromagnetic motors is very important to minimize losses due to failures. Detecting anomalies using the changes compared with the initial state is a possible solution, but there are issues such as a lack of training data for machine learning and the need to install multiple sensors. Therefore, an attempt was made to acquire the various operating states of a motor from magnetic signals using a single magnetic sensor capable of non-contact measurement. The relationships between the magnetic flux density from the motor and the other motor conditions were investigated. As a result, the magnetic spectrum was found to contain information on the rotor rotation frequency, torque, and output power. Therefore, the magnetic sensor can be applied to monitor a motor’s operating conditions, making it a useful tool for advanced data analysis.

The rainfall‐elevation relationship in the central Himalayan region (CHR) for pre‐monsoon and monsoon seasons is analyzed utilizing the 11‐year (1998–2008) high‐spatial‐resolution TRMM PR 2A25 near‐surface rainfall data. The results indicate a strong relationship between rainfall and elevation during both seasons. The investigation reveals a relatively large amount of rainfall over higher elevations during pre‐monsoon season. Interestingly, two significant rainfall peaks appear over the southern slope of the Himalayas during summer monsoon season. The first primary peak appears along the Sub‐Himalayas (∼500–700 m above MSL), while the second appears along the Lesser Himalayas (∼2,000–2,200 m above MSL). The former rainfall peak is attributed to fewer heavy rainfall events, and the latter to frequent, weak, but persistent rainfall. It is suggested that the atmosphere is insufficiently moist to trigger convections during the pre‐monsoon season, and sufficiently moist during summer monsoon season. The convections over the Sub‐Himalayas may moisten the middle layer, and the water vapor in the atmosphere condenses because of the forced lifting along the slope, forming the second rainfall band. The total rain amount is primarily determined by the frequency of rain. The rain‐conditioned rain rate along the slope monotonically decreases with elevation. This shows that the precipitation occurs because of forced lifting. In addition, our results show that seasonal variation of rainfall is rather similar to the variation of rainfall characteristics observed during active and break periods. Key Points The double rainfall bands appear over the central Himalayas Low‐altitude rainfall peak is primarily attributed to fewer heavy rainfall High‐altitude rainfall peak is attributed to weak but persistent rainfall

Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.

A tidy cell is a healthy cell Two papers this week suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the health of the nervous system than was thought. Both groups show that inhibition of autophagy in mouse brain cells results in neurodegeneration and early death. Autophagy, the protein degradation and recycling of cellular components, is important for the normal growth and development of a cell. The finding that the continual clearance of cellular components is essential for maintaining neuronal health should open up new avenues of research into the nature of neurodegenerative diseases. One of two papers showing that loss of autophagy in the central nervous system of mice causes the accumulation of protein aggregates in inclusion bodies, neurodegeneration and premature death of the mice. This demonstrates that continuous clearance of cellular components is essential for proper housekeeping and vital to keep the neurons in tiptop shape. Autophagy is an intracellular bulk degradation process through which a portion of the cytoplasm is delivered to lysosomes to be degraded 1 , 2 , 3 , 4 . Although the primary role of autophagy in many organisms is in adaptation to starvation, autophagy is also thought to be important for normal turnover of cytoplasmic contents, particularly in quiescent cells such as neurons. Autophagy may have a protective role against the development of a number of neurodegenerative diseases 5 , 6 , 7 , 8 . Here we report that loss of autophagy causes neurodegeneration even in the absence of any disease-associated mutant proteins. Mice deficient for Atg5 (autophagy-related 5) specifically in neural cells develop progressive deficits in motor function that are accompanied by the accumulation of cytoplasmic inclusion bodies in neurons. In Atg5 -/- cells, diffuse, abnormal intracellular proteins accumulate, and then form aggregates and inclusions. These results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.

Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect of Thymus vulgaris essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxis in vitro. In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema. However, only TEO and CVL inhibited leukocyte migration. In the in vitro chemotaxis experiment, CVL inhibited leukocyte migration, whereas thymol exerted a potent chemoattractant effect. In the ear edema model, CVL (10 mg/ear), applied topically, reduced edema formation, exerting a topical anti-inflammatory effect. Thymol did not reduce edema formation but rather presented an irritative response, probably dependent on histamine and prostanoid release. Our data suggest that the antiinflammatory effects of TEO and CVL are attributable to the inhibition of inflammatory edema and leukocyte migration.

Objective The purpose of this study is to determine the dose reduction of different shielding materials at various distances from a 177 Lu photon radiation source. Methods Two protective aprons with lead equivalent thicknesses of 0.25 mm and 0.35 mm and tungsten-containing rubber (TCR) were used as shielding materials. A vial containing 177 Lu was sealed in a lead container so that a narrow beam went out through a 3 mm-diameter hole. The dose rate was measured at distances of 0, 10, 50, 100, and 200 cm from the source using a NaI scintillation survey meter to obtain the rate of dose reduction. TCR was tested with thicknesses ranging from 0.3 to 1.0 mm at 0.1 mm intervals and from 1.0 to 4.0 mm at 0.5 mm intervals. Results At distances of 0, 10, 50, 100, and 200 cm, the dose reduction for the lead equivalent thickness of 0.25 mm were 32.7%, 54.5%, 93.1%, 97.9%, and 99.6%, respectively; and for the lead equivalent thickness of 0.35 mm were 53.4%, 70.6%, 95.6%, 98.9%, and 99.6%, respectively. Without any shielding, the dose rate decreased by 34.4% at 10 cm and by 88.8% at 50 cm from the radiation source. The dose reduction for the TCR thickness of 3.5 mm was 89.8% at 0 cm and 93.3% at 10 cm. The TCR thickness of 0.4 mm provided a dose reduction comparable to or greater than that of the 0.25 mm lead equivalent, whereas the TCR thickness of 1.0 mm or greater provided a dose reduction comparable to that of the 0.35 mm lead equivalent. Conclusions Achieving a reduction of 95% or more requires the 0.25 mm lead equivalent for a distance of 100 cm, the 0.35 mm lead equivalent for 50 cm, the TCR thickness of 0.3 mm for 100 cm, or the TCR thickness of 0.9 mm for 50 cm. Without wearing a protective apron, a reduction of approximately 95% is observed at distances greater than 100 cm. These findings would be useful for medical staff engaging in related activities.

Bacterial inactivation is a crucial aspect of sanitation and hygiene. The effectiveness of slightly acidic electrolyzed water (SAEW) for reduction or removal of Escherichia coli , Pseudomonas aeruginosa and Staphylococcus epidermidis was evaluated. The bactericidal activity of SAEW and sodium hypochlorite (NaOCl) against E. coli and P. aeruginosa were compared through in vitro experiments. The effectiveness of SAEW spray was tested against S. epidermidis . Results showed that SAEW had a more powerful bactericidal activity than NaOCl at the same available chlorine concentrations. For E. coli , SAEW decreased the bacterial counts from 8.4 log 10 CFU/mL to less than 3.9 log 10 CFU/mL; NaOCl with the same available chlorine of 0.5 mg/L, caused a decrease from 8.4 log 10 CFU/mL to 7.1 log 10 CFU/mL. For P. aeruginosa , SAEW caused bacterial counts to decrease from 8.5 log 10 CFU/mL to less than 4.1 log 10 CFU/mL against 8.5 log 10 CFU/mL to 6.2 log 10 CFU/mL for NaOCl with the same available chlorine of 0.5 mg/L. Spray experiments showed that 10 mg/L of SAEW spray decreased the bacterial counts of S. epidermidis from 3.7 log 10 CFU/m 3 to 2.8 log 10 CFU/m 3 , with 20 mg/L causing a reduction from 3.8 log 10 CFU/m 3 to 0 CFU/m 3 . The overall findings of this study indicate that SAEW may be a promising disinfectant agent either as a solution or spray.

Purpose Although the prevalence of drug–drug interactions (DDIs) in elderly outpatients is high, many potential DDIs do not have any actual clinical effect, and data on the occurrence of DDI-related adverse drug reactions (ADRs) in elderly outpatients are scarce. This study aimed to determine the incidence and characteristics of DDI-related ADRs among elderly outpatients as well as the factors associated with these reactions. Methods A prospective cohort study was conducted between 1 November 2010 and 31 November 2011 in the primary public health system of the Ourinhos micro-region, Brazil. Patients aged ≥60 years with at least one potential DDI were eligible for inclusion. Causality, severity, and preventability of the DDI-related ADRs were assessed independently by four clinicians using validated methods; data were analysed using descriptive analysis and multiple logistic regression. Results A total of 433 patients completed the study. The incidence of DDI-related ADRs was 6 % ( n  = 30). Warfarin was the most commonly involved drug (37 % cases), followed by acetylsalicylic acid (17 %), digoxin (17 %), and spironolactone (17 %). Gastrointestinal bleeding occurred in 37 % of the DDI-related ADR cases, followed by hyperkalemia (17 %) and myopathy (13 %). The multiple logistic regression showed that age ≥80 years [odds ratio (OR) 4.4; 95 % confidence interval (CI) 3.0–6.1, p  < 0.01], a Charlson comorbidity index ≥4 (OR 1.3; 95 % CI 1.1–1.8, p  < 0.01), consumption of five or more drugs (OR 2.7; 95 % CI 1.9–3.1, p  < 0.01), and the use of warfarin (OR 1.7; 95 % CI1.1–1.9, p  < 0.01) were associated with the occurrence of DDI-related ADRs. With regard to severity, approximately 37 % of the DDI-related ADRs detected in our cohort necessitated hospital admission. All DDI-related ADRs could have been avoided (87 % were ameliorable and 13 % were preventable). The incidence of ADRs not related to DDIs was 10 % ( n  = 44). Conclusions The incidence of DDI-related ADRs in elderly outpatients is high; most events presented important clinical consequences and were preventable or ameliorable.

Chromosome aberrations (CAs), a genotoxic potential of carcinogens, are believed to contribute to tumorigenesis by chromosomal rearrangements through micronucleus formation. However, there is no direct evidence that proves the involvement of CAs in tumorigenesis in vivo. In the current study, we sought to clarify the involvement of CAs in chemical carcinogenesis using a rat model with a pure CA‐inducer hepatocarcinogen, acetamide. Whole‐genome analysis indicated that hepatic tumors induced by acetamide treatment for 26–30 weeks showed a broad range of copy number alterations in various chromosomes. In contrast, hepatic tumors induced by a typical mutagen (diethylnitrosamine) followed by a nonmutagen (phenobarbital) did not show such mutational patterns. Additionally, structural alterations such as translocations were observed more frequently in the acetamide‐induced tumors. Moreover, most of the acetamide‐induced tumors expressed c‐Myc and/or MDM2 protein due to the copy number gain of each oncogene. These results suggest the occurrence of chromosomal rearrangements and subsequent oncogene amplification in the acetamide‐induced tumors. Taken together, the results indicate that CAs are directly involved in tumorigenesis through chromosomal rearrangements in an acetamide‐induced hepatocarcinogenesis rat model. The pure chromosome aberration‐inducer acetamide caused hepatocarcinogenesis in a rat model through chromosomal rearrangements characterized by copy number alterations and structural alterations. The chromosomal rearrangements induced some specific oncogene amplifications in hepatic tumors.