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"Kerr, James M"
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Dissecting the Molecular Basis of Phosphorus Cycling in Marine Phototroph-Heterotroph Interactions
Marine microbial interactions can be seen as a driver of the biogeochemical cycling of elements, and it is now understood that marine phototrophs are responsible for about half of all carbon dioxide fixation. Primary production by phototrophic picocyanobacteria and picoeukaryotes converts carbon dioxide into dissolved organic matter (DOM). Co-occurring heterotrophic organisms benefit from DOM as a source of carbon and energy, but phototrophs, lacking the necessary secreted enzymes, depend on the re-mineralised inorganic nutrients released by the heterotrophic community. This strategy is particularly important in the vast photic zones of the oligotrophic ocean, where availability of essential nutrients can be limiting. This project aimed to dissect the molecular mechanisms of this nutrient cycling. Using one-to-one co-cultures combined with mass spectrometric analysis, the change in exoproteomic profile between mono- and co- cultures of R. pomeroyi and 8 model phototrophs revealed generic and species-specific changes. Qualitative analysis of these changes revealed intriguing \"phytase-like\" secreted proteins in several of the phototrophic cultures, which became the basis for further investigation of phosphorous cycling in particular. One phytaselike protein was overexpressed and purified, showing some de-phosphorylation of different inositol phosphate (InsP) substrates in assay. Gene atlas tools revealed distribution of homologues across P-depleted ocean regions, and cross-domain patterns of expression. In investigating the origin of InsP substrates, and the role they play within marine microbial interactions, cell pellets of the diatoms were found to contain InsP, and an InsP biosynthetic pathway was proposed based on orthologues from the known pathway of A. thaliana. This research highlights the complexity of the molecular mechanisms underpinning phototroph-heterotroph nutrient cycling, and represents foundational research into the role of phytases, their substrates, and P cycling at large in the marine microenvironment.
Dissertation
الأداء الأمثل للشركات
يقدم هذا الكتاب طرقا بسيطة ومباشرة لتطبيق الأفكار الثاقبة في عالم إدارة النظم الاقتصادية الجديدة كما أنه يقدم حلولا شاملة للمشكلات الأساسية التي يواجهها مديرون الشركات فيما يتعلق بالموظفين وعمليات التشغيل والوسائل التكنولوجية ويكشف الكتاب النقاب عن كيفية تحسين أداء الموظفين بالشركات بداية من كبار المسئولين وحتى أصغر الموظفين ويستعرض كيفية تصميم نظم تكنولوجيا المعلومات للاستجابة لمتطلبات السوق بشكل سريع وزيادة العائدات على استثمارات هذه التكنولوجيا في الوقت نفسه ويناقش بعض الطرق التي تضيف أبعادا أخرى لأساليب إعادة هيكلة العمل وذلك بهدف تحسين الجودة وتنفيذ العمليات التجارية على النحو الأمثل والتنمية المستمرة لمهارات الموظفين.
BOOK
The information engineering paradigm
Information Engineering (IE) is a data-driven development methodology. It includes analysis and design techniques that support the logical design phase of the information systems (IS) development life cycle. Analysts using the approach must clearly define the data requirements of the system they are building before they designate the methods in which the data will be manipulated. Begun in the 1980s, IE is intended to exploit modern relational tools. It assists in achieving major IS management objectives, including flexible systems, integrated applications, and interruption-free development. IE also offers more subtle advantages, such as rapid design and lower IS expenses. A well-rounded strategy for institutionalizing IE includes: 1. an awareness program, 2. an IE task force, 3. a pilot project plan, 4. a peer support program, and 5. a policy creation and distribution. IE is poised to become the de facto IS development standard of the 1990s.
Journal Article
An Architecture for the Future ; You can't build a robust, agile enterprise architecture on the fly. You gotta make plans
Today, organizations need to learn to make workflow changes on the fly. Otherwise, consumers and trading partners alike are ready to move on. This puts tremendous pressure on organizations to fully automate business operations wherever possible and adjust them dynamically without any disruption. Businesses seeking to compete on a global scale should consider the following approach: 1. The first step is to establish a framework that presents a set of architectural principles that support the organizations business goals and strategic drivers. 2. Its important to get a baseline of the current environment, both business operations and IT systems, to define what works well and what must be improved in order to meet the future needs of the organization. 3. The target definition phase is designed to identify the new IT projects that must be staffed and funded down the road. 4. A gap analysis is required to compare the baseline with the target and identify what's missing. 5. Implementation planning and architecture administration are also required.
Trade Publication Article
