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Introduction We aimed to streamline the NIDA Phenotyping Assessment Battery (PhAB), a package of self‐report scales and neurobehavioral tasks used in substance use disorder (SUD) clinical trials, for clinical administration ease. Tailoring the PhAB to shorten administration time for a treatment setting is critical to expanding its acceptability in SUD clinical trials. This study's primary objectives were to develop a brief version of PhAB (PhAB‐B) and assess its operational feasibility and acceptability in a female clinical treatment sample. Methods Assessments of the original PhAB were evaluated along several criteria to identify a subset for the PhAB‐B. Non‐pregnant females (N=55) between ages 18–65, stabilized on buprenorphine for opioid use disorder (OUD) at an outpatient addiction clinic, completed this abbreviated battery remotely or after a provider visit in clinic. Participant satisfaction questions were administered. REDCap recorded the time to complete PhAB‐B measures. Results The PhAB‐B included 11 measures that probed reward, cognition, negative emotionality, interoception, metacognition, and sleep. Participants who completed the PhAB‐B (N =55) were 36.1 ± 8.9 years of age, White (54.5%), Black (34.5%), and non‐Latinx (96.0%). Most participants completed the PhAB‐B remotely (n = 42, 76.4%). Some participants completed it in‐person (n = 13, 23.6%). PhAB‐B mean completion time was 23.0 ± 12.0 min. Participant experiences were positive, and 96% of whom reported that they would participate in the study again. Conclusion Our findings support the clinical feasibility and acceptability of the PhAB‐B among a female opioid use disorder outpatient addiction treatment sample. Future studies should assess the PhAB‐B psychometric properties among broader treatment samples. This study's primary objectives were to develop a brief version of the NIDA Phenotyping Assessment Battery (PhAB) and assess its operational feasibility and acceptability in a female clinical treatment sample. Non‐pregnant females (N = 55) between ages 18–65, stabilized on buprenorphine for opioid use disorder (OUD) at an outpatient addiction clinic, completed this 11‐measure abbreviated battery (PhAB‐B). Findings support the clinical feasibility and acceptability of the PhAB‐B among a female OUD outpatient addiction treatment sample.

We have used generous assumptions in terms of production rates and ion fluxes to assess the production of O2- through ER reactions as a mechanism to explain Rosetta observations. Even with these assumptions, the amount of O2 produced is insignificant (by several orders of magnitude) with respect to what was detected by ROSINA–DFMS. There are not enough ions in the coma and the series of events required to trigger these processes are individually too rare. Furthermore, cometary ion fluxes are anti-correlated to the O2 densities observed by ROSINA. Finally, in terms of the instrument itself, there is little evidence of the production and detection of products O2- and energetic O2 by ROSINA–DFMS. While ER reactions may occur, they cannot explain the amounts of O2 detected. Primordial O21,3 remains compatible with the quantities and trends of molecular oxygen measured by ROSINA–DFMS, while other theories17 discuss other plausible sources.

The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. Herein, we tested whether anti-human apoE antibodies can decrease Aβ pathology in mice producing both human Aβ and apoE4, and investigated the mechanism underlying these effects. We utilized APPPS1-21 mice crossed to apoE4-knockin mice expressing human apoE4 (APPPS1-21/APOE4). We discovered an anti-human apoE antibody, anti-human apoE 4 (HAE-4), that specifically recognizes human apoE4 and apoE3 and preferentially binds nonlipidated, aggregated apoE over the lipidated apoE found in circulation. HAE-4 also binds to apoE in amyloid plaques in unfixed brain sections and in living APPPS1-21/APOE4 mice. When delivered centrally or by peripheral injection, HAE-4 reduced Aβ deposition in APPPS1-21/APOE4 mice. Using adeno-associated virus to express 2 different full-length anti-apoE antibodies in the brain, we found that HAE antibodies decreased amyloid accumulation, which was dependent on Fcγ receptor function. These data support the hypothesis that a primary mechanism for apoE-mediated plaque formation may be a result of apoE aggregation, as preferentially targeting apoE aggregates with therapeutic antibodies reduces Aβ pathology and may represent a selective approach to treat AD.

President Clinton has returned to playing the sax in public, Sister 2 Sister publisher Jamie Foster Brown told The Washington Post. Attending a $500,000 fund-raising dinner Saturday at the Beverly Hills spread of Babyface Edmonds, hard by the Playboy Mansion, Clinton blew riffs on Take Five and Greensleeves. But he didn't go next door to say hey to Hef. Did one of the Survivor refugees tell more than she should have? Jeannette Walls of MSNBC says that when 29-year-old chemist Ramona Gray got voted off the island last week, she went on CBS This Morning and co-host Jane Clayson asked her to describe the other castaways with one word. Gray described Jenna Klug as \"cheerleader,\" Gervase Peterson as \"my boy.\" When it came to describing Gretchen Cordy - the 38-year-old former survival skills instructor who many fans of the show have predicted will be the last remaining on the Island - Gray said \"survivor.\"

Background In the USA, infant mortality remains a major public health concern, particularly for Black women and their infants who continue to experience disproportionately high mortality rates. Prenatal care is a key determinant of infant health, with inadequate prenatal care increasing risk for prematurity, stillbirth, neonatal loss, and infant death. The aim of the present study was to determine if concurrent delivery of patient navigation and behavioral incentives to at-risk Black pregnant women could improve prenatal care attendance and associated maternal and infant outcomes. Methods Participants were 150 Black pregnant women recruited at first prenatal visit and screening at risk for adverse maternal and infant outcomes. Women were randomized to either the patient navigation + behavioral incentives intervention (PNBI) or assessment + standard care control (ASC) group. All were followed throughout pregnancy and 12-week postpartum. Group comparisons were made using intention-to-treat and per-protocol sensitivity analyses. Results While no group differences were found in prenatal care visits, the average number of visits for both groups (9.3 for PNBI and 8.9 for ASC) approached the American College of Obstetricians and Gynecologists (ACOG) recommended guidelines. There were also no group differences in maternal and infant outcomes. Both intention-to-treat and per-protocol sensitivity analyses, however, consistently found PNBI women attended more postpartum visits than ASC controls ( p = 0.002). Conclusions Given ACOG’s redefining of the postpartum period as the fourth trimester, study findings suggest PNBI may facilitate prevention and intervention efforts to more successfully reduce health disparities in outcomes for both mother and infant.

Wildland fires have a multitude of ecological effects in forests, woodlands, and savannas across the globe. A major focus of past research has been on tree mortality from fire, as trees provide a vast range of biological services. We assembled a database of individual-tree records from prescribed fires and wildfires in the United States. The Fire and Tree Mortality (FTM) database includes records from 164,293 individual trees with records of fire injury (crown scorch, bole char, etc.), tree diameter, and either mortality or top-kill up to ten years post-fire. Data span 142 species and 62 genera, from 409 fires occurring from 1981-2016. Additional variables such as insect attack are included when available. The FTM database can be used to evaluate individual fire-caused mortality models for pre-fire planning and post-fire decision support, to develop improved models, and to explore general patterns of individual fire-induced tree death. The database can also be used to identify knowledge gaps that could be addressed in future research.Measurement(s)plant morphology trait • tree mortality • fire • tree fire injury • wildfireTechnology Type(s)digital curationFactor Type(s)year of data collection • geographic location of fire • tree fire injurySample Characteristic - OrganismtreesSample Characteristic - Environmentforest ecosystemSample Characteristic - LocationCascades Region • Blue Mountains • Far Northern Rockies • Sierra Nevada • Piedmont Province • Region of Piedmont • Atlantic and Gulf Coastal Plain Floristic Province • Northern Rocky Mountains Provincial ParkMachine-accessible metadata file describing the reported data: 10.6084/m9.figshare.12369293