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PurposeBuildings consume a large amount of energy for space cooling during the summer season, creating an overall sustainability concern. The upfront cost associated with sustainability repels the decision-makers to often end up adopting solutions that have huge operations and maintenance costs. Therefore, the purpose of this study is to assess the lifecycle cost (LCC) implications of optimum configurations of active and passive strategies for reducing the cooling load in buildings.MethodsSeveral green building active and passive strategies and technologies were assimilated and their thermal performance in a hot semi-arid climate of Lahore in Pakistan using DesignBuilder V6.1 was simulated to obtain the most optimum cooling load configuration. Furthermore, LCC is estimated, and overall efficiency is evaluated to identify the most effective space cooling configuration.Results and discussionThe results suggest that a configuration of EPS for external wall insulation, vertical louvers for external shading, 6 mm blue HRG (low-E soft coated) + 12 mm air space + 6 mm clear glass for windows, polystyrene as roof insulation, cross ventilation through windows, and LED lighting system has the best performance. This is the first-of-its-kind study in the hot semi-arid climate of South Asia with the city of Lahore in Pakistan as the test case and can be generalized for places with similar conditions. The findings will help the decision-makers in selecting the most load-efficient and cost-effective green building technologies to help improve overall sustainability.ConclusionThe implementation of the proposed strategies not only aids in providing user-friendly and effective decision-making but also promotes the adoption of sustainability in buildings by leveraging the existing green building technologies to enhance the environmental and economic aspects. This is a promising approach to facilitate the spread of green building construction in developing countries. It is recommended to utilize the strategies grouped in Scenario 8 to achieve a reduced cooling load and LCC of a residential building throughout its lifecycle.

The remediation of pesticides from the environment is one of the most important technology nowadays. Herein, magnesium oxide (MgO) nanoparticles and calcium-doped magnesium oxide (Ca-doped MgO) nanoparticles were synthesized by the co-precipitation method and were used for the degradation of thiamethoxam pesticide in aqueous media. Characterization of the MgO and Ca-doped MgO nanoparticles were performed by XRD, SEM, EDX, and FT-IR analysis to verify the synthesis and variations in chemical composition. The band gap energy and crystalline size of MgO and Ca-doped MgO nanoparticles were found to be 4.8 and 4.7 eV and 33 and 34 nm respectively. The degradation of thiamethoxam was accomplished regarding the impact of catalyst dosage, contact time, temperature, pH, and initial pesticide concentration. The pH study indicates that degradation of thiamethoxam depends on pH and maximum degradation (66%) was obtained at pH 5 using MgO nanoparticles. In contrast, maximum degradation (80%) of thiamethoxam was observed at pH 8 employing Ca-doped MgO nanoparticles. The percentage degradation of thiamethoxam was initially increasing but decreased at higher doses of the catalysts. The degradation of the pesticide was observed to be increased with an increase in contact time while high at room temperature but decreased with a temperature rise. The effect of the initial concertation of pesticide indicates that degradation of pesticide increases at low concentrations but declines at higher concentrations. This research study reveals that doping of MgO nanoparticles with calcium enhanced the degradation of thiamethoxam pesticide in aqueous media.

The coronavirus disease of 2019 (COVID-19) pandemic represented a significant global event that disrupted the typical social lives of adolescents. Studies show that the pandemic negatively impacted adolescent well-being. Very little is known about the social–cognitive implications of wide-scale social distancing, school closures, and the transition to digital modes of communication for adolescents. This study aims to compare affective Theory of Mind (ToM), self-esteem, and self-perceptions before and after the COVID-19 pandemic. Drawing on existing data, this study compared two distinct but comparable samples of adolescents. Data from the pre-COVID-19 sample were collected in the 2016/2017 school year (N = 145, 60.7% female and 39.3% male, mean age 13.38 years. Data from the post-COVID-19 sample were collected over the 2021/2022 school year (N = 107 participants, 51% female, 48% male, and 1% genderqueer, mean age of 13 years). Independent-sample t-tests and two-tailed correlational analysis were used to compare associations and changes in affective ToM, self-perceptions, and self-esteem between the pre-COVID-19 and post-COVID-19 samples. The main findings of this study includes declines in affective ToM post-COVID-19, specifically related to the perception of negative affect. Further, perceived self-worth and behavioural conduct declined after the COVID-19 pandemic. Implications for social–emotional learning and future research are discussed.

The current study aimed to find out the anti-arthritic activity and safety study of Coronopus didymus aqueous extract (CDAE) as well as its chemical characterization by HPLC–DAD. Safety study including acute and subacute toxicity studies of the plant aqueous extract was also performed. In complete Freund’s adjuvant-induced arthritic model (CFA), 0.15 ml CFA was injected in the left hind paw at day 1 in all rats except normal rats. Treatment with CDAE at 200, 400, and 800 mg/kg and methotrexate (1 mg/kg) was administered at day 8 and continued till 28th day using oral gavage. The CDAE considerably ( p  < 0.05) reduced the paw swelling and arthritic score, and reinstated the body weight and blood parameters. The CDAE considerably modulated superoxide dismutase, catalase, reduced glutathione, and malondialdehyde level in liver homogenate in contrast to disease control. The CDAE at 400 mg/kg considerably reduced IL-6, IL -1β, COX-2, and NF-ĸβ, whereas elevated IL-10, IL-4, and I-kappa β as equated to disease and standard groups. The LD50 of CD AE > 2000 mg/kg. In subacute toxicity study, CDAE at 200–800 mg/kg did not exhibit clinical signs of toxicity, mortality, hematological, biochemical, and histological alteration in the liver heart, kidney, and lungs in contrast to the normal group. It was concluded that the presence of delphinidine-3-glucoside, diosmetin, 3-feruloyl-4,5-dicaffeoyl quinic acid, and gallic acid in CDAE might be accountable for its anti-arthritic activity and safe use for a long period. Graphical Abstract

The present study was focused on the preparation of cobalt oxide (CoO) and barium-doped cobalt oxide (Ba-doped CoO) by following the co-precipitation method for the degradation of Emamectin benzoate pesticide in the aqueous medium. The prepared catalysts were characterized using SEM, EDX, and XRD to confirm the formation of catalysts and to observe the variation in the composition of catalysts during the degradation study. It can be suggested from the results of SEM, EDX, XRD, and FTIR analyses that Ba atom has successfully incorporated in the crystalline structure of CoO. The degradation of Emamectin benzoate pesticide was studied under the influence of different factors like solution pH, the dose of catalyst, contact time, temperature, and initial concentration of pesticide. It was observed that solution pH affects the degradation of the pesticide, and maximum degradation (23% and 54%) was found at pH 5.0 and 6.0 using CoO and Ba-doped CoO, respectively. The degradation of pesticides was found to be increased continuously (27–35% in case of CoO while 47–58% in case Ba-doped CoO) with the time of contact. However, the degradation was found to be decreased (23–3% in case of CoO while 47–44% in case Ba-doped CoO) with an increase in temperature. Likewise, in the beginning, degradation was observed to be increased up to some extent with the dose of catalyst and initial concentration of pesticide but started to decrease with further augmentation in the dose of catalyst and initial concentration of pesticide. It may be concluded from this study that doping of Ba considerably enhanced the photocatalytic ability of CoO for Emamectin benzoate pesticide.

ABSTRACT Non-carious cervical lesions are frequently associated with sensitivity which is a major problem for the patients. Moreover, lesions occurring along the anterior teeth result in poor aesthetic. Thus, both functional and aesthetic concerns are associated with these lesions. The purpose of this study was to determine the frequency of possible factors associated with the NCCLs in permanent teeth. Ninetysix patients with an average age of 50.29years, who were referred to the operative department of Islamabad Medical and Dental Hospital with non-carious cervical lesions(NCCL)were clinically examined. A questionnaire of associated factors including parafunctional habits, type of toothbrush, brushing technique, gastro-reflux disorder, malocclusion and intake of carbonated drinks was designed to determine the frequency of possible factors associated with NCCLs. Descriptive statistics, frequencies and cross tabs were used for data analysis. Results showed a positive association between the NCCLs and possible factors under study. However, the highest frequency associated with NCCLs was recorded 85.4% with the use of carbonated drinks.

The finite element (FE) method is a powerful technique that can provide numerical solutions to the response of reinforced concrete (RC) structures. However, results obtained from FE models are often not objective in the sense that the numerical solutions of FE models depend on aspects such as the selection of mesh size, load step size etc. FE model objectivity aims at the development of FE models for which the predicted results converge with refinement. To date, many research studies have been carried out on the objectivity of FE solutions for RC structures. However, considerable uncertainty still exists because of the many parameters which are involved in the analysis. The parameters affecting FE analysis of RC structures may be divided into two groups: material parameters and procedural parameters. The main parameters related to the material behaviour are tension softening and interaction between steel reinforcement and concrete. On the other hand, the procedural parameters which affect directly the results of the analysis are the load step, mesh size, iterative scheme, and number of cracks allowed per load step, numerical integration rule, and the use of static vs. dynamic analysis. In an effort to investigate these parameters, the current research is primarily aimed towards developing finite element formulations and solution procedures that facilitate the objective modelling of RC structures. The present study focuses on a subset of the above parameters that appear to be most relevant to objective modelling. Two new formulations have been developed in this work which allows the objective modelling of RC beam-column members, including geometric and material nonlinearity as well as bond slip. Particular emphasis is placed on predicting crack localisation in the concrete and stress concentrations in the steel reinforcement across such cracks, as this is particularly relevant to the modelling of RC structures under extreme loading. Several verification and validation studies are presented in the thesis to illustrate the key features of the proposed formulations and their applicability to the objective modelling of RC framed structures.

The present study aimed to formulate 5-fluorouracil loaded cross linked chitosan nanoparticles based on chemical cross-linking of low molecular weight chitosan with glutaraldehyde by reverse micelles technique as 5-FU is less hydrophobic, relatively potent, has a shorter half-life, is rapidly metabolized, less tolerated, and has low oral bioavailability; therefore, we aimed to formulate potential nanocarriers of 5-FU for efficient drug delivery to specific targeted areas of action, reduce oral toxicity, improve tolerability and therapeutic outcomes of 5-FU, in a restricted fashion to enhance the bioavailability of 5-FU. Nanoparticles were formulated by the reverse micelle method based on the chemical cross-linking of glutaraldehyde (25% aqueous solution) into a w/o emulsion in different ratios. LMWCH-NPs were characterized for post-formulation parameters by mean particle size, zeta potential, %age yield, loading/entrapment efficiency, Fourier transform infrared spectroscopy (FTIR), DSC/TGA, TEM, PXRD, drug release at pH 1.2, and pH 7.4. 5-FU loaded NPs showed a size range (198 nm-200 nm) and zeta potential (−39mV to −41mV), which ensured mechanical stability and increased retention time in blood vessels by the sustained release properties of biodegradable nanocarrier drug delivery systems. % age yield showed the range 92% to 96% while % LC ranged 2.0% to 3.4% and %EE ranged 40% to 43%. The TEM images showed spherical nanoparticles. FTIR revealed the compatibility between the drug and the cross-linked polymer. DSC/TGA ensured the thermal stability of the drug, while the solid-state stability of the drug-loaded cross-linked chitosan nanoparticles was evaluated by powder X-ray diffraction (PXRD) analysis. Drug release studies were performed using the dialysis bag technique at both pH (1.2 and 7.4) to mimic the gastrointestinal tract. Highly stable NPs displayed targeted release in phosphate buffer pH 7.4 at 37°C. Fickian diffusion was the predominant release with an R2 value of 0.9975-0.9973—and an N value 0.45-0.53. Prepared nanoparticles are inert, biodegradable, and biocompatible drug delivery systems for sustained release of 5-FU with maximum therapeutic efficacy and bioavailability.

In agriculture, the search for higher net profit is the main challenge in the economy of the producers and nano biochar attracts increasing interest in recent years due to its unique environmental behavior and increasing the productivity of plants by inducing resistance against phytopathogens. The effect of rice straw biochar and fly ash nanoparticles (RSBNPs and FNPs, respectively) in combination with compost soil on bacterial leaf spot of pepper caused by Xanthomonas campestris  pv.  vesicatoria was investigated both in vitro and in vivo. The application of nanoparticles as soil amendment significantly improved the chili pepper plant growth. However, RSBNPs were more effective in enhancing the above and belowground plant biomass production. Moreover, both RSBNPs and FNPs, significantly reduced (30.5 and 22.5%, respectively), while RSBNPs had shown in vitro growth inhibition of X. campestris  pv.  vesicatoria by more than 50%. The X-ray diffractometry of RSBNPs and FNPs highlighted the unique composition of nano forms which possibly contributed in enhancing the plant defence against invading X. campestris  pv.  vesicatoria . Based on our findings, it is suggested that biochar and fly ash nanoparticles can be used for reclaiming the problem soil and enhance crop productivity depending upon the nature of the soil and the pathosystem under investigation.

The development of genotypes that can tolerate high levels of salt is crucial for the efficient use of salt-affected land and for enhancing crop productivity worldwide. Therefore, incorporating salinity tolerance is a critical trait that crops must possess. Salt resistance is a complex character, controlled by multiple genes both physiologically and genetically. To examine the genetic foundation of salt tolerance, we assessed 16 F1 hybrids and their eight parental lines under normal and salt stress (15 dS/m) conditions. Under salt stress conditions significant reduction was observed for plant height (PH), bolls/plant (NBP), boll weight (BW), seed cotton yield (SCY), lint% (LP), fiber length (FL), fiber strength (FS), potassium to sodium ratio (K + /Na + ), potassium contents (K + ), total soluble proteins (TSP), carotenoids (Car) and chlorophyll contents. Furthermore, the mean values for hydrogen peroxide (H 2 O 2 ), sodium contents (Na + ), catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and fiber fineness (FF) were increased under salt stress. Moderate to high heritability and genetic advancement was observed for NBP, BW, LP, SCY, K + /Na + , SOD, CAT, POD, Car, TSP, FL, and FS. Mean performance and multivariate analysis of 24 cotton genotypes based on various agro-physiological and biochemical parameters suggested that the genotypes FBS-Falcon, Barani-333, JSQ-White Hold, Ghauri, along with crosses FBS-FALCON × JSQ-White Hold, FBG-222 × FBG-333, FBG-222 × Barani-222, and Barani-333 × FBG-333 achieved the maximum values for K + /Na + , K + , TSP, POD, Chlb, CAT, Car, LP, FS, FL, PH, NBP, BW, and SCY under salt stress and declared as salt resistant genotypes. The above-mentioned genotypes also showed relatively higher expression levels of Ghi-ERF-2D.6 and Ghi-ERF-7A.6 at 15 dS/m and proved the role of these ERF genes in salt tolerance in cotton. These findings suggest that these genotypes have the potential for the development of salt-tolerant cotton varieties with desirable fiber quality traits.