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Global agricultural production cannot catch the increasing population’s exigency. At different times, the world has faced food crises of varying intensity. Many steps have been taken after that to encounter the rising concerns. Nowadays, nanofertilizers are being experimented with as an alternative to conventional fertilizers. Nanofertilizers can be classified as macronutrients and micronutrients nanofertilizers. Synthesis of macronutrient nanofertilizers (nitrogen, phosphorus, potassium, calcium, magnesium, etc.) and micronutrient nanofertilizers (iron, boron, zinc, copper, silicon, etc.) can be done using chemical and green synthesis methods, which involves reducing agents, capping agents, dendrimers, microbial synthesis, solvents, and others. Composition of the nanofertilizers can be done using top-down and bottom-up approaches incorporating hydrocarbon polymer, dendrimers, microbes, etc., which decides their usage in various crops depending upon the requirement of the plant. Engineered nanofertilizers can improve crop yield by mitigating environmental pollution, environmental stress, and plant diseases. However, the unsystematic use of nanofertilizers can be a hurdle in its utilization. This article discusses various types of nanofertilizers with their unique properties and applications. Each category of nanofertilizers is explained considering their composition, particle size, concentrations applied, benefited plant species, and plant-growth enhancement aspects.

The textile industry is reported as one of the most pollution-producing industries because of toxic colorants that are hard to remove by conventional treatment methods. These colorants have highly negative impacts on ecology and aquatic biota. Dye, which is a valuable resource, is discharged as waste in the effluent and is considered as an environmental threat, because of its low degradability. If this dye is recovered from wastewater, on the one side it can be reused and can give financial benefits, and on the other hand, its removal from the wastewater can be a secondary advantage for the environment as wastewater treatment could be simplified. Though various methods for the discoloration of textile effluent have been reported in the literature, but many of them are either expensive, inefficient, or environmentally unfriendly. The reported methods in the literature have different removal mechanisms which can be categorized as degrading mechanisms and non-degrading mechanisms. Though the removal of various dyes including indigo carmine is possible through both mechanisms, however for the recovery of these dyes from wastewater one should adopt a non-degrading mechanism. This article summarizes various reported dye removal methods and will relate the suitability of these methods and the extent to which they are suitable for dye recovery. Based on the nature of the treatment these methods are subclassified as physical, chemical, Physicochemical, biological, and physico-biological methods and this article will encapsulate the adaptivity, massiveness, and immensity of these methods for indigo dye removal and recovery. Upto 100% removal has been attained through various methods among which adsorption and filtration are the most feasible methods for recovery of Indigo dye from effluent.

Introduction Hypnosis (H) and Progressive Muscle Relaxation (PMR) have proven to be effective in a variety of medical settings; there is a paucity of their practical application in paediatric dentistry. The study aimed to comparatively evaluate the role of H and PMR on anxiety, heart rate (HR), oxygen saturation (SPO 2 ), blood pressure (BP), pain, and analgesic requirement during extraction in children. Materials and methods Sixty children aged 8–12 years undergoing primary molar extractions were randomly allocated to three groups—H, PMR, and control (C). The anxiety (proposed Visual Facial Anxiety scale), HR, and SPO 2 were measured pre/post-operatively with/without interventions (H, PMR, C) at 4 intervals. The BP and pain (Wong-Baker faces pain scale) were recorded pre- and post-operatively. Need for analgesic post-operatively was assessed. Results Statistically significant reduction in anxiety was noted post-extraction in H (0.30 ± 0.80), PMR (0.50 ± 0.69) ( p  < 0.001*). HR showed a statistically significant drop after H, PMR application. ( p  < 0.001*) No significant difference in SPO 2 was noted in the three groups ( p  > 0.05). Pain control was well achieved using H (85%), PMR (70%); BP was well-regulated in the H, PMR compared to C group ( p  < 0.001*). Need for analgesics was reduced in H (45%), PMR (50%) versus C (100%). Both techniques H, PMR were comparable in all measures. Conclusion Hypnosis and PMR are effective techniques for anxiolysis and pain control in paediatric dental patients.

The pomegranate butterfly Deudorix ( = Virachola ) livia is the major pest of pomegranate, a crop of economic importance, in Oman. A species of parasitoid wasp in the hymenopteran family Scelionidae is responsible for high levels of mortality of its eggs. This wasp is described herein as Telenomus nizwaensis Polaszek sp. n. , based on morphology and DNA sequence data. T . nizwaensis is currently known only from D . livia , which is also a pest of economic importance on other crops in North Africa, the Arabian Peninsula, and the Mediterranean. We summarise current knowledge of T . nizwaensis life-history and its potential to provide biological pest control.

Background: Hypertension is the most common cause of intracerebral hemorrhage (ICH). The presentation, etiology, and outcome of ICH among young adults may vary compared to other age groups. The prior literature from our region has described a variety of etiologies with an inconsistent relationship to hypertension, which is the commonest cause of primary ICH in adults overall. Objective: We aimed to determine the demographic pattern, clinical presentation, underlying etiology, radiological characteristics, and outcome of ICH among young adults in our population. Methods: This was an IRB‐approved chart review that included patients from January 2016 to December 2020. Descriptive young adults were defined as people between 15 and 45 years and arbitrarily divided into threee further age groups. A variety of demographic, clinical, and radiological features were compared among the subgroups and presented as descriptive and comparative analyses. Results: A total of 120 patients were included; 110 (91.7%) were males. The mean age was 26.8 ± 7.4 years. Majority, 86 (73.5%), presented with loss of consciousness; 22 (18.8%) had seizures, 14 (13.2%) had headaches, and 13 (11.9%) had vomiting. Traditional vascular risk factors, hypertension (5.8%) and diabetes mellitus (2.5%) were uncommon. Mean GCS was 7 ± 4. The commonest cause was trauma in 101 (84.2%) patients. Lobar hemorrhage was the commonest, 99 (83.2%); 92 (81.4%) had ICH volume < 30 mL, and ventricular involvement was seen in 43 (36.1%). Median ICH score was 2. Higher odds of mortality were observed among the oldest age group (OR 4.30, 95% CI 1.23–14.98, p = 0.022), higher ICH scores (OR 3.37, 95% CI 1.86–6.09, p < 0.001), ICH volume > 30 mL (OR 16.40, 95% CI 5.35–50.26, p < 0.001), ventricular extension (OR 5.60, 95% CI 2.14–14.68, p < 0.001), and nontraumatic ICH etiology (OR 3.59, 95% CI 1.26–10.26, p = 0.017). Conclusions: In our cohort, ICH was more common in young males; trauma being the leading cause of ICH. ICH resulted in significant morbidity and mortality in this population. Larger hemorrhages, ventricular involvement, and relatively older age were poor prognostic factors.

Key Points The South Asian region, which includes India, Pakistan, Sri Lanka and Bangladesh, has a high prevalence of stroke, especially in younger individuals, and short-term mortality from stroke is also high In addition to traditional risk factors for stroke, nontraditional factors including chewing tobacco are widespread in this region South Asia accounts for the largest proportion of the global burden of stroke in pregnancy and cerebral venous thrombosis Acute stroke care, including thrombolysis and stroke units, is limited in South Asia, and stroke prevention strategies are nonexistent at the national level Cost-effective interventions are needed owing to financial constraints Important areas of intervention include public awareness and physician training, as well as strong advocacy efforts and implementation research South Asia is thought to be the highest contributor to stroke mortality in the world, probably accounting for more than 40% of global stroke deaths. Wasay et al . review stroke epidemiology and management issues in four South Asian countries: India, Pakistan, Sri Lanka and Bangladesh. The authors highlight the prevalence of traditional and nontraditional stroke risk factors in this region, and consider the barriers to effective implementation of stroke prevention and treatment strategies. Three of the world's top 10 most populous countries are located in South Asia. The health-care problems of this region are different from those in the developed world, and the rapidly changing socioeconomic scenario, fast-increasing urbanization and longevity, changes in dietary patterns, and decrease in mortality from infectious diseases has made chronic illnesses of old age, such as coronary artery disease and stroke, an important area of focus. This article reviews stroke epidemiology and management issues in four South Asian countries: India, Pakistan, Sri Lanka and Bangladesh. The available literature is limited and mostly hospital-based, and differing study methodologies make direct comparisons difficult. The high prevalence of traditional risk factors, including hypertension, diabetes, dyslipidaemia and smoking, in these countries is alarming, and several nontraditional risk factors, such as water-pipe use, desi ghee, chewable tobacco, and infectious causes of stroke, are understudied. Access to tertiary stroke care is limited, and the use of tissue plasminogen activator is scarce. In addition, public and caregiver awareness of stroke risk factors and management is disappointing, and the interest of governments and policy makers in stroke is suboptimal. Interventions to reduce stroke burden and stroke-related mortality in South Asia should have a substantial impact at the global level.

Acute bacterial meningoencephalitis is still prevalent despite the widespread vaccination and still fatal despite the advances in antimicrobial therapy. Identifying patients at risk, lowering the threshold of clinical diagnosis and early treatment of such a curable disease will save patients' lives. Acute bacterial meningoencephalitis is still prevalent despite the widespread vaccination and still fatal despite the advances in antimicrobial therapy. Identifying patients at risk, lowering the threshold of clinical diagnosis and early treatment of such a curable disease will save patients' lives.

A new species of bethylid parasitoid wasp, Goniozus omanensis Polaszek sp. n., is described based on morphology and DNA sequence data. The species is currently known only from the lesser date moth Batrachedra amydraula, a pest of economic importance, but can be reared on two factitious host species. G. omanensis is compared with G. swirskiana, known from the same host in Israel. We summarise current knowledge of G. omanensis life-history, and its potential as an agent of biological pest control.

Breast cancer is one of the leading causes of death in women worldwide. Recent studies have demonstrated that inflammation due to infections with microorganisms could play a role in breast cancer development. One of the known human pathogens, Borrelia burgdorferi, the causative agent of Lyme disease, has been shown to be present in various types of breast cancer and is associated with poor prognosis. We reported that B. burgdorferi can invade breast cancer cells and affect their tumorigenic phenotype. To better understand the genome-wide genetic changes caused by B. burgdorferi, we evaluated the microRNA (miRNA or miR) expression profiles of two triple-negative breast cancer cell lines and one non-tumorigenic mammary cell line before and after B. burgdorferi infection. Using a cancer-specific miRNA panel, four miRNAs (miR-206, 214-3p, 16-5p, and 20b-5p) were identified as potential markers for Borrelia-induced changes, and the results were confirmed by quantitative real-time reverse transcription (qRT-PCR). Among those miRNAs, miR-206 and 214 were the most significantly upregulated miRNAs. The cellular impact of miR-206 and 214 was evaluated using DIANA software to identify related molecular pathways and genes. Analyses showed that the cell cycle, checkpoints, DNA damage–repair, proto-oncogenes, and cancer-related signaling pathways are mostly affected by B. burgdorferi infection. Based on this information, we have identified potential miRNAs which could be further evaluated as biomarkers for tumorigenesis caused by pathogens in breast cancer cells.

The aim of this study was to compare the efficacy of articaine versus lidocaine, both containing epinephrine, using a single buccal infiltration for extraction of primary molars.A total of 100 children requiring primary molar extraction received buccal infiltration using either 4% articaine or 2% lidocaine, both with epinephrine, with 50 children in each group. The Wong-Baker Facial Pain Scale (FPS) was used to evaluate pain perception subjectively. The heart rate and the blood pressure values were assessed objectively as an indirect measure of physiological pain perception. The Wilcoxon-Mann-Whitney test was used for comparing mean pain scores, heart rate, and blood pressure in both the groups. Single buccal infiltration with articaine was sufficient for achieving palatal or lingual anesthesia in all the children receiving it while all children in the lidocaine group required supplemental anesthesia. The mean FPS value was found to be higher in lidocaine group and was statistically significant. The mean heart rate recorded during the intervention was less than the mean baseline values in the articaine group, which was found to be statistically significant. For pediatric patients age 7 to 12 years, single buccal infiltration with 4% articaine with 1:100,000 epinephrine is more effective compared to 2% lidocaine with 1:80,000 epinephrine for primarly molar extraction.