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The Chicago-Quick Hand Function Test (C-QHFT) is a brief performance-based measure of unilateral hand function. Before widespread use, evidence of validity, reliability, and normative performance is required. To evaluate content and face validity, inter-rater reliability, intra-rater reliability, test-retest reliability, and normative reference values for the C-QHFT. Clinical measurement and normative study. This four-phase study included expert review, iterative refinement of administration and scoring procedures, normative sampling, and repeated administrations across multiple sites. Content and face validity were assessed through structured expert feedback. Reliability was examined using intraclass correlation coefficients, standard error of measurement, minimal detectable change, and Bland-Altman methods. Normative data were collected from healthy adults aged 18 years and older, stratified into age groups. Expert reviewers supported strong content and face validity (S-CVI/Ave = 0.95). Inter-rater reliability for the total score was excellent (ICC [3,1] = 0.999) and intra-rater reliability was high (ICC [1,1] = 0.946), with small SEM and MDC₉₅ values. Test-retest reliability, quantified using ICC (2,1) and Pearson correlations, showed moderate-to-high stability (r = 0.67-0.82) and narrow Bland-Altman limits of agreement for both hands. Age-stratified normative values derived from ANOVA/MANOVA demonstrated expected age-related slowing of performance. The C-QHFT demonstrates strong validity evidence, excellent inter-rater and intra-rater reliability, and stable test-retest performance. The normative reference values enhance its clinical and research utility. The C-QHFT is a concise and reliable assessment of unilateral hand function for adult populations. •C-QHFT captures IHM and psychomotor elements often missed by performance-based OMs.•Adult norms and age-group cutoffs established (n = 273).•Excellent reliability: inter-rater ICC ≈ 0.99; intra-rater ICC ≈ 0.95.•Strong test-retest (r ≈ 0.67-0.82).•Moderate concurrent validity vs Nine-Hole Peg Test (r ≈ 0.35-0.44).

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the United States and is considered predominately a hypokinetic movement disorder. However, recent research has focused on the common non-motor symptoms such as mood disorders and apathy. Copious research supports exercise as an effective treatment intervention to slow the progression of PD. However, there is a paucity of research exploring the traits of the caregiver and the role of the non-motor symptom of apathy in PD health behaviors related to exercise and exercise adherence. The primary aim of this study was to explore the relationship between the apathy levels of the PD individual and the apathy levels of their caregiver. A significant negative correlation was found (rpb = −0.539, n = 14, p = 0.047). Similarly, the grit levels of these two groups were also explored, which found a positive correlation which was not significant (rpb = 0.344, n = 14, p = 0.228). In addition, the secondary aims were to explore the apathy and grit levels of the PD sample related to adherence to a biweekly, eight-week community exercise program. It was found that in this sample apathy and grit had no correlation to community exercise program adherence. Qualitative data was also gathered which identified the themes of self-efficacy and social support when participants reflected on their own apathy and grit levels compared to their partners. Further sub-themes under the category of self-efficacy emerged: current persistence, past experience, and change in motivation over time. This supports current literature on grit and exercise health behavior related to the Transtheoretical Model (TTM). Sub-themes which emerged under the theme of social support were positive partner support and social accountability. These qualitative themes fit with the Social Network Theory and emphasized the mutually beneficial nature of the PD/caregiver dyad. Further research into the social and behavioral interactions between the PD population and caregivers is warranted. The caregiver relationship is a critical role that health care providers and public health professionals need to consider when providing treatment intervention and creating future public health policy.

The Mendelian Phenotype Search Engine (MPSE), a clinical decision support tool using Natural Language Processing and Machine Learning, helped neonatologists expedite decisions to whole genome sequencing (WGS) to diagnose patients in the neonatal intensive care unit. After the MPSE was introduced, utilization of WGS increased, time to ordering WGS decreased, and WGS diagnostic yield increased.

BackgroundThe 0.2 µg/day fluocinolone acetonide (FAc) implant delivers continuous, low-dose, intravitreal corticosteroid for the treatment of diabetic macular oedema (DMO). This ongoing, 3-year, observational clinical trial provides long-term, ‘real-world’ safety results for the FAc implant in DMO.MethodsThis 24-month interim analysis of a prospective, observational study investigated patients with DMO receiving the commercially available intravitreal 0.2 µg/day FAc implant. The primary outcome was incidence of intraocular pressure (IOP)-lowering procedures. Other IOP-related signals and their relationship to previous corticosteroid exposure, best-corrected visual acuity, central subfield thickness (CST), ocular adverse events and frequency of other treatments were also measured.ResultsData were collected from 95 previously steroid-challenged patients (115 study eyes) for up to 36 months pre-FAc and 24 months post-FAc implant. Mean IOP for the overall population remained stable post-FAc compared with pre-FAc implant. IOP-related procedures remained infrequent (two IOP-lowering surgeries pre-FAc; two trabeculoplasties and four IOP-lowering surgeries post-FAc). Mean visual acuity was stable post-FAc (mean improvement of 1–3 letters) and fewer DMO treatments were required per year following FAc implant. Mean CST was significantly reduced at 24 months post-FAc implant (p<0.001) and the percentage of patients with CST ≤300 µm was significantly increased (p=0.041).ConclusionFew IOP-related procedures were reported during the 24 months post-FAc implant. Positive efficacy outcomes were noted after treatment, with stabilisation of vision and reduction in inflammation, demonstrated by CST. The FAc implant has a favourable benefit–risk profile in the management of DMO, especially when administered after a prior steroid challenge.Trial registration number NCT02424019.

The present study explored the component structure of coping in preschoolers as measured by the Children's Coping Scale — Revised (CCS-R) through principal component analysis (PCA). The study also examined the relationship between different coping patterns and mental health (as measured by the Strengths and Difficulties Questionnaire; SDQ) in preschoolers. One hundred and thirty-two parents of preschoolers enrolled at a university-affiliated Early Learning Centre in Melbourne, Australia completed the CCS-R and the SDQ as part of a larger project. The PCAs found that a three-component structure of coping in preschoolers best fit the data for all general and situation-specific forms of the CCS-R. The majority of the forms, for both mothers and fathers, resulted in the components of: (1) Positive Coping, (2) Negative Coping — Emotional Inhibition, and (3) Negative Coping — Emotional Expression. The Situation Specific Coping forms resulted in the most reliable components, and the items that loaded on each component were the most consistent with previous research, underscoring a need to focus on situation-specific, as opposed to general, coping in preschoolers. Results for the relationship between the CCS-R and the SDQ found associations between positive coping and positive mental health, and negative coping was associated with some aspects of poor mental health. The patterns of associations provide evidence of construct validity for the component structure of the CCS-R and also highlight opportunities for intervention for this age group. Understanding the processes involved in managing and adapting to stress provides the opportunity to develop prevention and intervention approaches targeted at healthy adaption. Coping in preschoolers, and the degree to which preschoolers’ coping is associated with mental health, is largely under-studied in comparison to other life stages. The present study contributes to this small body of research in an effort to help inform teaching and therapeutic approaches for preschoolers.

Table of contents O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role of KCNQ1 in epithelial barrier repair Daniel Creegan, Viviana Bustos, Brian J. Harvey O3: The suitability of non-small cell lung cancer cytology preparations for the analysis of anaplastic lymphoma kinase gene rearrangements Alexander Dalphy, Anthony O’Grady, Elaine Kay O4: Penetrating keratoplasty and descemet’s stripping automated endothelial keratoplasty may lead to deterioration in glaucoma management Katarzyna Samelska, Justyna Izdebska, Anna Kurowska O5: The effect of Resolvin D1 on normal and cystic fibrosis human bronchial epithelium Rena Al-Zubaidy, Magdalena Mroz, Brian Harvey O6: Validity of clinical assessment compared with plantar fascia thickness on ultrasound for plantar fasciitis: a cross-sectional study Ryan Fagan, Helen French, Vanessa Cuddy, Jennifer Ashton, Michelle Clarke P1: Undergraduate medical research in Gulf Cooperation Council (GCC) countries: A descriptive study of students’ views Zaid Sayedalamin, Mukhtiar Baig, Osama Almutairi, Hassan Allam, Taher F. Halawa, Hazem M. Atta P2: Positive fluid balance as a prognostic factor in children with sepsis during first 3 hours of resuscitation in intensive care unit Linda Sirone, Renars Erts, Jana Pavare P3: Patients on aspirin: Too little or too much? Louis Richter, Joseph Morris, Irene Oglesby, Eimear Dunne, Dermot Kenny P4: Beta catenin/TCF4 activation reduces KCNQ1 current in colonic monolayers Ibrahim Mohammed Mahdi Khayyat, Viviana Bustos Salgado, Brian J. Harvey P5: Size Matters. Abdominal aortic aneurysm: adherence to surveillance imaging guidelines Jonavan Tan, Daragh Moneley, Austin Leahy, Patricia Fitzgerald P6: Endoscopic retrograde cholangiopancreatography in the west of Ireland: Procedural outcomes and peri-procedural complications Evelyn Fennelly, Grace Harkin, John Lee P7: The effect of the extracellular redox environment on polyamine-platelet interactions Erica O’Sullivan, Brian Kirby, Sarah O’Neill P8: Functionalized gold nanoparticles: preliminary data on in vitro toxicity and comparative photothermal effect Diana Gonciar, Teodora Mocan, Cristian Matea, Lucian Mocan, Cornel Iancu P9: Imaging proteasomal inhibition after seizures in the brain: A study into cellular activity in the hippocampus of epileptic transgenic mice Chloe Doran, Sarah Hoolahan, Tobias Engel P10: Investigating the ability of the Olfactory epithelial stem cells to differentiate into glial cells by assessing cell morphology and marker expression Maha Alkhattab, Tijna Alekseeva, William Lackington, Fergal O’Brien P11: Beaumont Hospital cystic fibrosis service audit and annual report Nabeehah Moollan, Chloe Doran, Noel Gerry McElvaney, Cedric Gunaratnam P12: Quick cognitive screening: the 6-item cognitive impairment test and the temporal orientation score Lorraine Scanlon, Noeleen Brady, Suzanne Timmons P13: Granular analysis of causes of peritoneal dialysis technique failure in the first six months of therapy Richard Bresler, Zita Abreu, Stefan Trohonel, Joanne Bargman P14: Job satisfaction of surgeons working in hajj pilgrimage: a multicenter study Ahmad A. Mirza, Ahmed Badrek-Amoudi, Rakan H. Aun, Hussam A. Senan, Abdulrahim A. Mirza, Mohammed S. Binsaad, Mian U. Farooq P15: Investigation of the role of Bok using wild-type, bax-, bok-, and bax/bok-double-deficient mice Saheli Nandi, Beatrice D’Orsi, Jochen Prehn P16: Is it possible to predict resistance of an organism to stress based on the level of corticosterone? Mariia Zharova, Pavel Umrukhin P17: Investigating the strength model of self-regulation (ego depletion) and medical decision making and error in medical students Wendy Evans-Uhegbu, Frank Doyle, Hope Kudryashova, Derek Dorris, Anthony Cummins P18: Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves? Jemma Doheny-Shanley, Mark Woodward, Wesley Hayes P19: Investigating the role of Stonin 2, a Clathrin Mediated Endocytosis adaptor protein, in altered hippocampal synaptic transmission characterized in schizophrenia Marina Yostos, David Cotter, Melanie Focking P20: Predicting complications after colon resection Samantha Stancu, Florin Iordache, Bogdan A. Popescu P21: Knowledge, attitude and practice of the methods of primary and secondary prevention of cervical cancer among NYSC members in Lagos state, Nigeria Muhammad-Mujtaba A. Akanmu, Alero A. Robert, Ezekiel O. Oridota P22: Incidental glucose and lipid metabolisms disorders among office workers: a cross sectional study Ahmad A. Mirza, Ali K. Alzahrani, Omar Alfarhan, Essam Nour Eldin P23: Differentiating clinically significant spinal injuries; a review of emergency department presentations Bronagh MacManus, Owen Keane, Patrick Hillery, James Lee, Hugh O’Reilly, Niamh Collins P24: Pattern of renal colic occurrence due to urinary stones during Ramadan and other months of the year at King Abdulaziz Medical City, Riyadh, KSA Ibrahim Abu saq, Abdullah Al Mufarrih, Muath Jaafari, Abdullah Al Mahayni, Amen Bawazir, Sultan Alkhateeb P25: Proteomic analysis reveals novel AIB1 co-factors that may contribute to acquired endocrine resistance in breast cancer Amenah Dhannoon, Damir Vareslija, Arnold Hill, Leonie Young P26: Improving sedation practice in general ICU in Beaumont Hospital Declan Donoghue, Criona Walsh, Aileen McCabe, John Pope, Saturnino Pasco, Caroline Fallon, Don Solanki, Fiona Kiernan, Sinead Galvin, Jquan Mucvimicc, Johanna Mulvihill P27: Diagnosis and control of hypertension as indicators of the level of awareness among relatives of medical students Ahmad A. Mirza, Soha A. Elmosry P28: Evaluation of the antitumor potential from extracts of endemic plants of Brazilian caatinga against melanoma and hepatocarcinoma Lorenza Andres Ameida De Souza, Yuri de Oliveira, Diego Menezes, Alene Vanessa Santos P29: The role of Chromogranin A as a biomarker in drug resistant neuroblastoma Ahmad Zaki Asraf, Raymond Stallings, Olga Piskareva, Ross Conlon P30: Membrane sweep at term gestation in CUMH; a case-control study Siún Sweeney-Landers, Cathy Burke P31: Study of the variability of glucose levels in patients with diabetes undergoing continuous glucose monitoring Paraic Behan, Seamus Sreenan P32: Inflammatory cytokine response to decreased plasma alpha-1 antitrypsin levels in individuals with the MZ genotype Ahmed Organjee, Tatsiana Crosbie-Staunton, Emer Reeves, Noel McElvaney P33: Analysing the role of SRC-1 in breast cancer stem cell formation and activity Crystal Mieres, Leonie Young, Sara Charmsaz P34: Screening Streptococcus pneumoniae isolates for virulence genes Aya Al-Jalamdeh, Mary Corcoran, Martha McElligott, Niall Stevens, Hilary Humphreys P35: Assessment of the relevance of admission clerking criteria taught to medical students at King Abdulaziz University to real hospital practice Rashid Barnawi, Abdulaziz Ghurab, Sultan Alfaer, Hassan Balubaid, Kamal Hanbazazah, Mohammed Bukhari P36: Pattern of emergency department visits during Hajj period Mohammed Alsakkaf, Ahmad Mirza, Amrallah Mohammed P37: Anti-Dengue activity of Aspergillus terreus (sulochrin); An in vitro study Anastasia Pratanata, Maria Nathania, Tsabita Annisa, Beti Dewi P38: The comorbidome in alpha-1 antitrypsin deficiency Kuok Zhen Lee, Tomas P. Carroll, Laura Fee, Noel G. McElvaney P39: MLO-Y4 cells behave more like osteocytes in response to mechanical stimulation when cultured in 3D Rachel C. White, Robert T Brady, Fergal O’Brien