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"Kim, David"
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Protein structure determination using metagenome sequence data
Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families and that metagenome sequence data more than triple the number of protein families with sufficient sequences for accurate modeling. We then integrate metagenome data, contact-based structure matching, and Rosetta structure calculations to generate models for 614 protein families with currently unknown structures; 206 are membrane proteins and 137 have folds not represented in the Protein Data Bank. This approach provides the representative models for large protein families originally envisioned as the goal of the Protein Structure Initiative at a fraction of the cost.
Journal Article
A kids book about change
\"Change is impossible to avoid because it happens ALL the time! In this book, the author speaks on how to cope with and embrace life's changes by recounting personal stories and asking kids pointed questions. Empathetic and encouraging, this book emphasizes talking through life's many changes with the people you care about and trust.\"-- Back cover.
CHILDBOOK
Impact of ionizing radiation on superconducting qubit coherence
Technologies that rely on quantum bits (qubits) require long coherence times and high-fidelity operations
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. Superconducting qubits are one of the leading platforms for achieving these objectives
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,
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. However, the coherence of superconducting qubits is affected by the breaking of Cooper pairs of electrons
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–
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. The experimentally observed density of the broken Cooper pairs, referred to as quasiparticles, is orders of magnitude higher than the value predicted at equilibrium by the Bardeen–Cooper–Schrieffer theory of superconductivity
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–
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. Previous work
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–
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has shown that infrared photons considerably increase the quasiparticle density, yet even in the best-isolated systems, it remains much higher
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than expected, suggesting that another generation mechanism exists
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. Here we provide evidence that ionizing radiation from environmental radioactive materials and cosmic rays contributes to this observed difference. The effect of ionizing radiation leads to an elevated quasiparticle density, which we predict would ultimately limit the coherence times of superconducting qubits of the type measured here to milliseconds. We further demonstrate that radiation shielding reduces the flux of ionizing radiation and thereby increases the energy-relaxation time. Albeit a small effect for today’s qubits, reducing or mitigating the impact of ionizing radiation will be critical for realizing fault-tolerant superconducting quantum computers.
Ionizing radiation from environmental radioactivity and cosmic rays increases the density of broken Cooper pairs in superconducting qubits, reducing their coherence times, but can be partially mitigated by lead shielding.
Journal Article
Isle of you
Some days are harder to get through than others, but when you're sad, or lonely, or angry, it helps to remember these words: the Isle of You. Take a moment to shake off your worries, then set sail to a land where your dreams can come true. Soar on the back of an eagle, hunt for treasure, watch dancing polar bears on roller skates -- anything you can imagine is yours. Hopeful and dreamlike, Jaime Kim's paintings illuminate a way for young readers to visualize a brighter, happier mood in this compassionate story by David LaRochelle.--Provided by publisher.
Book
Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review
Long acting injectable (LAI) antipsychotics are an alternative to oral antipsychotic (OAP) treatment and may be beneficial for patients in the early stages of schizophrenia. This study aims to provide a comprehensive review on the efficacy of first-generation and second-generation LAI antipsychotics in recent-onset, first-episode, and early psychosis patients.
MEDLINE, EMBASE, PsycINFO, and Web of Science Core databases were used to search for studies that used LAIs in early psychosis patients. Studies published up to 06 Jun 2019 were included with no language restrictions applied. Inclusion criteria were a diagnosis of schizophrenia or related disorder, where patients were in their first episode or had a duration of illness ≤5 years.
33 studies were included: 8 RCTs, 4 post-hoc analyses, 2 case reports, and 19 naturalistic studies. The majority of studies evaluated risperidone LAIs (N = 14) and paliperidone palmitate (N = 10), while the remainder investigated fluphenazine decanoate (N = 3), flupentixol decanoate (N = 2), and aripiprazole (N = 1). Two studies did not specify the LAI formulation used, and one cohort study compared the efficacy of multiple different LAI formulations.
While the majority of data is based on naturalistic studies investigating risperidone LAIs or paliperidone palmitate, LAIs may be an effective treatment for early psychosis patients in terms of adherence, relapse reduction, and symptom improvements. There is still a need to conduct more high quality RCTs that investigate the efficacy of different LAI formulations in early psychosis patients.
Journal Article
The traveling artist in the Italian Renaissance : geography, mobility, and style
\"This important and innovative book examines artists' mobility as a critical aspect of Italian Renaissance art. It is well known that many eminent artists such as Cimabue, Giotto, Donatello, Lotto, Michelangelo, Raphael, and Titian traveled. This book is the first to consider the sixteenth-century literary descriptions of their journeys in relation to the larger Renaissance discourse concerning mobility, geography, the act of creation, and selfhood.\"--Publisher's website.
Book
Accounting for Nonhealth and Future Costs in Cost-Effectiveness Analysis: Distributional Impacts of a US Cancer Prevention Strategy
To provide up-to-date and comprehensive US data tables to estimate future net resource use, including nonlabor market production, and examine distributional impacts of including nonhealth and future costs in cost-effectiveness results.
Using a published US cancer prevention simulation model, the paper evaluated the lifetime cost effectiveness of implementing a 10% excise tax on processed meats across age- and sex-specific population subgroups. The model examined multiple scenarios accounting for cancer-related healthcare expenditure (HCE) only, cancer-related and unrelated background HCE, adding productivity benefits (i.e., patient time, cancer-related productivity loss, and background labor and nonlabor market production), and with nonhealth consumption costs, adjusted for household economies of scale. Additional analyses include using population-average versus age-sex-specific estimates for quantifying production and consumption value, as well as comparing direct model estimation versus postcorrections with Meltzer's approximation for incorporating future resource use.
Accounting for nonhealth and future costs impacted cost-effectiveness results across population subgroups, often leading to changes in \"cost-saving\" determination. Including nonlabor market production had a noticeable impact on estimating future resource use and reduced the bias toward undervaluing productivity among females and older populations. The use of age-sex-specific estimates resulted in less favorable cost-effectiveness results compared with population-average estimates. Meltzer's approximation provided reasonable corrections among the middle-aged population for re-engineering cost-effectiveness ratios from a healthcare sector to a societal perspective.
With updated US data tables, this paper can help researchers conduct a comprehensive value assessment to reflect net resource use (health and nonhealth resource use minus production value) from a societal perspective.
Journal Article
Intercultural transmission in the medieval Mediterranean
This volume presents evidence of the extent and effects of intercultural contacts across Europe and the Mediterranean rim, opening up a new understanding of early medieval civilisation and its continuing influence in both Western and Eastern cultures today.
Book
Medicare Part D Coverage of Antiobesity Medications — Challenges and Uncertainty Ahead
Medicare Part D Coverage of Antiobesity MedicationsMedicare could soon be compelled to cover antiobesity medications, which intensifies the need to address questions of effectiveness and cost among its beneficiaries.
Journal Article