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The objective of this study is to examine the relationship between publisher volume—the number of journals a publisher produces—and journal publishing patterns in Scopus, including various journal metrics such as the h-index, SCImago Journal Rank (SJR), and journal quartiles. The SCImago database, which is derived from Scopus data, serves as a proxy for journal impact and influence. The analysis also considered factors such as Open Access (OA) status, geographical location, and subject areas. Using the 2023 SJR dataset, publishers were classified into four categories: V1 (single journal), V2 (2–9 journals), V3 (10–99 journals), and V4 (100+ journals). The findings showed that V4 publishers accounted for 44.5% of Scopus-indexed journals despite comprising only 0.3% of all publishers, whereas V1 publishers represented 78.6% of all publishers but contributed only 21.3% of journals. High-volume publishers had more journals ranked in Q1 and Q2, while lower-volume publishers were more concentrated in Q3 and Q4. Results from the linear mixed-effects model indicated that publisher volume was associated with journal metrics, with higher-volume publishers generally achieving higher h-index and SJR scores. Western Europe and North America had the highest number of V4 publishers, whereas China, Spain, and Italy exhibited strong journal production but had fewer publishers in the highest-volume category. These results illustrate the dominance of a small group of high-volume (V4) publishers and the challenges smaller publishers face in gaining visibility and impact. They also underscore the need to consider policies that foster a more balanced and equitable scholarly publishing environment, particularly for underrepresented regions and subject areas.

Journals that have consistently maintained uninterrupted indexing over an extended period can be assumed to possess stability and sustainability in journal indexing. Building on this assumption, the objective of this study is to scrutinize the years omitted in the indexing of Scopus-indexed journals. To conduct this study, three coverage duration indicators—nyears-covered (total years covered), nyears-skipped (years skipped), and skipped/covered ratio (proportion of years skipped to total years covered)—were formulated. Data from SCImago Journal Rank (SJR) for 2022, consisting of 16,762 records (62% of downloaded data) with a coverage duration of 25 years or less, were used for this study. The results revealed that around 10% of Scopus-indexed journals experienced exclusions or coverage gaps. Longer coverage correlates positively with documents published, h-index, and citations, while skipped years decrease with these indicators. Open access (OA) journals exhibited a lower skipped/covered ratio than non-OA journals, suggesting a better sustainability of indexing than non-OA journals. Disciplinary differences in Scopus journal coverage duration revealed notable variation, suggesting that coverage duration indicators can be effectively used to evaluate journal stability within Scopus. Overall, the coverage gaps reflect Scopus’s efforts to regulate the journals it indexes. The coverage duration indicators proposed in this study can be applied to assess the stability of periodicals in any database, providing insights into the broader dynamics and quality standards maintained by a database, where the database periodically adds and removes its indexed contents.

Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute to cancer cell death, but paradoxically, radiotherapy also causes the activation of damage-repair and survival signaling to alleviate radiation-induced cytotoxic effects in a small percentage of cancer cells, and these activations are responsible for tumor radio-resistance. The present study describes the molecular mechanisms responsible for radiation-induced cellular stress response and radioresistance, and the therapeutic approaches used to overcome radioresistance.

The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin 1 (NPM1) gene. As a step toward clinical translation of menin-MLL1 inhibitors, we report development of MI-3454, a highly potent and orally bioavailable inhibitor of the menin-MLL1 interaction. MI-3454 profoundly inhibited proliferation and induced differentiation in acute leukemia cells and primary patient samples with MLL1 translocations or NPM1 mutations. When applied as a single agent, MI-3454 induced complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia, including patient-derived xenograft models, through downregulation of key genes involved in leukemogenesis. We also identified MEIS1 as a potential pharmacodynamic biomarker of treatment response with MI-3454 in leukemia, and demonstrated that this compound is well tolerated and did not impair normal hematopoiesis in mice. Overall, this study demonstrates, for the first time to our knowledge, profound activity of the menin-MLL1 inhibitor as a single agent in clinically relevant PDX models of leukemia. These data provide a strong rationale for clinical translation of MI-3454 or its analogs for leukemia patients with MLL1 rearrangements or NPM1 mutations.

The objective of this study is to investigate the landscape of AI use policies in library and information science (LIS) journals and examine their association with key journal metrics. The study analyzed 232 LIS journals indexed in the 2023 Scimago Journal Rank (SJR) portal, focusing on AI use policies, guidelines for declaring AI use, and references to the Committee on Publication Ethics (COPE) for establishing guidelines. Data on journal metrics, including quartiles, SJR, h-index, total documents published in 2022 (TD2023), publisher volume, and citations per document over 2 years (CITES2YR), were collected from the SJR portal. Several key findings emerged: the majority of LIS journals did not have explicit AI use policies, although AI tools were generally permitted for manuscript editing. Logistic regression analysis revealed a significant association between higher journal metrics, particularly citations (CITES2YR), and the presence of AI use policies, while other metrics, such as SJR and h-index, were not consistently significant. Furthermore, larger publishers were more likely to have AI use policies but showed flexibility by not mandating AI use declarations. Significant differences were found across journal quartiles, with Quartile 1 journals being more likely to adopt AI use policies than Quartile 4. These findings highlight the influential role of large-volume publishers in shaping AI use policies and emphasize their importance in setting scholarly norms in the LIS community.

Religious “nones” is currently used in academia as a category referring to individuals who do not have a specific religious belief or do not belong to a specific religious organization. The increase in the number of religious nones is a distinct religious, cultural, and social trend not only in the West but also around the world, and South Korea is no exception. The following questions arise: What are the trends of religious nones in South Korea? What are their characteristics? What are the historical, cultural and social factors for the large number of the irreligious in the country? This paper shows that South Korea boasts one of the highest percentages of the population with no religious affiliation in the world. The paper also finds that religious nones in the country tend to be “spiritual but not religious”, i.e., they have the characteristic of pursuing spirituality by practicing their faith in their own way outside of the institutional system. As for the factors for the high rate of religious nones, the paper argues that the phenomenon of irreligion in South Korea has a long history, e.g., suppression of shamanism and Buddhism during the Joseon dynasty (1392–1910), and that the popularity of shamanism and Confucianism, which are often seen more as spiritual practice and a philosophical system, respectively, has also been a contributing attribute. The rapid economic development, improved living standard, high education attainment level, and the rise of leisure culture are other factors for the rise in religious nones in Korea. The paper closes by reflecting on the implications of increasing religious nones for the concept of secularization.

Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizing the need for small-molecule inhibitors with well-defined mechanisms of action. Here, we describe the development of compounds that directly bind to RING1B–BMI1, the heterodimeric complex constituting the E3 ligase activity of PRC1. These compounds block the association of RING1B–BMI1 with chromatin and inhibit H2A ubiquitination. Structural studies demonstrate that these inhibitors bind to RING1B by inducing the formation of a hydrophobic pocket in the RING domain. Our PRC1 inhibitor, RB-3, decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples. In summary, we demonstrate that targeting the PRC1 RING domain with small molecules is feasible, and RB-3 represents a valuable chemical tool to study PRC1 biology. Fragment screening and medicinal chemistry optimization led to development of a small-molecule inhibitor of RING1B–BMI1 E3 ligase, blocking the H2A ubiquitination activity of the Polycomb repressive complex 1 and inducing differentiation in leukemia cells.

The purpose of this study was to compare Asian law journals published in Asia with those published in Western countries to determine the characteristics of the journals in relation to the geographic region in which they are published. In this study, Western countries refer to the Anglo-Saxon English-speaking countries, such as the United States and the United Kingdom. Using the Scimago Journal and Country Rank (SJR), 12 Asian law journals published in Asia and 8 Asian law journals published in Western countries were analyzed for performance, authorship, and topical research areas. Human rights issues affecting Asian countries were more prevalent in journals published in Western countries. In terms of journal performance, Asian law journals published in Western countries had a higher h-index, SJR, and citation rate than those published in Asia. Journals published in Western countries are published by reputable commercial publishers or university presses, and journals published in Western countries have longer coverage years. These reasons likely contributed to better visibility, which resulted in better performance.

This study evaluates digital object identifier (DOI) hallucination in large language model (LLM)-generated scholarly citations, with a focus on systematic geographic disparities. To conduct this study, we systematically evaluated four LLMs (GPT-4o-mini, Claude-3-haiku, Gemini-2.0-flash-lite, and DeepSeek V3) using standardized information behavior prompts across ten countries with diverse income levels. The models generated 3451 citations, which we validated using the CrossRef API. The results showed that DOI hallucination follows systematic patterns influenced by model choice, geographic context, and publication recency. Hallucination rates exceeded 80% in lower-income countries and increased sharply for publications from the 2020s across all regions. Fabricated citations—citations that appear structurally complete but contain invalid DOIs—were especially prevalent in countries such as India and Bangladesh. Model-specific factors showed the strongest association with hallucination, followed by income level and publication period. These findings raise concerns about the epistemic reliability of LLM-generated scholarly references and underscore the need for region-aware training, real-time DOI validation, and robust verification protocols in academic contexts.

The objective of this study is to examine disparities in Scopus-indexed journal production between BRICS and G7 countries from 2013 to 2023, focusing on growth trends, open access (OA) and non-OA production, subject representation, and quality metrics. Using data from the SCImago Journal Rank portal, the analysis evaluated growth rates, quartile rankings, and publisher dynamics. G7 countries maintained their global leadership, characterized by stable production systems and high-impact journals predominantly managed by commercial publishers. In contrast, the countries of Brazil, Russia, India, China, and South Africa (BRICS) exhibited diverse trends: China and Russia demonstrated rapid expansion through state-backed initiatives and the rise of domestic publishers, aiming to reduce reliance on foreign publishers and enhance global visibility. However, India experienced a decline, while Brazil and South Africa showed only modest growth in Scopus-indexed journal production. Similarly, G7 countries displayed internal variability, with the UK and Italy achieving notable growth, whereas Japan and France faced declines. These disparities within both groups underscore the critical influence of national research policies and infrastructure on journal production. BRICS countries showed a strong focus on STEM disciplines, with China emerging as a leader in both OA and non-OA journal production. Conversely, G7 countries maintained a balanced representation across STEM and social sciences. These findings suggest that national policies and infrastructure investments are key drivers of journal production growth, with BRICS countries leveraging new initiatives for expansion and G7 countries maintaining dominance through established systems.