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"Kim, Janet"
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Additive Function-on-Function Regression
We study additive function-on-function regression where the mean response at a particular time point depends on the time point itself, as well as the entire covariate trajectory. We develop a computationally efficient estimation methodology based on a novel combination of spline bases with an eigenbasis to represent the trivariate kernel function. We discuss prediction of a new response trajectory, propose an inference procedure that accounts for total variability in the predicted response curves, and construct pointwise prediction intervals. The estimation/inferential procedure accommodates realistic scenarios, such as correlated error structure as well as sparse and/or irregular designs. We investigate our methodology in finite sample size through simulations and two real data applications.
Journal Article
The second chance convenience store
Seoul Station is home to Dokgo, a man shrouded in mystery with no memories of his past. Until one day his subdued existence is disrupted when he stumbles upon a lost wallet, triggering a chain of events that will change the course of his life. Enter Mrs. Yeom, a retired history teacher turned convenience store owner, who, upon discovering Dokgo's act of kindness in returning her purse, offers him a meal as a token of her gratitude. Their chance encounter blossoms into an unexpected alliance when the man's bravery saves the store from ruin, earning him not just a job but a place in the heart of the neighbourhood. But just when things are looking up for Dokgo, Mrs. Yeom's troubled son, eager to sell the store, hires a detective to dig into the mysterious man's past and unearth what he seems to be trying so hard to forget.
BOOK
Teledentistry Platforms for Orthodontics
Technology has transformed almost every aspect of our lives. Smartphones enable patients to request, receive, and transmit information irrespective of the time and place. The global pandemic has forced healthcare providers to employ technology to aid in ‘flattening the curve. The Novel Coronavirus, which is responsible for COVID-19, is transmitted primarily through person-to-person contact but may also be spread through aerosol generating procedures, so many clinics have severely limited interpersonal interactions. The purpose of this article is to provide helpful information for those orthodontists considering some form of remote practice. Various HIPAA-compliant telecommunication or teledentistry systems that can be used for orthodontic treatment are introduced and discussed. Detailed information about each platform that can potentially be used for orthodontics is provided in Figure 1. The authors do not endorse any of the products listed and the included software is not all inclusive but instead is a glimpse into the options available.
Journal Article
The waiting
\"Keum Suk Gendry-Kim was an adult when her mother revealed a family secret: she was separated from her sister during the Korean War. It's not an uncommon story--the peninsula was split down the 38th parallel, dividing one country into two. As many fled violence in the north, not everyone was able to make it south. Her mother's story inspired Gendry-Kim to begin interviewing her and other Koreans separated by the war; that research fueled a deeply resonant graphic novel. The Waiting is the fictional story of Gwija, told by her novelist daughter Jina. When Gwija was 17 years old, after hearing that the Japanese were seizing unmarried girls, her family married her in a hurry to a man she didn't know. Japan fell, Korea gained its independence, and the couple started a family. But peace didn't come. The young family--now four--fled south. On the road, while breastfeeding and changing her daughter, Gwija was separated from her husband and son. Then 70 years passed. Seventy years of waiting. Gwija is now an elderly woman and Jina can't stop thinking about the promise she made to help find her brother.\"-- Provided by publisher
A Novel, Dose-Adjusted Tacrolimus Trough-Concentration Model for Predicting and Estimating Variance After Kidney Transplantation
Background and Objective
Given that a high intrapatient variability (IPV) of tacrolimus whole blood concentration increases the risk for a poor kidney transplant outcome, some experts advocate routine IPV monitoring for detection of high-risk patients. However, attempts to estimate the variance of tacrolimus trough concentrations (TTC) are limited by the need for patients to receive a fixed dose over time and/or the use of linear statistical models. A goal of this study is to overcome the current limitations through the novel application of statistical methodology generalizing the relationship between TTC and dose through the use of nonparametric functional regression modeling.
Methods
With TTC as a response and dose as a covariate, the model employs an unknown bivariate function, allowing for the potentially complex, nonlinear relationship between the two parameters. A dose-adjusted variance of TTC is then derived based on standard functional principal component analysis (FPCA). To assess the model, it was compared against an FPCA-based model and linear mixed-effects models using prediction error, bias, and coverage probabilities for simulated data as well as phase III data from the Astellas new drug application studies for extended-release tacrolimus.
Results
Our numerical investigation indicates that the new model better predicts dose-adjusted TTCs compared with the prediction of linear mixed effects models. Estimated coverage probabilities also indicate that the new model accurately accounts for the variance of TTC during the periods of large fluctuation in dose, whereas the linear mixed effects model consistently underestimates the coverage probabilities because of the inaccurate characterization of TTC fluctuation.
Conclusion
This is the first known application of a functional regression model to assess complex relationships between TTC and dose in a real clinical setting. This new method has applicability in future clinical trials including real-world data sets due to flexibility of the nonparametric modeling approach.
Journal Article
Grass
\"Grass is a powerful anti-war graphic novel, offering up firsthand the life story of a Korean girl named Okseon Lee who was forced into sexual slavery for the Japanese Imperial Army during the second World War - a disputed chapter in 20th century Asian history. Beginning in Lee's childhood, Grass shows the leadup to World War II from a child's vulnerable perspective, detailing how one person experienced the Japanese occupation and the widespread suffering it entailed for ordinary Korean folk. Keum Suk Gendry-Kim emphasizes Lee's strength in overcoming the many forms of adversity she experienced. Grass is painted in a black ink that flows with lavish details of the beautiful fields and farmland of Korea and uses heavy brushwork on the somber interiors of Lee's memories\"-- Provided by publisher.
Book
Tumor Membrane Vesicle Vaccine Augments the Efficacy of Anti-PD1 Antibody in Immune Checkpoint Inhibitor-Resistant Squamous Cell Carcinoma Models of Head and Neck Cancer
Immune checkpoint inhibitor (ICI) immunotherapy improved the survival of head and neck squamous cell carcinoma (HNSCC) patients. However, more than 80% of the patients are still resistant to this therapy. To test whether the efficacy of ICI therapy can be improved by vaccine-induced immunity, we investigated the efficacy of a tumor membrane-based vaccine immunotherapy in murine models of HNSCC. The tumors, grown subcutaneously, are used to prepare tumor membrane vesicles (TMVs). TMVs are then incorporated with glycolipid-anchored immunostimulatory molecules GPI-B7-1 and GPI-IL-12 by protein transfer to generate the TMV vaccine. This TMV vaccine inhibited tumor growth and improved the survival of mice challenged with SCCVII tumor cells. The tumor-free mice survived for several months, remained tumor-free, and were protected following a secondary tumor cell challenge, suggesting that the TMV vaccine induced an anti-tumor immune memory response. However, no synergy with anti-PD1 mAb was observed in this model. In contrast, the TMV vaccine was effective in inhibiting MOC1 and MOC2 murine oral cancer models and synergized with anti-PD1 mAb in extending the survival of tumor-bearing mice. These observations suggest that tumor tissue based TMV vaccines can be harnessed to develop an effective personalized immunotherapy for HNSCC that can enhance the efficacy of immune checkpoint inhibitors.
Journal Article
Gloeostereum cimri, a novel shelf fungus isolated from a human pulmonary cyst
Filamentous basidiomycetes are uncommon agents of human diseases, despite their ubiquitous presence in the environment. We present a case of symptomatic pulmonary infection in a 38-year-old male with cough and fever; a thin-walled cyst in the posterior left upper pulmonary lobe was revealed by radiography. A non-sporulating fungus was isolated from sputum and biopsy material from the cyst. ITS and LSU sequences placed the fungus phylogenetically in Agaricales, family Cyphellaceae, and identified it as a member of shelf fungi in Gloeostereum, but without identity to any known species. The new species is described as Gloeostereum cimri. The clinical strain showed high MIC to voriconazole (>8 µg/ml) but had low MIC to amphotericin B (0.5 µg/ml).
Journal Article
