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"Kim, Jung"
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The nine cloud dream
\"A new translation of Korea's literary masterpiece about a young monk's punishment of reincarnation and his journey through a new life\"-- Provided by publisher.
Book
Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics
Receptor-interacting protein kinase-3 （RIP3 or RIPK3） is an essential part of the cellular machinery that executes ＂programmed＂ or ＂regulated＂ necrosis. Here we show that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death. However, we show that RIP3 expres- sion is often silenced in cancer cells due to genomic methylation near its transcriptional start site, thus RIP3-depen- dent activation of MLKL and downstream programmed necrosis during chemotherapeutic death is largely repressed. Nevertheless, treatment with hypomethylating agents restores RIP3 expression, and thereby promotes sensitivity to chemotherapeutics in a RIP3-dependent manner. RIP3 expression is reduced in tumors compared to normal tissue in 85% of breast cancer patients, suggesting that RIP3 deficiency is positively selected during tumor growth/develop- ment. Since hypomethylating agents are reasonably well-tolerated in patients, we propose that RIP3-deficient cancer patients may benefit from receiving hypomethylating agents to induce RIP3 expression prior to treatment with con- ventional chemotherapeutics.
Journal Article
Outward and upward mobilities : international students in Canada, their families, and structuring institutions
\"People move out to move up. Like other migrant groups, student mobility is a form of social mobility, and one that requires access from a host state. But there are multiple institutions with which students interact and that influence the processes of social mobility. Outward and Upward Mobilities investigates the connection between student and institution. The collection features work by key scholars in the field and considers international students from across Canada regardless of legal status. Exploring how international students and their families fare in local ethnic communities, educational and professional institutions, and the labour market, this volume demonstrates the need to ask more critical questions about the short- and long-term effects of temporary legal status, how student and family experiences differ by educational level and region of settlement, the barriers to and facilitators of adaptation and integration, and ultimately, to what extent individual, familial, institutional, and state goals function in harmony and in discord.\"-- Provided by publisher.
Book
Electrochemical ammonia synthesis via nitrate reduction on Fe single atom catalyst
Electrochemically converting nitrate, a widespread water pollutant, back to valuable ammonia is a green and delocalized route for ammonia synthesis, and can be an appealing and supplementary alternative to the Haber-Bosch process. However, as there are other nitrate reduction pathways present, selectively guiding the reaction pathway towards ammonia is currently challenged by the lack of efficient catalysts. Here we report a selective and active nitrate reduction to ammonia on Fe single atom catalyst, with a maximal ammonia Faradaic efficiency of ~ 75% and a yield rate of up to ~ 20,000 μg h
−1
mg
cat.
−1
(0.46 mmol h
−1
cm
−2
). Our Fe single atom catalyst can effectively prevent the N-N coupling step required for N
2
due to the lack of neighboring metal sites, promoting ammonia product selectivity. Density functional theory calculations reveal the reaction mechanisms and the potential limiting steps for nitrate reduction on atomically dispersed Fe sites.
Developing green and delocalized routes for ammonia synthesis is highly important but still very challenging. Here the authors report an efficient ammonia synthesis process via nitrate reduction to ammonia on Fe single atom catalyst.
Journal Article
Highly active and selective oxygen reduction to H2O2 on boron-doped carbon for high production rates
Oxygen reduction reaction towards hydrogen peroxide (H
2
O
2
) provides a green alternative route for H
2
O
2
production, but it lacks efficient catalysts to achieve high selectivity and activity simultaneously under industrial-relevant production rates. Here we report a boron-doped carbon (B-C) catalyst which can overcome this activity-selectivity dilemma. Compared to the state-of-the-art oxidized carbon catalyst, B-C catalyst presents enhanced activity (saving more than 210 mV overpotential) under industrial-relevant currents (up to 300 mA cm
−2
) while maintaining high H
2
O
2
selectivity (85–90%). Density-functional theory calculations reveal that the boron dopant site is responsible for high H
2
O
2
activity and selectivity due to low thermodynamic and kinetic barriers. Employed in our porous solid electrolyte reactor, the B-C catalyst demonstrates a direct and continuous generation of pure H
2
O
2
solutions with high selectivity (up to 95%) and high H
2
O
2
partial currents (up to ~400 mA cm
−2
), illustrating the catalyst’s great potential for practical applications in the future.
Oxygen reduction reaction provides an environmentally-benign route for hydrogen peroxide production but lacks efficient catalysts to achieve high selectivity and activity simultaneously. Here, the authors report a boron-doped carbon catalyst which shows great promise with outstanding performance.
Journal Article
High-energy and durable lithium metal batteries using garnet-type solid electrolytes with tailored lithium-metal compatibility
Lithium metal batteries using solid electrolytes are considered to be the next-generation lithium batteries due to their enhanced energy density and safety. However, interfacial instabilities between Li-metal and solid electrolytes limit their implementation in practical batteries. Herein, Li-metal batteries using tailored garnet-type Li
7-x
La
3-a
Zr
2-b
O
12
(LLZO) solid electrolytes is reported, which shows remarkable stability and energy density, meeting the lifespan requirements of commercial applications. We demonstrate that the compatibility between LLZO and lithium metal is crucial for long-term stability, which is accomplished by bulk dopant regulating and dopant-specific interfacial treatment using protonation/etching. An all-solid-state with 5 mAh cm
−2
cathode delivers a cumulative capacity of over 4000 mAh cm
−2
at 3 mA cm
−2
, which to the best of our knowledge, is the highest cycling parameter reported for Li-metal batteries with LLZOs. These findings are expected to promote the development of solid-state Li-metal batteries by highlighting the efficacy of the coupled bulk and interface doping of solid electrolytes.
Lithium-metal batteries (LMBs) have attracted intense interest but the instability issues limit its practical deployment. Here, the authors report a durable LMB with high energy density using a garnet-type solid electrolyte with a tailored Li-metal compatibility.
Journal Article
Nobody checks the time when they're happy
No One Checks the Time When They're Happy is a collection of stories, by turns sad and funny, about the thwarted expectations of the young as they grow older. Eun Heeyung's characters are misfits who, by virtue of their bodies or their lack of social status, are left to dream of momentous changes that will never come. Unsatisfied with work, with family, and with friends, they lose themselves in diets, books, and blogs. Her work humorously but humanely depicts the loneliness and monotony found in many modern lives.
Book
Coronavirus Disease Outbreak in Call Center, South Korea
We describe the epidemiology of a coronavirus disease (COVID-19) outbreak in a call center in South Korea. We obtained information on demographic characteristics by using standardized epidemiologic investigation forms. We performed descriptive analyses and reported the results as frequencies and proportions for categoric variables. Of 1,143 persons who were tested for COVID-19, a total of 97 (8.5%, 95% CI 7.0%-10.3%) had confirmed cases. Of these, 94 were working in an 11th-floor call center with 216 employees, translating to an attack rate of 43.5% (95% CI 36.9%-50.4%). The household secondary attack rate among symptomatic case-patients was 16.2% (95% CI 11.6%- 22.0%). Of the 97 persons with confirmed COVID-19, only 4 (1.9%) remained asymptomatic within 14 days of quarantine, and none of their household contacts acquired secondary infections. Extensive contact tracing, testing all contacts, and early quarantine blocked further transmission and might be effective for containing rapid outbreaks in crowded work settings.
Journal Article