Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
4,253
result(s) for
"Kim, Sarah"
Sort by:
Ben says goodbye
When Ben's best friend Peter moves away, Ben decides that he'll move, too--into a \"cave\" under the kitchen table. Caveman Ben doesn't need any friends except his tame (stuffed) lion. He hunts for his food (thoughtfully left on a plate by Mom and Dad) and communicates in grunts. And in the safety of his cave he can imagine a world where friends control their own destinies and distance is no obstacle.
Book
Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage
Intermittent fasting （IF）, a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor （VEGF） expression in white adipose tissue （WAT）. Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.
Journal Article
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune escape
1
,
2
. Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo CRISPR–Cas9 screens targeting 936 chromatin regulators in mouse tumour models treated with immune checkpoint blockade. We identified the H3K9 methyltransferase SETDB1 and other members of the HUSH and KAP1 complexes as mediators of immune escape
3
–
5
. We also found that amplification of
SETDB1
(1q21.3) in human tumours is associated with immune exclusion and resistance to immune checkpoint blockade. SETDB1 represses broad domains, primarily within the open genome compartment. These domains are enriched for transposable elements (TEs) and immune clusters associated with segmental duplication events, a central mechanism of genome evolution
6
. SETDB1 loss derepresses latent TE-derived regulatory elements, immunostimulatory genes, and TE-encoded retroviral antigens in these regions, and triggers TE-specific cytotoxic T cell responses in vivo. Our study establishes SETDB1 as an epigenetic checkpoint that suppresses tumour-intrinsic immunogenicity, and thus represents a candidate target for immunotherapy.
A CRISPR–Cas9 screen of chromatin regulators in mouse tumour models treated with immune checkpoint blockade identifies SETDB1 as an epigenetic checkpoint protein that suppresses tumour-intrinsic immunogenicity.
Journal Article
The best American science and nature writing 2017
Presents a collection of nature and science essays published in American periodicals in the previous year, including works by such authors as Sarah Everts, Nathaniel Rich, and Kathryn Joyce.
BOOK
Anti-oxidant copper layer by remote mode N2 plasma for low temperature copper–copper bonding
An anti-oxidant Cu layer was achieved by remote mode N
2
plasma. Remote mode plasma treatment offers the advantages of having no defect formation, such as pinholes, by energetic ions. In this study, an activated Cu surface by Ar plasma chemically reacted with N free radicals to evenly form Cu nitride passivation over the entire Cu surface. According to chemical state analysis using XPS, Cu oxidation was effectively prevented in air, and the thickness of the Cu nitride passivation was within 3 nm. Based on statistical analysis using the DOE technique with N
2
plasma variables, namely, RF power, working pressure, and plasma treatment time, we experimentally demonstrated that a lower RF power is the most effective for forming uniform Cu nitride passivation because of a lower plasma density. When the N
2
plasma density reached approximately 10
9
cm
−3
in which the remote mode was generated, high energy electrons in the plasma were significantly reduced and the amount of oxygen detected on the Cu surface was minimized. Finally, low temperature (300 °C) Cu–Cu bonding was performed with a pair of the anti-oxidant Cu layers formed by the remote mode N
2
plasma. Cu atomic diffusion with new grains was observed across the bonded interface indicating significantly improved bonding quality over bare Cu–Cu bonding.
Journal Article
The new voices of science fiction
\"Your Future Is Bright! After all, your mother is a robot, your father has joined the alien hive mind, and your dinner will be counterfeit 3D-printed steak. Even though your worker bots have staged a mutiny, and your tour guide speaks only in memes, you can always sell your native language if you need some extra cash.\" -- From publisher's description.
Book
Patients’ preferences for primary health care – a systematic literature review of discrete choice experiments
Background
Primary care is a key element of health care systems and addresses the main health problems of the population. Due to the demographic change, primary care even gains in importance. The knowledge of the patients’ preferences can help policy makers as well as physicians to set priorities in their effort to make health care delivery more responsive to patients’ needs. Our objective was to describe which aspects of primary care were included in preference studies and which of them were the most preferred aspects.
Methods
In order to elicit the preferences for primary care, a systematic literature search was conducted. Two researchers searched three electronic databases (PubMed, Scopus, and PsycINFO) and conducted a narrative synthesis. Inclusion criteria were: focus on primary health care delivery, discrete choice experiment as elicitation method, and studies published between 2006 and 2015 in English language.
Results
We identified 18 studies that elicited either the patients’ or the population’s preferences for primary care based on a discrete choice experiment. Altogether the studies used 16 structure attributes, ten process attributes and four outcome attributes. The most commonly applied structure attribute was “Waiting time till appointment”, the most frequently used process attribute was “Shared decision making / professional’s attention paid to your views”. “Receiving the ‘best’ treatment” was the most commonly applied outcome attribute. Process attributes were most often the ones of highest importance for patients or the population. The attributes and attribute levels used in the discrete choice experiments were identified by literature research, qualitative research, expert interviews, or the analysis of policy documents.
Conclusions
The results of the DCE studies show different preferences for primary health care. The diversity of the results may have several reasons, such as the method of analysis, the selection procedure of the attributes and their levels or the specific research question of the study. As the results of discrete choice experiments depend on many different factors, it is important for a better comprehensibility of the studies to transparently report the steps undertaken in a study as well as the interim results regarding the identification of attributes and levels.
Journal Article
Positive Psychology Interventions in Practice
\"This book presents recent advancements in positive psychology, specifically its application across broad areas of current interest. Chapters include submissions from various international authors in the field and cover discussion and presentation of relevant research, theories, and applications. The volume covers topics such as CBT, Psychotherapy, Coaching, Workplaces, Aging, Education, Leadership, Emotion, Interventions, Measurement, Technology, Design, Health, Relationships, Experiences, Communities. With the growing interest in the applications of positive psychology across diverse fields within psychology and beyond, this book will make a worthwhile contribution to the field. It will also fill the current need for a volume that highlights specifically the various recent advancements in positive psychology into diverse fields and as such will be of benefit to a wide range of professionals, including psychologists, educators, clinicians, therapists, and many others.\" -- Publisher's website.
Book
Application of Smart Watch-Based Functional Evaluation for Upper Extremity Impairment: A Preliminary Study on Older Emirati Stroke Population
Smartwatch-based functional assessments for upper extremity movement are a promising tool for a detailed and serial assessment during stroke rehabilitation, but their clinical application remains challenging. In this study, nine patients with hemiparesis due to a stroke participated in occupational therapy sessions using virtual reality-based rehabilitation devices. An Action Research Arm Test (ARAT) was performed at baseline and after intervention, with wrist smartwatch sensors recording motion data. We extracted acceleration and gyro sensor data from smartwatches and calculated the average motion segment size (MSS) as a measure of motion smoothness. Among the included patients, four participants completed all 10 therapy sessions and the follow-up evaluation. The average MSSs of acceleration for all x, y, and z directions were significantly correlated with the ARAT scores across all task domains. For angular motion, the average MSS in the gross movement task (domain 4) showed strong correlations with the ARAT scores: roll (rs = 0.735, p = 0.004), pitch (rs = 0.715, p = 0.009), and yaw (rs = 0.704, p = 0.007). At the serial follow-ups, most participants showed a considerable increase in the average MSSs of the roll, pitch, and yaw angles measured during domain 4, alongside improvements in their clinical ARAT scores. Our findings support the feasibility of using commercial smartwatch-based parameters for upper extremity functional evaluations during stroke rehabilitation and highlight their potential for serial follow-up assessments.
Journal Article