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A state of matter in which molecules show a long-range orientational order and no positional order is called a nematic liquid crystal. The best known and most widely used (for example, in modern displays) is the uniaxial nematic, with the rod-like molecules aligned along a single axis, called the director. When the molecules are chiral, the director twists in space, drawing a right-angle helicoid and remaining perpendicular to the helix axis; the structure is called a chiral nematic. Here using transmission electron and optical microscopy, we experimentally demonstrate a new nematic order, formed by achiral molecules, in which the director follows an oblique helicoid, maintaining a constant oblique angle with the helix axis and experiencing twist and bend. The oblique helicoids have a nanoscale pitch. The new twist-bend nematic represents a structural link between the uniaxial nematic (no tilt) and a chiral nematic (helicoids with right-angle tilt). Theories predict the existence of a nematic liquid crystal phase with a local twist-bend structure, but no experimental proof is available over the past 40 years. Borshch et al. identify this phase for the first time in two different materials containing dimeric molecules.

Sr 2 IrO 4 bears a striking electronic resemblance to the cuprate superconductors, except the iridate is an insulator. Introducing electrons into Sr 2 IrO 4 leads to a d -wave gap, suggesting superconductivity or something equally exotic. High-temperature superconductivity in cuprates emerges out of a highly enigmatic ‘pseudogap’ metal phase. The mechanism of high-temperature superconductivity is probably encrypted in the elusive relationship between the two phases, which spectroscopically is manifested as Fermi arcs—disconnected segments of zero-energy states—collapsing into d -wave point nodes upon entering the superconducting phase. Here, we reproduce this distinct cuprate phenomenology in the 5 d transition-metal oxide Sr 2 IrO 4 . Using angle-resolved photoemission, we show that the clean, low-temperature phase of 6–8% electron-doped Sr 2 IrO 4 has gapless excitations only at four isolated points in the Brillouin zone, with a predominant d -wave symmetry of the gap. Our work thus establishes a connection between the low-temperature d -wave instability and the previously reported high-temperature Fermi arcs in electron-doped Sr 2 IrO 4 (ref.  1 ). Although the physical origin of the d -wave gap remains to be understood, Sr 2 IrO 4 is the first non-cuprate material to spectroscopically reproduce the complete phenomenology of the cuprates, thus offering a new material platform to investigate the relationship between the pseudogap and the d -wave gap.

Cyclostationary empirical orthogonal functions, derived from satellite altimetry, are combined with historical sea level measurements from tide gauges to reconstruct sea level fields from 1950 through 2009. Previous sea level reconstructions have utilized empirical orthogonal functions as basis functions, but by using cyclostationary empirical orthogonal functions and by addressing other aspects of the reconstruction procedure, an alternative sea level reconstruction can be computed. The procedure introduced here is capable of capturing the annual cycle and El Niño–Southern Oscillation (ENSO) signals back to 1950, with correlations between the reconstructed ENSO signal and common ENSO indices found to be over 0.9. The regional trends computed from the new reconstruction show good agreement with the trends obtained from the satellite altimetry, but some discrepancies are seen when comparing with previous sea level reconstructions over longer time periods. The computed rate of global mean sea level rise from the reconstructed time series is 1.97 mm/yr from 1950 to 2009 and 3.22 mm/yr from 1993 to 2009. Key Points A new sea level reconstruction has been developed using CSEOFs CSEOFs allow for improved reconstruction of large‐scale signals like ENSO Regional trend estimates differ from previous reconstructions

The strongest gamma-ray burst (GRB) of the century, GRB20221009A, has been detected by the Korean Pathfinder Lunar Orbiter Gamma-ray Spectrometer (KGRS) instrument onboard the Korean Pathfinder Lunar Orbiter (KPLO). KGRS uses a LaBr 3 detector to measure GRB counts with five energy bins in the energy range from 30 keV to 12 MeV. KGRS detected GRB221009A at a distance of 1.508 million kilometers from the Earth. The full duration of the main burst was recorded between 13:20 and 13:26 on October 9, 2022 with peak counts of over 1000 times background. The dead time of KGRS reached as high as 50%, and the intrinsic gamma-ray spectrum of LaBr 3 was significantly altered.

High-temperature superconductivity in cuprates arises from an electronic state that remains poorly understood. We report the observation of a related electronic state in a noncuprate material, strontium iridate (Sr2IrO4), in which the distinct cuprate fermiology is largely reproduced. Upon surface electron doping through in situ deposition of alkali-metal atoms, angle-resolved photoemission spectra of Sr2IrO4 display disconnected segments of zero-energy states, known as Fermi arcs, and a gap as large as 80 millielectron volts. Its evolution toward a normal metal phase with a closed Fermi surface as a function of doping and temperature parallels that in the cuprates. Our result suggests that Sr2IrO4 is a useful model system for comparison to the cuprates.

Thermal comfort could indicate human thermal sensation when exposed to a local meteorological condition. Because humans can suffer illness when exposed to heat or even die, it is essential to assess human comfort levels to increased temperature and to provide this information to the public. This study aims to estimate thermal comfort using the human heat balance model combined with a numerical meteorological model in Seoul mega city during the heat wave periods experienced during 2016. The gridded thermal comfort index of physiological subjective temperature (PST) was calculated based on the Man-Environment Heat Exchange (MENEX) model, which used as inputs the meteorological parameters, clothing insulations, and metabolic rates. High-resolution meteorological parameters were obtained by coupling Weather Research and Forecasting (WRF) model with Building Effect Parameterization (BEP) + Building Energy Model (BEM) using detailed urban classification. The modeling results showed that the PST distribution has a clearly heterogeneous spatial distribution during the heat wave period. The high PST values were largely found in the residential area during the day, due to the high temperature and low wind speed associated with high-density buildings, and the daily maximum PST reached a very hot level (44.1–54.0 °C). Our study suggested that the human heat balance model combined with the numerical meteorological model could be used to provide more reliable information about thermal comfort to groups that may be vulnerable to the effects of heat waves in complex urban environments.

Frequency mixing an ultrafast-pulse laser's fundamental and second-harmonic fields in semiconductors 1 , 2 , atomic gases 3 , 4 , and on metal surfaces 5 generates a directional electrical current for which the magnitude and polarity depend upon the relative phase between these two fields 1 , 2 , 3 , 4 , 5 . As this current occurs on the timescale of the duration of the laser pulse, in the case of ultrafast lasers (<100 fs), this process can generate electromagnetic radiation at terahertz frequencies. Although such terahertz generation has been observed in semiconductors 6 and air 7 , 8 , 9 , 10 , 11 , 12 , 13 , the terahertz generation mechanism is not well understood and the terahertz yield has not been optimized. Here, we demonstrate a coherent control scheme to optimize terahertz generation in gases, yielding a new source of high-energy (>5 µJ), super-broadband terahertz radiation (∼75 THz) as well as an enhanced accompanying third harmonic. We also present a unifying explanation for such extremely broad electromagnetic radiation generation. Frequency mixing the fundamental-and second-harmonic fields of an ultrafast laser in any one of a number of materials can generate radiation at terahertz frequencies. A better understanding of this process leads to a brighter source of light at these very useful wavelengths.

Background: MicroRNAs are noncoding regulatory RNAs strongly implicated in carcinogenesis, cell survival, and chemosensitivity. Here, microRNAs associated with chemoresistance in ovarian carcinoma, the most lethal of gynaecological malignancies, were identified and their functional effects in chemoresistant ovarian cancer cells were assessed. Methods: MicroRNA expression in paclitaxel (PTX)-resistant SKpac sublines was compared with that of the PTX-sensitive, parental SKOV3 ovarian cancer cell line using microarray and qRT–PCR. The function of differentially expressed microRNAs in chemoresistant ovarian cancer was further evaluated by apoptosis, cell proliferation, and migration assays. Results: Upregulation of miR-106a and downregulation of miR-591 were associated with PTX resistance in ovarian cancer cells and human tumour samples. Transfection with anti-miR-106a or pre-miR-591 resensitized PTX-resistant SKpac cells to PTX by enhancing apoptosis (23 and 42% increase), and inhibited their cell migration (43 and 56% decrease) and proliferation (64 and 65% decrease). Furthermore, ZEB1 was identified as a novel target gene of miR-591, and BCL10 and caspase-7 were target genes of miR-106a, as identified by immunoblotting and luciferase assay. Conclusion: MiR-106a and miR-591 have important roles in conferring PTX resistance to ovarian cancer cells. Modulation of these microRNAs resensitizes PTX-resistant cancer cells by targeting BCL10, caspase-7, and ZEB1.

The genetics behind the progression of myelodysplasia to secondary acute myeloid leukemia (sAML) is poorly understood. In this study, we profiled somatic mutations and their dynamics using next generation sequencing on serial samples from a total of 124 patients, consisting of a 31 patient discovery cohort and 93 patients from two validation cohorts. Whole-exome analysis on the discovery cohort revealed that 29 of 31 patients carry mutations related to at least one of eight commonly mutated pathways in AML. Mutations in genes related to DNA methylation and splicing machinery were found in T-cell samples, which expand at the initial diagnosis of the myelodysplasia, suggesting their importance as early disease events. On the other hand, somatic variants associated with signaling pathways arise or their allelic burdens expand significantly during progression. Our results indicate a strong association between mutations in activated signaling pathways and sAML progression. Overall, we demonstrate that distinct categories of genetic lesions play roles at different stages of sAML in a generally fixed order.

A bstract Using the data samples of 102 million Υ(1 S ) and 158 million Υ(2 S ) events collected by the Belle detector, we search for a pentaquark state in the pJ/ψ final state from Υ(1 , 2 S ) inclusive decays. Here, the charge-conjugate is included. We observe clear pJ/ψ production in Υ(1 , 2 S ) decays and measure the branching fractions to be and . We also measure the cross section of inclusive pJ/ψ production in e + e − annihilation to be σ ( e + e − → pJ/ψ + anything ) = [108 ± 11( stat. ) ± 6( syst. )] fb at GeV using an 89 . 5 fb − 1 continuum data sample. There is no significant P c (4312) + , P c (4440) + or P c (4457) + signal found in the pJ/ψ final states in Υ(1 , 2 S ) inclusive decays. We determine the upper limits of to be at the 10 − 6 level.