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David Kimball Anderson : works 1969-2017
Spanning nearly five decades of David Kimball Anderson's work, this monograph presents a comprehensive look at the artist's practice. Curator Susan Hillhouse notes, 'Not only is his work aesthetically sound, the clear articulation of his sensitive and unique vision is profoundly compelling. His art is never obvious, never redundant and never overworked. Rather, it has a beautiful, economic mystery about it.' Anderson's sculpture manipulates a range of materials--steel, fiberglass, bronze, aluminum, wood--to create objects that appear simultaneously delicate and heavy, industrial and exquisite. The book also includes an insightful essay by MaLin Wilson-Powell and a full chronology of Anderson's work to date.
Book
The COVID-19 pandemic and research shutdown: staying safe and productive
The coronavirus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2, has caused severe disease outcomes and widespread infections not seen in terms of its case fatality rate and global economic impact since the 1918 to 1919 Spanish flu, with the latter leading to 675,000 deaths in the United States (US) (50 million worldwide) (1). The US currently has the largest number of SARS-CoV-2 infections in the world, with tremendous health, economic, and social ramifications, including closing of schools, businesses, and all public gatherings in order to maximize social distancing and prevent virus spread. Here, we address the major impact of the COVID-19 pandemic on biomedical research, the challenges created by the COVID-19 pandemic for research-intensive institutions, and what investigators can do to maintain some level of research activity while keeping their coworkers and trainees safe and engaged. While research unrelated to COVID-19 has slowed and remote work has placed significant constraints on the efficiency of operations, research on COVID-19 has exploded with energy and urgency.
Journal Article
Entrepreneurship Skills for New Ventures
As business schools expand their entrepreneurship programs and organizations seek people with entrepreneurial skills, it has become clear that the skills and mindset of an entrepreneur are highly valued in all business contexts. This latest edition of Entrepreneurship Skills for New Ventures continues to focus on helping students develop entrepreneurial skills, whether they seek to become entrepreneurs or employees.
Focusing on the entrepreneurial startup process, the fourth edition of Entrepreneurship Skills for New Ventures takes the reader through the steps of selecting, planning, financing, and controlling the new venture. The authors cover multiple forms of new ventures, as well as ways to utilize entrepreneurial skills in other contexts, encouraging students to engage with the material and apply it to their lives in ways that make sense for them. Skill development features include:
New exercise on analyzing the lean entrepreneurship option
Entrepreneurial profiles of small-business owners
Personal applications for students to apply questions to their new venture or a current business
Global and domestic cases
Elevator pitch assignments that put students in the venture capitalist position
Application exercises and situations covering specific text concepts
Business plan prompts to help students construct a business plan over the course of a semester
Featuring pedagogical tools like review questions and learning outcomes, as well as online materials that expand upon skill development and offer instructor resources, the fourth edition of Entrepreneurship Skills for New Ventures is the perfect resource for instructors and students of entrepreneurship.
eBook
Why Americans split their tickets
Why do some voters split their ballots, selecting a Republican for one office and a Democrat for another? Why do voters often choose one party to control the White House while the other controls the Congress? Citizens and politicians have been grappling with the consequences of such \"divided government\" for thirty years. In Why Americans Split their Tickets, Barry C. Burden and David C. Kimball address these fundamental puzzles of American elections. Burden and Kimball explain the causes of divided government and, rejecting the dominant explanations for split-ticket voting, they debunk the myth that voters prefer divided government to one-party control. Likewise, they make a case against interpreting the frequency of divided government as a mandate for compromise between the parties' extremist positions. Instead, the authors argue that ticket splitting and divided government are the unintentional results of lopsided campaigns and the blurring of party differences. In Why Americans Split their Tickets, Burden and Kimball use new quantitative methods to analyze the important changes in presidential, House, and Senate campaigns in the latter half of the twentieth century. Their approach explains the effects on voters' behavior of such developments as the rise of incumbency advantage and the increasing importance of money to campaigns in the 1960s and 1970s. The authors also observe that ticket splitting has declined in recent years. They link this emerging voting pattern to the sharpening policy differences between parties, illuminating the ways that ideological positions of candidates still matter in American elections.
eBook
Representative Bureaucracy and Partisanship: The Implementation of Election Law
Studies of representative bureaucracy argue that public administrators hold attitudes that are generally representative of the public and will implement policy in accordance with those attitudes. However, studies of representative bureaucracy generally have not considered the partisanship of local administrators. Many local election officials affiliate with a political party, and there is concern that partisan officials will manipulate election procedures to help their party. The authors analyze a survey of local election officials about their attitudes toward provisional voting. Findings show that Democratic local election officials have significantly more positive attitudes toward provisional voting programs in highly Democratic jurisdictions and significantly less positive attitudes in highly Republican jurisdictions. No such relationship occurs for Republican administrators. In addition, positive attitudes toward provisional voting are associated with more provisional votes being cast and counted in the 2004 presidential election. This work questions whether representative bureaucracy—when it concerns partisanship—is always a desirable outcome.
Journal Article
Voter Competence with Cumulative Voting
Objective. This article evaluates the voting experience in the first election using cumulative voting for the Board of Trustees in Port Chester, New York. A growing number of local jurisdictions in the United States are using cumulative voting for multimember elections. While the Port Chester election included some other new features in addition to cumulative voting, the village implemented an extensive voter education program to prepare voters and candidates for the election. Methods. We conducted an exit poll of 1,946 Port Chester voters in June 2010, more than half of the voters in the local election. We used a variety of survey questions to measure voting experience and voting behavior. We also examined election returns for Port Chester, including the 2010 and 2013 elections using cumulative voting. Results. We find that the voter education program helped inform residents about casting a ballot with cumulative voting. Port Chester voters, and Hispanic voters in particular, reported a positive experience in the 2010 election. A large majority of voters also indicated that they understood cumulative voting and cast all of the votes allotted to them. Finally, we find evidence of strategic use of cumulative voting in order to help elect a candidate of one’s choice. Conclusions. Our results indicate that voters are capable of effectively participating in elections with cumulative voting. Communities that are weighing the adoption of cumulative voting for local elections should also be prepared to implement a parallel voter education effort.
Journal Article
How Local Media Coverage of Voter Fraud Influences Partisan Perceptions in the United States
Extant findings show that voter fraud is extremely rare and difficult to prove in the United States. Voter’s knowledge about voter fraud allegations likely comes through the media, who tend to sensationalize the issue. In this study, we argue that the more voters are exposed to media coverage of voter fraud allegations, the more likely that they will perceive that voter fraud is a frequent problem. We merge the 2012 Survey of Performance of American Elections with state-level media coverage of voter fraud leading up to the 2012 election. Our results show that media coverage of voter fraud is associated with public beliefs about voter fraud. In states where fraud was more frequently featured in local media outlets, public concerns about voter fraud were heightened. In particular, we find that press attention to voter fraud has a larger influence on Republicans than Democrats and Independents. We further find that media coverage of voter fraud does not further polarize partisan perceptions of voter fraud. Rather, political interest moderates state media coverage on voter fraud beliefs only among Republicans. Last, our results provide no support that demographic changes, approval of election administration, or information concerning actual reported voting irregularities have any discernable effects on partisan perceptions.
Journal Article
Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation
Triple negative breast cancer (TNBC) is an aggressive subset for which effective therapeutic approaches are needed. A significant proportion of TNBC patients harbor either germline or somatic mutations in BRCA1, or epigenetic silencing of BRCA1, which renders them deficient in DNA repair. Virtually all BRCA1 deficient breast cancers harbor mutations in TP53 suggesting that inactivation of p53 is a requirement for tumor progression in the setting of BRCA1 deficiency. Due to this dependency, we hypothesized that restoring wild type p53 function in BRCA1 deficient breast cancer would be therapeutic. The majority of TP53 mutations are missense, which generate a defective protein that potentially can be targeted with small molecules. Zinc metallochaperones (ZMCs) are a new class of anti-cancer drugs that specifically reactivate zinc-deficient mutant p53 by restoring zinc binding. Using ZMC1 in human breast cancer cell lines expressing the zinc deficient p53R175H, we demonstrate that loss of BRCA1 sensitizes cells to mutant p53 reactivation. Using murine breast cancer models with Brca1 deficiency, we demonstrate that ZMC1 significantly improves survival of mice bearing tumors harboring the zinc-deficient Trp53R172H allele but not the Trp53−/− allele. We synthesized a new formulation of ZMC1 (Zn-1), in which the drug is made in complex with zinc to improve zinc delivery, and demonstrate that Zn-1 has increased efficacy. Furthermore, we show that ZMC1 plus olaparib is a highly effective combination for p53R172H tumor growth inhibition. In conclusion, we have validated preclinically a new therapeutic approach for BRCA1 deficient breast cancer through reactivation of mutant p53.
Journal Article
Ballot Design and Unrecorded Votes on Paper-Based Ballots
The 2000 presidential election focused attention on the problem of unrecorded votes, in which a person casts a ballot but fails to record a valid vote for a particular contest. Although much recent research has evaluated voting technologies and their effects on unrecorded votes, there has been little research on the effects of ballot design. We argue that the same theories used to design and evaluate self-administered surveys can be used to analyze ballot features. We collect and code paper-based ballots used in the 2002 general election from 250 counties in 5 states. We code the ballots in terms of several graphic design elements, including the content and location of ballot instructions and the layout of candidate names and office titles. Our analysis suggests that several ballot features are associated with unrecorded votes (both overvotes and undervotes) in the gubernatorial contests. We also find that ballot design features exacerbate the racial disparity in unrecorded votes. Ballot design can be an important factor in determining whether voters are able to cast a ballot accurately, which can influence the legitimacy of elections.
Journal Article