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The article raised issues related to the design and execution of low-energy objects in Polish conditions. Based on the designed single-family house, adapted to the requirements of the National Fund for Environmental Protection and Water Management (“NF40” standard), the tools to assist investment decisions by investors were shown. An economic analysis and a multi-criteria analysis were performed using AHP method which had provided an answer to the question whether it is worthwhile to bear higher investment costs in order to adjust to the standards of energy-efficient buildings that fulfil a minimal energy consumption's requirements contained in Polish law. In addition, the variant of object that had optimal characteristics due to the different preferences of investors was indicated. This paper includes analysis and observations on the attempts to unify that part of the building sector, which so far is considered to be personalized, and objects in accordance with the corresponding idea are designed as “custom-made”.

The study aimed to improve the effectiveness of treatment and prevention of recurrences of bacterial vaginosis (BV) in postmenopausal women. 87 women with BV aged 50 to 65 who received a course of antibacterial therapy with control clinical and laboratory recovery were examined. In the future, two groups were selected: the first group (42 women) received probiotics in suppositories (live lactobacillus strains L. aktobacillus plantarum 8P-A3 or L. plantarum 38, or L. fermentum 90T-C4, or L. fermentum 39) vaginally 2 times a day for 10 days. Women of the second group (45 patients) received probiotics vaginally once a day for 20 days and a suppository with estriol 0.5 mg vaginally once a day for 2 weeks, and then 2 times a week for 3 months. Evaluation of effectiveness was carried out after 3 and 6 months. A gynecological examination, determination of the pH reaction of vaginal contents, aminotest, microscopy of vaginal smears, bacteriological cultures on nutrient media for the determination of facultatively anaerobic bacteria, Gardnerella vaginalis, quantitative analysis of vaginal microflora, species composition and frequency of lactobacilli were performed. In the women of the first group, the risk of recurrence of the laboratory criteria of BV increases after 3 months: an increase in the pH of the vaginal contents by 1.2 times (p<0.05), the appearance of a positive aminotest in 38.1% of patients, the presence of Gardnerella vaginalis in 26.2% women with a pathological number of 104-105 CFU/ml, regression of the pool of lactobacilli with worsening of the situation and the appearance of clinical manifestations of the disease after 6 months. In the second group, there was a decrease in cases of recovery of laboratory markers after 3 months and clinical and laboratory criteria of BV after 6 months. The study proves the necessity of determining the laboratory criteria for the diagnosis of BV in dynamics 3 months after the main course of antimicrobial therapy in women without a clinical picture of recurrence. The effectiveness of intravaginal use of probiotics and vaginal estriol at a dose of 0.5 mg for the treatment and prevention of BV recurrences in postmenopausal women with a long course has been shown (4 months).

T-cell receptor excision circles (TRECs) and kappa-deleting recombinant excision circles (KRECs) are circular DNA molecules that are formed in the process of maturation of T and B cells of the human immune response and can be markers of the development and number of the immune response cells. The authors determined the number of TREC and KREC copies in different biological material and their informativeness for screening patients with inborn errors of immunity. The number of TREC and KREC molecules was determined using a real-time polymerase chain reaction followed by the analysis of melting curves in the material of neonatal dry spots and DNA bank of patients with inborn errors of immunity. The determination of the number of copies of TREC molecules reveals 100% sensitivity for the detection of Nijmegen breakage syndrome and 84% for ataxia–telangiectasia. The determination of KREC index demonstrated a significantly lower sensitivity (56 and 37%, respectively). The calculations carried out when performing 1500 tests indicate an index of TREC determination specificity at the level of 97.6% for the first blood spot and 97.3% after the repeated sampling. Performing this study on a large sample of healthy newborns (more than 10 000) should be the next stage of the work in order to establish the limit values for the number of TREC and KREC copies in our population. The determination of TREC and KREC copies is a rapid and accessible method and can be suitable for use in screening programs provided that the results obtained are replicated on a larger sample. The determination of the number of TREC copies using the proposed method demonstrated the sensitivity of 93.6% and specificity of 97.3% for detecting the cases of inborn errors of immunity accompanied by T lymphopenia.

The article presents own evaluation methodology of the tourism infrastructure development at the state level. To obtain data on the state and trends of national tourism development the authors chose economic diagnosis based on an evaluation of industry infrastructure provision. The following objects were selected for study: sanatoriums and resorts, guest houses and lodges, hotels, child resort and health centers. Their state, features of their use and their material and technical base were evaluated. Using own evaluation methodology of level of tourism resource provision the indicator of objects density was calculated and the results of calculations were summarized. According to the results of determined partial indicators the integrated evaluation of tourism infrastructure provision was made and the dynamics of integral index of infrastructure provision according to the Ukrainian regions was presented.

Basic structural properties of Russian railways are explored through the complex network scope. We imply ontology where railway stations portray nodes, while links are represented by trains plying among stations. The information L- network model founded on route is built and its topology is compared with Indian and Pakistan analogues. The network model demonstrates small world properties and its assortative nature. Structural vulnerability is assessed for random attacks, and those on degree and strength targets. Taking into account series of the node centralities, the most important sites are identified as those that could help in clarifying the sensitive points in the network. These sites should be in the focus of pre-protection and post hazard recovery. Also, a P-model is touched and an S- and H- model idea is proposed for further analysis of transportation networks.

Often network science with complex networks as its basic entity has attracted scientific societies with their diverse practical capacities. Some entities (objects, processes, and data) having their built-in web nature might be considered as networks seamlessly. Contrary, network mapping for Network -Unlike Data (NUD), i.e. images and time series, is extremely complicated and manifold, so that explorers face with a tough problem which converting algorithm they should apply. We put in central focus separating data properties in line with their scale diversity - in distance, time, and nature and suggested a three step algorithm (scale-based one) to map NUD into complex networks. The algorithm was applied to networkalize two types of geographic maps of Olkhon district, Baikal Natural Territory, Irkutsk region, Russian Federation. It was underlined that the algorithm models coarse-graining and area-like linking and forms thoroughly output structures of really complex topologies with intrinsic scale-free and small world properties. In addition to simple examples transformation of NUD into multiplex networks is considered as a promising approach to study more complex systems of the real world. Networkalization concerned challenges in extracting the pertinent information from huge data resources conveyed by a network imprint for each file is also discussed.

Aim. Purposeful preparation of polymeric surfactants combining hydrophobic fluorine-containing and hydrophilic synthetic and natural blocks via radical and non-radical reactions using peroxide, epoxide and/or amino- terminal groups of the polymeric elementary blocks. Methods. Radical and non-radical condensation reactions, polymerization, spectral (NMR- and luminescence spectroscopy), gel-permeation chromatography and other analytical techniques`. Results. Primary oligomers poly(F-MA)-MP were synthesized via radical polymerization of fluorine-alkyl methacrylate (F-MA) in the presence of peroxide-containing telogen (MP). That provides controlling the oligomer chain length and architectures as well as entering a terminal peroxide group in the macromolecules. Radical polymerization of vinyl pyrrolidone (NVP) initiated by poly(F-MA)-MP as macroinitiator in the presence of epoxide-containing derivative of cumene (CGE) was used for obtaining water soluble poly(F-MA)-block-poly(NVP)-CGE. Finally oligonucleotide (ONC) was attached via condensation reaction of ONC primary amino group with terminal epoxide group of poly(F-MA)-block-poly(NVP)-CGE. Conclusions. A series of novel block/comb-like copolymers with synthetic and natural parts was synthesized. Obtained tri-block copolymers can be used as markers for labeling bacteria and pathological items including cancer cells.