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Background and Objectives: To evaluate factors affecting aneurysm rupture, present our surgical experience with intracranial aneurysms, specifically using the picket-fence clipping technique for giant aneurysms, and highlight the complementary roles of sodium fluorescein (Na-Fl) and indocyanine green (ICG) videoangiography in enhancing surgical precision and patient outcomes. Materials and Methods: We retrospectively analyzed 47 patients who underwent microsurgical clipping of intracranial aneurysms with intraoperative Na-Fl and ICG videoangiography between September 2015 and February 2024. We assessed relationships between patient comorbidities, family history of subarachnoid hemorrhage (SAH), smoking history, aneurysm location and size, and SAH occurrence. Concordance between intraoperative videoangiography and postoperative digital subtraction angiography (DSA) for detecting residual aneurysms was also evaluated. Results: Of the 47 patients (31 female, 16 male; mean age 51.78 ± 11.16 years), 11 (23.4%) presented with SAH. The most common aneurysm location was the middle cerebral artery (MCA) (68.1%). Hypertension and smoking history were significantly higher in the hemorrhage group (p < 0.05). Aneurysm size and anterior communicating artery (AComA) location were also significantly associated with hemorrhage (p < 0.05). Aneurysm size demonstrated significant discriminative power for hemorrhage [AUC: 0.884 (0.827–0.941)], with a cutoff of 7.1 mm yielding 90.9% sensitivity and 94.4% specificity. Five giant MCA aneurysms were treated with the picket-fence technique, with intraoperative ICG and Na-Fl confirming parent artery patency and complete aneurysm occlusion, subsequently confirmed by postoperative DSA. Small remnants were detected in 2 cases (4.26%) on postoperative DSA, both in distal ACA aneurysms, which were also detected by intraoperative videoangiography. Conclusions: Hypertension, smoking history, aneurysm size, and location were important predictors of aneurysm rupture. Intraoperative ICG and Na-Fl videoangiography provide real-time, high-resolution visualization crucial for complex intracranial aneurysm surgery, including the picket-fence technique for giant aneurysms. Their complementary use enhances surgical safety, guides intraoperative decision-making, and contributes to improved outcomes in challenging cases.

Objective To evaluate the feasibility and safety of sodium fluorescein (Na-Fl)–guided surgery with the use of the PENTERO 900 surgical microscope (Carl Zeiss, Meditec, Oberkochen, Germany) equipped with the YELLOW-560-nm filter and low-dose Na-Fl (2 mg/kg) in pediatric brain tumor surgery. Methods The study included 23 pediatric patients with various intracranial pathologies, who underwent Na-Fl-guided surgery between April 2015 and February 2018. Clinical features, surgical observations, extent of resection, and tumor histopathology were retrospectively analyzed. The use of YELLOW-560-nm filter was found “helpful” if the discrimination of the pinkish brain tissue and bright yellow stained tumor tissue was clear. Otherwise, it was described as “not helpful.” Results There were 11 female and 12 male patients with a mean age of 9.4 years. There were 7 brain stem/tectal plate gliomas, 6 supratentorial tumors, 4 intraventricular tumors, 2 pineal tumors, 2 infratentorial tumors, 1 clivus tumor, and 1 tumor with supra- and infratentorial extensions in the current series. Na-Fl was found helpful by means of the tumor demarcation in 20 instances (87%). In 11 of these 20 operations (55%), a total resection was achieved regardless of the tumor pathology. A subtotal resection was achieved in the remaining 9 patients (45%). No adverse events or side effects were encountered with regard to Na-Fl use. Conclusion Na-Fl guidance with the use of the YELLOW-560 filter is safe and effective during brain tumor surgery in pediatric age group.

Indocyanine green (ICG) and sodium fluorescein (Na-Fl) are two fluorophores, which are used for videoangiography purposes. This prospective study reports our experience by using surgical microscopes equipped with two special filters. We compared the imaging efficacy of Na-FL and ICG videoangiography techniques during aneurysm and arteriovenous malformations (AVM) surgeries. Patient and methods: Fourtynine consecutive patients were operated between September 2015 and December 2022. Patients with ruptured/unruptured aneurysms or with AVMs presented with/without hemorrhage were included to the current study. There were a total of 48 aneurysms and 11 AVMs in 49 patients in the current study. Na-Fl enables the surgeon to manipulate vessels and aneurysms real-time. ICG provides the ability to watch the videoangiography repeatedly and understand the angioarchitecture. The use of FLOW-800 module allows the surgeon to make concrete judgements about the flow dynamics of AVMs and therefore ICG videoangiography found useful in AVM surgery. Na-Fl has been found more useful for the evalution of the low caliber perforating arteries and anatomical features of the aneursym dome in aneurysm surgery. The results of our series demonstrated the safety and efficacy of Na-Fl use in the surgery of aneurysms and AVMs. Both the ICG and Na-Fl videoangiographies are easy to perform and complimentary to each other. Combined use of these two mediums may provide better surgical results, considering the separate advantages and disadvantages of these both techniques.

Background Gangliogliomas are rare tumors primarily arising from the central nervous system, mostly in the temporal lobes, with brain stem involvement being particularly infrequent. To the best of our knowledge, this is the first reported instance of a brainstem ganglioglioma exhibiting an extension to foramen of Luschka. Case presentation We present a unique case of ganglioglioma of the brainstem. 23-year-old Turkish patient presented with flashing lights in the peripheral visual fields. Imaging studies revealed a distinct mass lesion adjacent to the brainstem, demonstrating an unusual exophytic growth pattern that extended towards the foramen of Luschka. Surgical intervention was performed to prevent tumor progression and obtain a definitive diagnosis. The surgical approach employed was the telovelar approach, which provides excellent visualization of the posterior fossa. Histopathological examination of the resected specimen confirmed the diagnosis of grade 1 ganglioglioma. Postoperative magnetic resonance imaging scans displayed gross total resection of the tumor. The patient’s postoperative course was uneventful, and the initial symptom of flashing lights resolved in the postoperative period. Conclusion This case report highlights the uniqueness of a dorsally exophytic brain stem ganglioglioma extending to the foramen of Luschka. Utilization of the telovelar approach and sodium fluorescein in the surgical management of this challenging case underscores its efficacy in managing deep-seated lesions within the posterior fossa. Although presenting infrequently, gangliogliomas should be considered in the differential diagnosis of lesions of the foramen of Luschka because early recognition is important for the management and prognosis.

Background and Objectives: The authors aimed to describe their experience performing frameless stereotactic biopsies using an Autoguide Robotic Platform and to compare the outcomes with a frame-based stereotactic technique. We would like to emphasize the importance of this study, as it is the first in the literature to use sodium fluorescein for confirmation in intracranial biopsies taken with a Stealth Autoguide Robotic Platform. Materials and Methods: We retrospectively evaluated 30 patients who underwent a stereotactic intracranial biopsy between June 2018 and March 2024. The patients were divided into two groups: The robotic biopsy group (n = 15) underwent a frameless image-guided stereotactic intracranial biopsy with a Stealth Autoguide Robotic Platform and optical neuronavigation system (Stealth-Station S8, Medtronic, Minneapolis, MN, USA) using intraoperative sodium fluorescein. The frame-based (Integra, CRW, New Jersey, USA) stereotactic biopsy group (n = 15) underwent a stereotactic biopsy with the use of a stereotactic planning system (Atlas Integra Software, NJ, USA and Brainlab AG, Munich, Germany) without sodium fluorescein. Preoperative MRI and CT scans were performed in all the patients. Their external cranial anatomy was registered using either facial tracing or O-Arm (Medtronic Sofamor Danek, Inc., Memphis, TN, USA). Results: The robotic biopsy group demonstrated a diagnostic yield of 93.3% (14/15), while the frame-based group achieved 100% (15/15), with no significant difference (p = 0.609). The mean calculated tip error in the robotic biopsy group was 0.42 ± 0.19 mm (range: 0.1–0.7 mm) and the postoperative targeting accuracy in the frame-based biopsy group was 0.51 ± 0.23 mm (range: 0.2–0.9 mm), with no significant difference (p = 0.287). The robotic biopsy group demonstrated a significantly shorter mean surgical time (40.26 ± 6.13 vs. 52.47 ± 8.92 min, p = 0.002). Conclusions: Both frame-based and robotic-assisted stereotactic biopsy techniques achieve comparable diagnostic accuracy and targeting precision. However, a robotic biopsy significantly reduces the surgical time compared to a frame-based technique. The use of intraoperative sodium fluorescein is a valuable adjunct method for confirming that biopsy specimens are obtained from the intended target site.

Purpose In this study, we aimed to evaluate the effectiveness and safety of UBS (Ultrasonic Bone Scalpel) and HSD (High-speed drill) for performing anterior or posterior decompressions in patients with pathologies in cervical and lumbar regions. Methods Between October 2022 and June 2024, 60 patients underwent surgery in which a UBS (Sonopet UST-2001; Stryker Neuro Spine ENT, MI, USA) and High-speed Midas Rex MR8 (Medtronic, Fort Worth, TX, USA) drill was used. Informed consent was obtained from all patients. The study included 27 men and 33 women with a mean age of 59,5 ± 14.6 years (range: 28–85). The following patient data were recorded: preoperative and postoperative JOA scores, intraoperative blood loss, and operative time for decompression in lumbar and cervical region. Results In UBS group, the mean intraoperative blood loss was 166.0 ± 64.3 ml. The mean preoperative and postoperative JOA scores were 4.5 ± 1.0 and 8.6 ± 1.8 and the mean postoperative follow-up duration was 6.1 ± 4.4 months in UBS group. The mean intraoperative blood loss was 221.2 ± 93.4 ml in HSD group. The mean preoperative and postoperative JOA scores were 5.2 ± 1.1 and 8.2 ± 1.2 in HSD group. In the HSD group, the blood loss (BL) value was significantly higher ( p  < 0.05) compared to the UBS group. The preoperative/postoperative JOA score improvement in the UBS group was significantly higher ( p  < 0.05) than in the HSD group. Conclusions The UBS can be safely used in spinal surgery. It reduces intraoperative blood loss and provide better clinical improvement. Authors would like to emphasize that the UBS resects the bone with oscillatory movements rather than rolling motions and this mechanism of action is important in reducing the risk of dura mater injury.

Highlights • Na-Fl accumulates in tumoral tissues via disrupted blood-brain barrier. • Na-Fl is used to increase the extent of resection in brain tumor surgery. • The cost of the drug is relatively low compared to 5-ALA. • Na-Fl guidance with the use of a YELLOW 560 filter is safe and effective.

Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS.

•Na-Fl accumulates in tumoral tissues via disrupted blood-brain barrier.•Na-Fl is used to increase the extent of resection in brain tumor surgery.•The cost of the drug is relatively low compared to 5-ALA.•Na-Fl guidance with the use of a YELLOW 560 filter is safe and effective. Sodium fluorescein (Na-Fl) is a fluorescent dye that accumulates in tumoral tissues via disrupted blood-brain barrier. It has been used in fluorescence-guided surgery for various brain tumors. Herein, we report our initial experience and preliminary results for the first 28 patients who were operated on under Na-Fl guidance with the use of a special filter on the surgical microscope. Between January and November 2015, 200mg (2–4mg/kg) of Na-Fl was administered in 28 patients (30 surgeries) after anesthesia induction. The clinical features, surgical observations, extent of resection on the postoperative magnetic resonance imaging (MRI) and histopathology of the tumors were retrospectively analyzed. The use of YELLOW 560nm filter was found “helpful” if the discrimination of the pinkish brain tissue and bright yellow stained tumor tissue was clear. Otherwise, it was described as “not helpful. There were 23 high-grade and 7 metastatic tumors in our study group. Na-Fl was found helpful by means of the tumor demarcation in 29 of 30 operations (97%). In 23 of these 29 operations (79%), a total resection was achieved regardless of the tumor pathology. No adverse events were encountered regarding the use of Na-Fl. Na-Fl guidance with the use of a YELLOW 560 filter is safe and effective in high-grade glioma and metastatic tumor surgery. We think it is feasible for increasing the extent of resection in these tumors.