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The effect of provocation on left ventricular (LV) outflow was studied by continuous-wave Doppler echocardiography in 103 nonselected, consecutively enrolled patients with LV hypertrophy (LVH), either due to pressure overload (97 patients) or hypertrophic cardiomyopathy (HCM, 6 patients). In 34 patients with LVH, outflow acceleration (gradients ranging from 18 to 122 mm Hg) was induced or accentuated by the Valsalva maneuver after 1.6 mg nitroglycerine sublingually independent of LVH etiology. Factors associated with LV outflow acceleration were female sex, small body surface area and LV cavity size, increased relative wall thickness, LV contractility, and resting LV outflow velocity, mitral anulus calcifications and systolic anterior movement of the mitral valve. It is concluded that dynamic, intracavity LV gradients are a nonspecific flow abnormality that merit consideration because they can be frequently found in LVH patients.

A new design of a detector plane of sub-millimetre thickness for an electromagnetic sampling calorimeter is presented. It is intended to be used in the luminometers LumiCal and BeamCal in future linear \\(e^+e^-\\) collider experiments. The detector planes were produced utilising novel connectivity scheme technologies. They were installed in a compact prototype of the calorimeter and tested at DESY with an electron beam of energy 1-5 GeV. The performance of a prototype of a compact LumiCal comprising eight detector planes was studied. The effective Moli`ere radius at 5 GeV was determined to be (8.1 +/- 0.1 (stat) +/- 0.3 (syst)) mm, a value well reproduced by the Monte Carlo (MC) simulation (8.4 +/- 0.1) mm. The dependence of the effective Moli`ere radius on the electron energy in the range 1-5 GeV was also studied. Good agreement was obtained between data and MC simulation.

A prototype of a luminometer, designed for a future e+e- collider detector, and consisting at present of a four-plane module, was tested in the CERN PS accelerator T9 beam. The objective of this beam test was to demonstrate a multi-plane tungsten/silicon operation, to study the development of the electromagnetic shower and to compare it with MC simulations. The Molière radius has been determined to be 24.0 +/- 0.6 (stat.) +/- 1.5 (syst.) mm using a parametrization of the shower shape. Very good agreement was found between data and a detailed Geant4 simulation.

We present a study of showers initiated by electrons, pions, kaons, and protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE scintillator-tungsten analogue hadronic calorimeter. The data were recorded at the CERN Super Proton Synchrotron in 2011. The analysis includes measurements of the calorimeter response to each particle type as well as measurements of the energy resolution and studies of the longitudinal and radial shower development for selected particles. The results are compared to Geant4 simulations (version 9.6.p02). In the study of the energy resolution we include previously published data with beam momenta from 1 GeV to 10 GeV recorded at the CERN Proton Synchrotron in 2010.

Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.

In Germany the in-hospital rehabilitation of patients with cardiac diseases is standard. Especially because of criticism of effectiveness and wasting of resources we evaluated in a pilot study a rehabilitation program with an in-hospital start, followed facultatively on ambulatory basis at the same institution, at the cardiac rehabilitation clinic. The aims of the study were to find out the acceptance of the the program by the patients, the safety and the impact of the facultative ambulatory rehabilitation program on cardiovascular risk factors. From January 1993 to December 1995 the primary enclosing criteria (cardiac disease suitable for rehabilitation, age < 70 years, lodging < 40 km) were fulfilled by 612 patients, 122 female. 268 (43.8%) were disclosed on medical grounds because of the rigid pilot character of the study, for 74 (12.1%) patients was the participation on organisational grounds not possible. Sixty-six of the remaining 270 patients preferred the facultative continuation of the rehabilitation on ambulatory basis for 1 or 2 weeks, the entire rehabilitation lasting up to 4 weeks. During the ambulatory phase the patients slept at home, otherwise these patients followed the same procedure as the in-hospital participants. Despite of severe medical concerns 4 further patients wished to participate on facultative ambulatory continuation of the rehabilitation, among these were 2 women, only 5 of the total 70 patients of the facultative ambulatory program group being female. There were no significant differences among 24 patients with CAD of both groups during the rehabilitation and in a control after 14.8 months (Table 3). The impact on serum total cholesterol and LDL cholesterol was positive (Table 2), albeit after 14.8 months no more significant. Over the control period there were a negative development of serum triglyceride level and significant negative effects on the body weight. There were no complications among the 66 patients during the facultative ambulatory phase of the rehabilitation, in contrast to those 37 of 268 patients who had to be disclosed because of medical concerns (Table 1). During the rehabilitation the drug therapy was optimized for many participants. The control after 14.8 months revealed that these remedies were followed with great accuracy by the physicians at home (Figure 1). In conclusion, a cardiac rehabilitation program with an in-hospital start of 2 weeks, going over to ambulatory rehabilitation for 1 to 2 weeks, is as effective and safe as an in-hospital cardiac rehabilitation. As known, amelioration of the long-term results has yet to be achieved.

The Compact Linear Collider (CLIC) is an option for a future ${\\mathrm{e}^{+}}{\\mathrm{e}^{-}} $ collider operating at centre-of-mass energies up to $3\\,\\text {TeV} $ , providing sensitivity to a wide range of new physics phenomena and precision physics measurements at the energy frontier. This paper is the first comprehensive presentation of the Higgs physics reach of CLIC operating at three energy stages: $\\sqrt{s} = 350\\,\\text {GeV} $ , 1.4 and $3\\,\\text {TeV} $ . The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung ( ${\\mathrm{e}^{+}}{\\mathrm{e}^{-}} \\rightarrow {\\mathrm{Z}} {\\mathrm{H}} $ ) and ${\\mathrm{W}} {\\mathrm{W}} $ -fusion ( ${\\mathrm{e}^{+}}{\\mathrm{e}^{-}} \\rightarrow {\\mathrm{H}} {{\\nu }}_{\\!\\mathrm{e}} {\\bar{{\\nu }}}_{\\!\\mathrm{e}} $ ), resulting in precise measurements of the production cross sections, the Higgs total decay width $\\varGamma _{{\\mathrm{H}}}$ , and model-independent determinations of the Higgs couplings. Operation at $\\sqrt{s} > 1\\,\\text {TeV} $ provides high-statistics samples of Higgs bosons produced through ${\\mathrm{W}} {\\mathrm{W}} $ -fusion, enabling tight constraints on the Higgs boson couplings. Studies of the rarer processes ${\\mathrm{e}^{+}}{\\mathrm{e}^{-}} \\rightarrow \\mathrm{t} {\\bar{\\mathrm{t}}} {\\mathrm{H}} $ and ${\\mathrm{e}^{+}}{\\mathrm{e}^{-}} \\rightarrow {\\mathrm{H}} {\\mathrm{H}} {{\\nu }}_{\\!\\mathrm{e}} {\\bar{{\\nu }}}_{\\!\\mathrm{e}} $ allow measurements of the top Yukawa coupling and the Higgs boson self-coupling. This paper presents detailed studies of the precision achievable with Higgs measurements at CLIC and describes the interpretation of these measurements in a global fit.

We investigate the three dimensional substructure of hadronic showers in the CALICE scintillator-steel hadronic calorimeter. The high granularity of the detector is used to find track segments of minimum ionising particles within hadronic showers, providing sensitivity to the spatial structure and the details of secondary particle production in hadronic cascades. The multiplicity, length and angular distribution of identified track segments are compared to GEANT4 simulations with several different shower models. Track segments also provide the possibility for in-situ calibration of highly granular calorimeters.

Interferometers with atomic ensembles are an integral part of modern precision metrology. However, these interferometers are fundamentally restricted by the shot noise limit, which can only be overcome by creating quantum entanglement among the atoms. We used spin dynamics in Bose-Einstein condensates to create large ensembles of up to 10⁴ pair-correlated atoms with an interferometric sensitivity $ - 1.61_{ - 1.1}^{ + 0.98}$ decibels beyond the shot noise limit. Our proof-of-principle results point the way toward a new generation of atom interferometers.

In 1935, Einstein, Podolsky and Rosen (EPR) questioned the completeness of quantum mechanics by devising a quantum state of two massive particles with maximally correlated space and momentum coordinates. The EPR criterion qualifies such continuous-variable entangled states, where a measurement of one subsystem seemingly allows for a prediction of the second subsystem beyond the Heisenberg uncertainty relation. Up to now, continuous-variable EPR correlations have only been created with photons, while the demonstration of such strongly correlated states with massive particles is still outstanding. Here we report on the creation of an EPR-correlated two-mode squeezed state in an ultracold atomic ensemble. The state shows an EPR entanglement parameter of 0.18(3), which is 2.4 s.d. below the threshold 1/4 of the EPR criterion. We also present a full tomographic reconstruction of the underlying many-particle quantum state. The state presents a resource for tests of quantum nonlocality and a wide variety of applications in the field of continuous-variable quantum information and metrology. Continuous-variables EPR states present a resource for applications to quantum information processing and metrology, but these states have been created until now only with photon pairs. Here, the authors report the creation of an EPR-correlated two-mode squeezed states in an ultracold atomic ensemble.