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\"Amateur Craft presents a historical and theoretical framework for understanding amateur craft in the modern era, from 19th century Sunday painters and amateur carpenters to present day railway modellers and IKEA hackers. Stephen Knott's fascinating study explores the curious and unexpected attributes of things made outside standardised models of mass production, arguing that amateur craft practice is 'differential' - a temporary moment of control over work that both departs from and informs our productive engagement with the world. Knott's discussion of the theoretical aspects of amateur craft practice is substantiated by historical case studies that cluster around the period 1850 - 1950. Looking back to the emergence of the modern amateur, he makes reference to contemporary art and design practice that harnesses or exploits amateur conditions of making. From Andy Warhol to Simon Starling, such artistic interest elucidates the mercurial qualities of amateur craft. Invaluable for students and researchers in art and design, contemporary craft, material culture and social history, Amateur Craft counters both the marginalisation and the glorification of amateur craft practice. It is richly illustrated with 55 images, 14 in colour, including 19th century ephemera and works of contemporary art\"-- Provided by publisher.

Genomic vulnerability analyses are being increasingly used to assess the adaptability of species to climate change and provide an opportunity for proactive management of harvested marine species in changing oceans. Southeastern Australia is a climate change hotspot where many marine species are shifting poleward. The turban snail, Turbo militaris is a commercially and culturally harvested marine gastropod snail from eastern Australia. The species has exhibited a climate-driven poleward range shift over the last two decades presenting an ongoing challenge for sustainable fisheries management. We investigate the impact of future climate change on T. militaris using genotype-by-sequencing to project patterns of gene flow and local adaptation across its range under climate change scenarios. A single admixed, and potentially panmictic, demographic unit was revealed with no evidence of genetic subdivision across the species range. Significant genotype associations with heterogeneous habitat features were observed, including associations with sea surface temperature, ocean currents, and nutrients, indicating possible adaptive genetic differentiation. These findings suggest that standing genetic variation may be available for selection to counter future environmental change, assisted by widespread gene flow, high fecundity and short generation time in this species. We discuss the findings of this study in the content of future fisheries management and conservation.

In this trial involving patients with atherosclerotic disease who were receiving effective statin therapy, those who were assigned to receive anacetrapib, a CETP inhibitor, had a lower risk of major coronary events than did those in the placebo group.

Vitamin D deficiency is common in adult renal transplant recipients, but data in children are scarce. Vitamin D is shown to have multiple effects on the cardiovascular system, renal function, and maintenance of bone health. We hypothesized that 25(OH)D deficiency is common in pediatric renal transplant recipients, and may be associated with hyperparathyroidism, short stature, renal function, and blood pressure control. We recruited 106 children during the winter/spring season who had a functioning renal transplant for at least 3 months. Twenty-five hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH) 2 D] were measured and correlated with clinical and biochemical parameters. Of the renal transplant patients, 38% were 25(OH)D deficient, 54% had insufficient levels, and only 8% had adequate 25(OH)D levels. Despite alfacalcidol supplementation in 59 (56%) patients, parathyroid hormone was increased in 58 (55%) and showed an inverse correlation with 25(OH)D ( p  = 0.0003, r  = 0.61) but not with 1,25(OH) 2 D levels. Height standard deviation score (SDS) correlated with 25(OH)D ( p  = 0.007, r  = 0.42) and time post transplantation ( p  = 0.02, r  = 0.23); both were significant and independent predictors of height SDS. 25(OH)D inversely correlated with systolic BP SDS ( p  = 0.02, r  =−0.26); this association was lost on multiple regression analysis, but 25(OH)D was the only modifiable risk factor for hypertension. There was no correlation with estimated GFR or proteinuria. In conclusion, 25(OH)D deficiency is common in pediatric renal transplant recipients and correlates with hyperparathyroidism and short stature. 25(OH)D deficiency may be a modifiable risk factor for hypertension in transplant recipients. Further studies are required to test if routine supplementation with ergo or cholecalciferol is safe and effective in children after renal transplantation.

Background: BPSA is a “benign” form of free prostate-specific antigen (PSA) that is increased in prostate transition zone tissues of men with pathologic benign prostatic hyperplasia (BPH). We developed an immunoassay to determine the concentration of BPSA in the serum of men with BPH. Methods: The BPSA antigen was purified by HPLC, and murine monoclonal antibodies were prepared by standard methods. A fluorogenic ELISA was developed with high specificity for BPSA and no cross-reactivity with other forms of PSA. Results: The BPSA immunoassay had a lower limit of detection of 6 ng/L and a cross-reactivity of <1% with all other clipped and nonclipped forms of PSA. The BPSA antibody was specific for the internal Lys182 cleavage site that characterizes BPSA. Biopsy-negative men with a median total PSA of 4.8 μg/L had a median of 0.22 μg/L BPSA, representing 25% of the free PSA in serum. BPSA ranged from 0% to 60% of the free PSA in serum. BPSA in a cohort of cancer serum also comprised 25% of the free PSA. Control serum from women or men without increased PSA had nondetectable BPSA. Conclusions: BPSA is a significant percentage of the free PSA in BPH serum but not in control serum. The presence of prostate cancer does not alter the relative proportions of BPSA in sera with <10 μg/L PSA. BPSA has a wide distribution of concentrations in the serum and may provide clinical information for the study of men with BPH.

The connectomics community is acquiring volumetric electron microscopy (EM) images of the brain at an unprecedented rate with the aim of mapping out and understanding in detail the physical correlates of information processing in animals. Reliable automatic segmentation is urgently needed for upcoming whole-brain data sets (>100 terabytes (TB) per volume). Manual analysis, despite impressive progress in collaborative annotation1, will not scale to this massive task. We present an algorithm and software package to segment such data sets with low error rates. The software is made available open source in the Supplementary Software and at online repositories, and we also provide precompiled binaries (see Supplementary Note 1).

This doctoral dissertation provides a theoretical examination of amateur craft as a differential practice. Concepts drawn from an inter-disciplinary source base are used to define, characterise and elucidate features of amateur craft practice that have long been presumed superfluous and opposite to valorised ‘professional’ practice. I investigate the attraction, motivation and complexities that lie behind this widespread, yet largely understudied, phenomenon of modern culture. Studies of everyday life, social history, aesthetics, material culture, art criticism and craft theory help conceptualise the position of the amateur, and case studies from the nineteenth and twentieth centuries – including the paint-by-number mania in 1950s USA, suburban chicken keeping, and amateur railway modelling – serve to substantiate the theoretical claims made.The thesis is not comprehensive in its coverage of either a specific craft medium or a particular chronology or geography. Instead the thesis is divided into three thematic chapters: amateur surface intervention, amateur space, and amateur time. These chapters reveal some of the unexpected consequences of subjecting amateur practice to serious study. The examples demonstrate how amateur craft practice is differential within capitalism, dependent on its structures while simultaneously stretching, refracting, and quietly subverting them. As a reprieve or a supplement to an individual’s primary occupation, the constrained freedom of amateur craft practice fulfils an essential role within modern life, providing a temporary moment of autonomous control over labour-power in which the world can be shaped anew.

Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate. How to protect protected areas Protected areas are a key component of tropical forest conservation strategy, but how well are they performing? These authors assemble a large data set from 60 protected areas across the globe, assessing 31 functional groups of species and 21 drivers of environmental change. They find that about half of the reserves are succeeding but half are experiencing substantial losses of biodiversity, driven as much by environmental change outside the reserves as by change within them. To protect what remains of these habitats, the authors suggest that it is vital to establish sizeable buffer zones around reserves, maintain substantial reserve connectivity to other forest areas and promote low-impact land uses near reserves. The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon 1 , 2 , 3 . With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses 4 , 5 , 6 , 7 , 8 , 9 . As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world’s major tropical regions. Our analysis reveals great variation in reserve ‘health’: about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.

Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity. Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

This paper examines the policies, regulations and social controversies surrounding wind farm noise in Ontario. Through a case study of Ontario's wind power regulatory and policy development, we ask how and why noise became a controversy for wind development. The paper examines the nature of the health risks posed by wind turbine noise, provides a detailed description of how Ontario established policies and regulations to address turbine noise, outlines the main controversies in the policy and presents a series of findings based on analysis of the case. In particular, we find that the controversies stem from: (i) different interpretations of global and local risks; (ii) conflation of noise issues with other issues such as property value; (iii) inadequate communication and public engagement; (iv) the loss of local government authority over planning matters; and (v) a growing mistrust in government and industry's ability to effectively and fairly manage the risks of wind turbine noise.