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Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death. Methods Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre and King’s College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality. Results Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR): 1.97 (95% confidence interval (CI): 1.15–3.38)], Asian ethnicity [3.42 (1. 59–7.35)], haematological cancer [2.03 (1.16–3.56)] and a cancer diagnosis for >2–5 years [2.81 (1.41–5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis). Conclusions Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.

Cancer has been one of the biggest silent killers during the 20ths and 21st centuries. In addition to this disease, one of the social factors that promote the chances of having diseases is stress. Recent studies have shown that chronic stress can lead to gastric cancer by activating adrenergic signaling pathway which plays a fundamental role in tumorigenesis. Furthermore, the plasma levels of catecholamines and cortisol elevate in stressful situations. These hormones play a role in inducing progress and metastasis of gastric carcinoma. Stress management has been a vital factor for the people of this century. Although stress is not well-explained clearly, recent studies have shown that people with low income, loads of work, family problems, etc. are of environmentally challenging and present a high possibility of being victim to gastric neoplasms and other diseases.