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Chanarin-Dorfman syndrome (CDS) is a rare medical condition that is inherited in an autosomal recessive pattern. In CDS, a comparative gene identification-58 gene mutation causes the accumulation of triglycerides in neutrophils, which can be observed as vacuoles on a peripheral smear. CDS patients present with a characteristic dermatological finding, ichthyosis, which is a non-bullous white scaling of the skin. Here, we describe a case report of a one-year-old boy who presented to the pediatric outpatient department (OPD) with chief complaints of peeling of the skin and ballooning of the abdomen since birth. Our patient had achieved all the developmental milestones pertaining to his age. Genetic testing was positive for heterozygous alleles in both parents.

BackgroundColorectal Cancer (CRC) emerges as the third most formidable cause of death and disability across Southeast Asia (SEA), East Asia (EA), and Oceania (OC). Previously, the region lacked consistent and comparative burden estimates. This pioneering study provides the first comprehensive evaluation of CRC’s impact over the past thirty years in these regions, including an analysis of the initial two years of the COVID-19 pandemic—an era that posed substantial challenges to the management of non-COVID health issues.MethodsOur study estimated the incidence, prevalence, mortality, Disability-adjusted Life Years (DALYs), and Years Lived with Disability (YLDs) across SEA, EA, and OC from 1990 to 2021. Utilizing global burden of disease methodologies, we stratified our findings by age, sex, year, and geographic location. The outcomes were presented in both absolute counts and age-standardized rates (per 100,000 person-years).ResultsThe total number of prevalent cases increased from 771,663 (95% Uncertainty Interval: 676,409-873,070) in 1990 to 4.2 million (3.5-4.9 million) in 2021. The Average Annual Percentage Change (AAPC) in incidence rose by 4.68%, followed by deaths at 2.97%, and DALYs at 2.43% from 1990-2021 (IDDF2024-ABS-0440 Figure 1). The highest Total Percentage Change (TPC) in incidence was observed in Mauritius at 112%, and the death rate increased by 71%. Taiwan recorded the highest death rate at 21.86 (18.95-24.57) cases per 100,000 in 2021. The highest incidence was attributed to diets low in milk (68,621), followed by diets low in whole grain (64,881), and diets high in red meat (55,476) in 2021 (IDDF2024-ABS-0440 Figure 2). The age group 75+ showed the highest increase in TPC of incidence by 513%, followed by deaths at 293% from 1990-2021 (IDDF2024-ABS-0440 Figure 3).Abstract IDDF2024-ABS-0440 Figure 1Abstract IDDF2024-ABS-0440 Figure 2Abstract IDDF2024-ABS-0440 Figure 3ConclusionsDiets low in milk accounted for 18.66% and low in whole grain for 17.64% of all CRC-related deaths in 2021. It is essential to implement public health awareness through e-health or health education to address modifiable risk factors. Strategic interventions are needed to reduce these risks effectively.

Background and Aim Chronic alcoholism and nutrition play an important role in liver and pancreatic diseases. To compare drinking habits and nutritional data in patients with alcoholic liver disease (ALD) and alcoholic pancreatitis (ALP). Methods Clinical, anthropometric, dietary intake, laboratory, and imaging data were recorded in consecutive patients of ALD and ALP. Results In 150 patients of ALP (n = 76) and ALD (n = 74), the age of starting alcohol consumption (19.03 ± 3.78 vs 18.0 ± 2.59 years) and the mean amount of alcohol consumed per day (165.63 ± 87.99 vs 185.50 ± 113.54 g; P = 0.230) were similar. Patients with ALD consumed alcohol on a daily basis more frequently (90.5 vs 72.3%; P = 0.003) and had a longer duration of alcohol intake (21.6 + 0.2 vs 14.5 + 6.9 years; P < 0.0001) than patients in the ALP group. Binge drinking was more common in patients with ALP compared to patients with ALD (60.5 vs 20.3%); P < 0.0001). Patients with ALP had a lower body mass index (19.9 ± 3.49 vs 22.64 ± 4.88 kg/m2; P = 0.001) and more frequent decrease in mid arm circumference (57.9 vs 44.6%; P = 0.042) and triceps skin fold thickness (67.1 vs 52.7%; P = 0.072) compared to patients with ALD. Conclusion There was no difference in the age of starting alcohol consumption and mean amount of alcohol consumption per day between the groups. Patients with ALD were more likely to be daily drinkers with a longer duration of alcohol intake. However, binge drinking and malnourishment was more common in the ALP group. We aimed to compare drinking habits and nutrient intake in patients with alcoholic liver disease (ALD) and alcoholic pancreatitis (ALP). There was no difference in the age of starting alcohol consumption and mean amount of alcohol consumption between the groups. Patients with ALD were more likely to be daily drinkers (90.5 vs. 72.3%; P = 0.003) with a longer duration of alcohol intake (21.6 + 0.2 vs 14.5 + 6.9 years). However, binge drinking (60.5 vs 20.3%); P < 0.0001) and malnourishment (BMI—19.9 ± 3.49 vs. 22.64 ± 4.88 kg/m2; P = 0.001) were more common in the ALP group.

COVID-19 has profoundly impacted people's physical, emotional, and financial well-being. Vaccinations were developed to combat the physical health threats of the virus. However, studies suggest that the vaccinations themselves have contributed to anxiety, stress, and worry, leading to a lower rate of inoculation. Understanding and managing a pandemic requires a deep dive into how people are emotionally affected during such times and how they respond to public health initiatives like vaccines. To this end, a framework was proposed that analyzes behavioral responses from the general public's uninhibited discourses over one and a half years across five countries. The framework is built on the principle of knowledge differentiation, recognizing the mined emotional responses as basic knowledge nuggets (level zero of abstraction). Higher levels of abstraction are achieved by differentiating these basic knowledge nuggets. Simple, intuitive, and novel metrics for knowledge modelling was proposed, which consolidate and model the discovered knowledge, making it ready for practical use. From this framework, useful and insightful inferences have been drawn. The study analyzed 16 vaccines introduced in five countries over three different periods. Covaxin, initially available in Brazil and India, emerged as the most successful positive emotional influencer. AstraZeneca, first available in Brazil and the USA, was second, followed by Covishield in India and CoronaVac in Brazil. The framework also identified vaccines with the highest emotional intensities and top emotional ranks during the study periods. The insights from this proposed framework can guide government organizations in making informed decisions about the success of immunization drives and effectively curbing a pandemic. This approach highlights the importance of understanding emotional responses to enhance public health initiatives and pandemic management.