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The study and analysis of malacofauna from cores of bottom sediments and cores of the Azov spits showed the nature of the change during the transition from the Ancient Azovian to the New Azovian layers and the uneven distribution of communities in time and space. Shell material from littoral malacocenosis and shallow-water banks is the main component for the formation of spits. Based on a series of cores up to 25 m thick from the Dolgaya Spit, it is shown that its formation began about 2500 years ago, and carbonate material reflects the history of the development of the benthic fauna of the sea.

An Erratum to this paper has been published: https://doi.org/10.1134/S1028334X23050161

The results of comprehensive study of borehole sections drilled on the coastal spits of Taganrog Bay of the Sea of Azov and bottom sediment columns recovered in the water area are presented. A detailed analysis of the former malacological communities, an important participant in the sedimentary process, has made it possible to trace changes in their habitat conditions in the Holocene. Based on determining the absolute age ( 14 C) from the valves of mollusk shells buried in-situ, it is shown that at the beginning of the Phanagorian regression, in the area of the distal part of Dolgaya spit, there was a sea reservoir with a Sea of Azov–Black Sea complex of index species. By the results of palynological analysis, the changes in the natural conditions of the Azov region over the past nine thousand years are reconstructed and arid and humid climatic phases are identified.

The contemporary distribution of macrozoobenthic communities of the Yeisk estuary is considered. Four basic types of communities are classified. Communities with domination of Tubificidae (Oligochaeta) occupy the greatest part of the estuary. Communities with domination of Amphipoda (Corophiidae) remained only in the northeast part of the reservoir. The unstable hydrological conditions and the absence of clearly expressed horohalinicum lead to mixing of Ponto-Caspian and Azov-Black Sea faunas in the Yeisk estuary.

Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of different GBM cell populations remain unclear. Here, we found that the compositions of ribosomes of GBM cells in the tumour core and edge differ due to alternative RNA splicing. The acidic pH in the core switches before messenger RNA splicing of the ribosomal gene RPL22L1 towards the RPL22L1b isoform. This allows cells to survive acidosis, increases stemness and correlates with worse patient outcome. Mechanistically, RPL22L1b promotes RNA splicing by interacting with lncMALAT1 in the nucleus and inducing its degradation. Contrarily, in the tumour edge region, RPL22L1a interacts with ribosomes in the cytoplasm and upregulates the translation of multiple messenger RNAs including TP53. We found that the RPL22L1 isoform switch is regulated by SRSF4 and identified a compound that inhibits this process and decreases tumour growth. These findings demonstrate how distinct GBM cell populations arise during tumour growth. Targeting this mechanism may decrease GBM heterogeneity and facilitate therapy. Larionova et al. identify a mechanism by which acidification of the tumour microenvironment within the glioblastoma core induces the generation of an alternative splice isoform of ribosomal protein RPL22L1, which regulates cell stemness and increases tumour heterogeneity.

A bstract Charged lepton flavor violation is forbidden in the Standard Model but possible in several new physics scenarios. In many of these models, the radiative decays τ ± → ℓ ± γ ( ℓ = e, μ ) are predicted to have a sizeable probability, making them particularly interesting channels to search at various experiments. An updated search via τ ± → ℓ ± γ using full data of the Belle experiment, corresponding to an integrated luminosity of 988 fb − 1 , is reported for charged lepton flavor violation. No significant excess over background predictions from the Standard Model is observed, and the upper limits on the branching fractions, B ( τ ± → μ ± γ ) ≤ 4 . 2 × 10 − 8 and B ( τ ± → e ± γ ) ≤ 5 . 6 × 10 − 8 , are set at 90% confidence level.

The low predictability of the effects of autologous platelet-rich plasma (PRP) in regenerative therapy for patients with type 1 and type 2 diabetes mellitus (DM) underscores the need for further research assessing the reparative effects of PRP based on the type of DM. The aim of this study was to evaluate the regenerative potential of PRP from young donors (30–40 years old) with DM1 and DM2 in vitro, specifically its effects on human dermal fibroblast cell culture. The in vitro effects of PRP from patients with type 1 and type 2 DM were investigated using a culture of human dermal fibroblasts (hTERT-HDFa) to evaluate metabolic activity, migration, proliferation of the cells, and their ability to release growth factors and exosomes. The study of the biological effects of PRP from donors with DM on hTERT-HDFa revealed a decrease in proliferative effects, an increase in prooxidant action, and toxic influences of PRP from patients, characterized by reduced metabolic activity and cell viability in culture, along with an increase in the percentage of necrosis. These effects were most pronounced in type 1 DM. The secretory response of hTERT-HDFa upon stimulation with PRP varied depending on the type of DM. Correlations indicated the differing significance of PAI-1, TGFB-1, PDGF, VEGF, and IL-6 in assessing the reparative potential across different types of DM.