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"Kramer, A"
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Tuttle concise Indonesian dictionary : Indonesian-English, English-Indonesian
This volume contains over 20,000 words and expressions, carefully selected to cover all important aspects of life and commerce in Indonesia. In addition, extensive information on Indonesian grammar and Indonesian pronunciation are included.
Book
Power and Connection: Imperial Histories of the United States in the World
Kramer argues for the utility of the \"imperial\" in placing the history of the US in a global context. Combining historiographic review, critique, and prescription, he suggests three necessary pursuits that the imperial facilitates: the study of the ways power operates through long-distance linkages; the mutual and uneven transformation of societies through these connections; and comparisons between large-scale systems of power and their histories. He proceeds to assess the prospects and limits of the imperial in US historiography across a variety of themes, offering along the way a copious review and analysis of a range of historical literature, both older and more recent.
Journal Article
تركيا المتغيرة تبحث عن ثوب جديد : التحدي الماثل أمام كل من أوروبا والولايات المتحدة
يقدم الكتاب سردا تفصيليا لجملة هذه التغيرات مع تسليط الضوء على تأثيرها في نظرة البلد إلى السياسة الخارجية ويركز على التغييرات الداخلية التي تمنع تركيا من استغلال فرصها الجديدة على صعيد السياسة الخارجية بصورة كاملة واهتمامه على بيئة البلاد السياسية الجديدة على الصعيدين الخارجي والأمني بما فيها المناورات الجيوسياسية حول موارد الطاقة في حوض بحر قزوين والخارطة الاستراتيجية المتغيرة للشرق الأوسط ثم يقدم تحليلا لمجموعة السياسات الأمريكية والأوربية تجاه تركيا وليعرض أفكارا من شأنها أن تساعد على تحسين إدارة هذه العلاقات.
Book
Mitochondrial protein interaction landscape of SS-31
Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, cancer, neurodegenerative diseases, and the general aging process. Therapeutics that restore healthy mitochondrial function hold promise for treatment of these conditions. The synthetic tetrapeptide, elamipretide (SS-31), improves mitochondrial function, but mechanistic details of its pharmacological effects are unknown. Reportedly, SS-31 primarily interacts with the phospholipid cardiolipin in the inner mitochondrial membrane. Here we utilize chemical cross-linking with mass spectrometry to identify protein interactors of SS-31 in mitochondria. The SS-31-interacting proteins, all known cardiolipin binders, fall into two groups, those involved in ATP production through the oxidative phosphorylation pathway and those involved in 2-oxoglutarate metabolic processes. Residues cross-linked with SS-31 reveal binding regions that in many cases, are proximal to cardiolipin–protein interacting regions. These results offer a glimpse of the protein interaction landscape of SS-31 and provide mechanistic insight relevant to SS-31 mitochondrial therapy.
Journal Article
الأساطير السومرية : دراسة في المنجزات الروحية والأدبية في الألف الثالث قبل الميلاد
يتناول كتاب (الأساطير السومرية : دراسة في المنجزات الروحية والأدبية في الألف الثالث قبل الميلاد) والذي قام بتأليفه (صموئيل نوح كريمر) ويقع في حوالي (212) صفحة من القطع المتوسط مستعرضا المحتويات التالية : الفصل الأول : الأساطير السومرية مضمونها وأهميتها، الفصل الثاني : أساطير النشوء، الفصل الثالث : أساطير (كور)، الفصل الرابع : أساطير منوعة .. الطوفان.
BOOK
Metabolic Plasticity in Resting and Thrombin Activated Platelets
Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events. We hypothesized that there is flexibility in the fuels that can be utilized to serve the energetic and metabolic needs for resting and thrombin-dependent platelet aggregation. Using platelets from healthy human donors, we found that there was a rapid thrombin-dependent increase in oxidative phosphorylation which required both glutamine and fatty acids but not glucose. Inhibition of fatty acid oxidation or glutamine utilization could be compensated for by increased glycolytic flux. No evidence for significant mitochondrial dysfunction was found, and ATP/ADP ratios were maintained following the addition of thrombin, indicating the presence of functional and active mitochondrial oxidative phosphorylation during the early stages of aggregation. Interestingly, inhibition of fatty acid oxidation and glutaminolysis alone or in combination is not sufficient to prevent platelet aggregation, due to compensation from glycolysis, whereas inhibitors of glycolysis inhibited aggregation approximately 50%. The combined effects of inhibitors of glycolysis and oxidative phosphorylation were synergistic in the inhibition of platelet aggregation. In summary, both glycolysis and oxidative phosphorylation contribute to platelet metabolism in the resting and activated state, with fatty acid oxidation and to a smaller extent glutaminolysis contributing to the increased energy demand.
Journal Article
Stoichiometry constrains microbial response to root exudation- insights from a model and a field experiment in a temperate forest
Plant roots release a wide range of chemicals into soils. This process, termed root exudation, is thought to increase the activity of microbes and the exoenzymes they synthesize, leading to accelerated rates of carbon (C) mineralization and nutrient cycling in rhizosphere soils relative to bulk soils. The nitrogen (N) content of microbial biomass and exoenzymes may introduce a stoichiometric constraint on the ability of microbes to effectively utilize the root exudates, particularly if the exudates are rich in C but low in N. We combined a theoretical model of microbial activity with an exudation experiment to test the hypothesis that the ability of soil microbes to utilize root exudates for the synthesis of additional biomass and exoenzymes is constrained by N availability. The field experiment simulated exudation by automatically pumping solutions of chemicals often found in root exudates (\"exudate mimics\") containing C alone or C in combination with N (C : N ratio of 10) through microlysimeter \"root simulators\" into intact forest soils in two 50-day experiments. The delivery of C-only exudate mimics increased microbial respiration but had no effect on microbial biomass or exoenzyme activities. By contrast, experimental delivery of exudate mimics containing both C and N significantly increased microbial respiration, microbial biomass, and the activity of exoenzymes that decompose low molecular weight components of soil organic matter (SOM, e.g., cellulose, amino sugars), while decreasing the activity of exoenzymes that degrade high molecular weight SOM (e.g., polyphenols, lignin). The modeling results were consistent with the experiments; simulated delivery of C-only exudates induced microbial N-limitation, which constrained the synthesis of microbial biomass and exoenzymes. Exuding N as well as C alleviated this stoichiometric constraint in the model, allowing for increased exoenzyme production, the priming of decomposition, and a net release of N from SOM (i.e., mineralization). The quantity of N released from SOM in the model simulations was, under most circumstances, in excess of the N in the exudate pulse, suggesting that the exudation of N-containing compounds can be a viable strategy for plant-N acquisition via a priming effect. The experimental and modeling results were consistent with our hypothesis that N-containing compounds in root exudates affect rhizosphere processes by providing substrates for the synthesis of N-rich microbial biomass and exoenzymes. This study suggests that exudate stoichiometry is an important and underappreciated driver of microbial activity in rhizosphere soils.
Journal Article
Nickelodeon pandemonium! 1, Channeling fun
Collects eleven stories featuring the stars of Nickelodeon, including Sanjay and Craig, Pig, Boat, Banana, and Cricket, and Fee and Foo.
Book
Aerobic exercise effects on cognitive and neural plasticity in older adults
Older adults frequently experience cognitive deficits accompanied by deterioration of brain tissue and function in a number of cortical and subcortical regions. Because of this common finding and the increasing ageing population in many countries throughout the world, there is an increasing interest in assessing the possibility that partaking in or changing certain lifestyles could prevent or reverse cognitive and neural decay in older adults. [...]it remains unknown whether longer durations of exercise produce longer-lasting and stronger effects than a 6 month intervention.
Journal Article